检索结果-南通市图书馆

Open Journal of Veterinary Medicine 2024年第6期14卷 137-154页

作者： Adrian Harrison dept for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen PAS Section for Physiology Frederiksberg Denmark

Background: Scientific procedures for addressing noseband fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseband while riding are either scarce or lacking. Purpose/Aim: To assess simple means of measuring pressure under different nosebands with a view to their adoption as scientific methodology. Method: Horses (n = 7) were fitted with five different bridles (A-E). Pressure distribution and intensity were measured using colour sensitive film (Fujifilm LLLW), assessing the level of pressure and distribution across the surface of the nosebands, as assessed and ranked by independent assessors. A CURO system was also used to measure pressure in real-time under nosebands whilst riding. Results: The colour-sensitive film for D & B were ranked 1st and 2nd, respectively. Regularity of pressure overall showed a statistical difference between nosebands (A & B significantly more unregular than the others). Pressure measurements revealed significantly different means (all P Conclusions: Pressures under nosebands can reach levels that appear capable of inflicting tissue damage, hence bridles and nosebands should be assessed using scientific methodology and not based on arbitrary and subjective criteria, as is currently the case.

关键词： Noseband Welfare Pain Bridle Fit Riding Tölt FEI

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun Nana Wang Yang Chen Chunsheng Dong Kin Yip Tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China dept.of physiology&medical Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of Biology and medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between BCL2 and BECN1/Beclin 1 by inhibiting BCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between BECN1 and BCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy BCL2 BECN1/Beclin 1 Dipeptide repeat Neurodegeneration

RELATIONSHIPS BETWEEN BLOOD VOLUME AND BIOELECTRICAL IMPEDANCE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RELATIONSHIPS BETWEEN BLOOD VOLUME AND BIOELECTRICAL IMPEDAN...

The 2004 Pre-Olympic Congress

作者： Stahn A Strobel G Terblanche E dept.medical physiology and biochemistry University of Stellenbosch Institut fur Sportmedizin Charite-UniversitatsmedizinCampus Benjamin FranklinFreie Universitat Berlin

＜正＞Introduction According to the follow-up to the National Institutes of Health Technology Assessment Conference on bioelectrical impedance analysis（BIA）the relationship between BIA and blood parameters is still poorly understood[1].In vitro studies suggest that these relationships offer the potential for several future clinical *** has recently been

关键词：

Effects of Atrazine on Blood Indices and Histopathology of Grass Carp (Ctenopharhyngoden idella)

在线全文

cnki会议

学校读者我要写书评

暂无评论

生态毒理学报 2013年第6期8卷 879-888页

作者： Soorena Abdali Ayoub Yousefi Jourdehi Rezvanollah Kazemi Ali Hallajian Tehran North branch Islamic Azad University International Sturgeon Research Institute of the Caspian Sea Physiology & Biochemistry Dept

Atrazine is currently the most widely used herbicide in the south of Iran. The chronic toxicity effects of atrazine(herbicide) on blood indices and histopathology of the gill, liver and kidney in grass carp(Ctenopharhyngoden idella) were studied by exposing them to sublethal concentrations of atrazine to 0, 10, 100, 1 000, 10 000 g atrazine per liter of water for a period of 30 days. Up to 100 g·L-1, atrazine did not show significant *** contrast, atrazine in the concentration of 1 000 and 10 000 g·L-1significantly increased toxicity effects on studied parameters. The highest mortality rate(100%) was observed at 10 000 g·L-1on the day 10 and at 1 000 g·L-1on the day 20. Cytological analysis showed that haematocrit(Hct) increased significantly with the increase of atrazine concentration and days. White blood cells(WBC), red blood cells(RBC) and hemoglobin(Hb) were changed significantly(p < 0.05) in different treatments. Biochemical analysis indicated that plasma total protein, albumin, glucose, cholesterol and triglycerides levels decreased significantly(p < 0.05) with the increase of atrazine concentrations and exposure days. Histopathological studies showed hyperplasia, hyperemia, necrosis, mucosa secretion, shortness of filaments, lamellar fusion in gills; necrosis, anemia, bile stagnation in liver; and cell atrophy, hyperemia, hemorrhage and necrosis in kidney which were more severed at 1 000 and 10 000 g·L-1. Therefore, mentioned effects on studied histopathological and some blood parameters were both dose-and time-dependent. In sum, the atrazine exposure of grass carp at concentrations 1 000 and 10 000 g·L-1induced significant changes in blood indices and structural disruptions in gill, liver and kidney organs on days 20 and 10, respectively. The obtained results indicated the atrazine is toxic and could damage vital organs and blood of grass carp. Therefore, the use of atrazine should be imperative and carefully monitored.

关键词：摘要编辑部编辑工作读者

Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2003年第1期5卷 27-31页

作者： Mahitosh Sarkar Gargi Ray Chaudhuri Aloke Chattopadhyay Narendra Mohan Biswas Reproductive physiology Unit dept. of physiology University Colleges of Science and Technology Calcutta University Calcutta-700 009 India

To investigate the effect of arsenic on spermatogenesis. Methods: Mature (4 months old) Wistar rats were intraperitoneally administered sodium arsenite at doses of 4, 5 or 6 mg-kg^-day1 for 26 days. Different varieties of germ cells at stage VII seminiferous epithelium cycle, namely, type A spermatogonia (ASg), preleptotene spermatocytes (pLSc), midpachytene spermatocytes (mPSc) and step 7 spermatids (7Sd) were quantitatively evaluated, along with radioimmunoassay of plasma follicle-stimulating hormone (FSH), lutuneizing hormone (LH), testosterone and assessment of the epididymal sperm count. Results: In the 5 and 6 mg/kg groups, there were significant dose-dependent decreases in the accessory sex organ weights, epididymal sperm count and plasma concentrations of LH, FSH and testosterone with massive degeneration of all the germ cells at stage VII. The changes were insignificant in the 4 mg/kg group. Conclusion: Arsenite has a suppressive influence on spermatogenesis and gonadotrophin and testosterone release in rats.

关键词： arsenite spermatogenesis gonadotrophins testosterone testis

Sulfur dioxide relaxes vessel tone via endotheliumdependen and independent mechanisms

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sulfur dioxide relaxes vessel tone via endotheliumdependen a...

第七届海峡两岸心血管科学研讨会

作者：林丽袁文俊 dept.of physiology Second Military Medical University dept.of physiology Ning-Xia Medical University

This work aimed to investigate the vasoactivity of sulfur dioxide(SO

关键词：

TXNIP acts on GLP-1 receptor to decrease proliferative sensibility of GLP-1 to islet beta cells

在线全文

cnki会议

学校读者我要写书评

暂无评论

TXNIP acts on GLP-1 receptor to decrease proliferative sensi...

2019年中国生理学会心血管生理学术研讨会

作者： ZHANG Wen-ting WANG Jin YUE Ji-ping JIN Wen-wen ZHANG Zhi-nan JIAO Xiang-ying dept.of physiology Shanxi Medical University

Objective This study is designed to observe TXNIP acting on the GLP-1 receptor to attenuate the effect of glucagon-like peptide-1（GLP-1） on pancreatic β-cell *** Western blot was used to detect the expression of TXNIP and proliferation-related indicator PCNA in db/m,db/db mice’pancreatic *** shape of the islets and the number of beta cells were observed by HE and *** was used to detect the expression of GLP-1 in *** level of GLP-1 R protein in pancreatic tissue were detected by Western blot and *** constructed TXNIP overexpressional（Ad-TXNIP-GFP） MIN6 islet β cell *** expression of TXNIP protein,GLP-1 receptor level and proliferation-related indicators were detected by Western blot and *** The expression of TXNIP in pancreatic tissues of db/db mice was increased（P＜0.05）,islet structure was destructed,beta cell number and PCNA expression were decreased in pancreatic tissue of db/db mice（P＜0.05）.GLP-1 levels in serum were reduced（P＜0.05）,and GLP-1 receptor levels of pancreatic tissue and islet were reduced（P＜0.01）.The TXNIP overexpression model was successfully constructed（P＜0.01）,and the level of GLP-1 receptor was decreased on islet β cells（P＜0.05）.The overexpression of TXNIP reduced the proliferative reactivity of islet β cells to GLP-1（P＜0.01）.CONCLUSION:TXNIP acts on the GLP-1 receptor to attenuate the sensibility of GLP-1 to islet beta cell proliferation.

关键词： thioredoxin interacting protein GLP-1 GLP-1 receptor cell proliferation

TXNIP reduces pro-proliferation effect of IGF-1 on islet β cells

在线全文

cnki会议

学校读者我要写书评

暂无评论

TXNIP reduces pro-proliferation effect of IGF-1 on islet β ...

2019中国生理学会学术年会暨张锡钧基金第十五届全国青...

作者：张文婷 WANG Jin YUE Ji-ping JIN Wen-wen ZHANG Zhi-nan JIAO Xiang-ying dept.of physiology Shanxi Medical University

Objective To observe the role of thioredoxin interacting protein（TXNIP） on IGF-1 receptor and its downstream signaling pathways in the proliferation of islet β cells promoted by insulin-like growth factor-1（IGF-1）.Methods TXNIP overexpression（Ad-TXNIP-GFP） MIN6 cells were constructed by stably transfected with lentivirus, which were divided into Control group,Ad-GFP group and Ad-TXNIP-GFP *** expressions of TXNIP, PCNA and IGF-1 R in pancreatic tissue were detected by Western *** expressions of PCNA, Ki67 and IGF-1 R were observed by *** morphology of islets and the number of β cells were observed by HE and *** expression of IGF-1 in serum was detected by *** overexpression（AdTXNIP-GFP） and silencing（TXNIP Sh-RNA） MIN6 cells were constructed by stably transfected with lentivirus;TXNIP expression, proliferation related index and p-PI3 K, p-AKT, p-mTOR protein expression were detected by Western blot;Real-time PCR and Western blot to detect IGF-1 receptor *** Islet structure was destructed, the number of β cells and PCNA expression were decreased in pancreatic tissue of db/db mice（P＜0.05）.The level of IGF-1 in serum was reduced（P＜0.01）, and the level of IGF-1 receptor in pancreatic tissue and islet were reduced（P＜0.01）.The expression of TXNIP in pancreatic tissue of db/db mice was increased（P＜0.05）.The TXNIP overexpression and silencing models were successfully constructed（P＜0.01）.The level of IGF-1 receptor was decreased in TXNIP overexpressing islet β cells（P＜0.01）, the overexpression of TXNIP reduced the proliferative effect of islet β cells to IGF-1（P＜0.01）, and the protein expression of p-PI3 K, p-AKT and p-mTOR were *** level of IGF-1 receptor was increased in TXNIP silencing cells（P＜0.01）, and the proliferative effect to IGF-1 was increased（P＜0.01）.TXNIP expression increased, proliferation level decreased, IGF-1 levels increased of serum, protein expression of IGF-1 R and its downstream p-PI3 K, p-AKT, p-mTOR decr

关键词： thioredoxin interacting protein IGF-1 IGF-1 receptor cell proliferation

The screening for active ingredient against morphine -induced Physical dependence in Salvia miltiorrhiza and its preliminary mechanism

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国药理通讯 2005年第4期22卷 10-11页

作者： Chen Chong - hong Qiu Hong - Qiang Yu Juan Zheng Xiang dept of Pharmacology Dept of Physiology and Pathophysiology Fujian Medical University Fuzhou 350004 China

The Effects of Using a Specially Designed Stirrup on Kinetic Energy Absorption by the Knee Joint of 12 Show Jumping/Eventing Riders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2023年第2期13卷 13-21页

作者： Marta Kulikowska Franziska C. Wagner Adrian Harrison Equi Physiq Esrumvej 435 Græsted Denmark Institute of Anatomy Histology and Embryology Faculty of Veterinary Medicine Leipzig University Leipzig Germany Faculty of Health & medical Sciences Dept for Veterinary and Animal Sciences (IVH) Section for Physiology University of Copenhagen PAS Frederiksberg Denmark

The use of Winderen Knee Protection Solution stirrups compared to standard iron stirrups, reveals the following benefits: 1) A reduction of stress or strain time in the order of 14 seconds per minute of activity whilst walking and 5 - 7 seconds less whilst trotting or cantering for muscles around the knee. 2) A reduction of stress or strain time in the order of 25 seconds per minute of activity whilst walking and 9 - 10 seconds less whilst trotting or cantering for ligaments around the knee. 3) A significant improvement in the E-score (less time exposed to stress and shock) and ST-score (lower force around the knee) whilst walking. 4) A considerable improvement in rider comfort and feeling of leg stability (self-assessment) compared with the owners current stirrups, whilst riding.

关键词： Stirrups Knee Stress Acoustic Myography Riders