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Anti-inflammatory activity and qualitative analysis of different extracts of Maytenus obscura(***.) *** high performance thin layer chromatography method

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 152-157页

作者： Mohamed F.Alajmi Perwez Alam deptartment of pharmacognosy College of Pharmacy.King Saud UniversityRiyadh.Kingdom of Saudi Arabia

Objective:To perform aqueous elhanol soluble fraction(AESK) and dichloromethane extract of aerial parts of Maytenus obscura(***.) *** high performance thin layer chromatography(HPTLC) and to test anti-inflammatory activity of these ***:HPTLC studies were carried out using CAM At;HPTLC system pquipped with Linomat IV applicator,TLC scanner *** *** ADC 2 and WIN CAT5-4 software were *** anti-inflammatory activity was tested by injecting different groups of rats(6 each) with formalin in hind paw and measuring the edema volume before and 1h later formalin *** group received saline *** extracts treatment was injected *** doses of 100 and 200 mg/kg 1h before formalin ***(30 mg/kg) was used as ***:The results of preliminary phytochemical studies confirmed the presence of protein,lipid,carbohydrate,phenol,***,triterpenoid,alkaloid and anthraquinonc in both *** was performed on glass-backed silica gel 60 F254 HPTLC plates with the green solvents toluene:ethyacetate:glacial acetic acid(5:3:0.2,v/v/v) as mobile *** printing of AESF revealed major eight peaks with R_f values in the range of 0.28 to 0.80 and the dichloromethane revealed major 11 peaks with R_f values in the range of 0.12 to *** purity of sample was confirmed by comparing the absorption spectra at start,middle and end position of the *** of rats(i.p.) with AESF and dirhloromethane in doses of 100 and 200 mg/kg inhibited singnificantly(P<0.05.n=6) formalin-induced inflammation by 50%.55.9%,45.5%,and51.4%.***:HPTLC finger printing of AESF and dichloromethane of Maytenus obscura revealed eight major spots for alcoholic extracts and nine major spots for dichloromethane *** HPTLC profiles may be of great usefulness in the quality control of herbal products containing these *** anti-inflammatory activity of both extract

关键词： Maytenus obscura Phytochemical screening Finger print Anti-inflammatory HPTLC

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Automatic Structure Determination of Organic Molecules: Principle and Implementation of the LSD Program

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Chinese Journal of Chemistry 2003年第10期21卷 1263-1267页

作者： NUZILLARD Jean-Marc pharmacognosy Laboratory

The LSD (Logic for Structure Determination) program generates organicmolecular structures from 1D and 2D NMR data without resorting to chemical shift databases. Its usein the resolution of natural product structure determination problems has been already reported inthe literature. This paper describes how data and structures are internally represented andprocessed by LSD to build solution structures.

关键词： structure elucidation nuclear magnetic resonance correlation spectroscopy

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New Myrsinol Diterpenes from Euphorbia prolifera

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Chinese Journal of Chemistry 2004年第1期22卷 103-108页

作者：张万金陈道峰侯爱君 Department of pharmacognosy School of PharmacyFudan University

Four new myrsinol diterpenes, euphorprolitherins AD (13, 5), were isolated from the ethanolic extract of the root of Euphorbia prolifera, along with a knownone, SPr5 (4). The structures were elucidated on the basis of their spectroscopic evidences. The structure and relative stereochemistry of 1 were confirmed by X-ray crystallog-raphy.

关键词： Euphorbia prolifera Euphorbiaceae myrsinol diterpene euphorprolitherins A—D

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Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study

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Chinese Journal of Natural Medicines 2018年第12期16卷 951-960页

作者： DING Pei-Lan HE Chang-Ming CHENG Zhi-Hong CHEN Dao-Feng Department of pharmacognosy School of Pharmacy Fudan University

Sophorae Flavescentis Radix(Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma(S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora(Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applications. In order to find out the characteristic chemical constituents potentially leading to the unique medicinal properties claimed for each of the two closely related TCMs, an HPLC fingerprint method was developed for analyses of the alkaloid and flavonoid constituents of SFR and STR, respectively, which were further evaluated and compared through similarity calculation and hierarchical clustering analysis(HCA). The results from the present study showed that the alkaloid fingerprints of the two herbs were similar, with many components co-existing in both drugs and various batches of samples from different species being mixed together in the HCA dendrogram. However, their flavonoid constituents were totally different with specific fingerprints being yielded for each herb, and further HCA analysis showed that the tested samples could almost be clearly divided into two groups based on their origins of species. The results from the present study indicated that the flavonoid constituents could serve as the differentially diagnostic constituents of SFR and STR and might potentially attributed to their distinct therapeutic effects.

关键词： Sophoraflavescens Sophora tonkinensis Alkaloids Flavonoids HPLC fingerprint Hierarchical clustering analysis

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Antiprotozoal assessment and phenolic acid profiling of five Fumaria(fumitory) species

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 283-286页

作者： Ilkay Erdogan Orhan Nilgun Ozturk Bilge Sener Department of pharmacognosy Faculty of PharmacyGazi University Department of pharmacognosy Faculty of PharmacyAnadolu University

Objective:To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal ***:Consequently,in the current study,antiprotozoal effect of the ethanol extracts obtained from five Fumaria species(Fumaria densiflora,Fumaria cilicica,Fumaria rostellata,Fumaria kralikii,and Fumaria parviflora)was investigated against the parasites;Plasmodium falciparum(malaria)and Trypanosoma bruceirhodesiense(human African trypanosomiasis)at 0.81 and 4.85μg/mL ***:Among them,Fumaria densiflora extract exerted the highest antiplasmodial(93.80%)and antitrypanasomal effect(55.40%),while the ethanol extracts of Fumaria kralikii(43.45%)and Fumaria rostellata(41.65%)showed moderate activity against Plasmodium ***,phenolic acid contents of the extracts were analyzed using high performance liquid chromatography(HPLC)and trans-cinnamic(4.32 mg/g)and caffeic(3.71 mg/g)acids were found to be the dominant phenolic acids in Fumaria ***:According to our results,Fumaria densiflora deserve further study for its promising antiprotozoal activity.

关键词： Fumaria Fumitory Antiprotozoal Malaria Trypanosomiasis Phenolic acid

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A New Bibenzyl Derivative from Dendrobium moniliforme

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Chinese Chemical Letters 2002年第6期13卷 535-536页

作者： Zhi Ming BI Li YANG Zheng Tao WANG Luo Shan XU Guo Jun XU Department of pharmacognosy China Pharmaceutical UniversityNanjing 210038

A new bibenzyl derivative, 3,4-dihydroxy-4,5-dimethoxy bibenzyl, was isolated from a orchid Dendrobium moniliforme. The structure elucidation and 1H,13C NMR assignments were achieved by spectroscopic method.

关键词： Orchidaceae Dendrobium moniliforme 3,4-dihydroxy-4,5-dimethoxy bibenzyl.

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Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors

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Acta Pharmaceutica Sinica B 2015年第6期5卷 506-519页

作者： Marton Siklos Manel Ben Aissa Gregory R.J.Thatcher Department of Medicinal Chemistry and pharmacognosy University of Illinois College of Pharmacy

Cysteine proteases continue to provide validated targets for treatment of human *** neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and *** reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is *** review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.

关键词： Cysteine protease Calpain Cathepsin Enzyme inhibitors Neurodegeneration Alzheimer’s disease

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Three New Anthraquinones from Polygonum cillinerve

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Chinese Chemical Letters 2005年第8期16卷 1050-1052页

作者： Huan Yang QI Chao Feng ZHANG Mian ZHANG Jian Qun LIU Zheng Tao WANG Department of pharmacognosy China Pharmaceutical University Nanjing 210038

Three new anthraquinones, emodin-8-β-D-（2＂-O-coumarate）glucoside 1, emodin-8-β-D-（6＇-O-acetyl）glucoside 2 and physicon-8-β-D-（6＇-O-acetyl）glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2-picrylhydrazyl （DPPH） radicals （the IC50 = 8.5 μmol/L）, and compound 1-3 showed no activities against HL-60 and BCJC-823 cells by MTT method in vitro.

关键词： Polygonum cillinerve anthraquinone antioxidant activity cytotoxic activity.

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In vitro cholinesterase inhibitory and antioxidant effect of selected coniferous tree species

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Asian Pacific Journal of Tropical Medicine 2015年第4期8卷 269-275页

作者： Fatma Sezer Senol Ilkay Erdogan Orhan Osman Ustun Department of pharmacognosy Faculty of PharmacyGazi University

Objective:To explore cholinesterase inhibitory and antioxidant effect of six coniferous trees(Abies bornmulleriana,Picea pungens,Juniperus communis,Cedrus libani,Taxus baccata,and Cupressus sempervirens ***).Methods:Acetone(Ace),ethyl acetate(EtOAc),and ethanol(EtOH)extracts prepared from the needles and shoots of the six coniferous trees were screened for their acetylcholinesterase(AChE)and butyrylcholinesterasc(BChE)inhibitory activity at 100μg/*** activity of the extracts was tested using 2,2-diphenyl-1-picrylhydrazyl(DPPH)and N,N-dimethyl-p-phenylendiamine(DMPD)radical scavenging,nietal-chelation capacity,ferric-(FRAP)and phosphomolibdenum-reducing antioxidant power(PRAP)*** of the assays were performed in ELISA microplate *** phenol and flavonoid amounts in the extracts were determined ***:Among thirty-six extracts in total,the shoot-Ace extract of Cupressus sempervirens *** exerted the highest inhibition against AChE[(54.84±2.51)%],while the needle-Ace extract of Cedrus libani was the most effective in inhibiting BChE[(67.54±0.30)%].The highest DPPH radical scavenging effect,FRAP and PRAP was observed in the shoot-Ace and EtOAc extracts from Taxus *** all the extracts showed a variable degree of scavenging effect against DPMD *** shoot-EtOAc extract of Cedrus libani had the highest metalchelation capacity[(58.04±0.70)%].The shoot extracts of Taxus baccata were determined to have the richest total phenol content,which may contribute to its marked antioxidant ***:The conifer species screened in this study may contain cholinesterase-inhibiting and antioxidant properties,which might be useful against Alzheimer's disease.

关键词： Conifer Cholinesterase inhibition Antioxidant activity Alzheimer’s disease Total phenol and flavonoid

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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein Abou Zeid Mohamed Ali Farag Manal Abdel Aziz Hamed Zeinab Abdel Aziz Kandil Radwa Hassan El-Akad Hanaa Mohamed El-Rafie pharmacognosy Department National Research Centre pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

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