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GCARDTI:Drug–target interaction prediction based on a hybrid mechanism in drug SELFIES

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Quantitative Biology 2024年第2期12卷 141-154页

作者： Yinfei Feng Yuanyuan Zhang Zengqian Deng Mimi Xiong School of Information and Control Engineering Qingdao University of TechnologyQingdaoChina Qingdao municipal hospital QingdaoChina

The prediction of the interaction between a drug and a target is the most critical issue in the fields of drug development and ***,there are still two challenges in current deep learning research:(i)the structural information of drug molecules is not fully explored in most drug target studies,and the previous drug SMILES does not correspond well to effective drug molecules and(ii)exploration of the potential relationship between drugs and targets is in need of *** this work,we use a new and better representation of the effective molecular graph structure,*** propose a hybrid mechanism framework based on convolutional neural network and graph attention network to capture multi-view feature information of drug and target molecular structures,and we aim to enhance the ability to capture interaction sites between a drug and a *** this study,our experiments using two different datasets show that the GCARDTI model outperforms a variety of different model algorithms on different *** also demonstrate the accuracy of our model through two case studies.

关键词： drug–target interaction drug SELFIES hybrid mechanism random forest

Increased N6-methyladenosine is related to the promotion of the methyltransferase METTL14 in ovarian aging

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Genes & Diseases 2024年第3期11卷 151-154页

作者： Chunfeng Qian Zhenxing Liu Yonghong Qian Jie Ding Rulei Chen Han Su Minghong Shen Hong Li Boxian Huang State Key Laboratory of Reproductive Medicine and Offspring Health Suzhou Affliated Hospital of Nanjing Medicine and Offspring HealthSuzhou Affiliated Hospital of Nanjing Medical UniversitySuzhouMunicipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China Department of Gynecology Affliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China Department of Pathology Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu School of Nanjing Medical UniversitySuzhouJiangsu 215002China

The ovary is a vital female reproductive organ that functions to produce oocyte gametes and cyclically expressed sex hormones to maintain reproductive capacity and hormone *** aging,characterized by declines in follicle quantity and oocyte quality,leads to premature ovarian failure,premature ovarian insufficiency,or diminished ovarian reserve,thus contributing to female *** gene-expression signatures from RNA transcriptional level and post-transcriptional regulation are relative to oocyte quality and reproductive age.

关键词： promotion signature maintain

IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

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Oncology Research 2024年第9期32卷 1453-1465页

作者： ZIYONG LIU TAO MA JINFANG LI WEI REN ZHIXIN ZHANG Department of Cardiothoracic Surgery 970th Hospital of the People’s Liberation ArmyWeihai264209China Department of Cardiac Ultrasound Weihai Municipal HospitalWeihai264200China

Background:Interleukin 13 receptor subunit alpha 2(IL13RA2)plays an essential role in the progression of many ***,the role of IL13RA2 in infantile haemangioma(IH)is still *** and Methods:IL13RA2 expression in IH tissues was analyzed using western blot,qRT-PCR,and *** role of IL13RA2 in haemangioma-derived endothelial cells(HemECs)was determined following knockdown or overexpression of IL13RA2 using CCK-8,colony formation,apoptosis,wound healing,tubule formation,Transwell,and western ***:IL13RA2 expression was upregulated in IH ***13RA2 overexpression promoted proliferation,migration,and invasion of HemECs and induced glycolysis,which was confirmed with a glycolysis ***,IL13RA2 interacted withβ-catenin and activated the Wnt/β-catenin pathway in HemECs,which were involved in the above-mentioned effects of ***:These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.

关键词： Infantile haemangioma IL13RA2 Glycolysis Wnt/β-catenin pathway

Treatment Efficacy and Safety of Bortezomib Combined with Dexamethasone and Lenalidomide Chemotherapy Regimen for Multiple Myeloma

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Journal of Clinical and Nursing Research 2024年第5期8卷 7-12页

作者： Changyong Yuan Na Cui Shumei Liu Department of Hematology Dezhou HospitalQilu HospitalShandong UniversityDezhou 253000Shandong ProvinceChina School of Clinical Medicine Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

Objective:To analyze the effect of bortezomib combined with dexamethasone and lenalidomide in the treatment of multiple ***:60 cases of multiple myeloma patients admitted to our hospital from January 2022 to December 2023 were selected randomly,with 30 cases in each *** combined with dexamethasone was administered in the control group,and bortezomib combined with dexamethasone and lenalidomide was given to the observation group,and the treatment effect was ***:After treatment,CD^(3+)and CD^(4+)of the observation group were higher than that of the control group,CD^(8+)was lower than that of the control group,and the total treatment efficiency was higher,which was statistically significant(P0.05).Conclusion:Bortezomib combined with dexamethasone and lenalidomide is effective in the treatment of multiple myeloma as it regulates the immune function and is safe,thus it can be promoted in clinical practice.

关键词： Multiple myeloma Bortezomib Dexamethasone Lenalidomide Efficacy Safety

Effects of Acupotomy on Immobilization-Induced Gastrocnemius Contracture and Fibrosis in Rats via Wnt/β-Catenin Signaling

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Chinese Journal of Integrative Medicine 2024年第7期30卷 633-642页

作者： HU Rui PAN Jun-kang LI Jia-hui ZHANG Han LI Shao-rong ZHANG Yi School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China Acupuncture Department Kunming Municipal Hospital of Traditional Chinese MedicineKunming650500China

Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling *** Thirty Wistar rats were randomly divided into 5 groups(n=6)by a random number table,including control,immobilization,passive stretching,acupotomy,and acupotomy 3 weeks(3-w)*** rat model of gastrocnemius contracture was established by immobilizing the right hind limb in plantar flexion for 4 *** in the passive stretching group received passive stretching at gastrocnemius,a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive *** in the acupotomy and acupotomy 3-w groups received acupotomy once and combined with passive stretching at gastrocnemius a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive ***,rats in the acupotomy 3-w group were allowed to walk freely for 3 weeks after 10-day *** treatment,range of motion(ROM),gait analysis[i.e.,paw area,stance/swing and maximum ratio of paw area to paw area duration(Max dA/dT)],gastrocnemius wet weight and the ratio of muscle wet weight to body weight(MWW/BW)were *** morphometric and muscle fiber cross-sectional area(CSA)were assessed by hematoxylin-eosin ***-related mRNA expressions(i.e.,Wnt 1,β-catenin,axin-2,α-smooth muscle actin,fibronectin,and types I and III collagen)were measured using real-time quantitative polymerase chain *** 1,β-catenin and fibronectin concentrations were measured by enzyme-linked immunosorbent *** I and III collagen in the perimysium and endomysium were analyzed using *** Compared with the control group,ROM,gait function,muscle weight,MWW/BW and CSA were significantly decreased in the immobilization group(all P<0.01),while protein levels of types I and III collagen,Wnt 1,β-catenin,fibronectin and mRNA levels of fibrosis-related genes were obviously increased(all P<0.01).Tr

关键词： acupotomy immobilization muscle contracture muscle fibrosis Wnt/β-catenin signaling

Trends in the Incidence of High-Risk Newborns Based on a New Conceptual Framework-Beijing municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 767-771页

作者： Yongxian Zhao Zhaoxia Jia Lei Wang Qingqing Wu Moning Guo Dong Han Lili Huang Junhua Wang Di Zhang Zhao Wang Minghui Wu Beijing Obstetrics and Gynecology hospital Capital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Beijing municipal Health Big Data and Policy Research Center BeijingChina

Summary What is already known on this topic?A new conceptual term,small and vulnerable newborns(SVN),bringing preterm birth,small for gestational age(SGA),or low birth weight(LBW)together is being advocated for assessing whether a child is at high *** is added by this report?According to the new conceptual term,the increasing incidence of high-risk newborns(from 9.82%to 10.96%)has been observed among 2,005,408 newborns over the period from 2013 to 2022,which is higher than using any of the three definitions of *** age≥35,primiparity,and multiple births are high risks for *** are the implications for public health practice?The new conceptual framework should be used to better assess the number of high-risk *** should be paid to multiple births to prevent preterm-related *** reduce term newborns who are SGA,we need to be concerned not only with multiple pregnancies but also with first-time mothers.

关键词： Beijing bringing mother

Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

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World Journal of Gastroenterology 2024年第35期30卷 3985-3995页

作者： Xin Zhang Wei-Wei Jin Hong-Gang Wang Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Nutrition Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Gastroenterology Taizhou Municipal HospitalTaizhou 524333Zhejiang ProvinceChina

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient *** To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with *** Patients diagnosed with IBS between January 2022 and January 2023 were selected for the *** individuals undergoing routine check-ups during the same period served as the control *** were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS *** IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy *** gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine ***,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel *** The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

关键词： Gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis Relationship study

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury

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Biomedical and Environmental Sciences 2024年第8期37卷 936-942页

作者： Huirong Jing Wenyan Jia Xuewen Tang Affiliated Banan hospital of Chongqing Medical University Chongqing 401320China Chongqing Traditional Chinese Medicine hospital Chongqing 400021China Qingdao municipal hospital Qingdao 266000ShandongChina Healthy Management&Physical Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Intestinal ischemia/reperfusion(II/R)is a severe clinical circumstance which is frequently apparent in situations including midgut volvulus,superior mesenteric vessels closure and hemorrhagic ***/R not only brings about severe intestinal local damage but also leads to remote organs injury including lung,liver etc[1].Lung injury is the most common and severe complications which manifested as pulmonary susceptibility,respiratory dysfunction,and even acute respiratory distress syndrome(ARDS)[2].

关键词： Lung respiratory organs

Pre-operative enhanced magnetic resonance imaging combined with clinical features predict early recurrence of hepatocellular carcinoma after radical resection

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1192-1203页

作者： Jian-Ping Chen Ri-Hui Yang Tian-Hui Zhang Li-An Liao Yu-Ting Guan Hai-Yang Dai Department of Intervention Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Meizhou People’s HospitalMeizhou 514031Guangdong ProvinceChina Department of Medical Imaging Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND Indentifying predictive factors for postoperative recurrence of hepatocellular carcinoma(HCC)has great significance for patient *** To explore the value of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)combined with clinical features in predicting early recurrence of HCC after *** A total of 161 patients with pathologically confirmed HCC were *** patients were divided into early recurrence and non-early recurrence group based on the follow-up *** clinical,laboratory,pathological results and Gd-EOB-DTPA enhanced MRI imaging features were *** Of 161 patients,73 had early recurrence and 88 were had non-early *** analysis showed that patient age,gender,serum alpha-fetoprotein level,the Barcelona Clinic Liver Cancer stage,China liver cancer(CNLC)stage,microvascular invasion(MVI),pathological satellite focus,tumor size,tumor number,tumor boundary,tumor capsule,intratumoral necrosis,portal vein tumor thrombus,large vessel invasion,nonperipheral washout,peritumoral enhancement,hepatobiliary phase(HBP)/tumor signal intensity(SI)/peritumoral SI,HBP peritumoral low signal and peritumoral delay enhancement were significantly associated with early recurrence of HCC after *** logistic regression analysis showed that patient age,MVI,CNLC stage,tumor boundary and large vessel invasion were independent predictive *** data validation indicated that the area under the curve of the combined predictors was 0.861,suggesting that multivariate logistic regression was a reasonable predictive model for early recurrence of *** Gd-EOB-DTPA enhanced MRI combined with clinical features would help predicting the early recurrence of HCC after operation.

关键词： Hepatocellular carcinoma Enhanced magnetic resonance imaging Microvascular invasion Hepatobiliary phase Recurrence