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Cellular & Molecular Immunology 2009年第2期6卷 111-116页

作者： Shafi Mojadadi Abbas Jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad Neuroscience research center Kerman University of Medical Sciences Department of Virology Faculty of medical science Tarbiat Modares University dept.of virology School of medicalsciences Tarbiat Modares University dept.of microbiology Arak University of Medical Sciences

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte （CTL） activity in the inhibition of herpes simplex virus type 1 （HSV-1） reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-γ. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

关键词： acute morphine herpes simplex virus-1 reactivation cell-mediated immunity

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Determination of Organochlorine Pesticide Residues in Pumpkin, Spinach and Sorrel Leaves Grown in Akwanga, Nasarawa State, Nigeria

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Journal of Environmental Protection 2018年第5期9卷 508-515页

作者： E. G. Ibrahim N. Yakubu L. Nnamonu J. M. Yakubu dept. of Pure and Applied Chemistry Plateau State University Bokkos Plateau Stae Nigeria Demonstration Secondary School College of Education Akwanga Nasarawa State Nigeria dept. of Chemistry and Agrochemical Technology University of Agriculture Ma-kurdi Benue State Nigeria dept. of microbiology Federal University Wukari Wukari Nigeria

Three green leafy vegetable samples of pumpkin leaves, spinach leaves, and sorrel leaves were collected from a farm in Akwanga and were tested for the presence of residues of organochlorine pesticides. The concentrations of all the pesticide residues in the vegetable samples were determined using GC/MS. Among the organochlorine pesticide p,p’-DDT was detected in pumpkin (0.75 mg/kg), spinach (0.319 mg/kg) and sorrel (0.219 mg/kg). θ-BHC and γ-BHC were detected only in pumpkin leaves (0.359 mg/kg and 0.647 mg/kg respectively). Dieldrin was detected in spinach and sorrel (0.124 mg/kg and 0.053 mg/kg respectively). Endrin was detected in pumpkin (0.732 mg/kg) and Aldrin in sorrel (0.095 mg/kg). All these values were above the maximum residue limit (MRL) value of the pesticides. Endosulfan II was detected in sorrel (0.306 mg/kg) below the MRL. The levels of most of the pesticide residues found in vegetables were above the maximum residue limits (MRLs) that call for laws to regulate the use and circulation of such chemicals. Routine monitoring of pesticide residues in this study area is necessary for the prevention, control and reduction of environmental pollution, to minimize health risks.

关键词： Akwanga Organochlorine Pesticide Residues Maximum Residue Limit Vegetables

Prevalence of Organophosphorous Pesticide Residues in Pumpkin, Spinach and Sorrel Leaves Grown in Akwanga, Nasarawa State, Nigeria

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Journal of Environmental Protection 2018年第5期9卷 516-524页

作者： E. G. Ibrahim N. Yakubu L. Nnamonu J. M. Yakubu dept. of Pure and Applied Chemistry Plateau State University Bokkos Jos Plateau Stae Nigeria Demonstration Secondary School College of Education Akwanga Nasarawa State Nigeria dept. of Chemistry and Agrochemical Technology University of Agriculture Ma-kurdi Benue State Nigeria dept. of microbiology Federal University Wukari Wukari Nigeria

Three green leafy vegetable samples of pumpkin leaves, spinach leaves, and sorrel leaves were collected from three different locations in a farm in Akwanga and were tested for the presence of organophosphorus (OP) compounds. The concentrations of all the pesticide residues in the vegetable samples were determined using gas chromatography with mass spectrometry (GC-MS). The organophosphorus pesticides detected include carbaryl (0.052 mg/kg) in pumpkin, this is below European maximum residues limit (EU MRL) of 0.1 mg/kg, Dimethoate was found in pumpkin (0.165 mg/kg), spinach (0.103 mg/kg) and sorrel (0.250 mg/kg) all above the EU MRL of 0.05 mg/kg. Dichlofenthion was detected in pumpkin (0.308 mg/kg), pirimiphos methyl was detected in pumpkin and spinach (0.428 mg/kg and 0.149 mg/kg respectively), all these were below the EU MRL of 0.5 mg/kg. Chlorpyrifos was found in spinach (0.230 mg/kg) and sorrel (0.192 mg/kg) only spinach was above the EU MRL of 0.2 mg/kg. The pesticide residue Bromophosethyl was detected in all vegetables, pumpkin leaves (0.501 mg/kg), sorrel (1.571 mg/kg) and spinach (7.981 mg/kg) all above the EU MRL of 0.5 mg/kg. The remaining pesticides detected were all below their EU MRL value;these are Ethion found in spinach (0.167 mg/kg), Methyl Parathion in spinach (0.103 mg/kg) and sorrel (0.335 mg/kg). The levels of some of the organophosphorus pesticide residues found in vegetables were above the maximum residue limits (MRLs) set by the European Union. This calls for laws to regulate the use and circulation of such chemicals. Based on the observation made in these studies, it is proposed that more extensive monitoring investigation covering all vegetables part in Akwanga Nasarawa state be carried out to find the exact position of pesticide residues.

关键词： Akwanga Pesticide Residues Organophosphorous Maximum Residue Limit

Determinants of quinolone resistance in Escherichia coli causing community-acquired urinary tract infection in Bejaia,Algeria

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Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 462-467页

作者： Yanat Betitra Vinuesa Teresa Vinas Miguel Touati Abdelaziz Laboratoire d'ecologie Microbiologie.Universite A/Mira de Bejaia Laboratory of Molecular microbiology and Antibiotics Dept.Pathology and Experimental therapeutics.Medical SchoolUniversity of Barcelona

Objective:To investigate the mechanisms of quinolone resistance and the association with other resistance markers among Esherichia coli(***) strains isolated from outpatient with urinary tract infection in north of ***:A total of 30 nalidixic acid-resistant *** isolates from outpatient with urinary tract infections from January 2010 to April 2011 in north of Algeria(Bejaia) were *** susceptibility was determined by disc diffusion assay,minimal inhibitory concentrations(MIC) of quinolone were determined by *** in the Quinolone Resistance-Determining Region(QRDR) of gyra and parC genes and screening for qnr(A,B and S) and bla genes were done by PCK and UNA ***:Most of the *** isolates(56.66%) were shown to carry mutations in gyrA and parC,igyra:Ser83Leu + Asp87Asn and parC:***.16.66 had only an alteration in gyrA:*** isolate produced qnrB-like and two *** isolates were CTXM-15 producers associated with TEM-1 producing in one ***-expression of bla_(LTV,M)_(15) and qnrB was determined in one *** ***:Our findings suggested the community emergence of gyrA and parC alterations and Qnr determinants that contributed to the development and spread of fluoroquinolone resistance in Algerian *** isolates.

关键词： Escherichia coli Community-acquired urinary tract infection QRDR Qnr ESBL

Regeneration of transgenic rice plants from protoplasts following plasmid uptake

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Rice Science 1994年第3期 1-2页

作者： S.Castiglione F.Sala dept.of Genetics and microbiology Univ of Pavia Italy

Embryogenic cell suspension was obtained fromthe calli developed from mature seeds of riceRoncarolo(Oryza sativa L., a japonica cultivarfrom Italy). The protoplasts were isolated fromcell suspension by treatment of en... 详细信息

关键词： gene DNA cell Regeneration of transgenic rice plants from protoplasts following plasmid uptake

Waste plastics-to-fuel using fly ash catalyst

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Waste Disposal and Sustainable Energy 2021年第1期3卷 13-30页

作者： Bijoy Kumar Mondal Falguni Guha MdNurul Abser Department of Chemistry Jahangirnagar UniversitySavarDhakaBangladesh Department of Biochemistry and microbiology North South UniversityDhakaBangladesh

Suitable disposal pathways of waste plastics and coal fly ash have yet not been established which is a matter of great envi-ronmental *** low-density polyethylene(LDPE)and high-density polyethylene(HDPE)were degraded using a semi-batch reactor along with acid or alkali modified fly ash *** high yield of liquid fuel product(about 87.24 wt%)was achieved for low-density polyethylene at a polymer and catalyst ratio of 25 w/*** 96%conversion was found with very few amount of gaseous *** of the waste plastics were degraded at 400-450℃.The liquid products were analyzed using Fourier-transform infrared spectroscopy(FTIR),nuclear magnetic resonance(^(1)H,^(13)C,and dept.135 NMR),and gas chromatography-mass spectrometry(GC-MS).Fly ash is an efficient catalyst to degrade waste plastic into light weight liquid(gasoline and kerosene)*** NMR results accompanied by GC-MS data ensure that obtained fuels contain both aliphatic(saturated and unsaturated)and aromatic *** plastic-to-fuel technology should be commercialized owing to be profitable and eco-friendly.

关键词： Solid waste Catalytic pyrolysis Liquid fuels

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印度中部的甲真菌病:临床病因的联系性

世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 30-31页

作者： Garg A. Venkatesh V. Singh M. 阎小宁 Post Graduate dept. of microbiology King George's Medical College CSM Medical University Lucknow India Dr.

Background. Onychomycosis is mainly caused by dermatophytes, but yeasts and nondermatophyte molds have also been implicated, giving rise to diverse clinical presentations. The etiological agents of the disease may show geographic variation. The aim of the present study was to isolate the causative pathogens and to determine the various clinical patterns of onychomycosis in central India. Methods. The study population comprised 90 patients with onychomycosis. Nail samples were collected for direct microscopic examination and culture. Clinical patternswere noted and correlatedwith causative pathogens. Results. The male: female ratio was 3:1 and the mean age was 29.40 ±13.61 years. Fingernails were involved in 60%, toenails in 26.67%and both fingernails and toenails in 13.34%of the 90 patients. The clinical types noted were distolateral subungual onychomycosis (64.44%), total dystrophic onychomycosis (17.78%), proximal subungual onychomycosis with paronychia (12.2%), proximal subungual onychomycosiswith-out paronychia (4.44%) and superficial white onychomycosis (1.11%). Dermatophyteswere themost common pathogens isolated, being found in 24 patients (26.36%) [Tricophyton rubrum (23.07%), Tricophyton verrucosum(2.22%) and Epidermophyton floccosum (1.11%)], followed by Candida albicans, which was found in 22 patients (24.27%). Thirty-six (39.58%) nondermatophyte molds were isolaled from 29 patients. Of these 29 cases, six were associated with Tricophyton rubrum, which was considered the primary pathogen. Conclusions. Distolateral subungual onychomycosis was the most common clinical presentation; however, total dystrophic onychomycosis and proximal subungual onychomycosiswere not uncommonin this part of India. Tricophyton rubrum and Candida albicans were the major pathogens. The clinicoetiologic correlation revealed that a single pathogen could give rise to more than one clinical type. 2004 The International Society of Dermatology.

关键词：甲真菌病临床病因皮肤癣菌疣状毛癣菌真菌培养红色毛癣菌下型联系性皮肤真菌临床表型

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Microbial Growth and Decay: A Commented Review of the Model

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Advances in microbiology 2024年第1期14卷 1-10页

作者： Alberto Schiraldi Formerly at dept. Food Environ. Nutr. Sci. (DeFENS) University of Milan (Italy) Milan Italy

The paper reviews previous publications and reports some comments about a semi empirical model of the growth and decay process of a planktonic microbial culture. After summarizing and reshaping some fundamental mathematical expressions, the paper highlights the reasons for the choice of a suitable time origin that makes the parameters of the model self-consistent. Besides the potential applications to predictive microbiology studies and to effects of bactericidal drugs, the model allows a suitable proxy of the fitness of the microbial culture, which can be of interest for the studies on the evolution across some thousand generations of a Long Term Evolution Experiment.

关键词： Microbial Cultures Model Time Scale Growth and Decay Evolution

重组人IL-6对NOD小鼠IDDM发病的影响及机制研究

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中国药理学通报 2003年第8期19卷 917-919页

作者：向明 Ferdinando icoletti1 华中科技大学同济药学院药理学教研室武汉430030 dept.of microbiology University of Milan

目的　探讨重组人白细胞介素 6(rhIL 6)对NOD小鼠自发性和环磷酰胺 (CY)诱发性Ⅰ型糖尿病 (IDDM)的影响及相关机制。方法　通过观察NOD小鼠用药后血糖和尿糖水平、胰腺组织病理学特征 ,及血清抗CD3抗体、LPS诱导的炎症因子IFN γ、TNF ... 详细信息

目的　探讨重组人白细胞介素 6(rhIL 6)对NOD小鼠自发性和环磷酰胺 (CY)诱发性Ⅰ型糖尿病 (IDDM)的影响及相关机制。方法　通过观察NOD小鼠用药后血糖和尿糖水平、胰腺组织病理学特征 ,及血清抗CD3抗体、LPS诱导的炎症因子IFN γ、TNF α水平的变化 ,以及CY诱导ID DM发生率 ,确定rhIL 6的抗IDDM作用。结果　 4wk龄♀NOD小鼠连续注射rhIL 6 1 6wk后 ,胰岛炎即胰腺淋巴细胞、单核细胞浸润明显减少 ,糖尿病的发病率明显降低(33 % )。与空白对照组相比 ,血清中炎症因子IFN γ、TNF α水平也呈显著的下降趋势。 1 2wk龄NOD小鼠连续 8wk应用rhIL 6 ,糖尿病发生率则无明显变化 ,且实验中未观察到rhIL 6对CY诱发IDDM的保护作用。结论　rhIL 6早期预防用药可降低NOD小鼠自发性IDDM的发生 ,该保护作用可能与其降低炎症因子TNF α、IFN

关键词： Ⅰ型糖尿病白细胞介素6 NOD小鼠环磷酰胺

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Effect of Ocimum sanctum on the development of protective immunity against Salmonella typhimurium infection through cytokines

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 682-686页

作者： Anjana Goel Sandeep Kumar Ashok Kumar Bhatia Department of microbiology & Immunology College of Veterinary Sciences & Animal HusbandryU.P.Pt Deen Dayal Upadhyay Pasu Chikitsa Vigyan Vishwavidyalaya evam Go Anusandhan Sansthan(DUVASU)Mathura281001U.P.India

Objective:To investigate the protective role of Ocimum sanctum（***） leaves against Salmonella ***（***） infection in rats by inducing TNF-α,IFN-γ& IL-2 ***:Wistar albino rats were fed with aqueous extract of *** leaves using 250 mg/kg body weight dose once a day for 20 consecutive *** rats were fed with *** were infected with LD50 dose of *** infection and monitored for their *** blood burden in both the groups was compared and numbers of activated peritoneal macrophages were *** of TNF-α,IFN-γand IL-2 cytokines in serum during different time intervals was assayed by sandwich ***:Rats of control group showed a high mortality rate and had higher bacterial blood burden when compared with *** extract fed *** was a significant increase in the number of *** engulfed peritoneal macrophages in the peritoneal fluid of *** fed *** protective control against bacterial infection in O,sanctum fed rats was associated with elevated level of TNF-α,IFN-γand IL-2 cytokines in ***:These findings suggest that orally administered *** leaves extract effectively enhanced activation in macrophage and lymphocytes,depicted by the elevated serum concentration of TNF-α,IFN-γand IL-2 cytokines,leading to induce a protective resistance against Salmonella typhimurium infection.

关键词： Ocimum sanctum Salmonella typhimurium TNF-α IFN-γ IL-2