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Solid cystic papillary tumor of pancreas in children

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外科研究与新技术 2003年第2期 80-80页

作者：周红 dept pediat Surg Beijing Children' s Hosp Affil Cap Univ Med Sci Beijing 100045

Objective To estimate the incidence and establish clinicopathological, immunohistochemical , diagnostic and therapeutic features in children with solid cystic papillary tumor (SCPT) of the pancreas in children. Methods Eleven cases (male 1,frmale 10) aging from 9 to 14 years with a mean of 11.1 years with SCPT were analyzed. The chief complains were abdominal pain and palpable mass. The tumors were often located in the head of pancreas. The mean diameter of tumors was 8. 7 cm. The procedures employed included local resections (6), distal pancreatectomy (2) and pancreatico-duodenectomies (3). Routine pathological, histochemical, and immunohistochemical methods were utilized to analyze the specimens. Representative blocks of SCPT specimens were immunostained for NSE, α-1 AT, S - 100, CgA, CK, EMA and insulin. Results The patients were followed-up for 1 to 15 years and were alive postoperatively. Histological examination showed solid with cystic areas and papillary protrusions. Immunohistochemically, the

关键词： papillary pancreas histochemical alive children Eleven incidence chief diagnostic blocks

胎儿期有轻、中度肾盂扩张婴儿的远期临床结果:新生儿明显泌尿系统疾病的超声筛查

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 40-41页

作者： Ismaili K. Avni F. E. Wissing K. M. Hall M. 贺莉 Hop. Univ. des Enf. -Reine Fabiola Dept. Perinatal Pediat. Nephrology 15 Avenue J. J. CROCQ 1020 Brussels Belgium

目的:评价胎儿期有轻、中度肾盂扩展的婴儿的远期结果,并且确定新生儿超声检查在识别明显的泌尿系统疾病的预测价值。试验设计:这是一个前瞻性研究。对213例出生前有轻、中度肾盂扩张的婴幼儿随访至2岁。在出生后5d、1月、3月、6月、1年... 详细信息

目的:评价胎儿期有轻、中度肾盂扩展的婴儿的远期结果,并且确定新生儿超声检查在识别明显的泌尿系统疾病的预测价值。试验设计:这是一个前瞻性研究。对213例出生前有轻、中度肾盂扩张的婴幼儿随访至2岁。在出生后5d、1月、3月、6月、1年和2年做肾脏超声检查。所有婴幼儿均接近膀胱尿道造影剂拍片检查。结果:213例中,130例(61%)

关键词：肾盂扩张胎儿期超声筛查泌尿系统疾病出生后膀胱尿道造影剂出生前 neonatal 超声检查

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对儿童外伤性疼痛给予口服吗啡

世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 12-13页

作者： Wille C. Bocquet N. Cojocaru B. G.Chéron 郭战宏 dept.des Urgences pediat. Hóp.Necker-Enfants-Malades Assit.Pub.-hpitaux de Paris 149 rue de Sévres 75743 Paris Cedex 15 France

Objectives.-To study the compliance of prescription, the efficacity and the adverse events of oral morphine used in the pediatric emergency departement (ED) in traumatic ***.-This prospective study was conducted in the ED from october 2002 to september *** aged six months to 16 years with a visual analogic scale (VAS) score higher than 70 or with a traumatic member deformation received oralmorphine (0,5 mg/kg).Pain was assessed every 30 minutes using two scales: behavioral observation by the faces scale and objective pain scale (OPS) for children less than five years, behavioral observation by the faces scale and self-report by VAS for children older than five *** compliance of prescription, the pain scores and the adverse events were ***.-Ninety-one children received oral morphine and seventy-four children were *** per cent of prescriptions were in accordance with the *** patients younger than five years a rapid decrease of pain was observed in thirty *** pain’s reduction was respectively 79 and 84%with faces scale and OPS when they left *** children older than five years, pain’s reduction was more important and more rapid when pain assessment was made by nurses than when it was self-reported in the first hour (pain reduction 58,2 and 36,1%).When leaving, pain reduction was the same with the two different *** major adverse event was ***.-Use of oral morphine in ED is simple, with a few numbers of adverse *** was *** is correct after 30 to 60 minutes.

关键词：急诊科依从性不良反应器官发生

Correlation of methylprednisolone chemosensitivity in vitro with C3435T MDR1 polymorphism and clinical outcome in childhood acute lymphoblastic leukemia.

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Correlation of methylprednisolone chemosensitivity in vitro ...

产前已诊断的小肠闭锁胎儿经腹腔镜手术:简单、安全且不留瘢痕

第十五届国际药理学大会

作者： Mirossay Ladislav Oravkinova Irina Tokarcikova Katarina Jamborova Erika Sarissky Marek Mojzis Jan Mirossay Andrej P.J.Safarik Univ. Fac. Med.Dept. Pharmacol.KosiceSlovak Republic. pediatric Hospital Dept.Pediat.Oncol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic.

＜正＞ Objective: Cellular drug resistance measured at initial diagnosis is associated with an increased relapse risk and unfavorable clinical outcome in childhood ALL. In addition, the presence of adverse clinical prognostic factors such as age. and pro - B and T - lineage immunophenotype have been shown to be associated with cellular resistance to drugs in children with ALL. P - glycoprotein （Pgp）, the gene product of MDR1, confers multidrug resistance to a number of antineoplastic agents. A silent mutation in the exon 26 （C3435T） has been associated with altered expression and function of Pgp in tissues. Methods: MIT cytotoxicity assay, PCR alnalysis of C3435T polymorphism in MDR1 gene. Results: We compared the impact of C3435T polymorphism on in vitro chemosensitivity of leukemia cells to methylprednisolone. CC genotype carriers showed higher IC50 values in comparison with the carriers of CT or TT genotype. Statistical analysis Mann- Whitney U test showed P = 0.035. Conclusions: The group of patients with CC genotype seems to be more resistant to glucocorticoids, or at least methyprednisolone.

关键词： ALL MDR1 gene polymorphism glucocorticoid

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 54-54页

作者： Yamataka A. Koga H. Shimotakahara A. 李丹 dept. Gen. Uro genital pediat. Surg. Juntendo Univ. School of Medicine Tokyo JapanDr.

Purpose The aim of this study was to describe a new technique for the surgical management of prenatally diagnosed small bowel atresia. Methods Under general a nesthesia, a 5-mm trocar was inserted using an open technique through an intrau mbilical incision. The proximal atretic bowel end was identified using laparosco py and mobilized toward the umbilicus using an additional 3-mm trocar inserted in the left lower quadrant. The umbilical trocar then was removed, and a ring re tractor was inserted into the trocar site and used to expand the wound to delive r both atretic bowel ends. The bowel was repaired and returned to the abdomen th rough the umbilical wound. The umbilical fascia and skin were closed conventiona lly. Results Three patients were reviewed. Two had minimal abdominal distension, and the atretic bowel ends could be identified easily; laparoscopy-assisted su rgery was successful. The third case had significant dilatation, and laparotomy was required. Postoperatively, there was minimal abdominal scarring, and the umb ilicus was normal in appearance. Conclusions Although this experience is limited to 3 patients, this technique is simple, safe, and virtually scar free and can be applied for the treatment of neonates with prenatally diagnosed small bowel a tresia, especially if there is minimal abdominal distension at birth.

关键词：肠闭锁腹腔镜手术腹部伤口牵引器左下腹部脐中生时

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多种微量营养素饮料中铁、锌的生物利用度

世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 31-31页

作者： Avalos Mishaan A.M. Zavaleta N. Griffin I.J. S.A.Abrams 王一飞 USDA/ARSChildren'sNutr.Res.C.Neonatology Acad.Pediat.Dept.Pediat.B.LimaPeru U

目的:为了验证微量营养素饮料能够提供给儿童日常所需的铁和锌的假设。研究设计:对40名6-9岁儿童进行了研究(利马,秘鲁)。4周内,受试儿童每天饮用含有多种微量营养素的饮料。之后连续2 d,受试儿童饮用稳定同位素标记的饮料并接受一次静... 详细信息

目的:为了验证微量营养素饮料能够提供给儿童日常所需的铁和锌的假设。研究设计:对40名6-9岁儿童进行了研究(利马,秘鲁)。4周内,受试儿童每天饮用含有多种微量营养素的饮料。之后连续2 d,受试儿童饮用稳定同位素标记的饮料并接受一次静脉锌注射,其中一部分儿童加餐一次。用质谱测量法评估铁和锌的生物利用度。结果:额外加餐的儿童,其铁的吸收率明显低于没有吃饭的儿童(9.8%±6.7% vs 11.6%±6.9%, P=0.04),但锌的吸收率的差异则不显著(24.5%±10.7% vs 22.8%±7.6%,P=0.2)。另外,每天给予儿童的微量营养素饮料能够基本满足其所需的铁和锌的量。结论:每天提供多营养素的饮料能够基本满足年幼儿童对矿物质的需求。食物对铁的吸收有一些抑制作用,但对锌则没有;因此,即使在吃饭的情况下,饮用这些饮料是有益的。

关键词：微量营养素生物利用度抑制作用同位素标记研究设计

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4岁男童不伴梗阻的回肠套叠1例

世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 29-29页

作者： zgüner I.F. Sava■ C. Baykal B. 郭战宏 dept. pediat. Surg. Suleyman D. Isparta Turkey

Intussusception is one of the most common causes of acute abdomen in the first year of life. Its clinical presentation is vomiting, bloody stools, severe colicky abdominal pain, and mass. The authors reported a case of intussusception with an inappropriate clinical picture, but both characteristic ultrasonography and computed tomography findings led to the diagnosis of ileoileal intussusception.

关键词：超声成像腹部绞痛

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早期发病的多发性硬化症患者CSF的特征

世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 48-48页

作者： PohlD. Rostasy K. Reiber H. Hanefeld F. 张玉龙 dept. of pediat. and pediat. Neurol. Georg- August- University Goettingen Robert- Koch- Stras- se 40 37075 Goettingen Germany Dr

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF- pleocytosis was observed in 66% , blood- CSF barrier dysfunction in 13% , and oligoclonal IgG in 92% of the early- onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult- onset MS.

关键词：多发性硬化症 CSF 血-脑脊液屏障 IgG 早期诊断

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糖尿病酮症酸中毒患儿胰酶增高

世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 38-38页

作者： Haddad N.G. Croffie J.M. E.A.Eugster 贺莉 Department of pediatricsSect.of Endocrinol.and Diabetology Dept.Pediat.Sect.G.IndianapolisINUnited States

采用前瞻性的研究,比较糖尿病酮症酸中毒(DKA) 患儿和新近诊断为糖尿病但没有DKA的患儿胰酶增高的情况。胰酶增高尤其是脂肪酶增高的现象很普遍,,但是没有明显的症状。在DKA患儿中,有20%被诊断为急性胰腺炎。

关键词：搪尿病