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Metabolic dysfunction-associated steatotic liver disease-associated fibrosis and cardiac dysfunction in patients with type 2 diabetes

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World Journal of Cardiology 2024年第10期16卷 580-594页

作者： Simona Cernea Danusia Onișor Andrada Larisa Roiban Theodora Benedek Nora Rat Department M3/Internal Medicine I George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540142Romania diabetes Nutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VII George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureşTârgu Mureş540142Romania Gastroenterology Clinic MureșCounty Clinical HospitalTârgu Mureş540103Romania diabetes compartment MediașMunicipal HospitalMediaș551030Romania Doctoral School of Medicine and Pharmacy George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department M3/Internal Medicine VI George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540142Romania Department of Cardiology Emergency County Clinical HospitalTârgu Mureş540136Romania

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in the presence of liver fibrosis,increases the risk of cardiovascular morbidity and mortality,but the nature of the cardio-hepatic interaction in the context type 2 diabetes mellitus(T2DM)is not fully *** To evaluate the changes in cardiac morphology and function in patients with T2DM and MASLD-associated liver *** T2DM patients with MASLD underwent a medical evaluation that included an assessment of lifestyle,anthropometric measurements,vital signs,an extensive laboratory panel,and a standard *** fibrosis was evaluated using two scores[Fibrosis-4(FIB4)and Non-alcoholic fatty liver disease-Fibrosis Score(NFS)],and subjects were classified as having advanced fibrosis,no fibrosis,or an indeterminate *** correlations between structural and functional cardiac parameters and markers of liver fibrosis were evaluated through bivariate and multiple regression *** significance was set at P<*** Data from 267 T2DM-MASLD subjects with complete assessment was *** with scores indicating advanced fibrosis exhibited higher interventricular septum and left ventricular(LV)posterior wall thickness,atrial diameters,LV end-systolic volume,LV mass index(LVMi),and epicardial adipose tissue thickness(EATT).Their mean ejection fraction(EF)was significantly lower(49.19%±5.62%vs 50.87%±5.14%vs 52.00%±3.25%;P=0.003),and a smaller proportion had an EF≥50%(49.40%vs 68.90%vs 84.21%;P=0.0017).Their total and mid LV wall motion score indexes were higher(P<0.05).Additionally,they had markers of diastolic dysfunction,with a higher E/e’ratio[9.64±4.10 vs 8.44(2.43-26.33)vs 7.35±2.62;P=0.026],and over 70%had lateral e’values<10 cm/second,though without significant differences between *** multiple regression analyses,FIB4 correlated with left atrium diameter(LAD;β=0.044;P<0.05),and NFS with both LAD(β=0.039;P<0.05)and right

关键词： Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes mellitus Liver fibrosis Cardiac dysfunction Sex-hormone binding protein

Is Surgery a Good Choice for Patients over 100 Years with Hip Fracture?

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Case Reports in Clinical Medicine 2015年第8期4卷 280-283页

作者： Bogdan Deleanu Radu Prejbeanu Dinu Vermesan Lucian Honcea Cristina Nuta Vlad Predescu Orthopedics and Traumatology Clinic Emergency Clinical County Hospital Timisoara Romania Victor Babes University of Medicine and Pharmacy Timisoara Romania Orthopedics Functional Recovery compartment Emergency Clinical County Hospital Timisoara Romania St. Pantelimon Emergency Hospital Carol Davila University of Medicine and Pharmacy Bucharest Romania

Introduction: Elderly patients represent a difficult category of surgical candidates for orthopedic surgery because they have multiple associated diseases and a high degree of osteoporosis. Presentation of Case: We present the case of a 103 years old woman with a pertrohanteric hip fracture treated successfully using a 135° dynamic hip screw. Discussion: There are many discussions about this kind of patients regarding postoperative complications, duration of hospitalization, stage of recovery and the patient’s status at discharge. Conclusion: We conclude that surgery may benefit patients who are over 100 year-old.

关键词： Osteoporosis Age Rehabilitation Complications

Body Roundness Index Is Significantly Associated with Prehypertension and Hypertension in Nonobese Chinese Subjects

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Biomedical and Environmental Sciences 2019年第11期32卷 854-859页

作者： LIU Xing Zhen QIAN Jian Dong LI Hui Hua WANG Li Jun WU Min Kui WANG Qian PAN Ting Yu LIU Lian Yong ZOU Da Jin Hangzhou Aeronautical Sanatorium of Chinese Air Force Hangzhou 310007ZhejiangChina Department of Cardiology Jingjiang People's HospitalJingjiang 214500JiangsuChina Departmemt of Endocrinology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China Department of Endocrinology The Third Affiliated Hospital of Soochow UniversityChangzhou 213000JiangsuChina Department of Endocriology Punan Hospital of Pudong New DistrictShanghai 200125China Thyroid Disease Research Center Tenth People’s Hospital of Tongji UniversityShanghai 200072China Obesity and diabetes Center of Naval Medical University Shanghai 2004BBChina

Prehypertension and hypertension have been considered significant public health issues worldwide[1].Disproportionate body fat distribution(excess fat stored in the liver and visceral compartment)is a well-established risk factor for prehypertension/hypertension[2].However,the most commonly used anthropometric indicators,such as body mass index(BMI)and waist circumference(WC)。

关键词： BMI Body Roundness Index Is Significantly Associated with Prehypertension and Hypertension in Nonobese Chinese Subjects

Alternative approaches to target Myc for cancer treatment

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1157-1170页

作者： Chen Wang Jiawei Zhang Jie Yin Yichao Gan Senlin Xu Ying Gu Wendong Huang Division of Medical Genomics and Cancer Institute(Key Laboratory of Cancer Prevention and Intervention Ministry of Education)the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Institute of Genetics Zhejiang University and Department of GeneticsSchool of MedicineZhejiang UniversityHangzhouChina Zhejiang Provincial Key Lab of Genetic and Developmental Disorder HangzhouZhejiang 310058China Molecular and Cellular Biology of Cancer Program&Department of diabetes Complications and Metabolism Beckman Research InstituteCity of HopeDuarteCAUSA Irell&Manella Graduate School of Biological Sciences Beckman Research InstituteCity of HopeDuarteCAUSA Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China

The Myc proto-oncogene family consists of three members,C-MYC,MYCN,and MYCL,which encodes the transcription factor c-Myc(hereafter Myc),N-Myc,and L-Myc,*** protein orchestrates diverse physiological processes,including cell proliferation,differentiation,survival,and *** modulates about 15%of the global transcriptome,and its deregulation rewires the cellular signaling modules inside tumor cells,thereby acquiring selective *** deregulation of Myc occurs in>70%of human cancers,and is related to poor prognosis;hence,hyperactivated Myc oncoprotein has been proposed as an ideal drug target for ***,no specific drug is currently available to directly target Myc,mainly because of its"undruggable"properties:lack of enzymatic pocket for conventional small molecules to bind;inaccessibility for antibody due to the predominant nucleus localization of *** the topic of targeting Myc has actively been reviewed in the past decades,exciting new progresses in this field keep *** this review,after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer,we also peer into the promising future of utilizing macropinocytosis to deliver peptides like Omomyc or antibody agents to intracellular compartment for cancer treatment.

关键词： treatment utilizing thereby