检索结果-南通市图书馆

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 48-49页

作者：王彬 dept gastroenterol&hepatol Tianjin Med Univ General HospTianjin Instit Dig DisTianjin Dig Dis Key LabTianjin 300052

Objective To compare the difference between gas volume score (GVS) method and combination of computed tomography (CT) image and calculation formula method (hereinafter referred to as CT method)in the detection of gast... 详细信息

关键词： patients dyspepsia gastrointestinal

Shuchang decoction for treatment of diarrhea predominant irritable bowel syndrome with Gan depression and Pi deficiency:a multicenter,randomized,double-blind,placebo controlled trial

在线全文

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 14-15页

作者：思璎桀 dept gastroenterol Longhua HospShanghai TCM UnivShanghai200032

Objective To observe the clinical efficacy and safety of Shuchang Decoction (SCD) in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D)with Gan depression and Pi deficiency syndrome.Methods A total... 详细信息

关键词： predominant double treatment

The diagnostic value of salivary pepsin test in gastroesophageal reflux disease

在线全文

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 49-50页

作者：陈蓉蓉 dept gastroenterol 1st Affil HospNanjing Med UnivNanjing 210029

Objective To explore the clinical application value of salivary pepsin test (Peptest) in the diagnosis of gastroesophageal reflux disease (GERD).Methods From April to October 2022,at the Department of gastroenterology... 详细信息

关键词： salivary diagnosis clinical

A multicenter cross-sectional study on the multidimensional clinical manifestations of irritable bowel syndrome

在线全文

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 46-47页

作者：周丹 dept gastroenterol Union HospTongji Med CollHuazhong Univ&TechnolWuhan 430022

Objective To assess the differences in multidimensional clinical manifestations between patients with irritable bowel syndrome (IBS) matching the RomeⅢcriteria but not matching RomeⅣand IBS patients matching the RomeⅣcriteria,among patients diagnosed with IBS according to RomeⅢcriteria.Methods From November 2016 to October 2017.

关键词： clinical matching patients

CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

在线全文

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2010年第23期16卷 2873-2880页

作者： Xia, Xian-Ming Wang, Fang-Yu Xu, Wen-An Wang, Zhen-Kai Liu, Jiong Lu, You-Ke Jin, Xin-Xin Lu, Heng Shen, Yun-Zhu Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM:To investigate the effects of the chemokine stromal cell-derived factor-1(CXCL12) receptor(CXCR4) antagonist AMD3100 on colonic inflammation and epithelial barrier in dextran sulfate sodium(DSS)-induced colitis in mice.METHODS:Experimental colitis was induced by administration of 5% DSS for 7 d,and assays performed on intestinal segments from the ileocecal valve to the anus.Colonic morphology was examined by hematoxylin and eosin staining.Colonic cytokines were determined by enzyme-linked immunosorbent assay.Myeloperoxidase(MPO) activity(indicator of inflammatory infiltration) was observed spectrophotometrically.Gut permeability was assessed by mucosal-to-serosal clearance of fluorescein isothiocyanate-conjugated dextran 4000(FD4) in everted gut sacs.The apoptosis of colonic epithelium was assessed by Hoechst-33342 staining.To further elucidate the role of CXCR4 in colonic inflammation,we also investigated the effect of AMD3100 on migration and cytokine production of isolated peripheral blood mononuclear cells(PBMCs).RESULTS:DSS-induced colitis was characterized by morphologic changes,as well as increased colonic cytokines,inflammatory infiltration,epithelial apoptosis,and intestinal permeability in mice.In AMD3100-treated mice,epithelial destruction,inflammatory infiltration,and submucosal edema were markedly reduced;colonic tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interferon-γ(IFN-γ) levels,as well as MPO activity were significantly decreased.Increased intestinal permeability in DSS-treated mice was signif icantly reduced by AMD3100.The number of apoptotic cells in colitis mice was markedly increased after DSS administration,and decreased when treated with the CXCR4 antagonist AMD3100.In pre-activated PBMCs,CXCL12 stimulation signif icantly increased the migration of PBMCs,and was inhibited by AMD3100.Moderately increased TNF-α,IL-6,and IFN-γ from CXCL12-treated PBMCs were also reduced by AMD3100.CONCLUSION:The CXCR4 antagonist AMD3100 exerts therapeutic effects on experimental colitis by inhi

关键词： Ulcerative colitis Chemokine stromal cellderived factor-1 receptor Inflammation Apoptosis Intestinal permeability Epithelial barrier

Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2010年第24期16卷 2994-3001页

作者： Xia, Xian-Ming Wang, Fang-Yu Wang, Zhen-Kai Wan, Hai-Jun Xu, Wen-An Lu, Heng Jinling Hosp Dept Gastroenterol & Hepatol Nanjing 210002 Jiangsu Prov Peoples R China

AIM: To investigate the effect of emodin on expression of claudin4, claudin5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. METHODS: Experimental pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Emodin was injected via the external jugular vein 3 h after induction of acute pancreatitis. Rats from sham operation group and acute pancreatitis group were injected with normal saline (an equivalent volume as emodin) at the same time point. Samples of lung and serum were obtained 6 h after drug administration. Pulmonary morphology was examined with HE staining. Pulmonary edema was estimated by measuring water content in lung tissue samples. Tumor necrosis factorα (TNFα) and interleukin6 (IL6) level were measured by enzymelinked immunospecific assay. Serum amylase and pulmonary myeloperoxidase (MPO) activity were detected by spectrophotometry. Alveolar epithelial barrier was assessed by pulmonary dye extravasation. Expression of claudin4, claudin5 and occludin in lung tissue samples was examined by immunohistology, quantitative realtime reverse transcription polymerase chain reaction and Western blotting analysis, respectively.RESULTS: Pancreatitis-associated lung injury was char-acterized by pulmonary edema, leukocyte infiltration, alveolar collapse, and elevated serum amylase level. The pulmonary damage, pulmonary pathological scores, serum amylase and MPO activity, TNF-α and IL-6 levels, and wet/dry ratio were decreased in rats after treatment with emodin. Immunostaining of claudin-4, claudin-5 and occludin was detected in lung tissue samples from rats in sham operation group, which was distributed in alveolar epithelium, vascular endothelium, and bron-chial epithelium, respectively. The mRNA and protein expression levels of claudin-4, claudin-5 and occludin in lung tissue samples were markedly decreased, the expression level of claudin-4, claudin-5 and occluding was increased, and the pulmonary

关键词： Acute pancreatitis Emodin Lung injury Claudin Occludin Epithelial barrier

Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model:A comparative study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2010年第4期16卷 501-507页

作者： Wu, Sheng-Di Wang, Ji-Yao Li, Lei Fudan Univ Zhongshan Hosp Dept Internal Med Div Gastroenterol & Hepatol Shanghai 200032 Peoples R China

AIM:To evaluate the efficacy of 6 noninvasive liver fibrosis models and to identify the most valuable model for the prediction of liver fibrosis stage in chronic hepatitis B(CHB) patients.METHODS:Seventy-eight CHB patients were consecutively enrolled in this study.Liver biopsy was performed and blood serum was obtained at admission.Histological diagnosis was made according to the METAVIR system.Significant fibrosis was defined as stage score ≥ 2,severe fibrosis as stage score ≥ 3.The diagnostic accuracy of 6 noninvasive liver fibrosis models,including serum aspartate aminotransferase(AST) to platelet ratio index(APRI),FIB-4,Forn's index,Fibrometer,Hepascore,and Shanghai Liver Fibrosis Group's index(SLFG),was investigated.RESULTS:The APRI,FIB-4 and Forn's index under receiver operating characteristic curve(AUROC) for sig-nificant fibrosis were 0.71,0.75 and 0.79,respectively,with a diagnosis accuracy of 67%,77% and 80%,respectively,and 0.80,0.87 and 0.86,respectively,under the AUROC for severe fibrosis.The Hepascore,SLFG,and Fibrometer were 0.80,0.83 and 0.85,respectively under the AUROC for significant fibrosis(P < 0.01).The diagnosis accuracy of Hepascore and SLFG was 86% and 88%,respectively.The Hepascore,SLFG,and Fibrometer were 0.95,0.93,and 0.94,respectively,under the AUROC for severe fibrosis(P < 0.01).CONCLUSION:The models containing direct serum markers have a better diagnostic value than those not containing direct serum markers.

关键词： Chronic hepatitis B Liver fibrosis Serum marker Noninvasive model Receiver operating curve

Compound Qingdai enema rapidly alleviates the inflammatory activity in patients with ulcerative colitis:a clinical observation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 15-15页

作者：钦丹萍 dept gastroenterol 1st Affil HospZhejiang CM UnivHangzhou 310006

Objective To observe the effect Compound Qingdai Enema on rapidly alleviating the inflammatory activity in patients with ulcerative colitis (UC).Methods A preand post-treatment self-controlled trail was used in this study.Totally 42 patients with active UC were treated with Compound Qingdai Enema by traditional rectal administration method.The main clinical symptoms,mucosal endoscopic manifestations,mucosal histopathology.

关键词： patients clinical Qing

Typical endoscopic appearance accurately predicts sporadic fundic gland polyps： a retrospective study of 47 771 endoscopies

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第15期126卷 2984-2986页

作者： CAO Hai-long SONG Shu-li YANG Bo-li ZHANG Zhi-hua ZHANG Hui QU Rui WANG Bang-mao Tianjin Med Univ Dept Gastroenterol & Hepatol Gen Hosp Tianjin 300052 Peoples R China Cangzhou Peoples Hosp Dept Gastroenterol & Hepatol Cangzhou 061000 Heibei Peoples R China Anhui Med Univ Dept Epidemiol Hefei 230032 Anhui Peoples R China

Sporadic fundic gland polyps （FGPs） account for 0.8%- 1.9% of all gastric polyps and are observed in patients undergoing esophagogastroduodenoscopy （EGD） in whom they account for more than 50% of all gastric polyps. The prevalence is increasing in recent years possibly due to decreased Helicobacter pylori （1t. pylori） infection rate and long-term proton pump inhibitor use. Generally, sporadic FGPs are assumed to be benign polyps with no risk of malignant transformation. We evaluated the feasibility of predicting sporadic FGPs based on typical endoscopic appearance in a large database of 47 771 endoscopies.

关键词： fundic gland polyps stomach neoplasms dysplasia endoscopy, gastrointestinal

The efficacy of modified Banxia Xiexin decoction on patients with functional dyspepsia and its impact on gastric function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Medical Abstracts(Internal Medicine) 2024年第1期41卷 46-46页

作者：张奕秉 dept gastroenterol Wenzhou Centr HospDingli Clin CollWenzhou Med UnivWenzhou 325000

Objective To investigate the efficacy of Modified Banxia Xiexin Decoction on patients with functional dyspepsia (FD) and its impact on gastric function.Methods From June 2021 to December 2022,at the Department of gastroenterology,Wenzhou Central Hospital,a total of 56 patients with FD who met the diagnostic criteria of RomeⅣwere prospectively enrolled.

关键词： patients dyspepsia gastric