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Two-Body Hadronic Weak Decays of Bottomed Hadrons

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Chinese Physics Letters 2024年第2期41卷 26-35页

作者：张颖何广朝叶全兴严大程华俊王倩 Key Laboratory of Atomic and Subatomic Structure and Quantum Control(MOE) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of MatterInstitute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China School of Mathematics and Physics Changzhou UniversityChangzhou 213164China Southern center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The structure of light diquarks plays a crucial role in formation of exotic hadrons beyond the conventional quark model, especially with regard to the line shapes of bottomed hadron decays. We study the two-body hadronic weak decays of bottomed baryons and bottomed mesons to probe the light diquark structure and to pin down the quark–quark correlations in the diquark picture. It is found that the light diquark does not favor a compact structure. For instance, the isoscalar diquark [ud] in Λ_(b)^(0) can be easily split and rearranged to form ■via the color-suppressed transition. This provides a hint that the hidden charm pentaquark states produced in Λ_(b)^(0) decays could be the ■chadronic molecular candidates. This quantitative study resolves the apparent conflicts between the production mechanism and the molecular nature of these P_(c) states observed in experiment.

关键词： transition structure quark

A reactive oxygen species burst causes haploid induction in maize

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molecular Plant 2022年第6期15卷 943-955页

作者： Chenglin Jiang Ju Sun Rui Li Shijuan Yan Wei Chen Liang Guo Guochen Qin Pengcheng Wang Cheng Luo Wenjie Huang Qinghua Zhang Alisdair R.Fernie David Jackson Xiang Li Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640China Shanghai center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China Department of molecular physiology Max-Planck-Institute of Molecular Plant PhysiologyAm Mühlenberg 114476 Potsdam-GolmGermany Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA State Key Laboratory of Plant Genomics and National center for Plant Gene research Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Hubei Hongshan Laboratory Wuhan 430070China

Haploid induction (HI) is an important tool in crop breeding. Phospholipase A1 (ZmPLA1)/NOT LIKE DAD (NLD)/MATRILINEAL (MTL) is a key gene controlling HI in maize;however, the underlying molecular mechanism remains unclear. In this study, to dissect why loss of ZmPLA1 function could mediate HI we performed a comprehensive multiple omics analysis of zmpla1 mutant anthers by integrating transcriptome, metabolome, quantitative proteome, and protein modification data. Functional classes of significantly enriched or differentially abundant molecular entities were found to be associated with the oxidative stress response, suggesting that a reactive oxygen species (ROS) burst plays a critical role in HI. In support of this, we further discovered that a simple chemical treatment of pollen with ROS reagents could lead to HI. Moreover, we identified ZmPOD65, which encodes a sperm-specific peroxidase, as a new gene controlling HI. Taken together, our study revealed a likely mechanism of HI, discovered a new gene controlling HI, and created a new method for HI in maize, indicating the importance of ROS balance in maintaining normal reproduction and providing a potential route to accelerate crop breeding.

关键词： haploid induction single-cell sequencing maize ROS peroxidase

Dinitrogen extrusion from diazene in organic synthesis

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Chinese Chemical Letters 2022年第8期33卷 3695-3700页

作者： Chunngai Hui Shiping Wang Chunfa Xu Institute of Pharmaceutical Science and Technology College of ChemistryFuzhou UniversityFuzhou 350108China National Engineering research center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350108China Max Planck Institute of molecular physiology Department of Chemical BiologyDortmund 44227Germany

Radical-mediated reactions have many advantages in the construction of complex molecular scaffolds by forging chemical bonds of high ***,including 1,1-diazenes and 1,2-diazenes,can generate biradical species via nitrogen extrusion under thermal or photochemical *** superior reactivity of the generated biradical enables various types of synthetic transformations with excellent chemoselectivity and has been applied to the complex natural products *** this mini-review,the modes of reaction are summarized and discussed,namely ring contraction via nitrogen deletion,homo or heterodimerization,trimethylenemethane(TMM)-diyl *** of these classes of reactions in complex natural product synthesis are *** but not least,the current state,future directions,and opportunities for dinitrogen extrusion reaction from diazenes are highlighted and discussed.

关键词： Diazene Biradical Dimerization Ring contraction Natural product synthesis

Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult

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Science China(Life Sciences) 2023年第5期66卷 1067-1078页

作者： Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchResearch Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular DiseasesChinese Academy of Medical SciencesBeijing 100191China Department of physiology and Pathophysiology Cardiovascular Research CenterSchool of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061China Department of Internal Medicine Frankel Cardiovascular CenterUniversity of MichiganAnn ArborMI48109USA Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100087China

Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully *** present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic *** bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 *** serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest *** the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 *** was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO ***,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 *** with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and *** conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult.

关键词： galectin-3 interleukin-18 β-adrenergic receptor macrophage inflammation fibrosis

Arabidopsis F-BOX STRESS INDUCED 4 is required to repress excessive divisions in stomatal development

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Journal of Integrative Plant Biology 2022年第1期64卷 56-72页

作者： Yi Li Shan Xue Qixiumei He Junxue Wang Lingling Zhu Junjie Zou Jie Zhang Chaoran Zuo Zhibin Fan Junling Yue Chunxia Zhang Kezhen Yang Jie Le Key Laboratory of Plant molecular physiology CAS Center for Excellence in Molecular Plant SciencesInstitute of BotanyThe Chinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China The Institute of Scientific and Technical Information of China Beijing 100038China Wenbo School Jinan 250100China Biotechnology research Institute Chinese Academy of Agricultural SciencesBeijing 100081China

During the terminal stage of stomatal development,the R2 R3-MYB transcription factors FOUR LIPS(FLP/MYB124) and MYB88 limit guard mother cell division by repressing the transcript levels of multiple cell-cycle genes. In Arabidopsis thaliana possessing the weak allele flp-1, an extra guard mother cell division results in two stomata having direct ***, we identified an ethylmethane sulfonatemutagenized mutant, flp-1 xs01 c, which exhibited more severe defects than flp-1 alone, producing gianttumor-like cell clusters. XS01 C, encoding F-BOX STRESS-INDUCED 4(FBS4), is preferentially expressed in epidermal stomatal precursor *** FBS4 rescued the defective stomatal phenotypes of flp-1 xs01 c and flp-1 mutants. The deletion or substitution of a conserved residue(Proline166) within the F-box domain of FBS4 abolished or reduced, respectively, its interaction with Arabidopsis Skp1-Like1(ASK1), the core subunit of the Skp1/Cullin/F-box E3 ubiquitin ligase complex. Furthermore, the FBS4 protein physically interacted with CYCA2;3 and induced its degradation through the ubiquitin-26 S proteasome pathway. Thus, in addition to the known transcriptional pathway, the terminal symmetric division in stomatal development is ensured at the post-translational level, such as through the ubiquitination of target proteins recognized by the stomatal lineage F-box protein FBS4.

关键词： cell division cell cycle F-BOX stomatal development ubiquitination

Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome

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Protein & Cell 2022年第3期13卷 203-219页

作者： Chaojuan Yang Yonglu Tian Feng Su Yangzhen Wang Mengna Liu Hongyi Wang Yaxuan Cui Peijiang Yuan Xiangning Li Anan Li Hui Gong Qingming Luo Desheng Zhu Peng Cao Yunbo Liu Xunli Wang Min-hua Luo Fuqiang Xu Wei Xiong Liecheng Wang Xiang-yao Li Chen Zhang State Key Laboratory of Membrane Biology PKU-IDG/McGovern Institute for Brain ResearchSchool of Life SciencesPeking UniversityBeijing 100871China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Life Sciences Tsinghua UniversityBeijing 100084China Britton Chance center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences(CAS)Beijing 100101China Institute of Laboratory Animal Science Peking Union Medical College/Chinese Academy of Medical ScienceBeijing 100021China Laboratory Animal center Fujian University of Tradition Chinese MedicineFuzhou 350122China State Key Laboratory of Virology CAS Center for Excellence in Brain Science andIntelligence TechnologyWuhan Institute of VirologyCASWuhan 430071China center for brain Science Key Laboratory of Magnetic Resonance in Biological Systems and State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Institute of Physics and MathematicsCASCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesWuhan 430071China Department of physiology Anhui Medical UniversityHefei 230032China Department of physiology Institute of Neuroscience and Collaborative Innovation Center for Brain ScienceSchool of MedicineZhejiang UniversityHangzhou 310058China

Many people affected by fragile X syndrome(FXS)and autism spectrum disorders have sensory processing deficits,such as hypersensitivity to auditory,tactile,and visual *** FXS in humans,loss of Fmr1 in rodents also cause sensory,behavioral,and cognitive ***,the neural mechanisms underlying sensory impairment,especially vision impairment,remain *** remains elusive whether the visual processing deficits originate from corrupted inputs,impaired perception in the primary sensory cortex,or altered integration in the higher cortex,and there is no effective *** this study,we used a genetic knockout mouse model(Fmr1^(KO)),in vivo imaging,and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex(V1).Specifically,Fmr1^(KO) mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity *** abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 *** effects were ameliorated by the acute application of GABAA receptor activators,which enhanced the activity of inhibitory neurons,or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult ***,V1 plays an important role in the visual abnormalities of Fmr1^(KO) mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients.

关键词： autism spectrum disorder calcium imaging fragile X syndrome primary visual cortex visual hypersensitivity

Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer,from bench to bed

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Science China(Life Sciences) 2023年第12期66卷 2773-2785页

作者： Zhengyang Guo Xiao Huo Xianlong Li Changtao Jiang Lixiang Xue center of Basic Medical research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Department of physiology and Pathophysiology School of Basic Medical SciencesPeking University and the Key Laboratory of Molecular Cardiovascular Science(Peking University)Ministry of EducationBeijing 100191China Peking University Third Hospital Cancer center Department of Radiation OncologyPeking University Third HospitalBeijing 100191China

Stearoyl-CoA desaturase 1(SCD1)converts saturated fatty acids to monounsaturated fatty *** expression of SCD1 is increased in many cancers,and the altered expression contributes to the proliferation,invasion,stemness and chemoresistance of cancer ***,more evidence has been reported to further support the important role of SCD1 in cancer,and the regulation mechanism of SCD1 has also been *** factors are involved in the regulation of SCD1,including metabolism,diet,tumor microenvironment,transcription factors,non-coding RNAs,and epigenetics ***,SCD1 is found to be involved in regulating ferroptosis *** on these findings,SCD1 has been considered as a potential target for cancer ***,the resistance of SCD1 inhibition may occur in certain tumors due to tumor heterogeneity and metabolic *** review summarizes recent advances in the regulation and function of SCD1 in tumors and discusses the potential clinical application of targeting SCD1 for cancer treatment.

关键词： cancer metabolism SCD1 fatty acid lipid metabolism ferroptosis ER stress drug resistance cancer therapy

Cavefish mount a rapid and sustained regenerative response following skeletal muscle injury

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Zoological research 2023年第4期44卷 776-778页

作者： Luke Olsen Huzaifa Hassan Fanning Xia Sarah Keaton Nicolas Rohner Stowers Institute for Medical research Kansas CityMO 64110USA Department of molecular&Integrative physiology University of Kansas Medical CenterKansas CityKS 66160USA Department of Biological Sciences DePaul UniversityChicagoIL 60614USA

Dear Editor,Physical injury and tissue damage are prevalent throughout the animal kingdom,with the ability to regenerate quickly and efficiently providing a selective *** most vertebrates,skeletal muscle possesses a remarkable ability to regenerate,making it a valuable model for investigating the cellular processes underpinning tissue *** damage,skeletal muscle mounts a complex regenerative cascade centered around dedicated muscle stem cells,i.e.,satellite *** satellite cells are,in turn,regulated by both resident and infiltrating innate immune cells of myeloid lineage,which play a crucial role in activating and guiding the transition of satellite cells towards maturation(Chen et al.,2020;Tidball,2017;Tidball&Villalta,2010).While critical for muscle regeneration,the innate immune system is energetically costly,resulting in many species decreasing immune investment under nutrient-limited *** this reduced investment results in a decreased capacity to mount a regenerative response following tissue damage remains ***,we utilized an emerging evolutionary model,the Mexican tetra(Astyanax mexicanus),to investigate the consequences of shifts in immune system investment on skeletal muscle regeneration.

关键词： sustained mount injury

Microbial transformations of bile acids and their receptors in the regulation of metabolic dysfunction-associated steatotic liver disease

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Liver research 2023年第3期7卷 165-176页

作者： Yuhua Gao Jun Lin Chuan Ye Siqi Guo Changtao Jiang Department of physiology and Pathophysiology School of Basic Medical SciencesPeking Universityand the Key Laboratory of Molecular Cardiovascular Science(Peking University)Ministry of EducationBeijingChina center of Basic Medical research Institute of Medical Innovation and ResearchThird HospitalPeking UniversityBeijingChina center for Obesity and Metabolic Disease research School of Basic Medical SciencesPeking UniversityBeijingChina

Bile acids(BAs)play important roles in the digestion of dietary fats and molecular signal transduction,and modulation of the BA composition usually affects the progression of metabolic *** the liver produces primary BAs,the gut microbiota modifies these products into various forms that greatly increase their diversity and biological ***,BAs can regulate their own metabolism and transport as well as other key aspects of metabolic processes via dedicated BA *** of BA transport and homeostasis leads to the progression of liver diseases,including metabolic dysfunction-associated steatotic liver disease(MASLD)and hepatocellular carcinoma(HCC).Here,we summarize the microbial transformations of BAs and their downstream signaling in the development of metabolic diseases and present new insights into novel therapeutic strategies targeting BA pathways that may contribute to these diseases.

关键词： Bile acids(BAs) Gut microbiota Metabolic dysfunction-associated steatotic liver disease(MASLD) Metabolic dysfunction-associated steatohepatitis(MASH) Hepatocellular carcinoma(HCC) Farnesoid X receptor(FXR) G protein-coupled bile acid receptor 1(TGR5)