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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 48-49页

作者：王彬 dept.gastroenterol.hepatol Tianjin Med Univ General HospTianjin Instit Dig DisTianjin Dig Dis Key LabTianjin 300052

Objective To compare the difference between gas volume score (GVS) method and combination of computed tomography (CT) image and calculation formula method (hereinafter referred to as CT method)in the detection of gast... 详细信息

关键词： patients dyspepsia gastrointestinal

Optimization of biopsy strategies for risk related staging of gastric cancer

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 106-107页

作者：兰雅迪 dept.gastroenterol Shandong Prov HospShandong UnivJinan 250021

Objective To investigate the correlation of atrophy and intestinal metaplasia (IM) stage with gastric cancer and to optimize biopsy *** Data of patients who underwent endoscopy and five-point biopsy at Shandong Provincial Hospital between November 2020and October 2022 were *** baseline characteristics of gastric cancer and non-gastric cancer patients,as well as the occurrence and severity of atrophy and IM in different areas were compared.

关键词： biopsy staging gastric

Shuchang decoction for treatment of diarrhea predominant irritable bowel syndrome with Gan depression and Pi deficiency:a multicenter,randomized,double-blind,placebo controlled trial

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 14-15页

作者：思璎桀 dept.gastroenterol Longhua HospShanghai TCM UnivShanghai200032

Objective To observe the clinical efficacy and safety of Shuchang Decoction (SCD) in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D)with Gan depression and Pi deficiency *** A total of 179 patie... 详细信息

关键词： predominant double treatment

Influencing factors for colonoscopic compliance to colorectal cancer screening in outpatients

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 105-106页

作者：谭雪娇 dept.gastroenterol 1st Affil HospShihezi UnivShihezi 832000

Objective To explore the influencing factors for compliance to colonoscopy screening for colorectal cancer in *** Patients aged 40-74 years who visited the outpatient gastroenterol.gy department of 7 tertiary hospitals in 7 regions of Xinjiang from January 2022 to June 2022 were *** for colonoscopy screening were made according to the patient's medical conditions,and the questionnaire was used to collect *** Chi-square test was used to compare the differences of compliant and noncompliant *** logistic regression was used to analyze the influencing factors of compliance to colonoscopy *** A total of 463 valid questionnaires were obtained from 7 centers,in which,427 outpatients(92.2%)followed the recommendation for colonoscopy screening,and 36(7.8%)did *** test results showed that there were statistically significant differences between the two groups in gender,age,education,subjective cognition of intestinal polyps,personal history of colorectal polyps,family history of colorectal cancer,family history of colorectal polyps。

关键词： colorectal outpatient colon

The diagnostic value of salivary pepsin test in gastroesophageal reflux disease

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 49-50页

作者：陈蓉蓉 dept.gastroenterol 1st Affil HospNanjing Med UnivNanjing 210029

Objective To explore the clinical application value of salivary pepsin test (Peptest) in the diagnosis of gastroesophageal reflux disease (GERD).Methods From April to October 2022,at the Department of gastroenterol.gy... 详细信息

关键词： salivary diagnosis clinical

A multicenter cross-sectional study on the multidimensional clinical manifestations of irritable bowel syndrome

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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 46-47页

作者：周丹 dept.gastroenterol Union HospTongji Med CollHuazhong Univ&TechnolWuhan 430022

Objective To assess the differences in multidimensional clinical manifestations between patients with irritable bowel syndrome (IBS) matching the RomeⅢcriteria but not matching RomeⅣand IBS patients matching the Rom... 详细信息

关键词： clinical matching patients

Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis

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World Journal of gastroenterol.gy 2010年第24期16卷 2994-3001页

作者： Xia, Xian-Ming Wang, Fang-Yu Wang, Zhen-Kai Wan, Hai-Jun Xu, Wen-An Lu, Heng Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM: To investigate the effect of emodin on expression of claudin4, claudin5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. METHODS: Experimental pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Emodin was injected via the external jugular vein 3 h after induction of acute pancreatitis. Rats from sham operation group and acute pancreatitis group were injected with normal saline (an equivalent volume as emodin) at the same time point. Samples of lung and serum were obtained 6 h after drug administration. Pulmonary morphology was examined with HE staining. Pulmonary edema was estimated by measuring water content in lung tissue samples. Tumor necrosis factorα (TNFα) and interleukin6 (IL6) level were measured by enzymelinked immunospecific assay. Serum amylase and pulmonary myeloperoxidase (MPO) activity were detected by spectrophotometry. Alveolar epithelial barrier was assessed by pulmonary dye extravasation. Expression of claudin4, claudin5 and occludin in lung tissue samples was examined by immunohistology, quantitative realtime reverse transcription polymerase chain reaction and Western blotting analysis, ***: Pancreatitis-associated lung injury was char-acterized by pulmonary edema, leukocyte infiltration, alveolar collapse, and elevated serum amylase level. The pulmonary damage, pulmonary pathological scores, serum amylase and MPO activity, TNF-α and IL-6 levels, and wet/dry ratio were decreased in rats after treatment with emodin. Immunostaining of claudin-4, claudin-5 and occludin was detected in lung tissue samples from rats in sham operation group, which was distributed in alveolar epithelium, vascular endothelium, and bron-chial epithelium, respectively. The mRNA and protein expression levels of claudin-4, claudin-5 and occludin in lung tissue samples were markedly decreased, the expression level of claudin-4, claudin-

关键词： Acute pancreatitis Emodin Lung injury Claudin Occludin Epithelial barrier

CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

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World Journal of gastroenterol.gy 2010年第23期16卷 2873-2880页

作者： Xia, Xian-Ming Wang, Fang-Yu Xu, Wen-An Wang, Zhen-Kai Liu, Jiong Lu, You-Ke Jin, Xin-Xin Lu, Heng Shen, Yun-Zhu Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in ***:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the *** morphology was examined by hematoxylin and eosin *** cytokines were determined by enzyme-linked immunosorbent ***(MPO) activity(indicator of inflammatory infiltration) was observed *** permeability was assessed by mucosal-to-serosal clearance of fluorescein isothiocyanate-conjugated dextran 4000(FD4) in everted gut *** apoptosis of colonic epithelium was assessed by Hoechst-33342 *** further elucidate the role of CXCR4 in colonic inflammation,we also investigated the effect of AMD3100 on migration and cytokine production of isolated peripheral blood mononuclear cells(PBMCs).RESULTS:DSS-induced colitis was characterized by morphologic changes,as well as increased colonic cytokines,inflammatory infiltration,epithelial apoptosis,and intestinal permeability in *** AMD3100-treated mice,epithelial destruction,inflammatory infiltration,and submucosal edema were markedly reduced;colonic tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interferon-γ(IFN-γ) levels,as well as MPO activity were significantly *** intestinal permeability in DSS-treated mice was signif icantly reduced by *** number of apoptotic cells in colitis mice was markedly increased after DSS administration,and decreased when treated with the CXCR4 antagonist *** pre-activated PBMCs,CXCL12 stimulation signif icantly increased the migration of PBMCs,and was inhibited by *** increased TNF-α,IL-6,and IFN-γ from CXCL12-treated PBMCs were also reduced by ***:The CXCR4 antagonist AMD3100 exerts the

关键词： Ulcerative colitis Chemokine stromal cellderived factor-1 receptor Inflammation Apoptosis Intestinal permeability Epithelial barrier

Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model:A comparative study

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World Journal of gastroenterol.gy 2010年第4期16卷 501-507页

作者： Wu, Sheng-Di Wang, Ji-Yao Li, Lei Fudan Univ Zhongshan Hosp Dept Internal Med Div Gastroenterol & Hepatol Shanghai 200032 Peoples R China

AIM:To evaluate the efficacy of 6 noninvasive liver fibrosis models and to identify the most valuable model for the prediction of liver fibrosis stage in chronic hepatitis B(CHB) ***:Seventy-eight CHB patients were consecutively enrolled in this *** biopsy was performed and blood serum was obtained at *** diagnosis was made according to the METAVIR *** fibrosis was defined as stage score ≥ 2,severe fibrosis as stage score ≥ *** diagnostic accuracy of 6 noninvasive liver fibrosis models,including serum aspartate aminotransferase(AST) to platelet ratio index(APRI),FIB-4,Forn's index,Fibrometer,Hepascore,and Shanghai Liver Fibrosis Group's index(SLFG),was ***:The APRI,FIB-4 and Forn's index under receiver operating characteristic curve(AUROC) for sig-nificant fibrosis were 0.71,0.75 and 0.79,respectively,with a diagnosis accuracy of 67%,77% and 80%,respectively,and 0.80,0.87 and 0.86,respectively,under the AUROC for severe *** Hepascore,SLFG,and Fibrometer were 0.80,0.83 and 0.85,respectively under the AUROC for significant fibrosis(P < 0.01).The diagnosis accuracy of Hepascore and SLFG was 86% and 88%,*** Hepascore,SLFG,and Fibrometer were 0.95,0.93,and 0.94,respectively,under the AUROC for severe fibrosis(P < 0.01).CONCLUSION:The models containing direct serum markers have a better diagnostic value than those not containing direct serum markers.

关键词： Chronic hepatitis B Liver fibrosis Serum marker Noninvasive model Receiver operating curve

随机单盲法评价CT结肠造影时的两种低容量肠道准备方法

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世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 10-11页

作者： Forbes G.M. Edwards J.T. Foster N.M. 徐瑞 dept. of gastroenterol. and hepatol. Royal Perth Hospital Wellington Street Perth WA 6001 Australia

Background: Bowel preparation is an important part of computed tomographic colonography (CTC); we evaluated two small-volume preparations for screening CTC with regard to quality of preparation and patient acceptability. Methods: Asymptomatic subjects at average risk for colorectal cancer from a community-based CTC screening program were randomized to bowel preparation comprising magnesium/bisacodyl/picolax or polyethylene glycol (PEG)/picolax. CTC images were evaluated by a blinded investigator for residual feces and fluid; subjects completed a questionnaire regarding acceptability of the preparation. Results: In 176 subjects randomized to magnesium/bisacodyl/picolax (n = 82) or PEG/picolax (n = 94), the former preparation was discontinued because of syncope or presyncope in four (5%) subjects. Another 137 subjects received PEG/picolax without a significant adverse event. There were no other major differences in acceptability of the preparations as reported by subjects. The quality of bowel preparations for reporting CTC was similar. Conclusion: For subjects having screening CTC, both small volume bowel preparations are generally well tolerated and result in minimal fluid and fecal residue; however, the magnesium/ bisacodyl/picolax preparation was accompanied by an unacceptable incidence of syncope and is no longer used by us.

关键词：肠道准备方法 CT 结肠造影随机单盲比沙可啶结直肠癌无症状随机分配问卷调查