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Genes & Diseases 2023年第5期10卷 1759-1762页

作者： Colemonts-Vroninks Haaike Norman P.Brendan Van Laere Sven Davison S.Andrew Marcélis Lionel Casimir Georges Goyens Philippe Claes Paul De Bundel Dimitri Martens Geert Ranganath Lakshminarayan Rao Vanhaecke Tamara Gallagher James A De Kock Joery Vrije Universiteit Brussel Liver Therapy&Evolution TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium Vrije Universiteit Brussel Experimental Pharmacology(EFAR)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium University of Liverpool Dept.of Musculoskeletal&Ageing ScienceInstitute of Life Course&Medical SciencesLiverpool L78TXUnited Kingdom Vrije Universiteit Brussel Interfaculty Center Data Processing and StatisticsFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium Liverpool University Hospitals NHS Foundation Trust Clinical Biochemistry and Metabolic MedicineLiverpool L35PSUnited Kingdom UniversitéLibre de Bruxelles Laboratoire de PédiatrieBrussels B-1050Belgium Vrije Universiteit Brussel In Vitro Liver Disease Modelling TeamIn Vitro Toxicology and Dermato-Cosmetology(IVTD)Research GroupFaculty of Medicine and PharmacyLaarbeeklaan 103Brussels B-1090Belgium AZ Delta General Hospital Department of Laboratory MedicineRoeselare 8800Belgium Ghent University Department of Biomolecular MedicineGhent 9052Belgium

Hereditary tyrosinemia type 1(HT1)is a life-threatening disease caused by the patient's inability to break down tyrosine due to loss-of-function mutations in the fumarylacetoacetate hydrolase(FAH)enzyme(Fig.S1).Currently,the only available life-saving treatment is nitisinone(NTBC).However,nitisinone therapy comes with debilitating side effects and requires a strict drug regime combined with a tyrosine-and phenylalanine-restricted ***,therapy adherence is often experienced as an additional *** this study,transcriptional profiling was conducted parallel to high-resolution metabolomics on,respectively,liver tissue and serum samples of Fah-deficient *** experimental workflow of our study is shown in Figure *** pathway analyses showed manifest activation of the NRF2-stress response,associated with hepatocellular damage and mainly driven by a markedly increased oxidative *** altered canonical pathways were primarily a downstream consequence of the ***,we observed an overall aminoacidemia and changes related to aminoacyl-tRNA biosynthesis,which postulates that short-term nitisinone discontinuation can already put the patient at risk for hepatocellular carcinoma ***,we did not only identify changes in numerous pathways,directly and indirectly,related to the metabolism of tyrosine and glutathione but also the presence of“side-chain”metabolites,such as y-glutamyl-and N-acetyl-coupled amino acids,indicating that non-directly related pathways like phase II biotransformation reactions are also affected.

关键词： continuation Figure hereditary

Pharmacological mechanism of Shen -wu capsule and Tetrahydroxystilbene glucoside on APP transgenic model of Alzheimer＇s disease

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中国药理通讯 2005年第4期22卷 26-27页

作者： Lan Zhang Lin Li Shun Yu Ying Xing Cui - fei Ye Yao - hua Li Biao Chen dept. pharmacology Xuan - wu hosp of Capital University of Medical Sciences Beijing Key Laboratory for Brain Aging Beijing P. R. China 100053 dept. Neurobiology Xuan - wu hosp of Capital University of Medical Sciences Beijing Key Laboratory for Brain Aging Beijing P. R. China 100053

化学引发毒性作用中的活性中间体及其作用(英文)

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化学引发毒性作用中的活性中间体及其作用(英文)

Guest Editors of Special Column on Drug Targets and Drug Development for Alzheimer’s Disease

第二届中国药物毒理学年会（2012）

作者： Terrence J.Monks Serrine S.Lau dept.of pharmacology＆Toxicology and the Southwest Environmental Health Sciences Center College of PharmacyUniversity of Arizona

＜正＞Chemical-induced toxicities are frequently mediated via the bioactivation of relatively stable organic molecules to reactive electrophilic ***,chemical-induced toxicities have long been known to be associated with the ability of electrophilic metabolites to react with a variety of targets within the cell,including their covalent adduction to nucleophilic residues（cysteine,lysine and histidine） in proteins,and primarily adenine and guanine nucleotides within ***,although we possess considerable knowledge

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1685-1685页

作者： Ding, Wen-Xing Swerdlow, Russell Univ Kansas Dept Pharmacol Toxicol & Therapeut Med Ctr Kansas City KS 66042 USA Univ Kansas Dept Neurol Sch Med Kansas City KS USA Univ Kansas Dept Mol & Integrat Physiol Sch Med Kansas City KS USA Univ Kansas Dept Biochem & Mol Biol Sch Med Kansas City KS USA

***-Xing Ding is the William Warner Abercrombie Professor at Department of pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,KS,*** graduated from Shanghai Medical University(now Fudan University)in China in 1992 and later obtained his PhD in Molecular Toxicology in 2002 from National University of *** then did his Postdoc training at University of Pittsburgh and became an assistant professor in 2009 at The University of Kansas Medical Center.

关键词： Kansas Singapore Pittsburgh

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Effect of metformin on miRNA expression in type 2 diabetic patients and potential targets

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China Medical Abstracts(Internal Medicine) 2022年第1期39卷 23-24页

作者：施洋 dept Pharm Karamy Municipal Peoples’ HospKaramay 834000

Objective To investigate the effect of metformin on the microRNA(miRNA)expression and screen potential target with network pharmacology analysis in patients with type 2 *** Fifteen patients with newly diagnosed type 2 diabetes admitted to our hospital were selected,who received metformin during hospitalization and after *** expression of serum matrix metalloproteinase(MMP)-9,transforming growth factor(TGF)-β1,and myocardial fibrosis related miRNAs were compared before and 6 month after metformin treatment.

关键词： patients admitted discharge.

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Quality aspects of coffees and teas: Application of electron paramagnetic resonance (EPR) spectroscopy to the elucidation of free radical and other processes.

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Agricultural Sciences 2013年第8期4卷 433-442页

作者： Bernard A.Goodman Chahan Yeretzian Klaus Stolze Deng Wen State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi UniversityNanningChina Zurich University of Applied Sciences Institute of Chemistry and Biological ChemistryWädenswilSwitzerland Institute of pharmacology and Toxicology Dept.Biomedical SciencesUniversity of Veterinary MedicineViennaAustria Department of Physics Guangxi UniversityNanningChina

Coffees and teas are beverages that are both exceptionally rich in antioxidant molecules, and are also both associated with beneficial health effects. Thus although the quality characteristics of these beverages are conventionally assessed on the basis of their sensory properties, their antioxidant contents represent an additional and increasingly valued attribute of quality based on their contributions to healthy diets. Both beverages are prepared by hot water extraction of a pure plant-derived product, and thus their compositions can potentially change quite rapidly as a result of oxidation in contact with air. Oxidative processes often proceed via free radical intermediates, and sometimes also result in the formation of stable radical end-products;thus EPR spectroscopy is a convenient technique for investigating some of the various free radical reactions that occur in these beverages. This paper reviews progress that has been made in elucidating free radical processes that occur during the preparation and storage of coffees and teas, and the results are discussed in terms of quality criteria of the beverages.

关键词： Coffee Tea Free Radicals Antioxidants EPR Spectroscopy Quality

O04 Four-Year experience of pharmacology Teaching in the Integrated Curriculum at Taipei Yang-Ming University

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中国药理通讯 2006年第2期23卷 4-4页

作者： Wynn HT PAN dept. of pharmacology School of Medicine National Yang-Ming University Taipei

National Yang-Ming University was established in 1971 at Taipei. We mainly train 7- year medical students immediately after high school education. Originally, the 4^th year students received their pharmacology teaching by an intensive course within one semester (4 hours/wk). We covered all 66 chapters in "Basic & Clinical pharmacology", with a total 72 lecture hours. In order to design a problem-based learning course for all the courses of previous 4^th year students, our pharmacology teaching must re-organize in this integrated curriculum from the year of 2001. The major changes include: decreasing total lecture hour (from 72 to 58), one semester course becoming one-year course (roughly 2 hours/wk), merely covering 80% of all 66 chapters in the textbook. We did student survey each year and the results will be presented in our presentation. Also, the advantages and disadvantages for this reform will be discussed.

关键词：药理学技术课程设置台北阳明大学专业设置

The present status of infectious diseases of laboratory animals in Bangladesh

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中国实验动物学报 2005年第S1期13卷 18-页

作者： Abdul Awal dept. of pharmacology Bangladesh Agricultural University Mymensingh-2202Bangladesh& President BALAS (Bangladesh Association for laboratory Animal Science)Md.DVM Ph.DProfessor

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三七总皂甙对小白鼠运动神经末梢递质释放的影响

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中国药理学通报 1987年第3期 137-140页

作者：关永源,Quastel D M J 中山医科大学药理教研组 dept of pharmacology Faculty of Medicine University of British Columbia 广州 Canada

胞内记录神经—终板电位及微终板电位,证明三七总皂甙不影响神经末梢去极化时Ca2+及Ba2+的内流,对同步、非同步及自发性的量子释放均无减弱。由于Cd2+能明显减弱量子释放,而PNS与nifedipine却无作用,提示胆碱能运动神经末梢上参与递质... 详细信息

胞内记录神经—终板电位及微终板电位,证明三七总皂甙不影响神经末梢去极化时Ca2+及Ba2+的内流,对同步、非同步及自发性的量子释放均无减弱。由于Cd2+能明显减弱量子释放,而PNS与nifedipine却无作用,提示胆碱能运动神经末梢上参与递质释放的Ca2+通道属于N型Ca2+通道。

关键词：三七总皂甙镉离子硝苯吡啶钙通道量子释放膈(月凡)