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China Medical Abstracts(Internal Medicine) 2024年第1期41卷 52-52页

作者：方琼琼 dept biol Shanghai Ocean UnivFisheries&Life Sci CollShanghai 201306

Objective To investigate the mechanism by which Liraglutide improves the inflammatory response in metabolic associated faty liver disease (MAFLD) by regulating the interferon gene stimulating factor (STING)signaling *... 详细信息

关键词： C57BL/6J liver inflammatory Liraglutide

Macroinvertebrate　assemblages　of　surface　mine　wetlands　of　Southwest　Virginia，USA

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Journal of Environmental Sciences 1996年第1期8卷 1-14页

作者： David H.Jones Robert B. Atkinson John Cairns,Jr.(Department of biology,Virginia Polytechnic Institute and State University, Blacksburg,Virginia 24061 USA) dept biol Virginia Poly Inst Blacksburg VA 24061 United States

The focus of this study was to investigate the macroinvertebrate community in surface mine wetlands. Nine wetlands were sampled for macroinvertebrates from July 1993 through May *** sites represented a range of physical,chemical, and biological parameters. Macroinvertebrates were found in all sites;a total of 14 orders, 40 families,and 70 genera were identified in the samples. Insects were the most common invertebrates,and most functional feeding groups were represented. Predators dominated with 63% of the taxa, followed by the collector/gathers with 20%,shredders 14%, and scrapers 3%. Sites differed in the number of taxa inhabiting *** ranged from 10 genera to *** lowest richness was found in two seasonal wetlands that were dry for the majority of the year. A permanently flooded site with no water quality problems and a dense growth of aquatic plants had the highest richness.

关键词： macroinvertebrate assemblages surface mine wetlands wetland faunas.

Relationship between LTP and the nuclear protein induced by calcineurin

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Chinese Science Bulletin 1998年第16期43卷 1384-1387页

作者： Jie Luo Qun Wei Beijing Normal Univ Dept Biol Biochem & Mol Biol Lab Beijing 100875 Peoples R China

Results demonstrate that calcineurin plays a role in long term potentiation (LTP) in the hippocampus. A 45 ku enzyme was administered, which exhibits Ca 2+/calmodulin independent activity to rats, and the protein components of nuclear extracts from the cell-free system of rat hippocampus were tested. It is found that the level of a component significantly increased in nuclear extracts following the activation of calcineurin. The concentration of the component in the nucleus is also markedly increased following hippocampal LTP elicited by ginsenosides. These results suggest that the activation of calcineurin induces a pre-existing protein component to translocate to the nucleus in the hippocampus. The nuclear translocation of the component may be required for LTP in the hippocampus.

关键词： calcineurin nuclear protein learning and memory long-term potentiation (LTP).

0.27-nm resolution crystal structure of Haemorrhagin I from snake venom of Agkistrodon acutus

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Chinese Science Bulletin 1997年第4期42卷 333-337页

作者： Gong, WM Teng, MK Niu, LW UNIV SCI & TECHNOL CHINA DEPT BIOLYOUNG SCIENTIST LAB STRUCT BIOLHEFEI 230026PEOPLES R CHINA

THE snake venom zinc-metalloproteinases and matrix metalloproteinases (MMP) have the similar active site and biological function. They all belong to the MMP super-family. Some

关键词： crystal structure Haemorrhagin mctalloproteinase snake venom.

Apoptosis in suspension culture of tobacco cells induced by heat shock

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Chinese Science Bulletin 1999年第12期44卷 1101-1106页

作者： Haoming Chen Changhui Yan Xiaofang Jiang Yaoren Dai Tsing Hua Univ Dept Biol Beijing 100084 Peoples R China

The induction of apoptosis in suspension culture of tobacco cells by heat shock is reported for the first time. Heat treatment (48℃ for 4 h) of tobacco cells led to the appearance of typical hallmarks of apoptosis. It was demonstrated by DNA laddering analysis that the cells treated with heat shock at 48℃ for 4 h had a serious degradation of nuclear DNA into multi-nu-cleosomal sizes, suggesting that heat shock activated endogenous nuclease which led to DNA cleavage at the linkage sites between the nucleosomes, but ladders were very faint for DNA from 2 and 9 h heat-treated cells. The terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labelling (TUNEL) detection also showed that most of these treated cells (48℃ for 4 h) displayed positive reactions, indicating a serious DNA 3’-OH cleavage in their nuclei. Moreover, some other cytological changes in apoptotic cells, such as cell shrinkage, chromatin aggregation, nucleus collapse, have also been observed by 4’,

关键词： apoptosis DNA ladder TUNEL Nicotiana tabacum .

Homologous analysis on centromeric region sequences of A and B chromosomes from rye by FISH

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Chinese Science Bulletin 1999年第8期44卷 704-707页

作者： Rongxin Zhang Chengbin Chen Wenqin Song Xiulan Li Ruiyang Chen Nankai Univ Dept Biol Tianjin 300071 Peoples R China

Four centromeric segments from B chromosomes (Bs) of rye have been microdis-sected and amplified by linker adapter PCR (LA-PCR). The PCR products ranged from 100 to 2 000 bp. Fluorescence in situ hybridization (FISH) experiment has been carried out using PCR products as the probe, which was labeled by DIG-11-dUTP. The result confirms that these PCR products from Bs centromeric region are homologous with that of A chromosomes (As) in rye. It also proves that Bs are originated from As.

关键词： B chromosome of rye centromeric region microdissection homology FISH.

Inhibitory effects of two oligosaccharideson murine melanoma experimental liver metastasis

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World Journal of Gastroenterology 1998年第2期4卷 11-13页

作者： Liu, YP Zhou, RL Wang, YF Cai, MC Beijing Med Univ Dept Cell Biol Beijing 100083 Peoples R China Second Mil Med Univ Dept Biol Shanghai 200433 Peoples R China Beijing Med Univ Dept Organ Chem Beijing 100083 Peoples R China

AIM To observe the effects of a chemically synthesized tetrose and a natural yeast mannan on experimental liver metastasis of mouse melanoma. METHODS After treated with 4mg tetrose (tetrose group) or 4mg mannan (mannan group) for 30 minutes at 37℃, 0 5ml 1×10 6 B16 MBK melanoma cells were injected into the spleen of mice. Fifty five days later, melanoma metastatic nodes on the surface of the liver and in other organs as well as mouse survival time were observed. RESULTS Of the 6 mice in control (B16 cell+PBS) group, 4 died naturally within 55 days, and 2 were killed on the 55th day. All of the 6 mice had metastases in livers, the total number of the melanoma nodes on each liver surface ranged from 2 to 30, with the largest one merging into the whole liver. One mouse had a neoplasm in the remnant site of injection, and 3 had metastases in lungs. In contrast, of the 6 mice in tetrose group, only one died on the 50th day after injection, with 3 metastases in the liver, the largest being 10mm in diameter, the other 5 mice survived until being dissected on the 55th day after injection and had no liver metastasis, but 3 of them had neoplasms in their remnant sites of injection. In mannan group, all of the 6 mice survived and no metastasis was seen except for 2 liver nodes in one mouse with the largest diameter of 1mm. Neither tetrose nor mannan group had metastasis out of the liver, and the weight of liver in the two groups was significantly lower than those in the control group. CONCLUSION Both tetrose and mannan had the effects of preventing melanoma cells from experimental metastasis to and out of the liver, and prolonging the survival time of the mouse.

关键词： liver neoplasms, experimental melanoma oligosaccharides neoplasm metastasis disease models, animal

Effects of low frequency electromagnetic fields on osteoblasts proliferation and cell cycle

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Chinese Science Bulletin 1999年第23期44卷 2174-2177页

作者： Qing Tang Nanming Zhao Tsing Hua Univ Dept Biol Sci & Biotechnol State Key Lab Biomembrane & Membrane Biol Beijing 100084 Peoples R China

After primary mouse osteoblasts and ROS osteo-like cells were exposed to 50 Hz low frequency electromagnetic fields (EMF), the MTT method and flow cytometry have been used to determine cell proliferation, cell cycle a... 详细信息

关键词： low frequency electromagnetic fields biological effects cell proliferation cell cycle.

The evolution simulation of zinc finger domain sequence——Application of genetic algorithms in protein structure study

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Chinese Science Bulletin 1997年第22期42卷 1925-1928页

作者： Sun, ZR Han, H Tsing Hua Univ Dept Biol Sci & Biotechnol Beijing 100084 Peoples R China

GENETIC algorithms are very efficient search mechanisms. The application of genetic algo-rithms in the protein structure study provides not only a convenience algorithm for the searchof the lowest energy status (accor... 详细信息

关键词： genetic algorithm zinc finger domain evolution simulation protein sequence.

Selection of Trypsin Inhibitors in Phage Peptide Library Using Model Pepeide Mimicking the Active Site of Trypsin

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Chemical Research in Chinese Universities 1996年第1期12卷 111-113页

作者： QI Jie FANG Rui LU Zhi-bin ZHou Hui LI Wei and SHEN Jia-cong(Department of Molecular biology, Jilin University, Changchun 130023, China)(Department of Chemistry, Jilin University) JILIN UNIV DEPT BIOL MOLECCHANGCHUN 130023PEOPLES R CHINA