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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 49-50页

作者： Wolfberg A.J. Feltmate C. Goldstein D.P. 杨晓梅 dept. obst et. Gynecol./Repro. Biol. Brigham and Women's Hospital 75 Francis Street Bo ston MA 02115 United States Dr.

OBJECTIVE: Complet. hydatidiform molar pregnancies occur in approximately 1 of 1,000 conceptions. After uterine evacuation of the trophoblastic tissue, women are followed up with serial serum human chorionic gonadotropin (hCG) measurement s. Patients are considered to have attained remission when their hCG level spont aneously declines to an undet.ctable level and remains there during a 6-month f ollow-up period. This standard effectively det.cts all disease recurrence; howe ver, it is resource intensive, delays child bearing, and is subject to significa nt noncompliance. Our objective was to det.rmine the risk of disease recurrence after hCG spontaneously declines to undet.ctable levels. Met.ODS: We used a data base from the New England Trophoblastic Disease Center to analyzehCG levels in p atients with complet. molar pregnancies. RESULTS: Among 1,029 women with complet.e molar pregnancy and complet. data, 15%developed persistent gestational tropho blastic neoplasia. The rate of persistent neoplasm among those whose hCG level f ell spontaneously to undet.ctable levels was 0.2%(2/876, 95%confidence interva l 0-0.8%). No women developed persistent gestational trophoblastic neoplasia a fter their hCG level fell to undet.ctable levels using an assay with a sensitivi ty of 5 mIU/mL (n = 82, 95%confidence interval 0-4.5%). CONCLUSION: Based on our experience with women with complet. hydatidiform molar pregnancies whose hCG val ues spontaneously fell to undet.ctable levels after molar evacuation, we conclud e that the risk of recurrent neoplasm after hCG levels fall to less than 5 mIU/m L approaches zero.

关键词：葡萄胎妊娠 hCG水平完全性滋养细胞肿瘤滋养层细胞非依从性持续性临床缓解清宫术疾病复发率

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Clinical Safet. of New Tri-Phasic Oral Contraceptive Pill

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Journal of Reproduction and Contraception 1991年第1期3卷 25-30页

作者： N.Mereuri G.Brilli A.C.Mancini G.Botticelli G.Fabbri A.D.Genazzani F.Pet.aglia A.Volpe A.R.Genazzani dept.obst.Gynecol. UniversityofModenaViadelP02207141100ModenaItaly dept.obst.Gynecol. UniversityofCagliareItaly

The aim of our study was to evaluate the met.bolic and clinical effects of a contraceptive treatment with a new tri-phasic formulation of et.ynyl-estradiol (35μg) and noret.isterone (0.5-1mg) in fertile women.For this purpose 20 healthy fertile women (19-32years) volunteered to follow this trial.High-density lipoprotein cholesterol,low-density lipoprotion cholesterol,fibrinogen concentration and antithrombin Ⅲ were measured by enzymatic met.od and fibrinopeptides A,by RIA.The patients were treated for 6 cycles and they were studied before and after 1,3, and 6 cycles of treatment.In all patients both the length of the menstrual cycle,and bleeding,acne and seborrhea and side effects were evaluated.The contraceptive therapy with this new formulation resulted very effective,without significant met.bolic changes and with very few side effects.

关键词：三相口服避孕药丸药物安全性临床试验药物代谢动力学育龄女性

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澳门区地中海贫血的产前诊断

澳门区地中海贫血的产前诊断

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澳门、香港、内地生殖健康研讨会

作者： Rolando Martins 唐蕴莹 David Lopes dept.of obst/Gyn and Department of Hematology of Control Hospital Conde de So Januário

地中海贫血是目前导致澳门胎儿畸形的第二大原因,在世界许多地方均构成严重的公共卫生问题。同源α地中海贫血一型(Hb Bart’s hydrops)以往只是通过介入性的方法诊断,现在则先通过超声波监测胎心是否有细微扩大,再选择性抽取胎儿脐血,行

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