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过敏性和刺激性接触性皮炎的动力学非侵入性评估

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 36-36页

作者： Astner S. González alez E. Cheung A.C. S.Gonzá Wellman 阎小宁 Dr. labs.of Photomedicine BAR 810 Massachusetts General Hospital Boston MA 02114 United States

Reflectance confocal microscopy (RCM) allows non- invasive visualization of human skin in vivo. It has been used to describe the histopathological features of acute contact dermatitis (CD). This work was designed to investigate the kinetics of both allergic and irritant CD (ACD and ICD) in vivo. Eighteen subjects with a prior diagnosis of ACD were patch tested with the specific allergen sodium lauryl sulfate as an irritant, and appropriate controls. RCM, transepidermal water loss (TEWL), and fluorescence excitation spectroscopy(FES) were performed at several time points within 2 wk after patch removal. After removal of the Finn chambers at 48 h, superficial epidermal changes, primarily involving the stratum corneum, and increased epidermal thickness were mainly present in ICD. ACD, on the other hand, showed microvesicle formation peaking at 96 h following patch removal. Both ACD and ICD showed exocytosis and similar degrees of spongiosis on RCM. TEWL and FES demonstrated a significant difference between ACD and ICD. RCM, TEWL, and FES are valuable non-invasive tools to quantitatively study the kinetics of the pathophysiology of acute CD reactions in vivo and monitor the changes at a cellular level.

关键词：刺激性皮炎荧光激发反射性组织病理学微血管形成过敏源十二醇胞外分泌病理生理学可比性

肯尼亚婴幼儿使用庆大霉素每日1次给药与每日多次给药的随机对照试验

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 20-20页

作者： English M. Mohammed S. Ross A. 刘健 Dr.CGMR-C KEMRI/Wellcome Trust Res. Labs. PO Box 230 Kilifi Kenya

目的:在监测对婴幼儿不能进行常规剂量给药的情况时,采用每日1次剂量(OD)给予庆大霉素的方法是否合适。方法:采用开放、随机对照试验,受试婴儿为肯尼亚农村地区医院新近收治的、怀疑为严重脓毒症的患儿,庆大霉素治疗分为1日1次给药和常... 详细信息

目的:在监测对婴幼儿不能进行常规剂量给药的情况时,采用每日1次剂量(OD)给予庆大霉素的方法是否合适。方法:采用开放、随机对照试验,受试婴儿为肯尼亚农村地区医院新近收治的、怀疑为严重脓毒症的患儿,庆大霉素治疗分为1日1次给药和常规的1日多次(MD)给药两组。结果:在297例随机分组的患儿中。

关键词：随机对照试验严重脓毒症地区医院几何均数肾脏毒性 regimen suitability routine admitted young

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利用电磁极化实现三倍无线通信容量

通信对抗 2020年第2期39卷 60-63页

作者： Michael R.Andrews Partha P.Mitra Robert deCarvalho 张建强(翻译) 常雷(审校) Bell labs Lucent TechnologiesMurray HillNew Jersey 07974USA Harvard University CambridgeMassachusetts 02138USA 不详

无线通信是现代信息基础设施的基本组成部分。无线带宽是珍贵的[1],这促使人们去仔细检视可用的使用电磁波的数据信道。传统方法是给每个频率分配一个信道,尽管很好理解平面波的两种极化状态[2]允许两种不同的信息信道,诸如极化分集技... 详细信息

无线通信是现代信息基础设施的基本组成部分。无线带宽是珍贵的[1],这促使人们去仔细检视可用的使用电磁波的数据信道。传统方法是给每个频率分配一个信道,尽管很好理解平面波的两种极化状态[2]允许两种不同的信息信道,诸如极化分集技术已经利用了这一点[3]。

关键词：无线通信频率分配信息信道极化状态信息基础设施数据信道极化分集电磁极化

A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

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Protein & Cell 2023年第12期14卷 888-907页

作者： Daoyuan Huang Yuesheng Zuo Chen Zhang Guoqiang Sun Ying Jing Jinghui Lei Shuai Ma Shuhui Sun Huifen Lu Yusheng Cai Weiqi Zhang Fei Gao Andy Peng Xiang Juan Carlos Izpisua Belmonte Guang-Hui Liu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stemcell and Regeneration CAsBeijing100101China China National Center for Bioinformation Beijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China 11Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Center for Stem Cell Biology and Tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhou510000China Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510000China Altos labs Inc.San DiegoCA 92121USA and Aging Biomarker Consortium China

The testis is pivotal for male reproduction,and its progressive functional decline in aging is associated with ***,the regulatory mechanism underlying primate testicular aging remains largely ***,we resolve the aging-related cellular and molecular alterations of primate testicular aging by establishing a single-nucleus transcriptomic ***-expression patterns along the spermatogenesis trajectory revealed molecular programs associated with attrition of spermatogonial stem cell reservoir,disturbed meiosis and impaired spermiogenesis along the sequential ***,Sertoli cell was identified as the cell type most susceptible to aging,given its deeply perturbed age-associated transcriptional ***,downregulation of the transcription factor Wilms'Tumor 1(WTi),essential for Sertoli cell homeostasis,was associated with accelerated cellular senescence,disrupted tight junctions,and a compromised cell identity signature,which altogether may help create a hostile microenvironment for ***,our study depicts in-depth transcriptomic traits of non-human primate(NHP)testicular aging at single-cell resolution,providing potential diagnostic biomarkers and targets for therapeutic interventions against testicular aging and age-related male reproductive diseases.

关键词： single-nucleus RNA sequencing primate testis aging WT1

Synthesis and Characterization of Mass Produced High Quality Few Layered Graphene Sheets via a Chemical Method

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Graphene 2014年第2期3卷 7-13页

作者： Mohammed Khenfouch U.Buttner Mimouna Baitoul Malik Maaza UNISA Africa Chair in Nanosciences-Nanotechnology College of ScienceEngineering and Technology Science CampusCorner of Christiaan de Wet Road&Pioneer AvenueFloridaJohannesburgSouth Africa Group of Polymers and nanomaterials Laboratory of Solid State PhysicsFaculty of Sciences Dhar el MahrazUniversity Sidi Mohamed Ben AbdellahAtlas FezMorocco iThemba labs-National Research Foundation of South Africa Old Faure RoadSomerset WestWestern Cape ProvinceSouth Africa Department of Electrical Engineering Electromech.Microsyst.&Polymer Integration Res.(EMPIRe)GroupKing Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia UNISA Africa Chair in Nanosciences-Nanotechnology College of Graduate StudiesUniversity of South AfricaMuckleneuk RidgePretoriaSouth Africa

Graphene is a two-dimensional crystal of carbon atoms arranged in a honeycomb lattice. It is a zero band gap semimetal with very unique physical and chemical properties which make it useful for many applications such as ultra-high-speed field-effect transistors, p-n junction diodes, terahertz oscillators, and low-noise electronic, NEMS and sensors. When the high quality mass production of this nanomaterial is still a big challenge, we developed a process which will be an important step to achieve this goal. Atomic Force Microscopy, Scanning Electron Microscopy, Scanning tunneling microscopy, High Resolution Transmission Electron Microscopy, X-Ray Diffraction, Raman spectroscopy, Energy Dispersive X-ray system were investigated to characterize and examine the quality of this product.

关键词： Graphene Powder Hummers

Search for two-neutrino double-beta decay of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels L.Darroch S.J.Daugherty J.Davis S.Delaquis A.Der Mesrobian-Kabakian R.DeVoe J.Dilling A.Dolgolenko M.J.Dolinski J.Echevers W.Fairbank Jr. D.Fairbank J.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil C.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.MacLellan T.McElroy T.Michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson J.Runge S.Schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler 无 Physics Department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Physics Department Carleton UniversityOttawaOntario K1S 5B6Canada Department of Physics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Physics Department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre“Kurchatov Institute” Moscow 117218Russia Department of Physics University of South DakotaVermillionSouth Dakota 57069USA SLAC National Accelerator Laboratory Menlo ParkCalifornia 94025USA TRIUMF VancouverBritish Columbia V6T 2A3Canada Institute of High Energy Physics Beijing 100049China Department of Physics Laurentian UniversitySudburyOntario P3E 2C6Canada Physics Department Colorado State UniversityFort CollinsColorado 80523USA Department of Physics and Physical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Physics Department and CEEM Indiana UniversityBloomingtonIndiana 47405USA Physics Department Stanford UniversityStanfordCalifornia 94305USA Department of Physics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst Center for Fundamental Interactions and Physics Department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Physics Department University of MarylandCollege ParkMaryland 20742USA Department of Physics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright Laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS Center for Underground Physics Daejeon 34126Korea Department of Physics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg Lab CaltechPasadenaCalifornia 91125USA LHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2νββdecay to the 0+1 state of 136Ba is 2.9×10^(24)yr using a total^(136)Xe exposure of 234.1 kg *** statistically significant evidence for 2νββdecay to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)yr at 90%confidence level,improved by 70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

ENABLING TECHNOLOGIES FOR AGILE MARITIME COMMUNICATION NETWORKS

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China Communications 2020年第3期17卷 I0001-I0003页

作者： Wei Feng Bin Lin Yunfei Chen Cheng-Xiang Wang Shengming Jiang Yuguang Fang Tsinghua Univ Dept Elect Engn Beijing Peoples R China Dalian Maritime Univ Dept Informat Sci & Technol Dalian Peoples R China George Washington Univ Washington DC USA Univ Warwick Coventry W Midlands England Hamburg Univ Technol Hamburg Germany Siemens AG Mobile Phones Munich Germany Univ Agder Grimstad Norway Heriot Watt Univ Edinburgh Midlothian Scotland Southeast Univ Nanjing Peoples R China Purple Mt labs Nanjing Peoples R China IET London England Clarivate Analyt Philadelphia PA USA Shanghai Maritime Univ Coll Informat Engn Shanghai Peoples R China Nanjing Petr Transportat Co Nanjing Peoples R China Hong Kong Univ Sci & Technol Dept Elect & Elect Engn Hong Kong Peoples R China Hong Kong Univ Sci & Technol Comp Sci Dept Hong Kong Peoples R China Natl Univ Singapore Ctr Wireless Commun Singapore Singapore Lab Inst Infocomm Res I2R Singapore Singapore Univ Glamorgan Pontypridd M Glam Wales South China Univ Technol Guangzhou Guangdong Peoples R China Univ Florida Dept Elect & Comp Engn Gainesville FL 32611 USA IEEE Piscataway NJ USA AAAS Washington DC USA

With the rapid development of maritime activities,there has been a growing demand for high data rate and ultra-reliable maritime ***,maritime communication services are provided mostly by maritime *** some places,shore and island-based base stations(BSs)can also be built to extend the coverage of terrestrial networks,providing the fourth-generation(4G)or even the fifth-generation(5G)*** further build up communication networks over the ocean for better coverage,unmanned aerial vehicles(UAVs)-aided and ship-borne BSs can be exploited to serve as supplementary relaying nodes.

关键词： communication networks island

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与重症患者讨论预后和治疗期望

英国医学杂志中文版 2022年第10期25卷 575-578页

作者： Justin J Sanders Leigh Manson Deborah Constien James Downar 蒋子涵(译) Pallative Care McGill Department of F amily MedicineMeGill UniversityMontreal Ariadne labs Brigham and Women's Hospital and Harvard TH Chan School of Public HealthBostonMassachusetts Health Quality and Safety Commission New Zealand Madison Wisconsin Department of Medicine University of Ottawa Bruyere Continuing Care Ottawa 中国医学科学院阜外医院心内科

医疗技术的进步使医生具有了前所未有的能力来延长患者寿命。然而,这种能力却不一定能帮助到身患重症的患者。重症是指死亡风险高、生活能力低、生活质量差、医护及家属照看压力大的疾病状态。对于重症患者来说,单纯延长生命可能并不是... 详细信息

医疗技术的进步使医生具有了前所未有的能力来延长患者寿命。然而,这种能力却不一定能帮助到身患重症的患者。重症是指死亡风险高、生活能力低、生活质量差、医护及家属照看压力大的疾病状态。对于重症患者来说,单纯延长生命可能并不是他们所期望的治疗目标,并可能会增加他们和家人的痛苦。

关键词：死亡风险重症患者疾病状态延长生命医护期望质量差

Metallophilicity-Induced Clusterization:Single-Component White-Light Clusteroluminescence with Stimulus Response

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CCS Chemistry 2022年第8期4卷 2570-2580页

作者： Xueqian Zhao Parvej Alam Jianyu Zhang Shiyun Lin Qian Peng Jun Zhang Guodong Liang Sijie Chen Jing Zhang Herman HYSung Jacky WYLam Ian DWilliams Xinggui Gu Zheng Zhao Ben Zhong Tang Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 MOE Key Laboratory of Organic OptoElectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084 CAS Key Laboratory of Organic Solids Institute of ChemistryBeijing National Laboratory for Molecular SciencesChinese Academy of SciencesBeijing 100190 School of Materials and Chemical Engineering Anhui Jianzhu UniversityHefei 230601 PCFM and GDHPPC labs School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275 Ming Wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Materials Science and EngineeringState Key Laboratory of Chemical Resource EngineeringBeijing University of Chemical TechnologyBeijing 100029 Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhenGuangdong 518172 Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 AIE Institute Guangzhou Development DistrictHuangpuGuangzhou 510530

Materials showing metallophilic interactions continue to attract considerable theoretical and experimental attention largely because of their unusual and unanticipated photophysical behavior as well as their unique stimuli-responsive behavior in an aggregate or solid *** interactions are mostly found between metals with either identical(d^(10)–d^(10))or different(s^(2)–d^(8),d^(8)–d^(10))*** various metallophilic interactions,aurophilic interactions(Au⋯Au)are well-known and widely *** this study,a new phosphorescent gold(I)complex,[(CF_(3)Ph)_(3)PAuC≡CPh](TPPGPA)was reported.

关键词： single-component white-light emission gold(I)complex aurophilic interactions stimuli-responsive materials metallophilicity-induced clusterization