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In vivo evaluation and mechanism prediction of anti-diabetic foot ulcer based on component analysis of Ruyi Jinhuang powder

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World Journal of Diabetes 2022年第8期13卷 622-642页

作者： Xiu-Yan Li Xiao-Tong Zhang Yi-Cheng Jiao Hang Chi Ting-Ting Xiong Wen-Jing Zhang Mi-Nan Li Yan-Hong Wang Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina College of Pharmacy Harbin Medical UniversityHarbin 150040Heilongjiang ProvinceChina Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese MedicineMinistry of EducationCollege of PharmacyHarbin 150040Heilongjiang ProvinceChina

BACKGROUND Diabetes is a metabolic disease with a high complication *** foot ulcers(DFUs)seriously affect the quality of life of patients.A total of 15%-20%of diabetic patients develop DFUs,which heal with difficulty over a long time and can result in amputation and *** Chinese medicine has a unique effect in the treatment of skin ulcerative *** Jinhuang powder(RHP)is one of the classic prescriptions in traditional Chinese medicine and is widely used in clinical *** To verify the ability of RHP to promote wound healing by electron microscopy analysis in animal models and hematoxylin-eosin(HE)*** effective components of RHP were extracted and identified by gas chromatography-mass spectrometry(GC-MS),and the obtained chemical components were analyzed by network pharmacology methods to predict its therapeutic *** Sprague Dawley rats were injected with streptozotocin to establish the DFU *** staining was used to observe the wound tissue under an electron *** chemical constituents of RHP were extracted first by supercritical fluid extraction and alcohol extraction,and then,GC-MS and ultra-performance liquid chromatography–MS were used to separately identify the chemical *** addition,the"herb-component-target"link was established through the Traditional Chinese Medicine Systems Pharmacology database to obtain the target information,and the molecular docking of important components and key targets was performed in Discovery Studio *** software was used to visualize and analyze the relationship between the chemical composition,targets and Traditional Chinese Medicine *** RHP promoted DFU healing in rats by affecting fibroblasts and nerve cells.A total of 89 chemical components were obtained by *** pharmacological analysis revealed that RHP was associated with 36 targets and 27 pathways in the treatment of DFU,of which the important componen

关键词： Ruyi Jinhuang powder Diabetic foot ulcer Mass spectrometry-chromatography Network pharmacology Hematoxylin-eosin staining Components analysis

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Wind tunnel experimental study on droplet drift reduction by a conical electrostatic nozzle for pesticide spraying

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 87-94页

作者： Zhang Wei Hou Yongrui Liu Xin Lian Qi Fu Xiaoming Zhang Bo Wang Haiyang Wang Yingqian College of Information Technology Heilongjiang Bayi Agricultural UniversityDaqing 163319China College of Engineering Heilongjiang Bayi Agricultural UniversityDaqing 163319China

Droplet drift wastes pesticide,pollutes the environment,and has become one of the focus issues of agricultural crop *** spray technology reduces drift to a certain *** order to investigate the droplet drift pattern of a conical electrostatic nozzle,the droplet drift mass center distance was defined as an experimental index and used to conduct experimental wind tunnel studies on droplet drift.A mathematical model of the droplet drift mass center distance versus electrostatic voltage and wind speed was created via the regression *** test results showed that the electrostatic voltage had an insignificant effect on droplet drift,the wind speed and its interaction with the electrostatic voltage had significant effects on droplet *** the wind speed was less than 3 m/s and stable,the crop adsorbability of a droplet had a dominant effect on the droplet drift;the droplet drift decreased with the increase of electrostatic *** the wind speed exceeded 3 m/s and was stable,the reduced droplet particle size had a dominant effect on droplet drift,where droplet drift increased as the electrostatic voltage *** the wind speed was 0 m/s and the electrostatic voltage was 12 kV,the minimum droplet drift mass center distance was 35.5 mm,which was 56 mm less than that of conventional nozzle droplet ***,a conical electrostatic nozzle is inapplicable for operation in an environment where wind speeds exceed 3 m/*** study provides a reference for optimizing operational parameters of conical electrostatic nozzles and improving the anti-drift capability of droplets.

关键词： pesticide spraying conical electrostatic nozzle droplet drift wind tunnel experimental study electrostatic sprayer

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Comparative Experimental Analysis on Coal Spontaneous Combustion

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Energy Engineering 2022年第5期119卷 2031-2047页

作者： Haitao Wang Yongli Liu Bin Shen Mengxuan Ren Qiyuan Shan School of Safety Engineering Heilongjiang University of Science and TechnologyHarbin150028China School of Resources Engineering Heilongjiang University of TechnologyJixi158100China

The goal of this study was to investigate coal quality features and their relationship to coal spontaneous combustion characteristics in multi-seam coal mines to better predict when coal spontaneous combustion is likely to *** that end,coal samples of various particle sizes were obtained from five coal seams(Nos.6,8,9,12 and 20)in the Shuangyashan City Xin’an Coal *** samples were then respectively heated using a temperature programming system to observe and compare similarities and differences in the sponta-neous combustion process of different particle sizes in response to rising *** experimental results show,that in all five coal seams,the concentration of CO,C_(2)H_(4),and C_(2)H_(6) increased with a certain degree of regularity as a function of rising ***,of these three gasses,only CO and C_(2)H_(4) can be used as indicators to predict coal mine spontaneous *** critical temperature for samples from all five coal seams ranged from 50–85℃,while the dry cracking temperature of coal seams 8 and 12(80–100℃)were lower than those of 6,9,and 20(100–120℃).Furthermore,the production rate of CO,C_(2)H_(4),and C_(2)H_(6) is related to both coal particle size and *** smaller the particle size,the faster the production rate;and the higher the temperature,the more gas that gets *** five coal seems are mainly com-posed of long flame ***,they differ in that the No.12 coal seam contains weak cohesive coal;the No.8 coal seam contains lean and gas coal;and the Nos.6,9,and 20 coal seams contain a certain amount of *** the programmed coal heating,the CO,C_(2)H_(4),and C_(2)H_(6) release trend for the coal seams was No.12>No.8>Nos.6,9,and *** results demonstrate that the presence of weak cohesive coal and anthracite highly influence the concentration of CO,C_(2)H_(4),and C_(2)H_(6) released during coal spontaneous combustion.

关键词： Coal quality analysis spontaneous combustion coal seam index gas

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Detection of Cyanide in Pollution-free Livestock Product Breeding Water by Ion Chromatography

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Asian Agricultural Research 2018年第1期10卷 34-36页

作者： Dongya HUANG Youkai PENG Jinting YAN Supervision Inspection & Testing Center of Agricultural Products Quality and Safety of Xi'an City

In order to verify the accuracy of ion chromatography for cyanide detection,optimization conditions were studied,and comparison was made for the detection results of cyanide between titration and isonicotinic acid pyrazolone spectrophotometry. The results showed that ion chromatography has good linearity and reproducibility,with the recovery rate of 95%-105% and the limit of detection of 0. 001 mg/L. This method is simple,rapid,safe,selective,and suitable for the determination of cyanide in pollution-free livestock product breeding water.

关键词： Ion chromatography Titration Spectrophotometry Pollution-free livestock product breeding water Cyanide

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Development of a reversed dispersive based graphene functionalized with multiwalled carbon nanotubes for detection ofβ2-agonists in pork by high-performance liquid chromatography

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Food Science and Human Wellness 2018年第2期7卷 163-169页

作者： Ying-Wen Qian Xia Hong Cai-Xia Yuan Xin-Kui Zhou Hai-Ning He Dong-Shuai Wang quality and Safety Technological Innovation Service Platform on Circulation of Animal Origin Gansu Institute of Business and TechnologyLanzhouGansu 730010China Key Laboratory of Animal products Safety Analysis and Detection Technology of Gansu Province LanzhouGansu 730010China

A reliable and inexpensive pretreatment procedure in the determination ofβ2-agonists in pork was *** procedure used a nanocomposite of multiwalled carbon nanotubes(CNTs)functionalized with graphene(rGO)as the reversed dispersive *** was analyzed after purification by highperformance liquid chromatography,the extraction time and the properties of the nanocomposite were *** optimized conditions,present method has linear response over concentration range of 0.5–50 ng/mL in pork samples with a satisfactory detection limit close to 0.1 ng/*** precisions of the current method(coefficient of variation)are lower than 5%,while recoveries are more than 98.3%.The nanocomposite exhibited high adsorptivity,long-term storage stability,satisfactory anti-interfering activity and high selectivity toward2-agonists compared with those of rGO and CNTs.

关键词： High-performance liquid chromatography Graphene Multiwalled carbon nanotube Ractopamine Salbutamol

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Prediction of salinity intrusion in the sheltered estuary of Terengganu River in Malaysia using 1-D empirical intrusion model

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Acta Oceanologica Sinica 2017年第5期36卷 57-66页

作者： LEE Hin Lee TANGANG Fredolin GISEN Jacqueline Isabella SURATMAN Saim Research centre for Tropical Climate Change Faculty of Science and TechnologyThe National University of MalaysiaUKM Bangi 43600Malaysia Research centre for Water quality and Environment National Hydraulic Research Institute of MalaysiaMinistry of Natural Resources and EnvironmentSeri Kembangan 43300Malaysia centre for Earth Resources Research and Management Faculty of Civil Engineering and Earth ResourcesThe Universiti Malaysia PahangPahang 26600Malaysia

Generally one dimensional （l-D） empirical salinity intrusion model is limited to natural alluvial estuary. However, this study attempts to investigate its ability to model a sheltered alluvial estuary of the Terengganu River in Malaysia. The constructed breakwater at the mouth of the river shelters the estuary from direct influence of the open sea. The salinity density along the estuary was collected during the wet and dry seasons for scenarios before and after the constructed breakwater. Moreover, the freshwater discharges, tidal elevations and bathymetry data were also measured as model inputs. A good fit was demonstrated between simulated and observed variables, namely salinity distribution and intrusion length for both scenarios. Thus, the results show that 1-D empirical salinity model can be utilized for sheltered estuarine condition at the Terengganu Estuary, but with an appropriate determination of an initial point. Furthermore, it was observed that the salinity intrusion in the study area is largely dependent on the freshwater discharge rather than tidal elevation fluctuations. The scale of the salinity intrusion length in the study area is proportional to the river discharge of the -1/2 power. It was appeared that the two lines of the 1-D empirical salinity model and discharge power based equation fitted well to each other, with the average predicted minimum freshwater discharge of 150 m^3/s is going to be required to maintain acceptable salinity levels during high water slack （HWS） near the water intake station, which is located at 10.63 km from river mouth.

关键词： salinity intrusion sheltered estuary freshwater discharge geometric characteristic empirical model

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Grain refinement of 5A06 aluminum alloy welds caused by tungsten inert gas welding arc characteristics under Ar-He alternating gas supply conditions:a coupled method of water-cooled copper plate test/numerical simulation

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Journal of Iron and Steel Research International 2024年第3期31卷 767-777页

作者： Hong-bin Dai Jian Miao Jia-xin Lin School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040HeilongjiangChina

The welding arc,as a carrier for the conversion of electrical energy to thermal energy,has a direct impact on the quality of welding by its properties and *** the tungsten inert gas(TIG)welding process under the condition of Ar-He alternating gas supply,the arc is alternately converted between Ar arc and He arc with an alternating gas supply cycle,which has obvious arc change *** FLUENT software was used to numerically simulate the characteristics of the TIG arc under the condition of alternating gas supply,and the arc temperature field,arc pressure,electric potential and current density distribution under the condition of alternating gas supply were *** with the real-time data of arc pressure measured by the water-cooled copper plate with holes,it is proved that the TIG arc has obvious dynamic characteristics under the condition of Ar-He alternating gas *** unique dynamic TIG arc acts on the 5A06 aluminum alloy weld,causing the molten pool to stir,resulting in uniform microstructure and grain refinement at the weld,and thereby improving the mechanical properties of the welded joint.

关键词： Alternating gas supply Grain refinement Numerical simulation Tungsten argon arc morphology Microstructure Mechanical property

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Uncertainty Evaluation of Simultaneous determination of Lead, Cadmium and Arsenic in Cosmetics by Inductively Coupled Plasma Mass Spectrometry

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China Detergent & Cosmetics 2020年第1期5卷 68-74页

作者： Cui Xiaojiao Wang Hui Zhou Peng Zhou Tanchun Cao Xiongjie Hu Yuge Changsha Institute for Food and Drug Control National Quality Supervision and Inspection Center of Liquor Products

This study aimed to evaluate the uncertainty of simultaneous determination of lead(Pb),cadmium(Cd)and arsenic(As)in cosmetics by microwave digestion-inductively coupled plasma mass spectrometry(ICP-MS)with ^72Ge,^115In and ^209Bi as internal *** to the method of Safety and Technical Standards for Cosmetics(2015),a mathematical model was established to evaluate the sources and components of uncertainty for the determination of lead,cadmium and arsenic in *** results showed that the uncertainties in the determination of lead,cadmium,and arsenic elements in cosmetics were(10.1±0.6)mg/kg,k=2,(4.84±0.28)mg/kg,k=2,(2.04±0.18)mg/kg,k=2,*** main factors that affect the uncertainty of determination results were standard substance,calibration curve,recovery and measurement repeatability.

关键词： cosmetics uncertainty inductively coupled plasma mass spectrometry(ICP-MS) heavy metals

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determination and evaluation on field control efficacy of Trichogramma dendrolimi against Ostrinia furnacalis

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环境昆虫学报 2011年第4期33卷 436-441页

作者： ZHAO Xiu-Mei ZHANG Shu-Quan LUO Bao-Jun QU Zhong-Cheng LI Min WANG Li-Da WU Lin-Lin LI Qing-Chao Qiqihar Sub-academy of heilongjiang Academy of Agricultural Sciences QiqiharHeilongjiang 161006China

The results of evaluation on field control efficacy of Trichogramma dendrolimi against Ostrinia furnacalis showed that the correction rates of Ostrinia furnacalis egg mass parasitism were 71.75% and 73.57%,the average control effect were 65.85% and 70.24%,the restoration yield loss rates were 6.78% and 7.97%,input-output ratio at 1:27.8 and 1:33.5 in Longjiang county of heilongjiang province in 2009 and 2010,*** technology is a integration of advanced,practical,environmental safety,effective biocontrol measures,embodies the "public plant protection,green plant protection" fully,has significant economic,social and ecological benefits.

关键词： Trichogramma dendrolimi Biological control Ostrinia furnacalis Field control efficacy

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A Novel Model of IDS Based on Fuzzy Cluster and Immune Principle

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 157-160页

作者： TAOXin-min LIUFu-rong CommunicationDepartment HarbinInstituteofTechnologyHarbin150001HeilongjiangChina

This paper presents a novel intrusion detection model based on fuzzy cluster and immune principle. The original rival penalized competitive learning (RPCL) algorithm is modified in order to address the problem of different variability of variables and correlation between variables, the sensitivity to initial number of clusters is also solved. Especially, we use the extended RPCL algorithm to determine the initial number of clusters in the fuzzy cluster algorithm. The genetic algorithm is used to optimize the radius deviation for the determination of characteristic function of abnormal subspace.

关键词： intrusion detection fuzzy cluster RPCL genetic algorithm correlation

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