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Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar Abbas Muhammed Mubarak Department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi Department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

Active versus passive reading:how to read scientific papers?

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National Science Review 2020年第9期7卷 1422-1427页

作者： Tung-Tien Sun departments of Cell Biology Dermatology & Urology New York University School of Medicine

‘Any man who reads too much and uses his own brain too little falls into lazy habits of thinking.’ Albert Einstein (1879–1955)‘Learning without thought is labor lost;thought without learning is perilous.’ Confucius (551–479 B.C.) The Confucian Analects,bk. 2:15 ‘To repeat what others have said, requires education; to challenge it, requires brains.’Mary Pettibone Poole, A Glass Eye at a Keyhole (1938)

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Randomized studies of PSA screening： an opinion

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Asian Journal of Andrology 2011年第3期13卷 364-365页

作者： Oliver Sartor departments of Medicine and urology Tulane MedicalSchool New Orleans LA USA

The issue of prostate cancer screening with prostate-specific antigen （PSA） has been contentious for nearly two decades due to lack of data from randomized trials, but that has now changed. A brief review of the available data is warranted as there is finally some clarity on this critically important topic. Knowing what to ignore, as well as what to focus on, is critical for understanding the current data.

关键词： Prostate Data

Potential synergistic implications for stromal-targeted radiopharmaceuticals in bone-metastatic prostate cancer

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Asian Journal of Andrology 2011年第3期13卷 366-368,510页

作者： Oliver Sartor departments of Medicine and urology Tulane Medical School New Orleans LA 70115 USA

Genetic heterogeneity and chemotherapy-resistant ＇stem cells＇ represent two of the most pressing issues in devising new strategies for the treatment of advanced prostate cancer. Though curative strategies have long been present for men with localized disease, metastatic prostate cancer is currently incurable. Though substantial improvements in outcomes are now possible through the utilization of newly approved therapies, novel combinations are clearly needed. Herein we describe potentially synergistic interactions between bone stromal-targeted radiopharmaceuticals and other therapies for treatment of bone-metastatic prostate cancer. Radiation has long been known to synergize with cytotoxic chemotherapies and recent data also suggest the possibility of synergy when combining radiation and immune-based strategies. Combination therapies will be required to substantially improve survival for men with castrate-resistant metastatic prostate cancer and we hypothesize that bone-targeted radiopharmaceuticals will play an important role in this Drocess.

关键词： bone immunotherapy metastasis prostate cancer radiopharmaceuticals radium samarium stroma strontium XL-184

Immunohistochemical measurement and expression of Mcl-1 in infertile testes

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Frontiers of Medicine 2015年第3期9卷 361-367页

作者： Raafat Hegazy Abdelmonem Hegazy Mustafa Ammar Emad Salem pathology Anatomy and Embryology urology of departments Faculty of Medicine Zagazig University Zagazig 44159 Egypt

The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 （Mcl-1） is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of McI-1 in testieular biopsies of subjects with azoospermia. Eighty-six cases with azoospermia were obtained from 509 infertile patients admitted to the Andrology Unit of the Zagazig University Hospitals from January 2010 to December 2011. Biopsies were diagnosed and classified using H＆E-stained slide sections. The specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopy. Forty-five cases of maturation arrest （25 at spermatids and 20 at the spermatocytes）, 31 cases of hypospermatogenesis （20 moderate and 11 severe）, 5 cases of Sertoli cell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular sclerosis were observed. Normal spermatogenesis was detected in 2 cases. A strong positive immunoreaction in Leydig cells was observed among all investigated specimens. A moderate reaction was detected in spermatocytes and spermatozoa in cases of normal spermatogenesis and hypospermatogenesis, but a negative reaction was detected in cases of maturation arrest and germ cell aplasia. Apoptosis was found to be associated with decreased rate of spermatogenesis. High apoptosis rates may result in azoospermia, which can occur despite normal spermatogenesis and absence of duct obstruction.

关键词： spermatogenesis testis Mcl-1 expression immunohistochemical study infertility

Denosumab in bone-metastatic prostate cancer： known effects on skeletal＇related events but unknown effects on quality of life

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Asian Journal of Andrology 2011年第4期13卷 612-613页

作者： Oliver Sartor departments of Medicine and urology Tulane University School of Medicine New Orleans LA USA

The purpose of new pharmaceuticals is to improve how patients feel, function or survive. Exceptions exist when surrogates are developed and we know that those surrogates correlate well with one of the above. Hypercholesterolemia is a well-accepted example. We know that high cholesterol is a reasonable indicator that results in increased risk of strokes and heart attacks. Thus, we treat hypercholesterolemia in hopes that our patients＇ health will improve.

关键词： new pharmaceuticals skeletal-related

The Institute of urology, Peking University prostatectomy score： a simple preoperative classification of prostate cancer for predicting surgical difficulty and risk

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Asian Journal of Andrology 2018年第6期20卷 581-586页

作者： Bing-Lei Ma Lin Yao Wei Yu Yu Wang Hai-Feng Song Zhe-Nan Zhang Si-Meng Lu Qian Zhang Zhi-Song He lie Jin Li-Qun Zhou Department of urology Peking University First Hospital and Institute of UrologyPeking UniversityBeijing 100034China.

Traditional laparoscopic radical prostatectomy is a treatment choice in many developing countries and regions for most patients with localized prostate cancer; however, no system for predicting surgical difficulty and risk has been established. This study aimed to propose a simple and standard preoperative classification system of prostate cancer using preoperative data to predict surgical difficulty and risk and to evaluate the relationship between the data and postoperative complications. We collected data from 236 patients and divided them into three groups to evaluate and validate the relationships among preoperative, operative, and postoperative data. This new scoring system is based on the body mass index, ultrasonic prostate volume, preoperative prostate-specific antigen level, middle lobe protrusion, and clinical stage. In the scoring group, we classified 89 patients into two groups： the low-risk group （score of 〈4） and high-risk group （score of ~4）, and then compared the postoperative data between the two groups. The positive surgical margin rate was higher in the high-risk group than low-risk group. The results in validation Groups A and B were similar to those in the scoring group. The focus of our scoring system is to allow for preliminary assessment of surgical difficulty by collecting the patients＇ basic information. Urologists can easily use the scoring system to evaluate the surgical difficulty and predict the risks of a positive surgical margin and urinary incontinence in patients undergoing laparoscopic radical prostatectomy.

关键词： laparoscopic radical prostatectomy prostate cancer scoring system surgical difficulty and risk

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang Bo Chen Hao Xu Deng Pan Yu-Yang Ma Kun Pang Department of urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Implications of the prostate intervention versus observation trial （PIVOT）

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Asian Journal of Andrology 2012年第6期14卷 803-804页

作者： Oliver Sartor departments of Medicine and urology Tulane University School of Medicine New Orleans LA 70112 USA

PSA screening improves early detection of prostate cancer but can lead to overtreatment if all of these cancers are treated. The first randomized treatment study for men with PSA detected cancers has now been reported.

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