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The Neurologist in the Emergency Room: Prospective Study of the Neurological Emergency Group in Lombardia

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Journal of Health Science 2019年第4期7卷 254-261页

作者： MariaLuisa Delodovici Marco Mauri Megi Meneri Marco Gallazzi Elena Ballabio Giuseppina Borutti Maria Vittoria Calloni Elisa Candeloro Bruno Censori Claudio De Piazza Laura Fusi Franca Mazzucchelli Ignazio Santilli Elisabetta Forapani Chiara Scaccabarozzi Maria Sessa Lucia Tancredi Massimiliano Braga dept. of neurology and Stroke Unit Ospedale di Circolo e Fondazione MacchiUniversità dell’InsubriaASST-Settelaghile Luigi Borri 57 21100 VareseItaly dept. of neurology Ospedale di Desio (MB) Director G. Mazzini 1 20832 Desio (MB)Italy dept. of neurology ASST Lecco-Ospedale A. Manzonidell’Eremo 9/11 23900 LeccoItaly dept. of neurology Ospedale di Cremona ASST Cremona Directorle Concordia 1 26100 CremonaItaly dept. of neurology Ospedale Sant’Anna ComoRavona 20 22042 SFermo della BattagliaComoItaly dept. of neurology Ospedale di Vimercate (MB) Santi Cosma e Damiano 10 20871 Vimercate (MB)Italy dept. of neurology Ospedale S. Carlo BorromeoA. Mosca 12 20152 MilanoItaly dept. of neurology Director Ospedale Civile di VogheraVolturno 14 Voghera 27058 (PV)Italy dept. of neurology Ospedale di Legnano ASST Ovest MilanesePapa Giovanni Paolo II20025 Legnano (MI)Italy dept. of neurology Fondazione IRCCS C. Mondino Mondino 2Pavia 27100Italy dept. of neurology ASST Papa Giovanni XXIII Piazza OMS 1 24127 BergamoItaly dept. of neurology Ospedale Valduce ComoDante Alighieri 11 22100 ComoItaly dept. of neurology Ospedale di Saronno ASST Valle olonaPiazzale Borella 1 Saronno 21047 (VA)Italy dept. of neurology Ospedale S. Antonio Abate Gallarate. Pastori 4 21013 Gallarate VareseItaly

Purpose of the work was to quantify the workloads and the neurologist’s commitment in ER, to verify the management of urgencies and appropriateness of neurological counseling requests. Neurologic emergencies are frequent in elderly patients and are associated with high morbidity and mortality. Due to the aging population, neurologic pathologies in emergency room (ER) are widely expected to increase. The role of the neurologist in this context is controversial. Methods: in 14 operative units of neurology a prospective collection of neurological evaluations in ER was carried out using boards of detection of the most frequent neurological clinical pictures seen in the course of a week. Data were collected from 738 cases. Attention was focused on cerebrovascular diseases (CVD), impairment of consciousness, epilepsy, headache, dizziness, head trauma and disorders of the peripheral nervous system (PNS). Achievements: neurological consultations were on average 5% of total accesses to ER. The most common pathology seen was ischemic stroke. After counseling most patients were discharged home. The CVD required the greatest commitment to the specialist. The usefulness of the specialized neurological “filter” has been confirmed in a non-simple operative context, aimed at optimizing the appropriateness of the hospitalization and the economy of the diagnostic path.

关键词： Emergency room neurological diseases neurology workload

Molecular mechanism of the anti-apoptotic activity of Methylprednisolone in spinal cord injury

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Molecular mechanism of the anti-apoptotic activity of Methyl...

中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Lee JM Hsu CY dept. neurology Washington University School of MedicineSt LouisMO 63110USA dept. neurology Washington University School of MedicineSt LouisMO 63110USA

＜正＞The therapeutic action of Methylprednisolone（MP） in SCI has been attributed to its anti-oxidant and anti-inflammatory activities. We found that MP reduced DNA fragmentation, caspase-3 activation and the expression of the anti-apoptotic protein, Bcl-xL, and MP selectively attenuated oligodendrocyte （OLG） but not neuronal death 8d after spinal cord injury （impact rat model）. To investigate the mechanism for its

关键词： anti-apoptotic activity Methylprednisolone spinal cord

Relationship between Alzheimer′s,Parkinson′s disease and Apolipoprotein E polymorphism in the Chinese

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白求恩医科大学学报 2001年第5期27卷 562-566页

作者： QIN Bin ZENG Xiang yu GUO Han bang TANG Wei qing XU Rong HE Jian xin WANG Shu XU Xian hao dept.of neurology Beijing HospitalBeijing 100730 China Biochemistry Division Institute of Gerontal Medicine

目的 :探讨阿尔茨海默病 (AD)、帕金森病 (PD)及帕金森病痴呆 (PDD)的发病机理和与载脂蛋白 E(Apo E)基因多态性的关系。方法 :对 AD组 (48例 )、PD组 (5 4例 )、PDD组 (43例 )和非痴呆对照组 (2 34例 )的 Apo E基因频率及基因型分布进... 详细信息

目的 :探讨阿尔茨海默病 (AD)、帕金森病 (PD)及帕金森病痴呆 (PDD)的发病机理和与载脂蛋白 E(Apo E)基因多态性的关系。方法 :对 AD组 (48例 )、PD组 (5 4例 )、PDD组 (43例 )和非痴呆对照组 (2 34例 )的 Apo E基因频率及基因型分布进行对照研究。结果 :非痴呆对照组 Apo Eε3基因频率最高 (0 .887) ,而 AD组 Apo Eε 4基因频率明显升高 (0 .2 19) ,显著高于非痴呆对照组 (0 .0 5 1) (P0 .0 5 )。结论 :Apo Eε4是导致 AD发病的易感或危险基因之一 ,而与 PD和 PDD的发病无关 ,说明 AD和 PD。

关键词：阿尔茨海默病帕金森病帕金森病痴呆基因多态性 AD PD PDD 载脂蛋白E 发病机制

Acute thrombosis of the carotid artery associated with positional nystagmus at multiple planes

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Journal of Otology 2019年第4期14卷 158-161页

作者： Sertac Yetiser Yasar Kutukcu Kutlay Kahraman Anadolu Medical Center Dept of ORL&HNSKocaeli41400Turkey Anadolu Medical Center Dept of NeurologyKocaeli41400Turkey Anadolu Medical Center Dept of RadiologyKocaeli41400Turkey

Objective:An acute onset central pathology without any clear neurological symptoms may mimic peripheral vestibular problem in an emergency setting.A 54-year-old man suddenly developed dizziness without any cranial nerve symptoms,paresis,cerebellar signs or sensory disturbances except upbeat positional nystagmus at multiple provoked positions which alerted for a possible acute central ***:An instantaneous magnetic resonance imaging and angiography studies further showed obstruction of the left internal carotid artery above the *** patient’s subsequent prognosis was consistent with good recovery following anti-coagulant therapy.A follow-up MRI and angiography showed resolution of ***:It should be kept in mind that positional nystagmus is likely to occur in central *** between benign paroxysmal positional vertigo and central positioning nystagmus is critical.

关键词： Upbeat nystagmus Positional maneuver Carotid artery occlusion

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脑深部电刺激术治疗基底节相关疾病

中国神经精神疾病杂志 2009年第4期35卷 193-202页

作者： Thomas Wichmann,Mahlon R. DeLong Mahlon R. DeLong 冼文彪(译) 陈玲(校) dept. neurology Emory University 101 Woodruff Circle Atlanta GA30322 中山大学附属第一医院神经科

简介 20世纪50－60年代,毁损性功能神经外科手术曾广泛应用于治疗帕金森病、震颤和肌张力障碍等运动障碍疾病。但自发现左旋多巴可治疗帕金森病以后,这些手术几乎被摒弃。然而,随着治疗时间的延长,药物治疗的缺点越来越明显,尤其是药物... 详细信息

简介 20世纪50－60年代,毁损性功能神经外科手术曾广泛应用于治疗帕金森病、震颤和肌张力障碍等运动障碍疾病。但自发现左旋多巴可治疗帕金森病以后,这些手术几乎被摒弃。然而,随着治疗时间的延长,药物治疗的缺点越来越明显,尤其是药物所致的不自主运动、运动波动和认知方面的副作用。基于这个事实,以及对疾病的病理生理更深入的认识,加上手术技术的改进,使功能神经外科手术在过去二十年中重新得到显著的发展。[第一段]

关键词：脑深部电刺激术帕金森病肌张力障碍强迫症抽动秽语综合征

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激素会妨碍脑腱黄瘤病的诊断吗?

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 60-61页

作者： Siman-Tov T. Meiner V. Gadoth N. 郭中孟(译) 不详 dept. neurology Meir General Hospital Kfar-Saba 44281 Israel

Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder of bile acid synthesis, caused by impaired hydroxylation of cholesterol side chains due to deficiency of the mitochondrial enzyme sterol 27-hydroxylase (CYP27A1), leading to accumulation of cholestanol and cholesterol in brain and other tissues. Elevated plasma cholestanol serves as a key marker for the clinical diagnosis of CTX. In the present report we describe a young man with CTX who was on high dose steroids for a misdiagnosed chronic inflammatory demyelinating polyneuropathy (CIDP) and had normal level of serum cholestanol. When steroids were discontinued, markedly elevated serum cholestanol was measured concomitant with marked clinical worsening. This observation may imply that steroids can lower plasma cholestanol, possibly by directly inducing residual CYP27A1 activity or by inducing alternative pathways for cholestanol elimination.

关键词：激素治疗黄瘤病常染色体隐性遗传性诊断脑胆固醇腱临床症状

Imaging Brain Activity during Natural Vision Using CASL Perfusion fMRI

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Imaging Brain Activity during Natural Vision Using CASL Perf...

第一届全国脑与认知科学学术研讨会

作者： Kathy Tang John A.Detre dept.of neurology ＆ Center for Functional Neuroimaging Univ.of Pennsylvania USA dept.of neurology ＆ Center for Functional Neuroimaging Univ.of Pennsylvania USA

＜正＞Introduction The neural substrates underlying the processes of natural scenes in everyday vision remains poorly understood, which may due to the much longer time-scales of natural vision than the duration of strictly controlled conditions in optimal BOLD fMRI studies, and the complex scenes of multiple objects moving in spatial and temporal dimensions. Recently, Arterial spin labeling （ASL） perfusion fMRI has emerged as an appealing alternative to BOLD fMRI for imaging the longitudinal processes like natural conditions because of its noninvasive quantification of absolute cerebral blood flow （CBF） and long term temporal stability. The

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The important role of lipid for the cognitive impairment

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The important role of lipid for the cognitive impairment

第11届全国脂质与脂蛋白学术会议

作者：崔德华 Neuroscience Research Institute & dept.of neurology Peking University

The current knowledge on circulating serum and plasma risk factors of cognitive decline of degenerative AD linked to cholesterol homeostasis and lipoprotein disturbances,*** cholesterol(TC),24S-hydroxy-cholesterol,lipoprotein(a) (Lp(a)),or apolipoprotein E(APOE).Lipoprotein lipase(LPL) is predominantly expressed in adipose and muscle where it plays a crucial role in the metabolism of triglyceride-rich plasma *** is also expressed in the brain with highest

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Restless legs syndrome:It's neurobiology and treatment a sleep-wake or a movement disorder?

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Restless legs syndrome:It's neurobiology and treatment a sle...

第2届中国睡眠医学论坛

作者： Richard P Allen PhD DABSM Dept of Neurology Johns Hopkins Univ．

RLS:sleep-wake disorder History -before and after sleep medicine Diagnosis -Clinical characteristics -Associated condition -Why and when to treat Pathology -Iron and dopamine Treatment and diagnosis implications Treat...

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