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The Efficacy and Safety of Drug-Coated Balloons in the Treatment of Acute Myocardial Infarction

World Journal of Cardiovascular Diseases 2024年第1期14卷 1-9页

作者： Mingliang Du Hui Hui Department of Coronary Heart Disease Dalian Municipal Central Hospital Dalian China

The incidence of acute myocardial infarction (AMI) is increasing year by year, which seriously endangers human health around the world. The preferred treatment strategy for AMI patients is the use of drug-eluting stents (DES), as there is ample evidence to suggest that stent implantation can reduce major adverse cardiovascular events (MACEs). With the application of drug-coated balloons (DCBs) and the enhancement of the concept of interventional without implantation, the question is whether DCBs can be safely and effectively used in patients with AMI? The purpose of this study was to investigate the safety and effectiveness of DCBs in the treatment of AMI. A retrospective review of clinical data was conducted on 55 AMI patients who underwent primary percutaneous coronary intervention (PCI) from January 2020 to December 2021. Of these patients, 25 were treated with DCBs and 30 were treated with DESs. Optical coherence tomography (OCT) was used to measure the minimum lumen diameter, lumen stenosis, and coronary artery dissection before and after surgery, and angina pectoris attacks and various MACEs were recorded at 1, 6, and 12 months after surgery. The results showed that there were no significant differences in clinical baseline data between the two groups. However, the minimum lumen diameter of the DCB group immediately after the operation was smaller than that of the DES group, and the stenosis degree of the lumen in the DCB group was higher than that in the DES group. The incidence of coronary artery dissection in the DCB group was significantly higher than that in the DES group, but the majority of them were type B. At 1, 6, and 12 months after treatment, there was no significant difference in the occurrence of MACEs between the two groups. In conclusion, DCBs is a safe and effective treatment for AMI. However, the incidence of coronary artery dissection in DCB patients is higher than that in DES patients, but the majority of them are type B. .

关键词： Myocardial Infarction Drug-Coated Balloon Drug-Eluting Stents

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Analysis of lymph node metastasis and survival prognosis in early gastric cancer patients: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1637-1646页

作者： Dong-Yuan Liu Jin-Jin Hu Yong-Quan Zhou Ai-Rong Tan Department of General Surgery The 971st Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Chest Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Oncology Qingdao Municipal HospitalQingdao 266000Shandong ProvinceChina

BACKGROUND Early gastric cancer(EGC)is a common malignant tumor of the digestive system,and its lymph node metastasis and survival prognosis have been *** retrospectively analyzing the clinical data of EGC patients,we can better under-stand the status of lymph node metastasis and its impact on survival and *** To evaluate the prognosis of EGC patients and the factors that affect lymph node METHODS The clinicopathological data of 1011 patients with EGC admitted to our hospital between January 2015 and December 2023 were collected in a retrospective cohort *** were 561 males and 450 *** mean age was 58±11 *** patient underwent radical *** status of lymph node metastasis in each group was determined according to the pathological examination results of surgical *** outcomes were as follows:(1)Lymph node metastasis in EGC patients;(2)Analysis of influencing factors of lymph node metastasis in EGC;and(3)Analysis of prognostic factors in patients with *** distributed measurement data are expressed as mean±SD,and a t test was used for comparisons between *** data are expressed as absolute numbers or percentages,and the chi-square test was used for comparisons between *** data were compared using a nonparametric rank sum test.A log-rank test and a logistic regression model were used for univariate analysis.A logistic stepwise regression model and a Cox stepwise regression model were used for multivariate *** Kaplan-Meier method was used to calculate the survival rate and construct survival curves.A log-rank test was used for survival *** Analysis of influencing factors of lymph node metastasis in *** results of the multifactor analysis showed that tumor length and diameter,tumor site,tumor invasion depth,vascular thrombus,and tumor differentiation degree were independent influencing factors for lymph node metastasis in patients with EGC(odds ratios=1.80,1.49,2.6

关键词： Gastric neoplasms Lymph node metastasis Prognosis Influencing factor Retrospective study

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Systematic Review: Psychological Changes in Women Diagnosed with Breast Cancer

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1096-1109页

作者： Hamilton Dos Prazeres Tavares Augusta Josefina Marques Sachiteque Silvina Georgina Tavares Fernando Mango Saiengue Alberto Capoco Sachiteque Cezaltina Nanduva Kahuli Job Monteiro Tavares Daniel Pires Capingana Suelma Beatriz Marques Prata Tavares Department of Gynecology and Obstetrics General Hospital of Huambo Huambo Angola Faculty of Medicine University Jos Eduardo dos Santos Huambo Huambo Angola Department of Gynecology and Obstetrics Hospital Municipal of Huambo Huambo Angola Department of Gynecology and Obstetrics Hospital Municipal of Bailundo Huambo Angola Department of Internal Medicine General Hospital of Huambo Huambo Angola Department of Gynecology and Obstetrics Hospital Municipal of Cala Huambo Angola

Breast cancer is considered one of the most common cancers among women, accounting for 25% - 29% of new cases worldwide each year. The diagnosis, living with the disease, as well as the different treatments can have important impacts on the Psychological and mental health of patients. Objective: To investigate the psychological aspects that women with breast cancer develop or may develop. Methodology: A systematic review using the PRISMA methodology was used. Results: 11 articles that met the inclusion and exclusion criteria were analysed. The largest flow of publications in relation to the effects of the patient with cancer, were carried out between the years 2000 and 2023. Conclusions: Psychological disorders (depression, anxiety, stress) are part of the lives of women diagnosed with breast cancer, and their prevalence varies from one woman to another.

关键词： Anxiety Depression Psychosis Sadness Cancer

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Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen Feng Yin Yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang Ao Shen Xi-Yong Yu The Fifth Affiliated hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

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Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation

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World Journal of Psychiatry 2024年第8期14卷 1216-1223页

作者： Xin Jin Chun-Yun Xu Jin-Feng Fei Yu Fang Cong-Hao Sun Department of Psychiatry Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the *** several treatment methods exist,their efficacy is *** recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric *** To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with *** This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third municipal hospital,affiliated with Huzhou University,between January 2020 and December *** received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment *** observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to ***,the observa-tion group showed a more pronounced decrease than the control *** T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 ***,the increase was particularly more substantial in the observation group than in the control *** patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the ***,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to th

关键词： Alzheimer's disease Non-persistentθshort array fast pulse mode Depression Clinical efficacy Dementia Repetitive transcranial magnetic stimulation

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Endoscopic submucosal dissection vs transanal endoscopic surgery for rectal tumors: A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第1期12卷 95-106页

作者： Long-Wu Huang Ying Zhong Department of Gastroenterology Huzhou Third Municipal Hospitalthe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)and transanal endoscopic submucosal dissection(TES)are widely employed surgical ***,the comparative efficacy and safety of both remain *** To comprehensively analyze and discern differences in surgical outcomes between ESD and *** We conducted a systematic search of the electronic databases PubMed,Embase,Cochrane Central Register of Controlled Trials,Scopus,and CINAHL from inception till August *** analyzed outcomes including recurrence rate,en bloc resection,R0 resection rate,perforation rate,procedure length,and hospital stay length applying a random-effects inverse-variance *** assessed publication bias by conducting an Egger’s regression test and sensitivity *** We pooled data from 11 studies involving 1013 *** found similar recurrence rates,with a pooled odds ratio of 0.545(95%CI:0.176-1.687).En bloc resection,R0 resection,and perforation rate values were also similar for both ESD and *** pooled analysis for procedure length indicated a mean difference of-4.19 min(95%CI:-22.73 to 14.35),and the hospital stay was on average shorter for ESDs by about 0.789 days(95%CI:-1.671 to 0.093).CONCLUSION Both ESD and TES displayed similar efficacy and safety profiles across multiple *** findings show that individualized patient and surgeon preferences,alongside specific clinical contexts,can be considered when selecting between these two techniques.

关键词： Endoscopic submucosal dissection Transanal endoscopic submucosal dissection Meta-analysis Surgical outcomes Rectal tumours

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Synthesis and potential osteogenic applications of Wnt3a-loaded ZIF-8 nanoparticles

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Chinese Chemical Letters 2024年第3期35卷 399-405页

作者： Hengfei Wang Song Chen Zihan He Junyu Chen Zhou Zhu Qianbing Wan Jian Wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical UniversityChongqing 400016China

The Wnt signaling pathway plays a critical role in bone homeostasis,and the related protein therapy strategies have been reported to have great potential in osseointegration;however,they face formidable challenges such as complex external environments and unavoidable protein *** this work,we report a novel approach combining the synthesis of metal–organic frameworks(MOFs)and protein encapsulation in a one-pot process based on zeolitic imidazolate framework-8(ZIF-8)and Wnt3a protein,with improved biomechanical behavior and enhanced protein biological *** combination was designed to enhance the Wnt3a protein function through the improved chemical stability provided by the ZIF-8 ***,the zinc ions contained in the ZIF-8 crystals induced bone homeostasis,further favoring the *** results showed that the Wnt3a protein-loaded ZIF-8 crystals served as efficient drug delivery vehicles to promote osteogenesis,preventing protein *** particular,Wnt3a-loaded ZIF-8 nanoparticles(Wnt3a@ZIF-8 NPs)had higher efficacy on bone marrow mesenchymal stem cells(BMSCs)than ZIF-8 NPs or Wnt3a proteins,contributing to the osteogenesis through ZIF-8 crystals and intracellular Wnt3a proteins released from Wnt3a@ZIF-8 ***,polymerase chain reaction(PCR)analysis showed that the osteogenic pathways were ***,the present one-pot process can open up new avenues to develop signaling protein-delivery systems for applications in protein therapy strategies.

关键词： Metal–organic frameworks Nanoparticle Drug release Osteogenesis Bone defects

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Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li Dong-Yuan Liu Jing Leng Xue-Mei Tao Hui-Qin Wu Yan-Peng Zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

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The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

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Neuroscience Bulletin 2024年第5期40卷 621-634页

作者： Xiuxiu Liu Ying Zhang Yanming Zhao Qian Zhang Feng Han Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases Ministry of EducationNanjing211166China International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjing211166China Institute of Brain Science The Affiliated Brain Hospital of Nanjing Medical UniversityNanjing211166China Gusu School Nanjing Medical UniversitySuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou210019China

Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous *** pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous *** current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting *** this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic *** early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic *** this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关键词： Epileptogenesis Neurovascular unit Molecular mechanisms Drug targets

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Compare clinical efficacy and safety of neoadjuvant therapy and neoadjuvant chemoradiotherapy for locally advanced rectal cancer: Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1845-1856页

作者： Ying Wang Yan Yang Qi-Qi Liu Shao-Zhao Wang Department of Anus Intestinal Surgery Feicheng People’s HospitalFeicheng 271600Shandong ProvinceChina Department of Gastroenterology Qingdao Hospital of University of Health and Rehabilitation Sciences(Qingdao Municipal Hospital)Qingdao 266011Shandong ProvinceChina Department of Gastrointestinal Surgery Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Anorectal Words Central Hospital Affiliated Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND To compare the efficacy and safety of total neoadjuvant therapy(TNT)and neoadjuvant chemoradiotherapy(nCRT)in the treatment of middle and low locally advanced rectal *** study will systematically collect and integrate studies to evaluate the ability of these two treatments to improve tumor shrinkage rates,surgical resection rates,tumor-free survival,and severe adverse *** To provide clinicians and patients with more reliable treatment options to optimize treatment outcomes and quality of life for patients with locally advanced rectal cancer by comparing the advantages and disadvantages of the two treatment *** A full search of all clinical studies on the effectiveness and safety of TNT and nCRT for treating locally advanced rectal cancer identified in Chinese(CNKI,Wanfang,China Biomedical Literature Database)and English(PubMed,Embase)databases was *** system assessors independently screened the studies according to the inclusion and exclusion *** evaluation and RESULTS Finally,14 studies were included,six of which were randomized controlled studies.A total of 3797 patients were included,including 1865 in the TNT group and 1932 in the nCRT *** two sets of baseline data were *** results of the meta-analysis showed that the pCR rate[odds ratio(OR)=1.57,95%confidence interval(CI):1.30-1.90,P<0.00001],T stage degradation rate(OR=2.16,95%CI:1.63-2.57,P<0.00001),and R0 resection rate(OR=1.42,95%CI:1.09-1.85,P=0.009)were significantly greater in the nCRT group than in the nCRT *** was no significant difference in the incidence of grade 3/4 acute toxicity or perioperative complications between the two *** 5-year OS[hazard ratio(HR)=0.84,95%CI:0.69-1.02,P=0.08]and DFS(HR=0.94,95%CI:0.03-1.39,P=0.74)of the TNT group were similar to those of the nCRT *** TNT has greater clinical efficacy and safety than nCRT in the treatment of locally advanced rectal cancer.

关键词： Neoadjuvant therapy Neoadjuvant chemoradiotherapy Advanced rectal cancer Clinical efficacy Meta-analysis

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