检索结果-南通市图书馆

Stochastic Systems Arising from Markov Modulated Empirical Measures

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2017年第5期30卷 999-1011页

作者： YIN Gang BUI Trang Department of Mathematics Wayne State UniversityDetroitMI 48202USA

This work is devoted to stochastic systems arising from empirical measures of random sequences(termed primary sequences) that are modulated by another Markov chain. The Markov chain is used to model random discrete events that are not represented in the primary sequences. One novel feature is that in lieu of the usual scaling in empirical measure sequences, the authors consider scaling in both space and time, which leads to new limit results. Under broad conditions, it is shown that a scaled sequence of the empirical measure converges weakly to a number of Brownian bridges modulated by a continuous-time Markov chain. Ramifications and special cases are also considered.

关键词： Brownian bridge limit empirical measure multi-scale modeling regime-switching model,weak convergence

INVARIANT DENSITY, LYAPUNOV EXPONENT, AND ALMOST SURE STABILITY OF MARKOVIAN-REGIME-SWITCHING LINEAR SYSTEMS

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2011年第1期24卷 79-92页

作者： Qi HE Gang George YIN Department of Mathematics Wayne State University Detroit MI 48202 USA

This paper is concerned with stability of a class of randomly switched systems of ordinary differential equations. The system under consideration can be viewed as a two-component process （X（t）, α（t））, where the system is linear in X（t） and α（t） is a continuous-time Markov chain with a finite state space. Conditions for almost surely exponential stability and instability are obtained. The conditions are based on the Lyapunov exponent, which in turn, depends on the associate invaxiant density. Concentrating on the case that the continuous component is two dimensional, using transformation techniques, differential equations satisfied by the invariant density associated with the Lyapunov exponent are derived. Conditions for existence and uniqueness of solutions are derived. Then numerical solutions are developed to solve the associated differential equations.

关键词： Invariant density Lyapunov exponent randomly switching ordinary differential equation.

Remodeling dendritic spines for treatment of traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第9期14卷 1477-1480页

作者： Ye Xiong Asim Mahmood michael Chopp Department of Neurosurgery Henry Ford HospitalDetroitMIUSA Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA

Traumatic brain injury is an important global public health *** brain injury not only causes neural cell death,but also induces dendritic spine *** neurons from cell death in the injured brain may exhibit dendrite damage,dendritic spine degeneration,mature spine loss,synapse loss,and impairment of *** degeneration and synapse loss may significantly contribute to functional impairments and neurological disorders following traumatic brain *** function of the nervous system depends on maintenance of the functionally intact synaptic connections between the presynaptic and postsynaptic spines from neurons and their target *** synaptic plasticity,the numbers and shapes of dendritic spines undergo dynamic *** of spine heads and the formation and stabilization of new spines are associated with long-term potentiation,while spine shrinkage and retraction are associated with long-term *** of memory is associated with remodeling and growth of preexisting synapses and the formation of new *** date,there is no effective treatment to prevent dendritic degeneration and synapse *** review outlines the current data related to treatments targeting dendritic spines that propose to enhance spine remodeling and improve functional recovery after traumatic brain *** mechanisms underlying proposed beneficial effects of therapy targeting dendritic spines remain elusive,possibly including blocking activation of Cofilin induced by beta amyloid,Ras activation,and inhibition of GSK-3 signaling *** understanding of the molecular and cellular mechanisms underlying synaptic degeneration/loss following traumatic brain injury will advance the understanding of the pathophysiology induced by traumatic brain injury and may lead to the development of novel treatments for traumatic brain injury.

关键词： traumatic brain injury dendritic spines synaptic plasticity spinogenic agents treatment spine remodeling memory functional recovery

Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft:A Feasible Option for Maxillary Bone Reconstruction

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta Ana Paula Ramos Soares Juliana Campos Hasse Fernandes Gustavo Vicentis Oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

Emerging potential of exosomes for treatment of traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第1期12卷 19-22页

Traumatic brain injury（TBI） is one of the major causes of death and disability *** effective treatment has been identified from clinical *** evidence exists that treatment with mesenchymal stem cells（MSCs） exerts a substantial therapeutic effect after experimental brain *** addition to their soluble factors,therapeutic effects of MSCs may be attributed to their generation and release of *** are endosomal origin small-membrane nano-sized vesicles generated by almost all cell *** play a pivotal role in intercellular *** delivery of MSC-derived exosomes improves functional recovery and promotes neuroplasticity in rats after *** effects of exosomes derive from the exosome content,especially micro RNAs（mi RNAs）.mi RNAs are small non-coding regulatory RNAs and play an important role in posttranscriptional regulation of *** with their parent cells,exosomes are more stable and can cross the blood-brain *** have reduced the safety risks inherent in administering viable cells such as the risk of occlusion in microvasculature or unregulated growth of transplanted *** a cell-free exosome-based therapy may open up a novel approach to enhancing multifaceted aspects of neuroplasticity and to amplifying neurological recovery,potentially for a variety of neural injuries and neurodegenerative *** review discusses the most recent knowledge of exosome therapies for TBI,their associated challenges and opportunities.

关键词： traumatic brain injury exosomes microRNAs mesenchymal stem cells treatment neuroplasticity cell therapy

Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

Elevated liver enzymes portends a higher rate of complication and death in SARS-CoV-2

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2021年第9期13卷 1181-1189页

作者： Emily E Currier Mohamad Dabaja Syed-Mohammed Jafri School of Medicine Wayne State UniversityDetroitMI 48201United States Department of Gastroenterology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Severe acute respiratory syndrome coronavirus 2,or coronavirus disease-2019(COVID-19),has infected millions worldwide since its discovery in Wuhan,China in December 2019,but little is still known about the disease *** research in China notes liver function tests(LFTs)abnormalities are common in COVID-19 patients,suggesting decreased hepatic function,and that abnormalities in LFTs are related to complicated disease course and negative ***,there has been limited large-scale data assessing COVID-19’s association with liver dysfunction and negative *** To investigate how COVID-19 affects the liver function and disease course in patients infected with the virus treated at Henry Ford Hospital from March to September *** A total of 8028 patients infected with COVID-19 were identified and included in the study at a single academic *** from medical charts on laboratory testing including aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(AP),and bilirubin levels,past history of liver disease,and disease course indicators including hospital admission,intensive care unit(ICU)admission,intubation,and death were recorded and *** liver enzymes were defined as ALT/AST greater than 60,AP greater than 150,or bilirubin greater than 1.5,super-elevated liver enzymes were defined as ALT/AST greater than 120,AP greater than 300,or bilirubin greater than *** A total of 8028 COVID-19 patients were identified and included in the *** from medical charts on LFTs(namely,AST,ALT,AP,and bilirubin levels),past history of liver disease,and disease course indicators(hospital/ICU admission,intubation,death)were recorded and *** from 3937 patients were available for interpretation.45% were found to have elevated or super-elevated *** compared to COVID-19 patients without elevated LFTs,this cohort was found to have significantly higher odds of hospital admittance

关键词： COVID-19 Hepatology Liver damage Complications Elevated liver function test

Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin Erin D.Lewis David C.Crowley Colleen E.May Malkanthi Evans KGK Science Inc. LondonOntarioCanada Graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(pmical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,suggesting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage

Inflammation and retinal degenerative diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第3期18卷 513-518页

作者： Geetika Kaur Nikhlesh K.Singh Integrative Biosciences Center Wayne State UniversityDetroitMIUSA Department of Ophthalmology Visual and Anatomical SciencesWayne State University School of MedicineDetroitMIUSA

Vision is an ability that depends on the precise structure and functioning of the *** kind of stress or injury can disrupt the retinal architecture and leads to vision impairment,vision loss,and *** system and immune response function maintain homeostasis in the *** genetic,metabolic,and environmental factors may alter retinal homeostasis,and these events may initiate various inflammatory *** prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma,age-related macular degeneration,diabetic retinopathy,and retinitis pigmentosa,which pose a threat to *** the current review,we attempted to provide sufficient evidence on the role of inflammation in these retinal ***,this review paves the way to focus on therapeutic targets of the disease,which are found to be promising.

关键词： age-related macular degeneration diabetic retinopathy glaucoma retina retinal degeneration retinitis pigmentosa