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Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis

Chinese Chemical Letters 2024年第8期35卷 475-480页

作者： Tong Zhang Chao Sun Shubin Yang Zimin Cai Sifeng Zhu Wendian Liu Yun Luan Cheng Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Central Research Laboratory Department of General Surgerythe Second Hospital of Shandong UniversityJi’nan 250033China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Orthopedics dept.1 Rushan people’s hospitalRushan 264500China Department of cardiology the Second Hospital of Shandong UniversityJi’nan 250033China

Idiopathic pulmonary fibrosis(IPF)is a chronic and fatal lung disease characterized by pulmonary inflam-mation,oxidative stress,and excessive extracellular matrix(ECM)*** anti-fibrotic drugs for IPF treatment in the clinic lack selectivity and demonstrate unsatisfactory efficacy,highlighting the urgent necessity for a novel therapeutic ***(TA),which has biological activities against lung injury induced by various factors,is a potential anti-IPF drug due to its anti-inflammatory,antiox-idant and lung-protective ***,the protective effect of TA on IPF has not been confirmed,and its clinical application is limited due to its poor aqueous *** this study,we demonstrated that TA could inhibit epithelial-mesenchymal transition(EMT)and migration of A549 cells by inhibiting the transforming growth factor-β1(TGF-β1)/Smad signaling *** improve the aqueous solubility and pulmonary administration performance of TA,we prepared TA loaded methoxy poly(ethylene glycol)-poly(d,l-lactide)(mPEG-PLA)/d-α-tocopheryl polyethylene glycol succinate(TPGS)mixed polymeric mi-celles(TA-PM).Then a MicroSprayer^(R) Aerosolizer was used to deliver TA-PM once every two days for three weeks to evaluate their therapeutic effects on bleomycin(BLM)-induced IPF *** results demonstrated that inhaled TA-PM significantly inhibited BLM-induced inflammation,oxidative stress and fibrosis in lung ***,TA-PM exhibited high pulmonary deposition and retention by pul-monary administration,along with a favorable safety ***,this study emphasizes the potential of inhaled TA-PM as a promising treatment for IPF,providing a new opportunity for their clinical appli-cation.

关键词： Taraxasterol Idiopathic pulmonary fibrosis Mixed polymeric micelles Pulmonary administration Bleomycin

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A study on the treatment of chloasma with moxibustion based on the theory of“Yang transforming Qi,and Yin shaping”

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Clinical Research Communications 2024年第3期7卷 23-28页

作者： Mi Yang Hong-Yi Lan Hong Wu Xu Wang Xin-Ju Li Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Tianjin 300193China. cardiology dept Wuxi Traditional Chinese Medicine HospitalWuxi 214071China. Acupuncture&Moxibustion dept Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300131China. College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human *** of the strengths of TCM in treating diseases is holistic *** theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic ***,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy *** occurrence and development of chloasma are closely related to internal *** paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of ***:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to *** belongs to the fire,and its warming effect can dissipate the tangible ***:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of ***:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma.

关键词： Yang Transforming Qi and Yin shaping moxibustion chloasma

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SHORT-TERM REPRODUCIBILITY OF INTRAVASCULAR ULTRASOUND IN VIVO

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Chinese Medical Journal 1995年第3期 77-78页

作者： Gunter Gorge Michael Haude Mahmoud Ashry Raimund Erbel dept of cardiology University Essen. GermanyDept of Cardiology University Essen. GermanyDept of Cardiology University Essen. GermanyDept of Cardiology University Essen. Germany

We studied 24 patients (18 males, 56.1 ± 6.2 years) who underwent coronary artery angioplasty for stenosis in the left anterior descending coronary artery (LAD), using a 3.5F or 4.8F intravascular ultrasound (IVUS) c... 详细信息

关键词： IVUS LAD SHORT-TERM REPRODUCIBILITY OF INTRAVASCULAR ULTRASOUND IN VIVO

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Protective Effect of Herba Dracocephali on Lipoperoxidation Damage in Patients with Coronary Heart Disease

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Chinese Journal of Integrative Medicine 1995年第4期1卷 275-277页

作者： Yang Shui-xiang (杨水祥) Li Tian-de (李天德) Yang Xing-sheng (杨兴生)(Department of cardiology, The General Hospital of PLA, Beijing 100853)Hong Xiu-fang (洪秀芳) Zhou Min (周明) Liu Wen-jie (刘文杰)(dept. of cardiology, Xinjiang Medical College, Xi Department of cardiology The General Hospital of PLA Beijing dept. of cardiology Xinjiang Medical College Xinjiang

In order to study the effects of Herba Dracocephali (HD) in treating coronary heart disease(CHD) and antiperoxidative damage. 40 patients of CHD were treated with HD and the changes ot plasma su-peroxide dismutase (SOD) , lipid peroxide (LPO) , thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 (6-keto-PGF1 ) as well as platelet LPO (PL-LPO) , SOD (PL-SOD) and selenium-glutathion peroxidase (SGP)were measured before and after treatment. Results showed that TXB2 , LPO and PL-LPO increased, whileSOD, PL-SOD decreased signiticantly in patients. After treatment by HD, the TXB2 , LPO, PL-LPO loweredand 6-keto-PGF1 , SOD, PL-SOD and SGP elevated obviotjsly. Electron microscopy showed that the ultra-structore of platelets improved and the activity ot adenylate cyclase increased markedly. The results suggest-ed that HD is a traditional Chinese herbal antioxidant and is hopeful tor treating CHD.

关键词： Herba Dracocephali coronary heart disease Platelet Thromboxane A2

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Value of the adenosine test for diagnosis of dual AV nodal physiology in patients with AV nodal reentrant tachycardia

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2002年第5期3卷 133-136页

作者：周斌全胡申江鲁端王建安 dept. of cardiology Sir Run Run Shaw Hospital Medical College Zhejiang University Hangzhou China dept. of cardiology First Affiliated Hospital Medical College Zhejiang University Hangzhou China

Objectives: This study was aimed at assessing the value of the adenosine test for noninvasive diagnosis of dual AV nodal physiology(DAVNP) in patients with AV nodal reentrant tachycardia (AVNRT). Methods: 53 patients with paroxysmal supraventricular tachycardia (PSVT) were given incremental doses of adenosine intravenously during sinus rhythm before electrophysiological study. The adenosine test was repeated on a subset of 18 patients with AVNRT after radiofrequency catheter ablation. Results: Sudden increments of PR interval of more than 60 msec between two consecutive beats were observed in 26(83.9%) of 31 patients with typical AVNRT and 2 (9.1%) of 22 patients with AVRT and AT ( P <0.01). The maximal PR increment between 2 consecutive beats in the AVNRT group(105±45ms) was significantly greater than that in the AVRT and AT group (20±13ms) ( P <0.01).In postablation adenosine test, DAVNP was eliminated in all 8 patients who underwent slow pathway abolition that EPS showed the slow pathway disappeared and 4 of 10 patients who underwent slow pathway modification that EPS showed the slow pathway persisted. Six of 10 patients who exhibited persistent duality showed a marked reduction in the number of beats conducted in the slow pathway after adenosine injection( P <0.01).Conclusions: Administration of adenosine during sinus rhythm may be a useful bedside test for diagnosis of DAVNP in high percentage of patients with typical AVNRT and additionally for evaluating the effects of radiofrequency ablation.

关键词： Adenosine Dual AV nodal Electrophysiology Tachycardia AV nodal reentrant

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64-row multi-dector computed tomography coronary image from a center with early experience: first illustration of learning curve

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Journal of Geriatric cardiology 2006年第1期3卷 29-34页

作者： Sze Piaw CHIN Tiong Kiam ONG Chee Khoon LIEW M.Tobias Seyfarth Fong Yean Yip ALAN Houng Bang LIEW Kui Hian SIM dept of cardiology Sarawak General Hospital Siemens Cardiac Solutions Erlangen Germany

Background and objectives The recent joint ACCF/AHA clinical competence statement on cardiac imaging with multi-detector computed tomography recommended a minimum of 6 months training and 300 contrast examinations, of which the candidate must be directly involved in at least 100 studies. Whether this is adequate to become proficient in interpretation of coronary computed tomogsignificant coronary stenosis in a center with 1 year's experience using a 64-row scanner. Methods A total of 778 patients underwent contrast-enhanced CTA between January and December 2005. Out of these patients, 301 patients also underwent contrast-enhanced conventional coronary angiography (CCA). These patients were divided into 4 groups according to the time the examination was underwent. Group Q1: first quarter of the year (n=20), Group Q2: second quarter (n=128), Group Q3: third quarter (n=134), and Group Results The sensitivity, specificity, positive, and negative predictive values were Q1 - 64%, 89%, 49% and 94%, respectively; Q2 -79%, 96%, 74% and 97%, respectively; Q3 - 78%, 96%, 74%, 97%, respectively, and Q4 - 100% for all. Conclusions In a center with formal training and high caseload, our accuracy in CTA analysis reached a plateau after 6 months experience. Test-bolus protocols produce better image quality and can improve accuracy. New centers embarking on CTA will need to overcome an initial 6-month learning curve depending upon the caseload during which time they should consider correlation with CCA.

关键词： computed tomography training angiography coronary artery disease

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Mid-ventricular hypertrophic obstructive cardiomyopathy(MVHOCM) complicated with coronary artery disease:a case report

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Journal of Geriatric cardiology 2008年第3期5卷 190-192页

作者： Haoming Song Cuimei Zhao Jinfa Jiang Yang Liu Yihan Chen Department of cardiology,Tongji Hospital, Tongji University, Shanghai, 200065, P.R.China dept. of cardiology Tongji Hospital Tongji University 389 Xincun Rd. Shanghai 200065 China

Mid-ventricular hypertrophic obstructive cardiomyopathy (MVHOCM) is a rare type ofcardiomyopathy that can be accompanied by apical *** presented here a case report of MVHOCM with cornary artery *** sixty-four years old man was sent to hospital because ofventricular *** inversion T wave was showed on electrocardiography in the presence of abnormal coronary arteries and normal cardiac *** showed an hourglass appearance of the left ventricle with an aneurysm in the apex and a pressure gradient between the outflow tract of left ventricle and the middle of the left ventricle was revealed by left-heart catheterization.

关键词： hypertrophic obstructive cardiomyopathy coronary artery disease echocardiography

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The four stages of development： a historical prospective of external counterpulsation

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Journal of Geriatric cardiology 2010年第2期7卷 74-78页

作者： John CK Hui Zhen-Sheng Zheng cardiology dept State University of New YorkStony BrookNew Yorkand Vasomedical IncWestburyNew YorkUSA The Key Laboratory of Assisted Circulation Health Ministry of China and Cardiology DeptThe First Affiliated HospitalSun Yet-sen UniversityGuangzhouChina

There are four stages in medical device *** beginning starts with some new understanding of physiological concepts which evolve into the formation of an innovative idea. The second stage is the technical development phase,from idea to the development of a design to technical reality. At this stage,capital funding and patent applications for the development are necessary but they are not considered here. The third stage is experimental and clinical studies,a data gathering phase to provide evidence of safety and effectiveness of the applications of the device.

关键词：历史体外技术开发医疗器械创新思想专利申请应用程序数据收集

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OBSERVATION OF THE VENOUS SYSTEM WITH INTRAVASCULAR ULTRASOUND

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Chinese Medical Journal 1995年第3期 78-78页

作者： Michael Haude Gunter Gorge Raimund Erbel dept of cardiology University Essen GermanyDept of Cardiology University Essen GermanyDept of Cardiology University Essen Germany

Intravascular ultrasound (IVUS) offers accurate morphological assessment of arterial vasculature. Here we present a preliminary observation on venous system in vivo with IVUS, Seven superior vena cava (SVC) and eight inferior vena cava (IVC) were studied in ten individuais [M / F = 7 / 3, mean age = 60.2 ±9.6 years (39-77 years)]with a 6.2F, 20MHz catheter. The cross-sectional shape, pulsation, spontaneous echo contrast (SEC) and plaque formation were analyzed. The maximal and minimal lumen diameters (Dmax, Dmin) and the area were measured. For each measurement three different frames were analyzed and the average value was taken.

关键词： IVC IVUS

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Acupuncture Effects on Heart Failure: How to Create Objective Study Designs

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 307-308页

作者： HJ Greten A Kick E Scholz J Fischer T Greten F Brazkiewicz F Schroder S Sertel Wendt M Goncalves O Karrer A Remppis German Society of Traditional Chinese Medicine Heidelberg Germany Porto University ICBAS Portugal dept. of Endocrinology and Metabolism University of Heidelberg Germany dept. of cardiology University of Heidelberg Germany Dept. of Otorhinolaryngology Head & Neck Surgery University of Heidelberg Germany

According to a modem understanding of acupuncture mechanisms, acupuncture may elicit vegetative reflexes, presumably influencing the systemwide vegetative dysregulation associated with the heart failure syndrome, a feature of which is low performance in the 6 min walk test. The author performed a preliminary prospective, randomized, single-blinded clinical trial （n=21） in a cross-over design comparing acupuncture treatment, which was either compatible with individual Chinese diagnosis according to the Heidelberg Model of TCM （i-ACU） or a standardized treatment on acupoints with no specific relation to TCM diagnosis （u-ACU）. The repeated measures analysis revealed a significant effect for i-ACU vs. u-ACU （F =7.2, df=1.37, P=-0.011）. The study revealed first evidence that acupuncture may prolong 6 min walk distance as a key parameter of heart failure.

关键词： Acupuncture Therapy Heart Failure Randomized Controlled Trial Humans

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