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Stereotactic surgery for refractory epilepsy complicated by mental disorders A retrospective case analysis

Neural Regeneration Research 2008年第6期3卷 690-693页

作者： Yifang Wang Aigang Xu Qifu Tan Zhengwei Wang Dongsheng Jiao Hao Zhu KaidongLiu Department of neurosurgery the 454 Hospital of Chinese PLA Nanjing 210002 Jiangsu Province China departrnent of neurosurgery Nanjing General Hospital of Nanjing Military Area Command of Chinese PLA Nanjing 210002 Jiangsu Province China

BACKGROUND： Anti-epilepsy and anti-psychosis drugs have traditionally been used in the clinic to treat epilepsy complicated by mental disorders. However, there is still no effective therapy for refractory epilepsy patients suffering from persistent mental disorders. OBJECTIVE： To explore the therapeutic effects of stereotactic multi-element localization and multi-target radiofrequency ablation on patients with refractory primary epilepsy and mental disorders. DESIGN： A retrospective case analysis. SETTING： Department of neurosurgery, the 454 Hospital of Chinese PLA. PARTICIPANTS： Between June and November 2004, 13 patients with refractory primary epilepsy complicated by persistent mental disorders were admitted to the Department of neurosurgery, the 454 Hospital of Chinese PLA. The patient group consisted of nine males and four females, with an average age of 25 years （range 18-39 years）, and a course of disease ranging 3-11 years. Diagnosis of mental disorders was in accordance with Chinese Classification of Mental Disorders. Written informed consent was obtained from all patients and their families, and the treatment protocol was approved by the Ethics Committee of the Hospital. METHODS： Under venous inhalation anesthesia, the disease targets, including bilateral corpus callosum, bilateral amygdala, and bilateral medial septal area, as well as unilateral Forel-H area, were coagulated by RFG-3CF radiofrequency thermocoagnlation at 75-80 ℃ for 60-70 seconds. During thermocoagulation, the targets were identified using deep-brain microelectrodes and localized according to electrophysiology and electric resistance values. MAIN OUTCOME MEASURES： One year post-surgery, epileptic seizures were assessed on the basis of the Tan classification, and psychogenic （non-epileptic） seizures were evaluated using a 5-grade system. RESULTS： All enrolled 13 epileptic patients were included in the final analysis. The results of follow-up evaluations demonstrated that epilepsy was well-

关键词： epilepsy metal disorders retrospective studies

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Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes

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Chinese Journal of Cancer Research 2017年第6期29卷 587-588页

作者： Guiping Wang Shanshan Guo Huashi Xiao Liang Zong Tetsuya Asakawa Masanobu Abe Wenqing Hu Jiafu Ji Medical Research Center Clinical Medical College of Yangzhou University(Northern Jiangsu People's Hospital)Yangzhou 225001China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China departrnent of Gastrointestinal Surgery Clinical Medical College of Yangzhou University(Northern Jiangsu People's Hospital)Yangzhou 225001China Department of neurosurgery Hamamatsu University School of MedicineHandayamaHamamatsu-cityShiznoka 431-3192Japan Division for Health Service Promotion University of Tokyo HospitalTokyo 113-003Japan Division for Health Service Promotion Heji Hospital of Changzhi Medical CollegeChangzhi 046011China

Sekeres et al. （1） conducted a multicenter randomized, controlled trial to compare whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates to azacitidine in the treatment of myelodysplastic syndromes （MDS）. In that trial, 224 patients with higher-risk MDS and 53 with chronic myelomonocytic leukemia （CMML） were enrolled and randomly assigned to the ＂azacitidine＂ group, ＂azacitidine plus lenalidomide＂ group or ＂azacitidine plus vorinostat＂ group. The researchers found that patients with MDS treated with azacitidine-based combinations had similar response rate to azacitidine monotherapy. Using genomic mutation analysis, they found that the overall response rate to azacitidine-based treatment was higher for patients with mutations in DNMT3A and lower for those with mutations in SRSF2. Whereas in another study, Welch et al. enrolled 26 patients with MDS and 90 with acute myeloid leukemia （AML） who were treated with decitabine, and they found that patients with TP53 mutations had a higher response rate, but not those with DNMT3A mutations （2）. We propose that this big discrepancy in the conclusions between the two studies might have been caused by the presence of many co-interacting factors, e.g. study aims, DNA demethylating agents, treatment protocols, and patient sources.

关键词： MDS DNA Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes

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