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Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

World Journal of Gastrointestinal pharmacology and Therapeutics 2015年第4期6卷 156-171页

作者： Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander Department of Medicine Section of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular physiology Louisiana State University Health Sciences Center Digestive Health Center of Louisiana Department of General and Visceral Surgery

Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed.

关键词： Inflammatory bowel diseases Pregnancy Biologics Br

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TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用

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神经损伤与功能重建 2018年第6期13卷 325-325页

作者： Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 Department of Pharmaceutical Chemistry Drug Analysis and Drug Information Research group Experimental Pharmacology (EFAR) Center for Neurosciences (C4N) Vrije Universiteit Brussel Department of In Vitro Toxicology and Dermato-Cosmetology Vrije Universiteit Brussel Center for Interdisciplinary Research in Biology (CIRB) Collège de France physiology group Department of Basic Medical Sciences Ghent University

越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此... 详细信息

越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。

关键词： TAT-Gap19 星形胶质细胞星形细胞连接蛋白43半通道毛果芸香碱癫痫

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Scope of translational medicine in developing boroncontaining compounds for therapeutics

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World Journal of Translational Medicine 2017年第1期6卷 1-9页

作者： Ana Karen García-ávila Eunice Dalet Farfán-García Juan Alberto Guevara-Salazar José Guadalupe Trujillo-Ferrara Marvin Antonio Soriano-Ursúa Department of Biochemistry and Section of Post Graduate Studies and Research Escuela Superior de MedicinaInstituto Politécnico Nacional Department of physiology and Section of Post Graduate Studies and Research Escuela Superior de MedicinaInstituto Politécnico Nacional

The ubiquitousness of naturally occurring boron-containing compounds(BCCs) has led to their constant contact with ***,many synthetic BCCs have been elaborated for a broad spectrum of purposes,especially boric,boronic and borinic *** BCCs were once employed primarily as antiseptics and later as antibiotics,they have become an increasingly relevant therapeutic ***,this potential of BCCs has been drastically limited due to some unfortunate intra-hospital accidents in the 1940 s and 1950 *** increasing use of BCCs as insecticides,antimicrobials,and other agents is providing new insights into their role in the physiology of several living species and in the pathophysiology of *** is becoming clear that BCCs act through a wide range of mechanisms,as do their corresponding boron-free *** comparing BCCs and similar boron-free compounds,in many cases the former show advantages in the medical *** current minireview focuses on how BCCs have been developed by means of translational medicine,a process connecting biomedical research with clinical *** process of discovery is currently in an exponential stage.

关键词： Boron Boron-containing compounds Drug development Toxicity Medicinal chemistry pharmacology

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Application of network pharmacology in uncovering the biological basis of using the Banxia Baizhu Tianma decoction for hypertension treatment

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TMR pharmacology Research 2022年第4期2卷 31-39页

作者： Yong Yang Jia-Ru Wang Rui-Zhu Jiang Yang Zheng Tie-Jian Zhao Ying Zhang College of Nursing Guangxi University of Chinese MedicineNanning 530200China Faculty of Chinese Medicine Science Guangxi University of Chinese MedicineNanning 530222China Department of physiology College of Basic MedicineGuangxi University of Chinese MedicineNanning 530200China

Background:The Banxia Baizhu Tianma decoction(BBTD)is widely used in the clinical treatment of hypertension and has definite curative ***,its active ingredients and mechanism of action in hypertension treatment are still *** this study,network pharmacology was used to elucidate the potential antihypertensive mechanism of ***:The active ingredients and targets of BBTD were screened in the pharmacological database of the Chinese medicine *** targets that are related to hypertension were obtained from the Online Mendelian Inheritance in Man(OMIM),Drugbank,and Genecards *** String database was used to analyze the prevention and treatment of hypertension by *** interaction of important targets was assessed,and the related network data was visualized using the Cytoscape *** OmicShare platform was employed in conducting enrichment analyses of gene functions and pathways of important targets,in addition to evaluating the relationship between important targets and the phenotype of *** docking of the main active ingredients with important targets was also ***:In this study,194 main active ingredients and 616 targets of BBTD were screened,and 5,819 related targets that are closely related to hypertension were unearthed.A total of 445 BBTD key targets for the treatment of hypertension were obtained,along with 73 core targets from performed network topology and module analysis on the key *** enrichment analyses of GO and KEGG showed that oxidative stress,HIF-1 signal,IL-17 signal,and TNF signal play a vital role in *** docking studies have revealed that the main biologically active components can be combined with key targets quite ***:The potential mechanism of BBTD in treating hypertension involves many components,targets,and *** of the potential targets for the prevention and treatment of hypertension are ESR1,MAPK,TP53,TNF,and ***

关键词： Banxia Baizhu Tianma decoction hypertension network pharmacology oxidative stress

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多囊卵巢综合征无排卵的胰岛素信号和雄激素合成的新遗传风险和代谢特征

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Engineering 2023年第4期23卷 103-111,M0005,M0006页

作者：吴效科黄志超曹义娟李建李志强马红丽高敬书常惠张多加丛晶王宇吴奇 Xiaoxiao Han Pui Wah Jacqueline Chung Yiran Li Xu Zheng Lingxi Chen Lin Zeng Astrid Borchert Hartmut Kuhn Zi-Jiang Chen Ernest Hung Yu Ng Elisabet Stener-Victorin 张和平 Richard S.Legro Ben Willem J.Mol 师咏勇 The First Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150040China Department of Reproductive Medicine Heilongjiang Provincial HospitalHarbin Institute of TechnologyHarbin 150030China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong 999077China Reproduction and Development Laboratory Li Ka Shing Institute of Health Sciences&Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive MedicineThe Chinese University of Hong KongHong Kong 999077China Center for Reproductive Medicine Xuzhou Central HospitalXuzhou 221009China Department of Obstetrics and Gynecology The Affiliated Hospital of Gui Zhou Medical UniversityGuiyang 550004China Biomedical Sciences Institute The Affiliated Hospital of Qingdao UniversityQingdao 266000China Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio-X InstitutesMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Department of Obstetrics and Gynecology Obstetrics and Gynecology HospitalFudan UniversityShanghai 200001China Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital Shanghai 200001China Shanghai Key Laboratory of Signaling and Disease Research Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200001China Department of Computer Sciences City University of Hong KongHong Kong 999077China Shanghai NewCore Biotechnology Co. Ltd.Shanghai 200240China Institute of Biochemistry Charité—University Medicine BerlinBerlin 10117Germany Center for Reproductive Medicine Shandong UniversityJinan 250001China Department of Obstetrics and Gynaecology The University of Hong KongHong Kong 999077China Department of physiology and pharmacology Karolinska InstitutetStockholm 17177Sweden Department of Biostatistics Yale School of Public HealthNew HavenCT 06520USA Department of Obstetrics and Gynecology Pennsylvania State University

促排卵是多囊卵巢综合征(PCOS)不孕症的一线治疗方案。卵巢对促排卵治疗的排卵应答差被认为与胰岛素抵抗和高雄激素血症相关。在一个包含1000名PCOS不孕妇女(PCOSAct)的前瞻性队列中,我们开展了一项全外显子联合靶向单核苷酸多态性(SNP... 详细信息

促排卵是多囊卵巢综合征(PCOS)不孕症的一线治疗方案。卵巢对促排卵治疗的排卵应答差被认为与胰岛素抵抗和高雄激素血症相关。在一个包含1000名PCOS不孕妇女(PCOSAct)的前瞻性队列中,我们开展了一项全外显子联合靶向单核苷酸多态性(SNP)测序以及代谢组学研究。在全基因组水平找出与无排卵显著相关的常见变异和罕见突变,并通过机器学习算法构建排卵预测模型。研究发现,ZNF438基因中标记为rs2994652(p=2.47×10^(-8))的常见变异和REC114基因中的一个罕见功能突变(rs182542888,p=5.79×10^(-6))与促排卵治疗失败显著相关。携带rs2994652 A等位基因和REC114 ***101Leu(rs182542888)的PCOS不孕妇女进行促排卵治疗的总排卵率更低(分别为比值比(OR)=1.96,95%置信区间(CI)[1.55~2.49];OR=11.52,95%CI[3.08~43.05]),出现排卵的间隔时间更长(平均56.7天vs.49.0天,p<0.001;78.1天vs.68.6天,p=0.014)。对于rs2994652突变者,L-苯丙氨酸水平升高并与胰岛素抵抗稳态模型(HOMA-IR)指数(r=0.22,p=0.05)和空腹血糖(r=0.33,p=0.003)呈正相关;对于rs182542888突变者,花生四烯酸代谢产物水平下降并与升高的抗苗勒管激素(r=-0.51,p=0.01)和总睾酮(r=-0.71,p=0.02)呈负相关。整合基因变异位点、代谢产物及临床特征的联合预测模型可提高对排卵的预测能力[曲线下面积(AUC)=76.7%]。ZNF438基因的一个常见变异和REC114基因的一个罕见功能突变,以及与二者相关的苯丙氨酸和花生四烯酸代谢物改变,与PCOS女性不孕症的促排卵治疗失败相关。

关键词： Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing Deep machine learning

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Disrupted Ca^(2+) h homeostasis and immunodeficiency in patients with functional IP_(3) receptor subtype 3 defects

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Cellular & Molecular Immunology 2023年第1期20卷 11-25页

作者： Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.Barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts David IYule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston VIB Center for Brain and Disease Research LeuvenBelgium Department of Microbiology and Immunology KU LeuvenLeuvenBelgium UZ Leuven LeuvenBelgium Department of pharmacology and physiology University of RochesterRochesterNY14526USA Laboratory of Molecular and Cellular Signaling Department of Cellular and Molecular MedicineLeuven KankerinstituutKU LeuvenLeuvenBelgium Laboratory of Immunobiology Department Microbiology and ImmunologyRega InstituteKU LeuvenLeuvenBelgium Department of Biochemistry and Molecular Biology Structural Biology Imaging CenterMcGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX77030USA Pediatric Department Academic Children Hospital Queen FabiolaUniversitéLibre de BruxellesBrusselsBelgium Department of Pediatric Neurology University Hospitals LeuvenLeuvenBelgium Department of Pulmonology University Hospitals LeuvenLeuvenBelgium Laboratory for Inborn Errors of Immunity Department of Immunology and MicrobiologyKU LeuvenLeuvenBelgium Laboratory for Allergy and Clinical Immunology and Immunogenetics Research Group Department of MicrobiologyImmunology and TransplantationKU LeuvenLeuvenBelgium Immunology Programme The Babraham InstituteBabraham Research CampusCambridgeCB223ATUK

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca^(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP_(3)R), a homo- or heterotetramer of the IP_(3)R1-3 isoforms, amplifies lymphocyte signaling by releasing Ca^(2+) from endoplasmic reticulum stores following antigen stimulation. Although knockout of all IP_(3)R isoforms in mice causes immunodeficiency, the seeming redundancy of the isoforms is thought to explain the absence of variants in human immunodeficiency. In this study, we identified compound heterozygous variants of ITPR3 (a gene encoding IP_(3)R subtype 3) in two unrelated Caucasian patients presenting with immunodeficiency. To determine whether ITPR3 variants act in a nonredundant manner and disrupt human immune responses, we characterized the Ca^(2+) signaling capacity, the lymphocyte response, and the clinical phenotype of these patients. We observed disrupted Ca^(2+) signaling in patient-derived fibroblasts and immune cells, with abnormal proliferation and activation responses following T-cell receptor stimulation. Reconstitution of IP_(3)R3 in IP_(3)R knockout cell lines led to the identification of variants as functional hypomorphs that showed reduced ability to discriminate between homeostatic and induced states, validating a genotype–phenotype link. These results demonstrate a functional link between defective endoplasmic reticulum Ca^(2+) channels and immunodeficiency and identify IP_(3)Rs as diagnostic targets for patients with specific inborn errors of immunity. These results also extend the known cause of Ca^(2+)-associated immunodeficiency from store-operated entry to impaired Ca^(2+) mobilization from the endoplasmic reticulum, revealing a broad sensitivity of lymphocytes to genetic defects in Ca^(2+) signaling.

关键词： Primary immunodeficiency Calcium signalling Whole exome sequencing

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多囊卵巢综合征无排卵的胰岛素信号和雄激素合成的新遗传风险和代谢特征（英文）

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Engineering 2023年第4期 103-111页

作者：吴效科黄志超曹义娟李建李志强马红丽高敬书常惠张多加丛晶王宇吴奇 Xiaoxiao Han Pui Wah Jacqueline Chung Yiran Li Xu Zheng Lingxi Chen Lin Zeng Astrid Borchert Hartmut Kuhn Zi-Jiang Chen Ernest Hung Yu Ng Elisabet Stener-Victorin 张和平 Richard S.Legro Ben Willem J.Mol 师咏勇 The First Affiliated Hospital Heilongjiang University of Chinese Medicine Department of Reproductive Medicine Heilongjiang Provincial Hospital Harbin Institute of Technology Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Reproduction and Development Laboratory Li Ka Shing Institute of Health Sciences & Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong Kong Center for Reproductive Medicine Xuzhou Central Hospital Department of Obstetrics and Gynecology The Affiliated Hospital of Gui Zhou Medical University Biomedical Sciences Institute The Affiliated Hospital of Qingdao University Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio-X Institutes Ministry of Education Shanghai Jiao Tong University Department of Obstetrics and Gynecology Obstetrics and Gynecology Hospital Fudan University Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital Shanghai Key Laboratory of Signaling and Disease Research Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University Department of Computer Sciences City University of Hong Kong Shanghai New Core Biotechnology Co. Ltd. Institute of Biochemistry Charité—University Medicine Berlin Center for Reproductive Medicine Shandong University Department of Obstetrics and Gynaecology The University of Hong Kong Department of physiology and pharmacology Karolinska Institutet Department of Biostatistics Yale School of Public Health Department of Obstetrics and Gynecology Pennsylvania State University Department of Obstetrics and Gynaecology Monash University Monash Medical Centre Aberdeen Centre for Women’s Health Research School of Medicine Medical Sciences and Nutrition University of Aberdeen

促排卵是多囊卵巢综合征(PCOS)不孕症的一线治疗方案。卵巢对促排卵治疗的排卵应答差被认为与胰岛素抵抗和高雄激素血症相关。在一个包含1000名PCOS不孕妇女(PCOSAct)的前瞻性队列中，我们开展了一项全外显子联合靶向单核苷酸多态性(SNP...

促排卵是多囊卵巢综合征(PCOS)不孕症的一线治疗方案。卵巢对促排卵治疗的排卵应答差被认为与胰岛素抵抗和高雄激素血症相关。在一个包含1000名PCOS不孕妇女(PCOSAct)的前瞻性队列中，我们开展了一项全外显子联合靶向单核苷酸多态性(SNP)测序以及代谢组学研究。在全基因组水平找出与无排卵显著相关的常见变异和罕见突变，并通过机器学习算法构建排卵预测模型。研究发现，ZNF438基因中标记为rs2994652 (p=2.47×10–8)的常见变异和REC114基因中的一个罕见功能突变(rs182542888,p=5.79×10–6)与促排卵治疗失败显著相关。携带rs2994652 A等位基因和REC114 ***101Leu (rs182542888)的PCOS不孕妇女进行促排卵治疗的总排卵率更低(分别为比值比(OR)=1.96,95%置信区间(CI)[1.55～2.49];OR=11.52,95%CI [3.08～43.05])，出现排卵的间隔时间更长(平均56.7天vs.49.0天，p<0.001;78.1天vs.68.6天，p=0.014)。对于rs2994652突变者，L-苯丙氨酸水平升高并与胰岛素抵抗稳态模型(HOMA-IR)指数(r=0.22, p=0.05)和空腹血糖(r=0.33, p=0.003)呈正相关；对于rs182542888突变者，花生四烯酸代谢产物水平下降并与升高的抗苗勒管激素(r=-0.51, p=0.01)和总睾酮(r=-0.71, p=0.02)呈负相关。整合基因变异位点、代谢产物及临床特征的联合预测模型可提高对排卵的预测能力[曲线下面积(AUC)=76.7%]。ZNF438基因的一个常见变异和REC114基因的一个罕见功能突变，以及与二者相关的苯丙氨酸和花生四烯酸代谢物改变，与PCOS女性不孕症的促排卵治疗失败相关。

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Electroacupuncture Alleviates Anxiety-like Behavior in Pain Aversion Rats by Attenuating the Expression of Neuropeptide Y in Anterior Cingulate Cortex

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Clinical Complementary Medicine and pharmacology 2022年第2期2卷 10-18页

作者： Fangbing Shao Junying Du Sisi Wang Rok Cerne Junfan Fang Xiaomei Shao Xiaoming Jin Jianqiao Fang Department of Neurobiology and Acupuncture Research the Third School of Clinical MedicineZhejiang Chinese Medical University.Hangzhou 310053ZhejiangChina Indiana Spinal Cord and Brain Injury Research Group Stark Neuroscience Research Institute&Department of AnatomyCell Biology and PhysiologyIndiana University School of MedicineIndianapolis 46202IndianaUSA

Background:Pain is considered as a multidimensional conscious experience that includes a sensory component and a negative affective-motivational ***(EA)is widely used to treat pain and paininduced negative emotions,however,little is known about the mechanisms underlying the effect of ***:This study investigated the effect of EA on alleviating the anxiety-like behaviors in pain aversion rats and its anterior cingulate cortex(ACC)regulation ***:After a Freund’s complete adjuvant(CFA)-conditioned place aversion(C-CPA)model was established in rats,EA treatment(2/100 Hz,30 min,once/day,4 days totally)was applied at bilateral Zusanli(ST36)and Kunlun(BL60)*** Frey filaments were used to measure changes of pain withdrawal threshold(PWT)at indicated time *** zero maze(EZM)was used to investigate the changes of pain-related anxiety and CPA was used to investigate the changes of pain *** protein expression levels of GAD67,PV,and NPY in ACC were detected by Western ***:Compared with the control group,the staying time in the"CFA-paired compartment"was significantly reduced,and the PWT was decreased in model *** the EZM assessment,the distance and the time in open arm,as well as the number of open arm entries of model group were significantly lower than those in the control *** the CPA assessment,the time spent in the"CFA-paired compartment"was significantly decreased in model group compared with control group,and EA reversed the changes in pain sensation and in pain-related *** blotting showed that the NPY level,but not the levels of GAD67 and PV,was significantly increased in the ACC of the model group compared to that of the control *** increased expression of NPY in the ACC was significantly downregulated by EA,while sham EA produced no such ***:EA can effectively relieve the pain and pain-related emotions,and its mechanism may be achieved by

关键词： Electroacupuncture Chronic pain Anterior cingulate cortex Aversion Anxiety Neuropeptide Y

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血管性认知损害诊断的进一步规范化：血管性认知损害分类共识研究组指南

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国际脑血管病杂志 2018年第4期26卷 241-250页

作者： Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂徐俊 Translational Health Sciences University of Bristol Bristol UK Sunnybrook Research Institute University of Toronto Ontario Canada Department of pharmacology National University of Singapore Singapore Department of Neurology and Center for Neuroscience University of California at Davis Sacramento California USA Neurology University of Helsinki and Helsinki University Hospital Helsinki Finland Divison of Medical Sciences Oxford University Oxford UK Institute of Neuroscience Newcastle University Newcastle UK Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK NEUROFARBA Department University of FlorenceFlorence Italy Inserm U1171 University of Lille Lille France Methodist Neurological Institute Houston Texas USA Memory Clinic at Department of Neuropsychiatry Sahlgrenska University Hospital Molndal Sweden Institute of Neuroscience and physiology Sahlgrenska AcademyUniversity of Gothenburg Sweden School of Psychiatry University of New South WalesSydney Australia Neuropsychiatric Institute Prince of Wales Hospital Randwick New South WalesAustralia Population Health Sciences University of Bristol Bristol UK Institute of Institute of Clinical Sciences Block B Queens University Belfast Belfast UK 116044 大连医科大学 116044 苏北人民医院神经内科扬州225001 首都医科大学附属北京天坛医院神经内科北京100069

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impair... 详细信息

引言血管性认知损害（vascular cognitive impairment,VCI）诊断共识的缺乏（体现为多种不同评估方案的使用）,妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究（Vascular Impairment of Cognition Classification Consensus Study,VICCCS）,旨在就VCI的诊断原则（VICCCS-1）和诊断方案（VICCCS-2）达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲（Delphi）调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65～79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网（National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN）发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作.

关键词：血管性认知损害血管性痴呆指南标准共识德尔菲法

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小胶质细胞控制成年小鼠海马中的谷氨酸能突触

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神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano Maria T Golia Alfonso Grimaldi Maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini Maria C Marrone Maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo Marie-Kim St-Pierre Micael Carrier Massimiliano Renzi Francesca Pagani Brijesh Modi Marcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia Marinelli Marie-Ève Tremblay Daniele Caprioli Laura Maggi Cristina Limatola Silvia Di Angelantonio Davide Ragozzino Department of physiology and pharmacology Sapienza University of RomeRomeItaly. Neurophysiology and Neuropharmacology Inflammaging Unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. Center for Life Nano-and Neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartimento di Biologia e Biotecnologie“Charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(IRCCS Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-Montalcini’ RomeItaly. CrestOptics S.p.A RomeItaly. Centre de Recherche du CHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Département de Médecine Moléculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research Council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and Neurobiology Unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of Medical Sciences University of VictoriaVictoriaCanada.1 Department of physiology and pharmacology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触

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