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Signal transduction pathways mediated by colony stimulating factor-1 receptor

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Chinese Science Bulletin 1998年第12期43卷 969-974页

作者： Luo Shouqing Zheng Dexian Chinese Acad med Sci Inst Hematol Natl Lab Expt Hematol Peking Union Med Coll Tianjin 300020 Peoples R China

Colony-stimulating factor-1 (CSF-1), which is necessary for cell proliferation and differentiation, regulates both immediate and delayed early responses throughout G1 phase. The binding of CSF-1 to its receptor (CSF-1R) triggers phosphorylation of the receptor and its intrinsic tyrosine kinase. The activated receptor binds directly to cytoplasmic effector proteins, which induce multiple-signal transduction pathways. CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins. The expression of c-fos/jun family genes is also targeted following the activation of Ras. CSF-1R activates STAT1 and STAT3 to participate in signaling, but JAKs do not appear to contribute to signaling by CSF-1R. CSF-1R activates PI3-kinase, and PI3-kinase can interact with downstream proteins by the MAPKK-related pathway independent of Ras/Raf. PC-PLC can enforce signaling in response to CSF-1. Furthermore, the turnover and dephosphorylation by the phosphatase SHPTP1 of CSF-1R are the major mechanism in the negative regulation of signaling by CSF-1R.

关键词： colony stimulating factor-1 receptor signal transduction phosphorylation.

Bispecific antibody and its clinical applications in cancer

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Chinese Science Bulletin 2001年第5期46卷 353-358页

作者： Yuanfu Xu Chunzheng Yang Zhenping Zhu Chinese Acad med Sci Peking Union Med Coll Inst Hematol Natl Lab Expt Hematol Tianjin 300020 Peoples R China

Bispecific antibody (BsAb) usually consists of two different antigen-binding arms, by which it is capable of simultaneously binding to target cells and effector cells, and can directly mediate the killing of target cells by retargeting and activating effector cells. The development of BsAb research goes through three main stages: chemical cross-linking of murine-derived monoclonal antibody, hybrid hy-bridomas and engineered BsAb. Among them, engineered BsAb has more formats than the other two, such as diabody, ScdHLX, ScZip, ScCH3, ScFab and BsIgG, etc. Compared with former murine-derived BsAbs, engineered BsAb has lower immunogenicity and stronger penetrating capacity, and currently, some of them appear suitable for clinical application in yields and qualities. Up to now, several phase I and phase II clinical studies of BsAb, for instance, some (Fab’)2 and Diabodies, have been performed. Among those BsAbs, anti-CD3/anti-tumor BsAbs is most common, they not only can activate T cell and induce CD3AK

关键词： bispecific antibody genetic engineering tumor therapy.

VIP immunoreactive nerves and somatostatin and serotonin containing cellsin Crohn′s disease

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World Journal of Gastroenterology 1999年第6期5卷 541-543页

作者： Lu SJ Liu YQ Lin JS Wu HJ Sun YH Tan YB Weifang med Coll Dept Pathol Weifang 261042 Peoples R China Tianjin med Univ Dept Pathol Tianjin 300070 Peoples R China

INTRODUCTIONWith the progress of the studies on neuroendocrine and immunology in the gastrointestinal tract, it has been recognized that the intestinal neuroendocrine system and the immune system can influence and modulate each other and a neuroendocrine immunomodulation network in the intestine has been established[1]. Neuropeptides, such as vasoactive intestinal peptide (VIP), substance P (SP), somatostatin (SS) etc. are widely distributed in the gastrointestinal tract and they play an important role in the immunomodulation of the intestinal mucosa.

关键词： vasoactive intestinal peptide somatostatin serotonin Crohn′s disease immunohistochemistry histomorphometry

Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2011年第3期6卷 219-223页

作者： Zhao, Jing Yu, Shanshan Li, Lan Lin, Xuemei Zhao, Yong Chongqing med Univ Dept Pathophysiol Chongqing 400016 Peoples R China Chongqing med Univ Dept Pathol Chongqing 400016 Peoples R China

Inflammatory reactions are important pathophysiological mechanisms of ischemic brain injury. The present study analyzed the anti-inflammatory characteristics of curcumin via myeloperoxidase activity and nitric oxide content after 2-hour ischemia/24-hour reperfusion in Sprague Dawley rats. In addition, expressions of nuclear factor kappa B, tumor necrosis factor-α and interleukin-lβ protein were measured. Curcumin significantly reduced myeloperoxidase and nitric oxide synthase activities and suppressed expressions of nuclear factor kappa B, tumor necrosis factor-α, and interleukin-lβ in ischemia/reperfusion brain tissue. Results suggested that the neuroprotective effect of curcumin following cerebral ischemia/reperfusion injury could be associated with inhibition of inflammatory reactions.

关键词： curcumin inflammation tumor necrosis factor-a nuclear factor kappa B neuroprotection stroke ischemiaJreperfusion

Prevention of common bile duct injury during laparoscopic cholecystectomy

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 414-417页

作者： Ou, Zhi-Bing Li, Sheng-Wei Liu, Chang-An Tu, Bing Wu, Chuan-Xin Ding, Xiong Liu, Zuo-Jin Sun, Ke Feng, Hu-Yi Gong, Jian-Ping Chongqing med Univ Affiliated Hosp 2 Dept Hepatobiliary Surg Chongqing 400010 Peoples R China Chongqing med Univ Affiliated Hosp 2 Chongqing Key Lab Hepatobiliary Surg Chongqing 400010 Peoples R China

BACKGROUND: Since the widespread adoption of laparoscopic cholecystectomy (LC) in the late 1980s, a rise in common bile duct (CBD) injury has been reported. We analyzed the factors contributing to a record of zero CBD injuries in 10 000 consecutive LCs. METHODS: The retrospective investigation included 10 000 patients who underwent LC from July 1992 to June 2007. LC was performed by 4 teams of surgeons. The chief main surgeon of each team has had over 10 years of experience in hepatobiliary surgery. Calot's triangle was carefully dissected, and the relationship of the cystic duct to the CBD and common hepatic duct was clearly identified. A clip was applied to the cystic duct at the neck of the gallbladder and the duct was incised with scissors proximal to the clip. The cystic artery was dissected by the same method. Then, the gallbladder was dissected from its liver bed. A drain was routinely left at the gallbladder bed for 1-2 days postoperatively. RESULTS: No CBD injuries occurred in 10 000 consecutive LCs, and there were 16 duct leaks (0.16%). Among these there were 10 Luschka duct leaks (0.1%) and 6 cystic duct leaks (0.06%). Four hundred thirty cases were converted to open cholecystectomy (OC), giving a conversion rate of 4.3%. After a mean follow-up of 17.5 months (range 6-24 months), no postoperative death due to LC occurred, and good results were observed in 95% of the patients. CONCLUSIONS: In our 10 000 LCs with zero CBD injuries, the techniques used and practices at our department have been successful. Surgeon's expertise in biliary surgery, preoperative imaging, precise operative procedures, and conversion from LC to OC when needed are important measures to prevent CBD injuries.

关键词： laparoscopic cholecystectomy open cholecystectomy common bile duct prevention

Optimizing Bayesian penalized likelihood algorithm for low count PET reconstruction to simulate low dose PET imaging

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China medical Abstracts(Internal medicine) 2024年第1期41卷 3-3页

作者：阮伟伟 dept Nucl med Union HospTongji Med CollHuazhong Univ Sci&TechnolHubei Prov KeyLabMolec ImagingWuhan 430022

Objective To study whether Bayesian penalized likelihood (BPL) and its optimized reconstruction algorithm can improve the reconstructed image quality of low count total-body *** Eight patients(5 males,3 females,age (67.2±6.3) years) who underwent hybrid^(18)F-FDG PET/MR total-body scans at Department of Nuclear medicine in Union Hospital.

关键词： likelihood medicine algorithm

Long-term outcomes ofintravascular ultrasound-guided drug-eluting stents implantation in patients with acute coronary syndrome:ULTIMATE ACS subgroup

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China medical Abstracts(Internal medicine) 2024年第2期41卷 95-95页

作者：高晓飞 dept Cardiol Nanjing 1st HospNanjing Med UnivNanjing 210006

Objective To explore the long-term effects of intravascular ultrasound(IVUS)guidance on patients with acute coronary syndrome(ACS)undergoing drugeluting stents(DES)*** Data used in this study derived from ULTIMATE trial,which was a prospective,multicenter,randomized study.A total of 1448 all-comer patients were enrolled between 2014 August and 2017 *** endpoint of this study was target vessel failure(TVF)at 3 years,including cardiac death,target-vessel-related myocardial infarction,and clinically-driven target vessel *** ACS was present in 1136(78.5%)patients,and 3-year clinical follow-up was available in 1423 patients(98.3%).TVF in the ACS group was 9.6%(109/1136),which was significantly higher than 4.5%(14/312)in the non-ACS group(log-rank P=0.005).There were 109 TVFs in the ACS patients,with 7.6%(43/569)TVFs in the IVUS group and 11.6%(66/567)TVFs in the angiography group(log-rank P=0.019).

关键词： patients coronary intravascular

Effect of miR-130a targeting phosphase and tensin homology deleted on chromosome ten/ phosphoinositol 3 kinase/protein kinase B axis on apoptosis of renal tissue cells in rats with diabetic kidney disease

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China medical Abstracts(Internal medicine) 2024年第2期41卷 94-94页

作者：许春梅 dept Nephrol Longyan 1st HospFujian Med UnivLongyan 364000

Objective To investigate the effect of miR-130a targeting phosphase and tensin homology deleted on chromosome ten(PTEN)/phosphoinositide 3 kinase(PI3K)/protein kinase B(AKT)pathway on renal tissue cell apoptosis in diabetic kidney disease(DKD)*** The DKD rat model was constructed by feeding high-sugar and high-fat diet combined with intraperitoneal injection of streptozotocin(STZ).72 rats were divided into normal control group(NC),DKD model group(DKD),miR-13Oa agonist negative control group(NC agomir),and miR-130a agonist group(miR-130a agomir),miR-130a agomir+PTEN overexpression negative control group(miR-13a agomir+pcDNA),and miR-130a agomir+PCDNA-PTEN over-expression group(miR-130a Agomir+PCDNA-PTEN),with 12 rats in each *** microalbumin kit was used to detect 24 h urine albumin(UAlb).Fasting blood glucose(FBG),serum creatinine(Scr)and blood urea nitrogen(BUN)were detected by automatic biochemical *** changes of renal tissue were detected by HE *** levels of serum IL-6 and TNF-αwere detected by *** apoptosis of renal tissue was detected by TUNEL *** expression of miR-130a was detected by qRT-PCR,and the expression of B-cell lymphoma-2-associated X protein(Bax).

关键词： miR rats kidney

Abnormal behavior of fluorescence quenching of gramicidin A inphase transition of lipid vesicles by hypocrellin B——Does anelectron transfer inverted region exist?

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Chinese Science Bulletin 1999年第21期44卷 1978-1983页

作者： Jiachang Yue Yeping Li Yaxian Su Kechun Lin Chinese Acad Sci Inst Biophys Natl Biol Macromol Lab Beijing 100101 Peoples R China Beijing med Univ Dept Biophys Beijing 100083 Peoples R China

The fluorescence of gramicidin A(GA) in lipid bilayer may be quenched by Hypocre-Ilin B. When the phospholipids undergo a phase transition from gel to liquid crystalline phase, the reaction rate decreases unusually. This phenomenon has been analyzed by Marcus’ pho-toinduced electron theory, and an electron transfer inverted region hypothesis is proposed,

关键词： fluorescence quenching hypocrellin B Marcus theory.