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CSEE Journal of Power and Energy Systems 2024年第5期10卷 1955-1964页

作者： Jingyi Li Jianjun Yang Xiaorong Xie Haozhi Li Ke Wang Zhaohui Shi Key Laboratory of Far-shore Wind Power Technology of Zhejiang Province Huadong Engineering Corporation LimitedPower ChinaHangzhou 310014China. State Key Lab of Control and Simulation of Power Systems and Generation Equipment(dept.of Electrical Engineering Tsinghua University)Beijing 100084China.

Establishing a suitable closed-loop transfer function model for the grid-connected PMSG system is the key basis in performing inter-harmonic characteristics *** closed-loop transfer functions can be constructed when different components of the converter controller are taken into ***,the effect of different components of the converter controller on inter-harmonic stability analysis is not *** this paper,the complete transfer function,considering different loops,is first *** on the complete closed-loop transfer function,the DC-link,PLL and voltage forward-feed are removed step by step to derive different closed-loop transfer *** inter-harmonic related poles of different closed-loop transfer functions are further calculated to analyze the effect of closedloop transfer functions on inter-harmonic characteristics ***,by performing time domain simulation,the correctness of the theoretical analysis results is *** results show that under the conditions of a weak AC system,each loop of the converter control system will reduce the stability of the interharmonic in the sub-synchronous frequency range and influence the inter-harmonic oscillation *** transfer function needs to consider the influence of each loop to accurately calculate the inter-harmonic stability of the system.

关键词： Closed-loop transfer function converter controller inter-harmonic characteristics PMSG

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun Nana Wang Yang Chen Chunsheng Dong Kin Yip Tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China dept.of Physiology&Medical Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCL2 and BECN1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECN1 and BCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECN1/Beclin 1 Dipeptide repeat Neurodegeneration

Slip-model Performance for Underexpanded Micro-scale Rocket Nozzle Flows

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Journal of Thermal Science 2007年第3期16卷 223-230页

作者： JoséA.Morí■igo JoséHermidaQuesada Francisco Caballero Requena dept.of Space Programmes dept.of

In aerospace Micro-Electro Mechanical Systems （MEMS）, the characteristic length scale of the flow approaches the molecular mean free path, thus invalidating the continuum description and enforcing the use of particle methods, like the Direct Simulation Monte Carlo （DSMC）, to deal with the non-equilibrium regions. Within the slip-regime （0.01〈Kn〈-0.1） both approaches, continuum and particle-based, seem to behave well in terms of accuracy. The present study summarizes the implementation and results obtained with a 2nO-order slip boundary condition in a Navier-Stokes solver to address the rarefaction near the nozzle walls. Its assessment and application to a cold-gas micro-scale conical nozzle of 300μm throat diameter, discharging into the low-pressure freestream, constitutes the major aim of the work. The slip-model incorporates the velocity slip with thermal creep and temperature jump, thus permitting to deal with non-isothermal flows as well. Results show that the gas experiences an intense rarefaction in the lip vicinity, pointing to the limits of model validity. Furthermore, a strong Mach deceleration is observed, attributed to the rather thick subsonic boundary layer and supersonic bulk heating caused by the viscous dissipation, in contrast with the expansion to occur in large rocket nozzles during underexpanded operation.

关键词： Slip flow MEMS micronozzles

Exposure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** responses

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Aquaculture and Fisheries 2024年第3期9卷 355-366页

作者： Suzanne C.Ball James P.Meador C.Andrew James Jenifer K.McIntyre Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA dept.of Environmental and Occupational Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Wastewater treatment plants release complex mixtures of chemicals into the aquatic environment as wastewater effluent(WWE);however,the effects of these mixtures are still poorly *** salmon(Oncorhynchus tshawytscha)are a culturally important species in the Pacific Northwest and are a vital food resource for southern resident killer whales(Orcinus orca)that are listed as‘critically endangered’under the *** Species Act(ESA).Chinook populations have declined drastically in this region and have failed to show significant recovery despite regional-to-federal efforts,resulting in many populations being listed as threatened under the *** source of stress to juvenile Chinook is chemical pollution from WWE during their outmigration along river corridors and residency in *** this study,we investigated effects of WWE on juvenile Chinook health in a ten-day exposure to dilutions of WWE from 0.1%to 20%.At the end of the exposure,we measured endpoints associated with endocrine disruption,brain function,osmoregulation,stress,and *** to WWE significantly(α=0.1 for all analyses)induced vitellogenesis,indicating endocrine system *** saw significant reductions in plasma glucose,an indication of stress,and brain Na+/K+-ATPase(NKA)activity,an enzyme essential for neuronal ***,metabolism was affected as evidenced by altered total protein,cholesterol,and albumin in plasma,a drastic decrease in whole body lipid content,and a significant increase in visible liver *** compared contaminant concentrations in exposure water with effects concentrations from the literature for chemicals known to induce vitellogenin or inhibit brain *** most contaminants,concentrations in exposure waters were several orders of magnitude below effects concentrations in the *** exception was estrogenic hormones,which were detected at similar concentrations in this study compared to concentrations in other studies tha

关键词： Wastewater effluent Chinook salmon Toxicity Sodium potassium ATPase Vitellogenin Physiology Metabolism Glucose

Exposure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** profiling

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Aquaculture and Fisheries 2024年第3期9卷 367-377页

作者： James P.Meador Suzanne C.Ball C.Andrew James Jenifer K.McIntyre dept.of Environmental and Occupational Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Targeted metabolomic analysis was conducted on juvenile Chinook salmon exposed for 10 days to wastewater effluent(WWE)from a large urban treatment *** included five dilutions of WWE(20%,5.3%,1.4%,0.4%,and 0.1%)and a control with 7 replicates per *** was extracted from fish and analyzed via liquid chromatography–mass spectrometry(LC-MS)for 361 endogenous metabolites,of which 185 were ***-versus-treatment comparisons identified several metabolites that were associated with altered biochemical pathways observed for all treatments,including several that are important for energy generation and *** altered pathways are crucial for fish health and may be an early indicator of potential adverse effects on growth,reproduction,behavior,and immune *** ocean-type Chinook salmon spend several days to weeks in the nearshore estuary where they may encounter high concentrations of WWE *** are exposed to a wide range of potent pharmaceuticals,personal care products,and industrial compounds from WWE that have the potential to affect physiological homeostasis and disrupt their normal life cycle.

关键词： Wastewater effluent Metabolomics Physiology Chinook salmon Pharmaceuticals Metabolic pathways Estuary

A Blind Batch Encryption and Public Ledger-Based Protocol for Sharing Sensitive Data

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China Communications 2024年第1期21卷 310-322页

作者： Zhiwei Wang Nianhua Yang Qingqing Chen Wei Shen Zhiying Zhang School of Computer Sciences Nanjing University of Posts and TelecommunicationsNanjing 210023China dept.of Intelligent Science and Information Law East China University of Political Science and LawShanghai 201620China Key Laboratory of Computational Science and Application of Hainan Province Hainan Normal UniversityHaikou 571158China State Key Laboratory of Public Big Data Guizhou UniversityGuizhou 550025China Yunnan Key Laboratory of Blockchain Application Technology Yunnan Innovation Research Institute of Beijing University of Aeronautics and AstronauticsKunming 650233

For the goals of security and privacy preservation,we propose a blind batch encryption-and public ledger-based data sharing protocol that allows the integrity of sensitive data to be audited by a public ledger and allows privacy information to be *** owners can tightly manage their data with efficient revocation and only grant one-time adaptive access for the fulfillment of the *** prove that our protocol is semanticallly secure,blind,and secure against oblivious requesters and malicious file *** also provide security analysis in the context of four typical attacks.

关键词： blind batch encryption data sharing onetime adaptive access public ledger security and privacy

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可动碘缺陷的管理与高稳定钙钛矿电池设计

可动碘缺陷的管理与高稳定钙钛矿电池设计

Pressure Wave and Fluid Velocity in a Bend-Mode Inkjet Nozzle with Double PZT Actuators

第十一届新型太阳能材料科学与技术学术研讨会

作者：袁永波黄劲松何军任晓雪王继飞林东旭高永立中南大学物理学院 dept.of Applied Physical Sciences U of North Carolina dept.of Physics and Astronomy U of Rochester

卤化物钙钛矿太阳电池是一种极有希望实现应用的新技术。然而,卤化物钙钛矿中的Pb-I键不够强,在电场（～0.2 V/μm）作用下容易发生离子迁移和聚集现象,或在高能量光子（>2.5 eV）照射下可缓慢发生光解现象。由于材料含有大量碘,Pb-I键... 详细信息

卤化物钙钛矿太阳电池是一种极有希望实现应用的新技术。然而,卤化物钙钛矿中的Pb-I键不够强,在电场（～0.2 V/μm）作用下容易发生离子迁移和聚集现象,或在高能量光子（>2.5 eV）照射下可缓慢发生光解现象。由于材料含有大量碘,Pb-I键断裂产生的碘单质在光照下一边破坏晶体结构,一边诱导形成更多有害单质碘,使钙钛矿的分解呈自加速趋势。因此本征稳定性不佳是钙钛矿电池的瓶颈。在当前仍需广泛使用基于Pb-I键钙钛矿的情况下,如何在结构设计层面探索电池保护策略,避免碘基缺陷破坏电池稳定性是重要课题。本报告将探讨钙钛矿中的有害碘自由基的产生和活动规律,首次提出利用界面亲碘材料（如C60和全氟葵烷碘PFI）的碘捕获策略可显著提升钙钛矿薄膜光热和紫外稳定性;同时探讨离子迁移及碘空位对电池反向偏压稳定性的不利影响,通过对碘捕获策略的改良,进一步提升电池反向偏压稳定性。基于FACs钙钛矿电池的紫外光照稳定性（395 nm,60 mW/cm）、光热加速老化稳定性（85℃,one sun）提升>10倍,反向偏压稳定性（如85℃,-4.5V）提升>1000倍。研究表明,碘缺陷的演变在钙钛矿层内形成闭循环的情况下,Pb-I键的断裂对钙钛矿电池稳定性不构成威胁,同时钙钛矿的反向偏压稳定性不会阻碍其走向应用。

关键词：钙钛矿太阳电池稳定性离子迁移碘缺陷

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Journal of Thermal Science 2013年第1期22卷 29-35页

作者： Sungu Kim Jaeyong Sung Myeong Ho Lee Graduate School Dept.of Mechanical EngineeringSeoulTech dept.of Mechanical and Automotive Engineering SeoulTech

A new concept of bend-mode inkjet nozzle with double PZT (lead zirconate titanate) actuators has been designed and fabricated in the present study. Then the pressure wave and fluid velocity at the nozzle exit have been investigated. The complex pressure behavior inside the channel was solved numerically based on the narrow channel acoustic theory. The two PZTs attached to a rectangular channel were actuated sequentially by setting the waveforms of each PZT to be center-aligned with various pulse widths. As a result, the double PZT actuation is superior to the single PZT actuation in view of strong momentum force and fast dissipation of residual pressure. The maximum fluid velocity at the nozzle exit is observed when the respective pulse widths equal to their optimum pulse widths. The numerical results are supported by the experimental results with the fabricated inkjet device by measuring the speed of meniscus just out of the nozzle.

关键词： double PZT actuators inkjet nozzle narrow channel theory pressure wave sequential actuation

Persisting challenges for performance-based building assessment

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 79-94页

作者： B.Bayhan I.Kazaz P.Gulkan dept.of Civil Engineering Bursa Technical University Assistant Professor dept.of Civil Engineering Erzurum Technical University Associate Professor dept.of Civil Engineering Cankaya University Professor

Intense research and refinement of the tools used in performance-based seismic engineering have been made,but the maturity and accuracy of these methods have not been adequately confirmed with actual data from the field. The gap between the assumed characteristics of actual building systems and their idealized counterparts used for analysis is wide. When the randomly distributed flaws in buildings as they exist in urban areas and the extreme variability of ground motion patterns combine,the conventional procedures used for pushover or dynamic response history analyses seem to fall short of reconciling the differences between calculated and observed damage. For emergency planning and loss modeling purposes,such discrepancies are factors that must be borne in mind. Two relevant examples are provided herein. These examples demonstrate that consensus-based analytical guidelines also require well-idealized building models that do not lend themselves to reasonably manageable representations from field data. As a corollary,loss modeling techniques,e.g.,used for insurance purposes,must undergo further development and improvement.

关键词： reinforced concrete building nonlinear analysis performance-based seismic assessment performance limits damage

Paederia foetida- a promising ethno-medicinal tribal plant of northeastern India

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Journal of Forestry Research 2013年第4期24卷 801-808页

作者： Silpi Chandadept.of Pharmacy Jaypee University of Information Technology Indira P Sarethy Biplab De Kuldeep Singh dept.of Biotechnology Jaypee Institute of Information Technology dept.of Pharmaceutical Science Assam University dept.of Pharmacy Jaypee University of Information Technology

The northeastern region of India constitutes one of the biodi- versity hotspots of the world. The ethnic groups inhabiting this region practice their distinctive traditional knowledge systems using biodiver- sity for food, shelter and healthcare. Among the less-studied plants, Paederia foetida has been used by various ethnic tribes as food and medicine. Many of its therapeutic properties relate to the gastrointestinal system and suggest its potential utility for gastrointestinal ailments. This is a review of the ethnobotanical uses, phytochemistry and therapeutic properties of P. foetida compiled from various reports. P. foetida is promising as a remedy for life-style related conditions, especially treat- ment of ulcers. Its utility highlights the need for proper evaluation of tribal plants as medicines and the species could be considered for devel- opment of new drugs.

关键词： Paederia foetida Tribal medicine ethnobotany phyto-chemistry therapeutic ulcer