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Chinese Medical Journal 2024年第8期137卷 1006-1008页

作者： Chuchu Huang Mengping Mao Yiran Peng Ben Wang Yuxuan Deng Hongfu Xie Dan Jian Department of dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of dermatology and Allergy and Christine Kühne-Center for Allergy Research and EducationUniversity Hospital of BonnD-53127BonnGermany

To the Editor:Acne vulgaris is a prevalent skin disorder affecting both physical and psychosocial health.[1]Although photodynamic therapy(PDT)exists for moderate-to-severe acne,due to its adverse reactions,we are still looking forward to a novel therapeutic option with fewer side ***,radiofrequency has been used to treat moderate acne.[2]In this study,we aimed to evaluate the efcacy and safety of moderate-to-severe acne treatment based on a single microneedle with radiofrequency(MRF)*** during three consecutive sessions through a prospective,randomized,and controlled trial study.

关键词： needle prospective randomized

The Application Progress of Skin Imaging Technology in Psoriasis

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Advances in Bioscience and Biotechnology 2024年第7期15卷 397-405页

作者： Qinyi Wang Jin Gong Department of dermatology The First Affiliated Hospital of Yangtze University Jingzhou China

Skin imaging technologies such as dermoscopy, high-frequency ultrasound, reflective confocal microscopy and optical coherence tomography are developing rapidly in clinical application. Skin imaging technology can improve clinical diagnosis rate, and its non-invasiveness and repeatability make it occupy an irreplaceable position in clinical diagnosis. With the “booming development” of medical technology, skin imaging technology can improve clinical diagnosis rate. Researchers have made significant advances in assisting clinical diagnosis, prediction, and treatment of disease. This article reviews the application and progress of skin imaging in the diagnosis of psoriasis.

关键词： Psoriasis Skin Imaging Technology High Frequency Ultrasound Optical Coherence Tomography

Clinical and dermoscopic features of livedoid vasculopathy

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Chinese Medical Journal 2020年第17期133卷 2137-2138页

作者： Juan Wen Xiao-Hong Li Qiu-Ping Yang Jian-Bin Yu Department of dermatology and venerology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China

To the Editor:Livedoid vasculopathy(LV)is a thromboocclusive disorder involving superficial and mid-dermis vessels,characterized by painful erythematous or purpuric macules or papules,small crusted ulcers,and porcelainwhite atrophic scars that remain after several months.[1,2]Dermoscopy is a non-invasive and effective image analysis technology[3]that can aid dermatologists in visualization of the pigmentation pattern and vascular structure,as well as other morphologic features of the epidermis and *** study was performed to identify the clinical and dermoscopic features of LV in patients with LV who were treated in our hospital from October 2017 to August *** study was approved by the Ethical Committee of the First Affiliated Hospital of Zhengzhou University(No.2018-YB-05).The study was performed in accordance with the established guidelines and *** have obtained all appropriate patient consent *** the form,the patients have given their consents for their images and other clinical information to be reported in the journal.

关键词： superficial features journal

X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du Xin-Lin Zhu Dong-Xing Zhang Xian-Zhen Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan Wan-Qing Liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

Two hits are better than one:rational dual strategy efficiently fights neuroblastoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1802-1804页

作者： Jacques Zimmer Camille Rolin Markus Ollert Department of Infection and Immunity Luxembourg Institute of HealthEsch-sur-AlzetteLuxembourg University of Luxembourg Esch-sur-AlzetteLuxembourg Department of dermatology and Allergy Center Odense Research Center for Anaphylaxis(ORCA)University of Southern DenmarkOdenseDenmark

The recently published landmark paper by Bergaggio et *** Roberto Chiarle’s group in Cancer Cell1 investigates an elegant double-hit strategy to improve anti-cancer *** important approach demonstrates in a preclinical model that chimeric antigen receptor(CAR)-T cell treatment can be rendered more efficient by increasing the cell surface expression of the CAR target structure via a small molecule.

关键词： neuroblastoma Cancer

Induction of ultra-morphological features of apoptosis in mature and immature sperm

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Asian Journal of Andrology 2017年第5期19卷 533-537页

作者： Sonja Grunewald Guenther Fitzl Christopher Springsguth Department of dermatology Venerology and Allergology University Hospital Leipzig Leipzig Germany Institute of Anatomy University of Leipzig Leipzig Germany

There is a fundamental body of evidence suggesting that activated apoptosis signaling in ejaculated human sperm negatively influences their fertilization potential. However, it is still controversial whether this apoptotic signaling is a relic of an abortive apoptosis related to spermatogenesis or if it should be regarded as a functional preformed pathway in mature sperm leading to stereotypical morphological changes reflecting nuclear disassembly. To address this question, apoptosis was induced using betulinic acid in mature and immature ejaculated human sperm enriched by density gradient centrifugation. Execution of apoptosis was monitored by observing ultra-morphological changes via transmission electron microscopy. Typical morphological signs of apoptosis in somatic cells include plasma membrane blebbing with the formation of apoptotic bodies, impaired mitochondrial integrity, defects of the nuclear envelope, and nuclear fragmentation; these morphologies have also been observed in human sperm. In addition, these apoptotic characteristics were more frequent in immature sperm compared to mature sperm. Following betulinic acid treatment, apoptosis-related morphological changes were induced in mature sperm from healthy donors. This effect was much less pronounced in immature sperm. Moreover, in both fractions, the betulinic acid treatment increased the percentage of acrosome-reacted sperm. The results of our ultra-morphological study prove the functional competence of apoptosis in mature ejaculated human sperm. The theory of a sole abortive process may be valid only for immature sperm. The induction of the acrosome reaction by stimulating apoptosis might shed light on the biological relevance of sperm apoptosis.

关键词： apoptosis electron microscopy human morphology sperm

Tofacitinib combined with local low-dose ixekizumab injection benefits those with peripheral psoriatic arthritis

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The Journal of Biomedical Research 2024年第1期38卷 92-94页

作者： Yours Sincerely Ruiyuan Xia Weixin Zhang Jing Hang Zhiqiang Yin Department of dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Ultrasound the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China.

Dear Editor,Treating psoriatic arthritis(PsA)is always *** treatments can be administered either orally or through intramuscular and intra-articular injection,including conventional synthetics,biologics and targeted synthetic disease-modifying antirheumatic drugs[1].The alternatives,topical external therapies,are not effective on joint lesions due to drug permeability *** injected into the articular cavity are also unsuitable for small peripheral joint lesions,the most common manifestations of *** limited treatment options for PsA present a challenge.

关键词： injection drugs cavity treatment

Lidocaine hydrochloride loaded isomaltulose microneedles for efficient local anesthesia of the skin

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Chinese Chemical Letters 2024年第4期35卷 298-302页

作者： Xuebing Jiang Siyi Wang Li Zhang Xian Jiang Maling Gou State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China Huahang Microcreate Technology Co. Ltd.Chengdu 610042China Department of dermatology West China HospitalSichuan UniversityChengdu 610041China

Lidocaine hydrochloride(LIDH) as an anesthetic is widely used in local anesthesia. Dissolving microneedles(MNs) have great application value in the field of skin anesthesia. However, the limited drug-loading of dissolving MNs is an existing challenge that affects clinical use. In this study, we have screened isomaltulose(ISO) as the proper matrix material for the MNs by using molecular dynamics(MD) simulation. Our findings indicate that ISO has good compatibility with LIDH, and the LIDH-loaded ISO MNs(LI-MNs) have high drug-loading capacity. The drug-loading capacity of LI-MNs could reach 80%, and it could effectively puncture the skin. In addition, the preparation method of customized LI-MNs was established based on three-dimensional(3D) printing technology. It was shown that the administration time of LI-MNs could be controlled within 3 min. Also, the LI-MNs were able to provide the local anesthetic efficacy within2 min and sustained for more than 2 h. Significantly, LI-MNs had more efficient drug efficacy compared to the topical creams and the majority of existing LIDH-loaded dissolving MNs. They even provided a longer duration of action than the injections. Overall, the LI-MNs with high drug-loading have a promising application prospect.

关键词： Microneedles Local anesthesia Lidocaine hydrochloride Isomaltulose Transdermal delivery

Blastic plasmacytoid dendritic cell neoplasm:Two case reports

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World Journal of Clinical Oncology 2024年第9期15卷 1207-1214页

作者： Yi-Qian Ma Zhan Sun Yu-Mei Li Hui Xu Department of dermatology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND Blastic plasmacytoid dendritic cell tumor(BPDCN)is a rare and highly invasive lymphohematopoietic tumor that originates from plasmacytoid dendritic *** has an extremely poor *** lesions are usually the first manifestation of BPDCN,although the tumor may also invade the bone marrow,lymph nodes,peripheral blood,and other parts of the body,leading to several other manifestations,requiring further differentiation through skin biopsy and *** SUMMARY In the present paper,the cases of 2 patients diagnosed with BPDCN are *** immunohistochemistry analysis of these 2 patients revealed positivity for CD4,CD56,and ***,no standard chemotherapy regimen is available for ***,intensive therapy for acute lymphoblastic leukemia was applied as the treatment method for these 2 *** Although allogeneic bone marrow transplantation could be further effective in prolonging the median survival the ultimate prognosis was *** treatment modalities tailored for elderly patients will help prolong survival.

关键词： Blastic plasmacytoid dendritic cell neoplasm Skin CD4 CD56 CD123 Venetoclax Case report

Recent advances on thermosensitive hydrogels-mediated precision therapy

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 5-25页

作者： Hao Chen Jiangmei Xu Jiangwei Sun Yongxin Jiang Wang Zheng Wei Hu Haisheng Qian Department of Clinical Pharmacology The Second Hospital of Anhui Medical UniversityAnhui Medical University Department of dermatology and Rheumatology Immunology Xinqiao HospitalArmy Medical University School of Biomedical Engineering Anhui Provincial Institute of Translational MedicineAnhui Medical University

Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse *** the past few years, sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential. These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature. Inspired by their unique properties, thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine. In this review, the state-of-theart developments in thermosensitive hydrogels for precision therapy are investigated,which covers from the thermo-gelling mechanisms and main components to biomedical applications, including wound healing, anti-tumor activity, osteogenesis, and periodontal,sinonasal and ophthalmic diseases. The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.

关键词： Thermosensitive hydrogels Injectable Sprayable Stimuli-responsive Precision therapy