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Epistasis-aware genome-wide association studies provide insights into the efficient breeding of high-yield and high-quality rice

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Journal of Integrative Agriculture 2024年第8期23卷 2541-2556页

作者： Xiaogang He Zirong Li Sicheng Guo Xingfei Zheng Chunhai Liu Zijie Liu Yongxin Li Zheming Yuan Lanzhi Li Hunan engineering&Technology Research Center for Agricultural Big Data Analysis&Decision-making/College of Plant Protection Hunan Agricultural UniversityChangsha 410128China Hubei Key Laboratory of food Crop Germplasm and Genetic Improvement/food Crop Institute Hubei Academy of Agricultural SciencesWuhan 430064China

Marker-assisted selection(MAS)and genomic selection(GS)breeding have greatly improved the efficiency of rice *** to the influences of epistasis and gene pleiotropy,ensuring the actual breeding effect of MAS and GS is still a difficult challenge to *** this study,113 indica rice varieties(V)and their 565 testcross hybrids(TC)were used as the materials to investigate the genetic basis of 12 quality traits and nine agronomic *** original traits and general combining ability of the parents,as well as the original traits and midparent heterosis of TC,were subjected to genome-wide association *** total,381 primary significantly associated loci(SAL)and 1,759 secondary SALs that had epistatic interactions with these primary SALs were *** these loci,322 candidate genes located within or nearby the SALs were screened,204 of which were cloned genes.A total of 39 MAS molecular modules that are beneficial for trait improvement were identified by pyramiding the superior haplotypes of candidate genes and desirable epistatic alleles of the secondary *** the SALs were used to construct genetic networks,in which 91 pleiotropic loci were ***,we estimated the accuracy of genomic prediction in the parent V and TC by incorporating either no SALs,primary SALs,secondary SALs or epistatic effect SALs as *** the prediction accuracies of the four models were generally not significantly different in the TC dataset,the incorporation of primary SALs,secondary SALs,and epistatic effect SALs significantly improved the prediction accuracies of 5(26%),3(16%),and 11(58%)traits in the V dataset,*** results suggested that SALs and epistatic effect SALs identified based on an additive genotype can provide considerable predictive power for the parental *** also provide insights into the genetic basis of complex traits and valuable information for molecular breeding in rice.

关键词： rice genome-wide association study epistasis gene pleiotropy maker-associated selection genome selection

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Simultaneous detection of 22 mycotoxins in grape by QuEChERS and ultra-high-performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry

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Journal of Future foods 2024年第4期4卷 369-375页

作者： Meirong Cao Jing Wang Mengtian Wang Xiaoxuan Yuan Xu Zhang Junzhan Ma Yan Zhang Qiang Li Hebei food Safety Key Laboratory Key Laboratory of Special Food Supervision Technology for State Market RegulationHebei Engineering Research Center for Special Food Safety and HealthHebei Food Inspection and Research InstituteShijiazhuang 050227China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China

To effectively assess the extent of the mycotoxin contamination of grapes,a method was developed to analyze 22 mycotoxins by ultra-high-performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry(UPLC-Q-Orbitrap HRMS).Samples were extracted and purified using the QuEChERS(quick,easy,cheap,effective,rugged,and safe)*** extracts were separated on a BEH Shield C18 column(100 mm×2.1 mm,1.7μm),using methanol and water with 0.1%formic acid solution and 2 mmol/L ammonium acetate as the mobile *** quantification was performed according to a matrix-matched external standard *** was a good linear relationship within the respective mass concentration ranges of 22 mycotoxins;the correlation coefficients were not less than *** limit of quantification was 0.3-10.0μg/*** recovery ranged from 68.6%to 109.0%,with a relative standard deviation of 1.28%-12.80%.The method is simple,rapid,highly sensitive,and accurate,making it useful for screening grapes for common and emerging mycotoxins.

关键词： Mycotoxins Ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry Grape

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Pomegranate juice combined with inulin promote their mutual metabolic transformation by gut microbiota and prevent HFD-induced metabolic disorder in rats

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food Science and Human Wellness 2024年

作者： Xiaoyu Song Zhuoting Luo Mengting Li Jianke Li Chen Hou College of food engineering and Nutritional Science Shaanxi Normal University University Key Laboratory of food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University

High-fat diet (HFD) promotes the imbalance of gut microbiota， contributing to the development of metabolic disorders. Pomegranate juice (PJ) and inulin， as dietary polyphenol and dietary fiber respectively， have been reported to ameliorate diet-induced gut microbiota dysbiosis and metabolic disorders. However， the combined effect of PJ and inulin on HFD-induced metabolic disorders has not been elucidated. In current study， we found that the combination of PJ and inulin prevent HFD-induced obesity， dyslipidemia， and gut microbiota dysbiosis. Moreover， the fecal levels of short-chain fatty acids (SCFAs) produced by inulin were increased after inulin combined with PJ. The levels of pomegranate polyphenol metabolites produced by PJ were also increased after PJ combined with inulin， especially pharmacokinetic analysis showed that the presence of inulin enhance the absorption level of urolithin A. Fecal metabolomic analysis found that PJ combined with inulin alter the metabolic status compared with PJ. It was also showed that the levels of SCFAs and pomegranate polyphenol metabolites among groups were correlated with gut microbiota and metabolic disorders indicators. Our results suggested that PJ combined with inulin prevent HFD-induced metabolic disorders， which may be attributed to the promotion of mutual metabolic transformation and absorption of PJ and inulin by gut microbiota.

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Beneficial effects of lacquer seed oil on bromocriptine-induced postpartum hypogalactia in rats

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food Science and Human Wellness 2024年

作者： Mengting Li Xiaoyu Song Lin Shi Jie Li Mayira·Ahat Yaojie Liu Chen Hou Jianke Li University Key Laboratory of food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University College of food engineering and Nutritional Science Shaanxi Normal University

The high incidence of postpartum hypogalactia hinders the healthy development of postpartum women and the next generation. Lacquer seed oil (LSO)， the oil extracted from the seeds of the lacquer tree， has been traditionally used as a dietary supplement for promoting postpartum lactation and recovery in some districts of China. However， its physiological effects have not been verified， and the mechanism and active components of LSO have not been analyzed. Thus， we applied LSO to bromocriptine-induced postpartum hypogalactia rats. The results showed that LSO supplement effectively improves bromocriptine-induced postpartum hypogalactia. LSO also increased prolactin levels reduced by bromocriptine， promoted JAK2/STAT5 and PI3K/AKT pathways and several gene expression levels of milk synthesis in mammary gland. Moreover， metabolomic and network pharmacological analysis further revealed that JAK2/STAT5， PI3K/AKT， and estrogen signaling pathway are the potential main regulatory sites for the beneficial effects of LSO on postpartum hypogalactia， and that quercetin， kaempferol， arachidonic acid， epicatechin， and β-sitosterol are the top 5 main active ingredients of LSO. Our results suggested that LSO has great potential in the application of the improvement of postpartum hypogalactia.

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Recent advances of rodent models for alcoholic liver disease in evaluating healthy effects of food bioactive ingredients

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food Science and Human Wellness 2024年

作者： Xiaoting Yu Xuedi Zhang Lijuan Zhang Haitao Wang Mingqian Tan State Key Lab of Marine food Processing & Safety Control Dalian Polytechnic University Academy of food Interdisciplinary Science School of food Science and Technology Dalian Polytechnic University National engineering Research Center of Seafood Dalian Polytechnic University engineering Research Center of Seafood of Ministry of Education of China Dalian Polytechnic University

The development of rodent models that accurately reflect the pathogenesis of alcoholic liver disease (ALD) in humans is crucial for evaluating the nutritional intervention of food bioactive ingredients in ALD. Although various models have been employed to establish ALD models over the past few decades， most successful cases are associated with high mortality rates， operational difficulties， and incompatibility formation mechanism compared to human ALD. However， the ALD models established by oral administration that simulate human drinking behavior often fail to induce significant liver damage. Therefore， it is imperative to explore simple and effective modes of oral administration for establishing ALD models consistent with the pathophysiological process of human ALD. Herein， we summarized the pathogenesis of ALD and discussed several issues related to construct ALD models with rodents (mainly mice and rats) by oral administration， including animal selection， animal feeding， alcohol intervention， and evaluation criteria. The purpose of this review is to provide a standardized and efficient formula for ALD modeling， so as to facilitate efficacy evaluation and mechanism analysis of food bioactive ingredients in ALD.

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Pomegranate peel polyphenols improves diet-induced obesity and promotes adipose browning development through gut microbiota in mice

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food Science and Human Wellness 2024年

作者： Zhuoting Luo Xiaoyu Song Mengting Li Jianke Li Chen Hou University Key Laboratory of food Processing Byproducts for Advanced Development and High Value Utilization Shaanxi Normal University College of food engineering and Nutritional Science Shaanxi Normal University

Gut microbiota regulate the activation of adipose browning， which promote energy dissipation and combat diet-induced obesity. Pomegranate peel polyphenols (PPPs) have been shown to reduce obesity， regulate lipid metabolism in adipose tissue， and modulate the composition of gut microbiota in animal fed high-fat diet (HFD). However， the role of gut microbiota in the improvement of obesity by PPPs has not been elucidated. In current study， we applied antibiotics to inhibit gut microbiota in mice fed HFD and treated with PPPs. The results showed that the inhibition of gut microbiota impair the effect of PPPs on reducing obesity and promoting adipose browning， and change the fecal metabolomic profiles in respond to PPPs. Moreover， the inhibition of gut microbiota supressed the promotive effects of PPPs on the levels of Akkermansia and microbiota-related metabolites， such as urolithin A， short-chain fatty acids (SCFAs)， and bile acids (BAs)， which were associated with activating adipose browning. Therefore， our results suggested that the presence of gut microbiota is essential for PPPs to ameliorate HFD-induced obesity. The related bacteria or metabolites generated by the interaction between PPPs and microbiota promote adipose browning and facilitate the beneficial effects of PPPs.

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Dietary Lipid Intervention in the Prevention of Brain Aging

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engineering 2024年第6期37卷 128-137页

作者： Wei Xiong Bing Fang Xiaoyu Wang Ming Zhang Min Du Jiazeng Sun Juan Chen Yixuan Li Changhao Sun Xingen Lei Xue Zhang Fazheng Ren Key Laboratory of Precision Nutrition and food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China Key Laboratory of Functional Dairy Co-Constructed by the Ministry of Education and Beijing MunicipalityCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of food Science and Chemical engineering Beijing Technology and Business UniversityBeijing 100048China Department of Animal Science Washington State UniversityPullmanWA 99164USA Department of Nutrition and food Hygiene School of Public HealthHarbin Medical UniversityHarbin 150028China Department of Animal Science Cornell UniversityIthacaNY 14853USA National Health Commission(NHC)and Chinese Academy of Medical Sciences(CAMS)Key Laboratory of Molecular Probe and Targeted Theranostics Harbin Medical UniversityHarbin 150028China

As people live longer,the burden of aging-related brain diseases,especially dementia,is *** aging increases the risk of cognitive impairment,which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid ***,supplemental dietary lipids have the potential to prevent brain *** review summarizes the important roles of dietary lipids in brain function from both structure and mechanism *** and animal studies have provided evidence of the functions of polyunsaturated fatty acids(PUFAs)in brain *** results of interventions indicate that phospholipids—including phosphatidylcholine,phosphatidylserine,and plasmalogen—are efficient in alleviating cognitive impairment during aging,with plasmalogen exhibiting higher efficacy than *** is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of *** research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

关键词： Brain aging Nutritional intervention Phospholipids Phosphatidylcholine Phosphatidylserine Plasmalogen

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Proteomic mechanism of Bacillus cereus endospore against plasma-activated water(PAW)

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food Science and Human Wellness 2024年

作者： Xiao Hu Jinsong Feng Xinyu Liao Tian Ding Ruiling Lü School of Biosystems engineering and food Science Zhejiang University Future food Laboratory Innovation Center of Yangtze River Delta Zhejiang University Ningbo Innovation Center Zhejiang University

Plasma-activated water (PAW) indicated promising potential in controlling the biological contamination of Bacillus cereus， which eliminated its evolutionary endospore that improves its survival ability. However， the spore inactivation mechanism by PAW at molecular level was not well understood. The mechanism of the Bacillus cereus endospore against PAW at proteomic levels was demonstrated. The Tandem Mass Tag (TMT) labeling was performed. By comparing the treatment groups with control (including PAW and PAW added superoxide dismutase (SOD)) ， the expression of 251 proteins (with the number of 207 up- and 44 down-regulated) and 379 proteins (with the corresponding number of 238 and 141) were drastically affected， separately. The six categories based on the protein-protein interaction (PPI) networks included oxidation-reduction， transport， sporulation and DNA topological change， gene expression， metabolism， and others. The three dehydrogenases (Gene hisD， BC＿2176， and asd) in PAW while oxidoreductase (Gene BC＿0399 and BC＿2529) in SOD were activated to maintain the antioxidation of spores. The proteins (BC＿4271 and BC＿2655) in SOD were dramatically activated， which were involved in the carbohydrate， amino acid， and energy-coupling transport. All the small， acid-soluble spore proteins were activated in both groups to protect the spores’ DNA. In SOD， genes metG2 and rpmC also were considered important factors in translation while this role was played in gene groES but not rpmF in PAW. The PAW activated the biogenesis of cell wall/membrane/envelope and phosphorelay signal transduction system to contribute to the survival of spores whereas the SOD damaged these two processes as well as cell division， chromosome separation， organic acid phosphorylation， base- and nucleotide-excision repair to lead to the death of spores. This would promise to lay the foundation for advancing the study of the intrinsic mechanism of spore killing against PAW and can also provide a reference f

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Balancing machine learning and artificial intelligence in soil science with human perspective and experience

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Pedosphere 2024年第1期34卷 9-12页

作者： David C.WEINDORF Somsubhra CHAKRABORTY Department of Earth and Atmospheric Science Central Michigan Universityount Pleasant M148859USA Agricultural and food engineering Department Indian Institute of TechnologyKharagpur 721302India

Machine learning and artificial intelligence continue to evolve at a rapid pace, with many potential applications related to soil science. Even so, human experience and perception play an invaluable role in characterizing soil properties, especially qualitative properties that may elude sensing/computer-based modeling approaches. The elegant solution to this conundrum relies on the synthesis of computer-aided predictive modeling with human insight and *** global population surpasses 8 billion, the importance of optimized agronomic production to feed a hungry world has never been more important.

关键词： soil elude qualitative

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Design and experiment analysis of the small maize harvester with attitude adjustment in the hilly and mountainous areas of China

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International Journal of Agricultural and Biological engineering 2024年第1期17卷 118-127页

作者： Meizhou Chen Guangfei Xu Yuanzhen Wei Yinping Zhang Peisong Diao Huanxiao Pang College of Agricultural engineering and food Science Shandong University of TechnologyZibo255000ShandongChina School of Mechanical and Automotive engineering Liaocheng UniversityLiaocheng252000ShandongChina Shandong Academy of Agricultural Machinery Sciences Jinan 250000China

To solve the problem of small planting plots and large sloping land for mechanized maize harvesting in China hilly and mountainous areas,a small maize harvester with attitude adjustment was designed to realize maize snapping,peeling,straw crushing and attitude adjusting at on time in this *** basic structure and working principle of the small maize harvester were described,and the key components were designed as *** maize snapping device adopted the combination form of maize snapping plates and straw pulling rollers,and the gap of the straw pulling rollers can be adjusted to adapt to different maize *** pairs of peeling rollers formed a groove arrangement to improve peeling rate and reduced ear grain *** pressure feeding device mainly comprised drive chain and three grade pressure feeding rollers to increase the friction between ears and the peeling rollers,and help ears *** attitude adjustment advice was designed according to the high point stationary pursuit leveling *** the attitude angle of the rack approached 0,the small maize harvester reached the level *** actual range of attitude adjustment was obtained and the accuracy of static attitude adjustment was verified through attitude adjustment *** influencing factors of ear loss rate and bract peeling rate were determined by orthogonal test,including the rotational speed of straw pulling rollers,peeling rollers and pressure feeding *** mathematical regression model between the experimental factors and indicators was established by using Design Expert,and through the analysis variance to verify the significance of the evaluation indicators,the best combination of operation parameters was determined that the rotational speed of straw pulling rollers,peeling rollers and pressure feeding rollers were 1440 r/min,1535 r/min and 406 r/*** the optimal combination of the operation parameters,the ear loss rate and bract peeling rate were 1.33%and 93.98%.T

关键词： maize harvester hilly and mountains areas attitude adjustment anti rollover structure

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