检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Author Spotlight

CCS chemistry 2021年第6期3卷 1576-1579页

作者： Backvall, Jan-E. Zhu, Xiaozhang Wang, Xi MIT Cambridge MA 02139 USA Royal Inst Technol Stockholm Sweden Uppsala Univ Organ Chem Uppsala Sweden Stockholm Univ Stockholm Sweden Ulm Univ Inst Organ Chem & Adv Mat 2 Ulm Germany JSPS Tokyo Japan Univ Tokyo Dept Chem Tokyo Japan ICCAS CAS Key Lab Organ Solids Beijing Peoples R China Natl Inst Mat Sci NIMS Japan Tokyo Japan

Jan-E.Bäckvall Prof.Bäckvall received his *** from the Royal Institute of Technology(Sweden)in 1975 under the supervision of ***örnÅ*** postdoctoral work(1975-1976)with *** Sharpless at Massachusetts Institute of Technology(USA),he joined the faculty at the Royal Institute of Technology in 1976 as Assistant *** was promoted to Associate Professor in *** was appointed Professor of Organic chemistry at Uppsala University(Sweden)in *** 1997,he moved to Stockholm University(Sweden)where he is currently Professor of Organic *** current research interests include transition metal-catalyzed organic transformations,biomimetic oxidations,and enzyme catalysis.

关键词： Sweden doctor Royal

LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroimmunology and Neuroinflammation 2019年第7期6卷 12-43页

作者： Shahani Noor Melody S.Sun Arden G.Vanderwall Mara A.Havard Jacob E.Sanchez Nathan W.Harris Monique V.Nysus Jeffrey P.Norenberg Harrison T.West Carsten R.Wagner Lauren L.Jantzie Nikolaos Mellios Erin D.Milligan Department of Neurosciences School of MedicineUniversity of New MexicoAlbuquerqueNM 87131USA Department of Anesthesiology and Critical Care University of New MexicoAlbuquerqueNM 87131USA Department of Pediatrics and Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205-2196USA Department of Radiopharmaceutical Sciences College of PharmacyNew Mexico Center for Isotopes in MedicineUniversity of New MexicoAlbuquerqueNM 87131USA Department of Medicinal chemistry University of MinnesotaCollege of PharmacyMinneapolisMN 55455USA

Aim:The majority of preclinical studies investigating aberrant glial-neuroimmune actions underlying neuropathic pain have focused on male rodent ***,studies have shown peripheral immune cells play a more prominent role than glial cells in mediating pathological pain in ***,we compared the onset and duration of allodynia in males and females,and the anti-allodynic action of a potentially novel therapeutic drug(BIRT377)that not only antagonizes the action of lymphocyte function-associated antigen-1(LFA-1)to reduce cell migration in the periphery,but may also directly alter the cellular inflammatory ***:Male and female mice were subjected to peripheral nerve injury chronic constriction injury(CCI)applying two methods,using either 4-0 or 5-0 chromic gut suture material,to examine potential sex differences in the onset,magnitude and duration of *** sensitivity before and after CCI and application of intravenous BIRT377 was *** and spinal tissues were analyzed for protein(multiplex electrochemiluminescence technology)and mRNA expression(quantitative real-time PCR).The phenotype of peripheral T cells was determined using flow ***:Sex differences in proinflammatory CCL2 and IL-1βand the anti-inflammatory IL-10 were observed from a set of cytokines analyzed.A profound proinflammatory T cell(Th17)response in the periphery and spinal cord was also observed in neuropathic ***377 reversed pain,reduced IL-1βand TNF,and increased IL-10 and transforming growth factor(TGF)-β1,also an anti-inflammatory cytokine,in both ***,female-derived T cell cytokines are transcriptionally regulated by BIRT377,as demonstrated by reducing proinflammatory IL-17A production with concurrent increases in IL-10,TGF-β1 and the anti-inflammatory regulatory T cell-related factor,***:This study supports that divergent peripheral immune and neuroimmune responses during neuropathy exists between males and

关键词： Neuropathic pain glia neuroimmune peripheral immune T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preface

Science China chemistry 2011年第2期54卷 263-273页

作者： Yang Bai Gao ChangYou Zhang XianZheng Zhejiang Univ Dept Polymer Sci & Engn Hangzhou Zhejiang Peoples R China Inst Mat Res & Engn Singapore Singapore Cornell Univ Ithaca NY 14853 USA Wuhan Univ Wuhan Peoples R China

Professors SHEN JiaCong, SHEN ZhiQuan and ZHUO RenXi are famous chemists and educationists of China, and academicians of the Chinese Academy of Sciences. Although born in 1931 and approaching their 80th birthdays, these scientists are still very active in both research and education. Many of their students have become professors and leaders at universities in China, the US, and other countries. The three professors have made significant contributions to the promotion and growth of polymer science in China. To commemorate their 80th birthdays, the editorial board of Science China chemistry has produced this special issue in Chinese and English Editions.

关键词：中国科学院院士美国大学科学发展教育家化学家科学家领导人编辑部

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preface

Science China chemistry 2013年第3期56卷 271-272页

作者： WANG Qian HUANG Zhen PU Lin Univ Lausanne CH-1015 Lausanne Switzerland Scripps Res Inst La Jolla CA USA Harvard Univ Sch Med Cambridge MA 02138 USA CUNY Brooklyn Coll Brooklyn NY 11210 USA Georgia State Univ Atlanta GA 30303 USA CALTECH Prof Robert H Grubbs Res Grp Pasadena CA 91125 USA N Dakota State Univ Dept Chem Fargo ND USA Univ Virginia Dept Chem Charlottesville VA 22903 USA Sichuan Univ Minist Educ Chengdu Peoples R China

The Eighth Sino-US chemistry Professors Conference: A Forum for chemistry and Chemical Biology The Eighth Sino-US chemistry Professors Conference,co-organized by Kunming Institute of Botany of Chinese Academy of Sciences (Professor Ninghua Tan as the Chairwoman), Yunan University (Professor Hongbin Zhanga s the co-Chairman) and CAPA (The Chinese-American chemistry & Chemical Biology Professors Association,

关键词： CAPA US Preface

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat Joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe Jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte Jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment