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Effects on the pouch of different digestive tract reconstruction modes assessed by radionuclide scintigraphy

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World Journal of Gastroenterology 2010年第11期16卷 1402-1408页

作者： Li, Dong-Sheng Xu, Hui-Mian Han, Chun-Qi Li, Ya-Ming China med Univ Affiliated Hosp 1 Dept Oncol Shenyang 110001 Liaoning Prov Peoples R China

AIM: To determine the effect of three digestive tract reconstruction procedures on pouch function, after radical surgery undertaken because of gastric cancer, as assessed by radionuclide dynamic imaging. METHODS: As a measure of the reservoir function, with a designed diet containing technetium-99m (99mTc), the emptying time of the gastric substitute was evaluated using a 99mTc-labeled solid test meal. Immediately after the meal, the patient was placed in front of a γ camera in a supine position and the radioactivity was measured over the whole abdomen every minute. A frame image was obtained. The emptying sequences were recorded by the microprocessor and then stored on a computer disk. According to a computer processing system, the half-emptying actual curve and the fitting curve of food containing isotope in the detected region were depicted, and the half-emptying actual curves of the three reconstruction procedures were directly compared. RESULTS: Of the three reconstruction procedures, the half-emptying time of food containing isotope in the Dual Braun type esophagojejunal anastomosis procedure (51.86±6.43 min) was far closer to normal, signif icantly better than that of the proximal gastrectomy orthotopic reconstruction (30.07±15.77 min, P=0.002) and P type esophagojejunal anastomosis (27.88±6.07 min, P=0.001) methods. The half-emptying actual curve and f itting curves for the Dual Braun type esophagojejunal anastomosis were fairly similar while those of the proximal gastrectomy orthotopic reconstruction and P type esophagojejunal anastomosis were obviously separated, which indicated bad food conservation in the reconstructed pouches. CONCLUSION: Dual Braun type esophagojejunal anastomosis is the most useful of the three procedures for improving food accommodation in patients with a pouch and can retard evacuation of solid food from the reconstructed pouch.

关键词： Isotope γ-scintigraphy T1/2 time Digestive tract reconstruction 99mTc-DTPA Emptying time

Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2010年第13期16卷 1649-1654页

作者： Lv, Jin Cao, Xiu-Feng Zhu, Bin Ji, Lv Tao, Lei Wang, Dong-Dong Nanjing med Univ Affiliated Nanjing Hosp 1 Dept Surg Ctr Oncol Nanjing 210006 Jiangsu Peoples R China

AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Using preoperative computed tomography (CT)-based staging criteria, 238 patients with ESCC (stage ⅡⅢ ) were enrolled in this prospective study between January 1997 and June 2004. With informed consent, patients were randomized into 3 groups: preoperative CRT (80 cases), postoperative CRT (78 cases) and surgery alone (S) (80 cases). The 1-, 3-, 5and 10-year survival were followed up. Progressionfree survival (PFS) was chosen as the primary endpoint by treatment arm measured from study entry until documented progression of disease or death from any cause. The secondary endpoint was overall survival (OS) determined as the time (in months) between the date of therapy and the date of death. Other objectives were surgical and adjuvant therapy ***: With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year OS (91.3%, 63.5%, 43.5%, 24.5% vs 91%, 62.8%, 42.3%, 24.4% vs 87.5%, 51.3%, 33.8%, 12.5%, P = 0.0176) and PFS (89.3%, 61.3%, 37.5%, 18.1% vs 89.1%, 61.1%, 37.2%, 17.8% vs 84.5%, 49.3%, 25.9%, 6.2%, P = 0.0151) were detected among the 3 arms. There were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). For the patients who had radical resection, significant differences in median PFS (48 mo vs 61 mo vs 39.5 mo, P = 0.0331) and median OS (56.5 mo vs 72 mo vs 41.5 mo, P = 0.0153) were detected among the 3 arms, but there were no significant differences in OS and PFS between the preoperative CRT and postoperative CRT arm (P > 0.05). The local recurrence rates in the preoperative CRT, postoperative CRT group and S group were 11.3%, 14.1% and 35%, respectively (P < 0.05). No significant differences were detected among the 3 groups when comparing complications but tended to be in favor

关键词： Esophageal cancer Surgery Esophagectomy Chemotherapy Radiation therapy

Role of RECK methylation in gastric cancer and its clinical significance

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World Journal of Gastroenterology 2010年第7期16卷 904-908页

作者： Du, Yun-Yi Dai, Dong-Qiu Yang, Zhi China med Univ Affiliated Hosp 1 Dept Surg Oncol Shenyang 110001 Liaoning Prov Peoples R China

AIM:To investigate the relation between RECK methylation and clinicopathological characteristics of gastric cancer patients and evaluate the role of RECK methylation in peritoneal metastasis of gastric ***:Methylation of RECK gene in 40 paired samples of gastric cancer and its corresponding adjacent normal mucosa,lymph nodes and peritoneal irrigation fluid was detected by methylation-specific polymerase chain ***:Aberrant methylation of RECK gene was detected in 27.5%(11/40)of the adjacent normal mucosa samples,in 47.5%(19/40)of gastric cancer samples,in 57.1%(12/21)of the lymph node samples,and in 35%(14/40)of peritoneal irrigation fluid samples,respectively,with a significant difference between the adjacent normal mucosa and lymph node samples(P=0.023).Presence of RECK methylation in the primary tumor samples was significantly correlated with tumor invasion(P=0.023).The accuracy of RECK methylation in peritoneal lavage fluid samples for the diagnosis of peritoneal metastasis of gastric cancer was 72.5%(26/40),with a sensitivity of 66.7%(6/9) and a specificity of 74.2%(23/31).CONCLUSION:Aberrant methylation of RECK gene may provide useful information for the early diagnosis and treatment of peritoneal metastasis of gastric cancer.

关键词： RECK gene Hypermethylation Gastric cancer Metastasis Peritoneal lavage fluid

Melatonin and Doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines

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World Journal of Gastroenterology 2010年第12期16卷 1473-1481页

作者： Fan, Lu-Lu Sun, Guo-Ping Wei, Wei Wang, Zhang-Gui Ge, Lei Fu, Wei-Zheng Wang, Hua Anhui med Univ Affiliated Hosp 1 Dept Oncol Hefei 230022 Anhui Peoples R China Anhui med Univ Inst Clin Pharmacol Key Lab Res & Dev Chinese Med Key Lab Antiinflammatory & Immunol Pharmacol Hefei 230022 Anhui Peoples R China Anhui med Univ Affiliated Prov Hosp Dept Oncol Hefei 230032 Peoples R China

AIM:To investigate whether Melatonin has synergistic effects with Doxorubicin in the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 and ***:The synergism of Melatonin and Doxorubicin inhibited the cell growth and induced cell apoptosis in human hepatoma cell lines HepG2 and *** viability was analyzed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide(MTT)*** apoptosis was evaluated using TUNEL method and flow ***-related protein Bax,Bcl-2 and caspase-3 expressions were measured by immunohistochemical ***:Treatment with Melatonin(10 -8 -10 -5 mol/L) alone had a dose-related inhibitory effect on cell proliferation but no cytotoxic effect on hepatoma cell lines HepG2 and ***,when combined with Doxorubicin,Melatonin significantly increased the effects of cell growth inhibition and cell ***,TUNEL staining and flow cytometry revealed that cooperative apoptosis induction was associated with decreased expression of Bcl-2 as well as increased expression of Bax and ***:The synergism of Melatonin and Doxorubicin inhibits hepatoma cell growth and induces cell apoptosis.

关键词： Melatonin Doxorubicin Human hepatoma cell line Apoptosis

Pathologic research update of colorectal neuroendocrine tumors

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World Journal of Gastroenterology 2010年第14期16卷 1713-1719页

作者： Ni, Shu-Juan Sheng, Wei-Qi Du, Xiang Fudan Univ Dept Pathol Canc Hosp Shanghai 200032 Peoples R China Fudan Univ Dept Oncol Shanghai Med Sch Shanghai 200032 Peoples R China

Colorectal neuroendocrine tumors (NETs) originate from neuroendocrine cells in the intestinal tract, and represent a small area within oncology, but one which has provided increasing new data during the past years. Although the World Health Organization has determined clinical and histological features to predict prognosis for such tumors, they may not be valid on an individual basis. We aim to give an overview of the recent findings with regard to pathology, molecular genetics and diagnosis of NETs.

关键词： Neuroendocrine tumors Carcinoid Colorectal World Health Organization classification Tumornode-metastases

Abdominal separation in an adult male patient with acute abdominal pain

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World Journal of Gastroenterology 2010年第26期16卷 3343-3346页

作者： Liu, Bao-Lin Chen, Yang Liu, Shi-Qing Zhang, Xiao-Bo Cui, Dong-Xu Dai, Xian-Wei China med Univ Shengjing Hosp Dept Surg Oncol & Organ Transplatat Div Shenyang 110004 Liaoning Prov Peoples R China

We report a male patient with prolonged post-prandial abdominal distension and a sudden onset of epigastric pain initially diagnosed as acute abdomen. The patient had no history of surgery. Physical examination revealed peritonitis and abdominal computed tomography scan showed upper abdominal mesentery intorsion. The patient then underwent surgical intervention. It was found that the descending mesocolon dorsal root was connected to the ascending colon and formed a membrane encapsulating the small intestine. The membrane also formed an orifice in the ileal pars caeca, from which a 30 cm herniated ileum formed a "C"-shaped loop which was strangulated by the orifice. An abdominal separation was diagnosed after surgery. We liberated the membranous peritoneum which incarcerated the intestinal canal from the root ofileocecal junction to Treitz ligament, and reduced the small intestinal malrotation. The patient had an uneventful recovery after opera-tion with his abdominal distention disappeared during the follow-up. Abdominal separation is a rare situation, which may be related with embryo development. Surgery is a choice of treatment for it.

关键词： Abdominal separation Abdominal pain Internal hernia Malrotation Acute abdomen

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 58-62页

作者： Chu, Kai-Jian Yao, Xiao-Ping Fu, Xiao-Hui Second Military med Univ Eastern Hepatobiliary Surg Hosp Dept Oncol Comprehens Treatment Shanghai 200438 Peoples R China

BACKGROUND: Pleural effusion frequently complicates hepatectomy and multiple factors contribute to its development following hepatectomy for primary liver cancer. The purpose of this study was to evaluate these factors. METHODS: From March 2003 to May 2005, 228 consecutive patients with primary liver cancer underwent hepatectomy in our department were evaluated retrospectively to identify factors related to postoperative pleural effusion. RESULTS: Among the 228 patients, postoperative pleural effusions arose in 58 (25.4%). Univariate analysis showed significant differences in postoperative ascites, subphrenic collection, Pringle manoeuvre length, drainage amount on postoperative day 1, albumin level on postoperative day 7, alanine aminotransferase (ALT) level on postoperative days I and 3, prealbumin level on postoperative days 3 and 7, and tumor size (P<0.05). Ordinal regression analysis revealed that subphrenic collection, drainage on postoperative day I and ALT plus prealbumin on postoperative days I and 3 were statistically significantly related to postoperative pleural effusion (P<0.05). CONCLUSION: Subphrenic collection and operative injury to the liver appeared to be significantly related to pleural effusion after hepatectomy for primary liver cancer.

关键词： postoperative pleural effusion primary liver cancer hepatectomy etiology

Role of BMP3 in progression of gastric carcinoma in Chinese people

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World Journal of Gastroenterology 2010年第11期16卷 1409-1413页

作者： Chen, Xue-Rong Wang, Jin-Wei Li, Xiang Zhang, Hong Ye, Zai-Yuan First Peoples Hosp Taizhou Dept Oncol Taizhou 318020 Zhejiang Peoples R China Zhejiang Prov Hosp Dept Surg Oncol Hangzhou 310012 Zhejiang Peoples R China

AIM:To investigate the relation between gastric cancer and microsatellite instability(MSI),loss of heterozygosity(LOH)and promoter region ***:Fifty primary gastric carcinoma specimens were collected from patients with no family history of *** addition,normal tissues were also collected from patients as *** was extracted by polymerase chain reaction for single-strand conformation polymorphism,bisulfite DNA sequencing,and methylation-specific band ***:The positive rate for MSI and LOH in gastric carcinoma was 16%and 20%,*** to the tumor,node and metastasis staging system,the LOH frequency was higher in gastric carcinoma at stages Ⅲ and Ⅳ than in gastric carcinoma at stagesⅠ and Ⅱ(P=0.01),which was also significantly correlated with lymph node metastasis and clinicopathological characteristics of gastric *** of bone morphogenetic protein 3(BMP3)gene promoter was detected in 64.44% of gastric carcinoma tissue ***,no statistical significance was observed between promoter region methylation and carcinoma ***,the BMP3 gene methylation rate was 71.05% and 28.58%,respectively,in MSI positive and negative cases(P=0.031),suggesting that BMP3 genetic instability and promoter methylation are initiated during gastric *** was detected mostly in the late stages of gastric carcinoma,indicating that gastric carcinoma at late stages has a higher infiltration and a poorer ***:Promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people.

关键词： Bone morphogenetic protein 3 gene Gastric carcinoma Microsatellite instability Loss of heterozygocity Methylation

The expression of N-cadherin/catenins/actin complex in human lung normal and carcinoma cells

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Chinese Science Bulletin 1998年第9期43卷 774-779页

作者： Wenjun Zhang Zhongxiang Lin Zhiqian Zhang Ying Hu Beijing Inst Canc Res Dept Cell Biol Beijing 100034 Peoples R China Beijing med Univ Sch Oncol Beijing 100034 Peoples R China

The difference between human normal and carcinoma lung cells was studied with regard to the protein expression level and localization of the cadherin/catenin/actin complex. Results demonstrated that normal lung cell RF expressed high levels of N-cadherin, β-catenin, α-catenin. These 3 proteins were colocalized at AJs and their submembrane adhesion plaques where they link the Rho-phalloidin-positive actin stress fibers, indicating the existence of N-cadherin/catenin/actin complexes at the AJs. Aberrant expression of AJ proteins and the actin cytoskelecton in carcinoma PG cells was observed: (1) inhibition of N-cadherin and to a degree of inhibition of α-catenin protein expression; (2) varied protein modification of β-catenin in cytoplasm soluble fraction and altered distribution of immunofluorescence: majorly in the cytoplasm and minorly on the membrane; (3) disassembly of actin stress fibers and formation of actin bodies in the cytoplasm. The data suggest that inhibited expression of AJ proteins is correlated with the disruption of the AJ complexes and the actin cytoskeleton in carcinoma PG cells, and responsible for its metastasis behaviors.

关键词： N-cadherin/catenin/actin complex protein expression human lung normal and carcinoma cells.