检索结果-南通市图书馆

Patients admitted in the intensive care unit after solid organ or bone marrow transplantation:Retrospective cohort study

引用

World Journal of Transplantation 2025年第1期15卷 95-104页

作者： Ana Vujaklija Brajkovic Iva Kosuta Lucija Batur Sara Sundalic Marijana Medic Andro Vujevic Luka Bielen Jaksa Babel department of internal medicine University Hospital Centre ZagrebZagreb 10000Croatia School of medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Solid organ transplantation(SOT)and hematopoietic stem cell transplantation(HSCT)revolutionized the survival and quality of life of patients with malignant diseases,various immunologic,and metabolic disorders or those associated with a significant impairment in a patient's quality of *** To investigate admission causes and treatment outcomes of patients after SOT or HSCT treated in a medical intensive care unit(ICU).METHODS We conducted a single-center,retrospective epidemiological study in the medical ICU at the University Hospital Centre Zagreb,Croatia covering the period from January 1,2018 to December 31,*** The study included 91 patients with either SOT[28 patients(30.8%)]or HSCT[63 patients(69.2%)].The median age was 56(43.2-64.7)years,and 60.4%of the patients were *** with SOT had more comorbidities than patients after HSCT[χ^(2)(5,n=141)=18.513,P<0.001].Sepsis and septic shock were the most frequent reasons for admission,followed by acute respiratory insufficiency in patients following *** rate significantly differed between SOT and HSCT[χ^(2)(1,n=91)=21.767,P<0.001].ICU survival was 57%in the SOT and 12.7%in the HSCT *** need for mechanical ventilation[χ^(2)(1,n=91)=17.081,P<0.001]and vasopressor therapy[χ^(2)(1,n=91)=36.803,P<0.001]was associated with *** necessity for acute renal replacement therapy did not influence patients'survival[χ^(2)(1,n=91)=0.376,P=0.54].In the subgroup of patients with infection,90%had septic shock,and the majority had positive microbiological samples,mostly Gram-negative *** ICU survival of patients with sepsis/septic shock cumulatively was 15%.The survival of SOT patients with sepsis/shock was 45%.CONCLUSION Patients with SOT or HSCT are frequently admitted to the ICU due to sepsis and septic *** advancements in critical care,the mortality rate of patients with refractory septic shock and multiorgan failure in this patient population is extremely hig

关键词： Liver transplantation Kidney transplantation Hematopoietic stem cell transplantation Critical care Sepsis Septic shock Mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Increased risk of colorectal cancer in young males with higher cardiovascular risk:A nationwide population-based cohort study

引用

World Journal of Gastrointestinal Oncology 2025年第3期17卷 69-80页

作者： Ji Hyun Song Su-Yeon Choi Young Sun Kim Sun Young Yang Kyung-Do Han internal medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 06236South Korea internal medicine Seoul National University HospitalSeoul National University College of MedicineSeoul 06236South Korea department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Although the link between cardiovascular disease(CVD)and various cancers is well-established,the relationship between CVD risk and colorectal cancer(CRC)remains *** To elucidate the relationship between CVD risk scores and CRC *** In this population-based cohort study,participants from the 2009 National Health Checkup were followed-up until *** cardiovascular(CV)risk score was calculated as the sum of risk factors(age,family history of coronary artery disease,hypertension,smoking status,and high-density lipoprotein levels)with high-density lipoprotein(≥60 mg/dL)reducing the risk score by *** primary outcome was incidence of newly diagnosed *** Among 2526628 individuals,30329 developed CRC during a mean follow-up of 10.1 *** by CV risk scores(0,1,2,and≥3).CRC risk increased with higher CV risk scores after adjusting for covariates[(hazard ratio=1.155,95%confidence interval:1.107-1.205)in risk score≥3,P<0.001].This association individuals not using ***,even in participants without diabetes,a higher CV risk was associated with an increased CRC *** Increased CV risk scores were significantly associated with higher CRC risk,especially among males,younger populations,and non-statin ***,males with a higher CV risk score,even at a younger age,are recommended to control their risk factors and undergo individualized CRC screening.

关键词： Colorectal cancer Cardiovascular disease Cohort study Age Gender

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitochondrial mt12361A>G increased risk of metabolic dysfunctionassociated steatotic liver disease among non-diabetes

引用

World Journal of Gastroenterology 2025年第10期31卷 38-50页

作者： Ming-Ying Lu Yu-Ju Wei Chih-Wen Wang Po-Cheng Liang Ming-Lun Yeh Yi-Shan Tsai Pei-Chien Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yi-Hung Lin Tyng-Yuan Jang Ming-Yen Hsieh Zu-Yau Lin Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming-Lung Yu Hepatitis center and Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of medicine and Doctoral Program of Clinical and Experimental medicine College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver DiseaseNational Sun Yat-sen UniversityKaohsiung 80708Taiwan

BACKGROUND Insulin resistance,lipotoxicity,and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD).Mitochondrial dysfunction impairs oxidative phosphorylation and increases reactive oxygen species production,leading to steatohepatitis and hepatic *** intelligence(AI)is a potent tool for disease diagnosis and risk *** To investigate mitochondrial DNA polymorphisms in susceptibility to MASLD and establish an AI model for MASLD *** Multiplex polymerase chain reaction was performed to comprehensively genotype 82 mitochondrial DNA variants in the screening dataset(n=264).The significant mitochondrial single nucleotide polymorphism was validated in an independent cohort(n=1046)using the Taqman®allelic discrimination *** forest,eXtreme gradient boosting,Naive Bayes,and logistic regression algorithms were employed to construct an AI model for *** In the screening dataset,only mt12361A>G was significantly associated with ***12361A>G showed borderline significance in MASLD patients with 2-3 cardiometabolic traits compared with controls in the validation dataset(P=0.055).Multivariate regression analysis confirmed that mt12361A>G was an independent risk factor of MASLD[odds ratio(OR)=2.54,95%confidence interval(CI):1.19-5.43,P=0.016].The genetic effect of mt12361A>G was significant in the non-diabetic group but not in the diabetic ***12361G carriers had a 2.8-fold higher risk than A carriers in the non-diabetic group(OR=2.80,95%CI:1.22-6.41,P=0.015).By integrating clinical features and mt12361A>G,random forest outperformed other algorithms in detecting MASLD[training area under the receiver operating characteristic curve(AUROC)=1.000,validation AUROC=0.876].CONCLUSION The mt12361A>G variant increased the severity of MASLD in non-diabetic *** supports the screening and management of MASLD in primary care settings.

关键词： Metabolic dysfunction-associated steatotic liver disease Mitochondrial DNA Artificial intelligence Machine learning Algorithm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Red cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease

引用

World Journal of Gastroenterology 2025年第3期31卷 1-10页

作者： Ming-Hua Zheng Amedeo Lonardo department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina department of internal medicine Azienda Ospedaliero-Universitaria of Modena(2023)Modena 41126Italy

Prognostication of compensated advanced chronic liver disease(cACLD)is of paramount importance for the physician-and-patient communication and for rational clinical *** paper published by Dallio et al reports on red cell distribution width(RDW)/platelet ratio(RPR)as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease(MASLD)-related *** from other biomarkers and algorithms,RPR is inexpensive and widely available,based on parameters which are included in a complete blood *** is computed on the grounds of two different items,one of which,RDW,mirrors the host’s response to a variety of disease stimuli and is *** second parameter involved in RPR,platelet count,is more specific and has been used in the hepatological clinic to discriminate cirrhotic from non-cirrhotic chronic liver disease for *** disease is the primary cause of mortality among MASLD subjects,followed by extra-hepatic cancers and liver-related ***,MASLD biomarkers should be validated not only in terms of liver-related events but also in the prediction of major adverse cardiovascular events and cardiovascular mortality and extra-hepatic *** sized multi-ethnic confirmatory investigation is required to define the role and significance of RPR in the stratification of MASLD-cACLD.

关键词： Cirrhosis Liver fibrosis Natural course Prognostication Stratification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in neoadjuvant therapy for resectable intrahepatic cholangiocarcinoma: An invited commentary

引用

Oncology and Translational medicine 2025年第1期11卷 1-4页

作者： Ruyu Han Peipei Song Wei Tang Tianqiang Song Lu Chen Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerNational Key Laboratory of Druggability Evaluation and Systematic Translational MedicineTianjin Key Laboratory of Digestive CancerTianjin’s Clinical Research Center for CancerTianjinChina department of Hepatobiliary Cancer Liver Cancer Research CenterTianjin Medical University Cancer Institute and HospitalTianjinChina National center for Global Health and medicine TokyoJapan

Intrahepatic cholangiocarcinoma(ICC)poses a significant threat to human health owing to its high malignancy rate and poor ***-gery is the most effective treatment option for ***,the prognosis remains unfavorable even after surgical ***,neo-adjuvant therapy has emerged as a potential treatment option for patients with *** therapy can improve patient prognosis by reducing the tumor size and eliminating tiny lesions that are not visible to the naked ***,specific treatment options for neoad-juvant therapy are *** review summarizes the studies on neoadjuvant therapy for ICC in the last decade,including chemotherapy,radiotherapy,interventional therapy,targeted therapy,and immunotherapy,with the aim of providing suggestions for the selection of clinical treatment options for patients with *** reports suggest that chemotherapy is the most effective neoadjuvant treatment ***-ever,radiotherapy and interventional therapies require further investigation to obtain conclusive *** targeted thera-pies and immunotherapies have been studied less extensively,several ongoing clinical trials are investigating these promising approaches.

关键词： Intrahepatic cholangiocarcinoma Resectable Neoadjuvant therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Procalcitonin and presepsin for detecting bacterial infection and spontaneous bacterial peritonitis in cirrhosis:A systematic review and meta-analysis

引用

World Journal of Gastroenterology 2025年第6期31卷 89-103页

作者： Salisa Wejnaruemarn Paweena Susantitaphong Piyawat Komolmit Sombat Treeprasertsuk Kessarin Thanapirom Division of Gastroenterology Department of MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Division of Nephrology Department of MedicineFaculty of MedicineKing Chulalongkorn Memorial HospitalChulalongkorn UniversityBangkok 10330Thailand center of Excellence for Metabolic Bone disease in CKD Patients Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand center of Excellence in Hepatic Fibrosis and Cirrhosis Chulalongkorn UniversityBangkok 10330Thailand Excellence center in Liver diseases King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand

BACKGROUND Diagnosing bacterial infections(BI)in patients with cirrhosis can be challenging because of unclear symptoms,low diagnostic accuracy,and lengthy culture testing *** biomarkers have been studied,including serum procal-citonin(PCT)and ***,the diagnostic performance of these markers remains unclear,requiring further informative studies to ascertain their diagnostic *** To evaluate the pooled diagnostic performance of PCT and presepsin in detecting BI among patients with *** Bacterial infections(BI)commonly occur in patients with cirrhosis,resulting in poor outcomes,including the development of cirrhotic complications,septic shock,acute-on-chronic liver failure(ACLF),multiple organ failures,and mortality[1,2].BI is observed in 20%-30%of hospitalized patients,with and without ACLF[3].Patients with cirrhosis are susceptible to BI because of internal and external *** major internal factors are changes in gut microbial composition and function,bacterial translocation,and cirrhosis-associated immune dysfunction syndrome[4,5].External factors include alcohol use,proton-pump inhibitor use,frailty,readmission,and invasive *** bacterial peritonitis(SBP),urinary tract infection,pneumonia,and primary bacteremia are the common BIs in hospit-alized patients with cirrhosis[6].Early diagnosis and adequate empirical antibiotic therapy are two critical factors that improve the prognosis of BI in patients with ***,early detection of BI in cirrhosis is challenging due to subtle clinical signs and symptoms,low sensitivity and specificity of systemic inflammatory response syndrome criteria,and low sensitivity of bacterial ***,effective biomarkers need to be identified for the early detection of *** biomarkers have been evaluated,but their efficacy in detecting BI is ***(PCT)is a precursor of the hormone calcitonin,which is secreted by parafollicular cells o

关键词： cirrhosis diagnosis detecting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding

引用

Chinese Chemical Letters 2025年第2期36卷 57-68页

作者： Liangliang Jia Ye Hong Xinyu He Ying Zhou Liujiao Ren Hongjun Du Bin Zhao Bin Qin Zhe Yang Di Gao The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University center of digestive Endoscopy Shaanxi Provincial Cancer Hospital department of Ophthalmology Xijing Hospital department of Epidemiology Shaanxi Provincial Cancer Hospital department of Gastroenterology Second Affiliated Hospital Xi'an Jiaotong University Research Institute of Xi'an Jiaotong University

Innovative anti-cancer therapies that activate the immune system show promise in combating cancers resistant to conventional treatments. Photodynamic therapy (PDT) is one such treatment, which not only directly eliminates tumor cells but also functions as an in situ tumor vaccine by enhancing tumor immunogenicity and triggering anti-tumor immune responses through immunogenic cell death (ICD). However, the effectiveness of PDT in enhancing immune responses is influenced by factors, such as photosensitizers and the tumor microenvironment, particularly hypoxia. Current clinically used PDT heavily relies on oxygen (O2) availability and can be limited by tumor hypoxia. Additionally, the tumor immunosuppressive microenvironment induced by hypoxia affects the anti-tumor immunity of tumor-infiltrating effector T cells. Meanwhile, the immunosuppressive myeloid-lineage cells are recruited to the hypoxic tumor tissue and exhibit higher immunosuppressive capabilities under hypoxia conditions. Consequently,numerous strategies have been developed to modulate tumor hypoxia or to create hypoxia-compatible PDT, aiming to reduce the effects of tumor hypoxia on PDT-driven immunotherapy. This review investigates these strategies, including approaches to alleviate, exploit, and disregard tumor hypoxia within the context of PDT/immunotherapy. It also emphasizes the role of advanced nanomedicine and its benefits in these strategies, while outlining current challenges and future prospects in the field.

关键词： Immunogenic cell death Immunotherapy Nanomedicine Photodynamic therapy Photosensitizers Tumor hypoxia

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Causal Associations between Particulate Matter 2.5(PM_(2.5)),PM_(2.5) Absorbance,and Inflammatory Bowel disease Risk:Evidence from a Two-Sample Mendelian Randomization Study

引用

Biomedical and Environmental Sciences 2025年第2期38卷 167-177页

作者： Xu Zhang Zhimeng Wu Lu Zhang Binglong Xin Xiangrui Wang Xinlan Lu Guifang Lu Mudan Ren Shuixiang He Yarui Li department of Gastroenterology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061ShaanxiChina Shannxi clinical research center of digestive disease(cancer division) Xi’an 710061ShaanxiChina Health Science center Xi’an Jiaotong UniversityXi’an 710061ShaanxiChina department of Urology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China State Key Laboratory of Systems medicine for Cancer Shanghai Cancer InstituteShanghai 200001China Shanxi Institute of Science and Technology Jincheng 048011ShanxiChina

Objective Several epidemiological observational studies have related particulate matter(PM)exposure to Inflammatory bowel disease(IBD),but many confounding factors make it difficult to draw causal links from observational *** objective of this study was to explore the causal association between PM_(2.5)exposure,its absorbance,and *** We assessed the association of PM_(2.5)and PM_(2.5)absorbance with the two primary forms of IBD(Crohn’s disease[CD]and ulcerative colitis[UC])using Mendelian randomization(MR)to explore the causal *** conducted two-sample MR analyses with aggregated data from the UK Biobank genome-wide association ***-nucleotide polymorphisms linked with PM_(2.5)concentrations or their absorbance were used as instrumental variables(IVs).We used inverse variance weighting(IVW)as the primary analytical approach and four other standard methods as supplementary analyses for quality *** The results of MR demonstrated that PM_(2.5)had an adverse influence on UC risk(odds ratio[OR]=1.010;95%confidence interval[CI]=1.001–1.019,P=0.020).Meanwhile,the results of IVW showed that PM_(2.5)absorbance was also causally associated with UC(OR=1.012;95%CI=1.004–1.019,P=0.002).We observed no causal relationship between PM_(2.5),PM_(2.5)absorbance,and *** results of sensitivity analysis indicated the absence of heterogeneity or pleiotropy,ensuring the reliability of MR *** Based on two-sample MR analyses,there are potential positive causal relationships between PM_(2.5),PM_(2.5)absorbance,and UC.

关键词： Particulate matter 2.5 Inflammatory bowel disease Mendelian randomization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modeling post-operative survival in patients with gallbladder cancer resections:The road to improved patient care?

引用

World Journal of Gastrointestinal Surgery 2025年第2期17卷 312-315页

作者： Nancy R Mayer Eli Daniel Ehrenpreis department of internal medicine Riverside Medical CenterKankakeeIL 60901United States department of internal medicine Lutheran General HospitalPark RidgeIL 60068United States

In this letter,we discuss the article by Li et al published in the World Journal of Gastrointestinal *** cancer is a rare but fatal cancer that is often detected unexpectedly and at an advanced stage following routine *** the prognosis is poor,curative resections often combined with postoperative chemotherapy and/or radiation therapy can improve ***,targeted patient selection for the appropriate therapeutic approach is critical to minimize unnecessary *** advanced statistical techniques,the authors developed a nomogram with the potential to predict survival after gallbladder cancer resection,identifying factors associated with long-and shortterm *** tool could improve patient selection for surgery and postoperative *** this letter,we provide background on survival nomograms including an in-depth discussion of statistical methods employed in this study,the use of nomograms in other forms of cancer,limitations to the model,and directions for future research.

关键词： Gallbladder cancer Nomograms Prognostic indicators Mathematical modeling Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrating artificial intelligence into radiological cancer imaging: from diagnosis and treatment response to prognosis

引用

Cancer Biology & medicine 2025年第1期22卷 6-13页

作者： Sunyi Zheng Xiaonan Cui Zhaoxiang Ye Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin's Clinical Research Center for Cancer State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine Tianjin Key Laboratory of Digestive Cancer Key Laboratory of Cancer Prevention and Therapy Department of Radiology

Cancer poses a serious threat to human health worldwide and is a leading cause of death1. The analysis of radiological imaging is crucial in early detection, accurate diagnosis, effective treatment planning, and ongoing monitoring of patients with cancer. However, several challenges impede the effectiveness of cancer imaging analysis in clinical practice.

关键词： intelligence prognosis imaging cancer from artificial diagnosis integrating into radiological

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：