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Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 426-440页

作者： SI Jianchao CHEN Xue QI Kerong LI Dongli LIU Bingbing ZHENG Yuying JI Ensheng YANG Shengchang Department of physiology Hebei University of Chinese MedicineShijiazhuang 050000China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050000China Department of geriatrics First People’s Hospital of XiaoganXiaogan 432000China

Chronic intermittent hypoxia(CIH),a principal pathophysiological aspect of obstructive sleep apnea(OSA),is associated with cognitive *** evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions(SMS-LD)can enhance cognitive function by nourishing yin and strengthening the *** study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by *** exposed C57BL/6N mice to CIH for five weeks(20%-5%O_(2),5 min/cycle,8 h/day)and administered SMS-LD intragastrically(15.0 or 30 g·kg^(-1)·day)30 min before each CIH ***,AG490,a JJanus kinase 2(JAK2)inhibitor,was administered via intracerebroventricular *** function was evaluated using the Morris water maze,while synaptic and mitochondrial structures were examined by transmission electron *** stress levels were determined using DHE staining,and the activation of the erythropoietin(ER)/ER receptor(EPOR)/JAK2 signaling pathway was analyzed through immunohistochemistry and Western *** further investigate molecular mechanisms,HT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIH for 48 *** results indicate that SMS-LD significantly mitigated CIH-induced cognitive impairments in ***,SMS-LD treatment enhanced dendritic spine density,ameliorated mitochondrial dysfunction,reduced oxidative stress,and activated the EPO/EPOR/JAK2 signaling ***,AG490 negated SMS-LD’s neuroprotective and cognitive improvement effects under CIH *** findings suggest that SMS-LD’s beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIH conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

关键词： Chronic intermittent hypoxia Cognitive impairment Shengmaisan Liuwei Dihuang Decoction Oxidative stress EPO/EPOR/JAK2 signaling pathway

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Overexpression of tonoplast Ca^(2+)-ATPase in guard cells synergistically enhances stomatal opening and drought tolerance

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Journal of Integrative Plant Biology 2024年第8期66卷 1587-1602页

作者： Jinghan Su Bingqing He Peiyuan Li Baiyang Yu Qiwen Cen Lingfeng Xia Yi Jing Feibo Wu Rucha Karnik Dawei Xue Michael R.Blatt Yizhou Wang Institute of Crop Science Zhejiang UniversityHangzhou 310058China Laboratory of Plant physiology and biophysics University of GlasgowGlasgow G128QQUK BGI Research Sanya 572025China College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 311121China Zhejiang Provincial Key Laboratory of Crop Germplasm Zhejiang UniversityHangzhou 310058China

Stomata play a crucial role in plants by controlling water status and responding to drought ***,simultaneously improving stomatal opening and drought tolerance has proven to be a significant *** address this issue,we employed the OnGuard quantitative model,which accurately represents the mechanics and coordination of ion transporters in guard *** the guidance of OnGuard,we successfully engineered plants that overexpressed the main tonoplast Ca^(2+)-ATPase gene,ACA11,which promotes stomatal opening and enhances plant ***,these transgenic plants also exhibited improved drought tolerance due to reduced water loss through their ***,OnGuard assisted us in understanding the mechanism behind the unexpected stomatal behaviors observed in the ACA11 overexpressing *** study revealed that the overexpression of ACA11 facilitated the accumulation of Ca^(2+)in the vacuole,thereby influencing Ca^(2+)storage and leading to an enhanced Ca^(2+)elevation in response to abscisic *** regulatory cascade finely tunes stomatal responses,ultimately leading to enhanced drought *** findings underscore the importance of tonoplast Ca^(2+)-ATPase in manipulating stomatal behavior and improving drought ***,these results highlight the diverse functions of tonoplast-localized ACA11 in response to different conditions,emphasizing its potential for future applications in plant enhancement.

关键词： ACA11 drought guard cells modeling stomata

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EventLFM:event camera integrated Fourier light field microscopy for ultrafast 3D imaging

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Light(Science & Applications) 2024年第7期13卷 1401-1415页

作者： Ruipeng Guo Qianwan Yang Andrew S.Chang Guorong Hu Joseph Greene Christopher V.Gabel Sixian You Lei Tian Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of physiology and biophysics Boston UniversityBostonMA 02215USA. Neurophotonics Center Boston UniversityBostonMA 02215USA. Research Laboratory of Electronics(RLE)in the Department of Electrical Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA. Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

Ultrafast 3D imaging is indispensable for visualizing complex and dynamic biological *** scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product(SBP).Emerging single-shot 3D wide-field techniques offer a promising alternative but are bottlenecked by the synchronous readout constraints of conventional CMOS systems,thus restricting data throughput to maintain high SBP at limited frame *** address this,we introduce EventLFM,a straightforward and cost-effective system that overcomes these challenges by integrating an event camera with Fourier light field microscopy(LFM),a state-of-theart single-shot 3D wide-field imaging *** event camera operates on a novel asynchronous readout architecture,thereby bypassing the frame rate limitations inherent to conventional CMOS *** further develop a simple and robust event-driven LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by *** results demonstrate that EventLFM can robustly reconstruct fast-moving and rapidly blinking 3D fluorescent samples at kHz frame ***,we highlight EventLFM’s capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely moving *** believe that the combined ultrafast speed and large 3D SBP offered by EventLFM may open up new possibilities across many biomedical applications.

关键词： field linking overcome

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Ryanodine receptors as pharmacological targets for heart disease

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Acta Pharmacologica Sinica 2007年第7期28卷 937-944页

作者： Marco SANTONASTAS Xander H T WEHRENS departments of Molecular physiology and biophysics departments of Molecular physiology and biophysics and Medieine(Cardiology) Baylor College of MedicineHoustonTexas 77030USA

Calcium release from intracellular stores plays an important role in the regulationof muscle contraction and electrical signals that determine the heart *** receptor （RyR） is the major calcium (Ca2+) release channel required forexcitation-contraction coupling in the *** studies have demonstratedthat RyR are macromolecular complexes comprising of 4 pore-forming channelsubunits,each of which is associated with regulatory *** andexperimental studies over the past 5 years have provided compelling evidencethat intracellular Ca2+release channels play a pivotal role in the development ofcardiac arrhythmias and heart *** in the channel regulation andsubunit composition are believed to cause diastolic calcium leakage from thesarcoplasmic reticulum,which could trigger arrhythmias and weaken ***,cardiac RyR have emerged as potential therapeutic tar-gets for the treatment of heart ***,there is a strong desire toidentify and/or develop novel pharmacological agents that may target these Ca2+signaling *** agents known to modulate RyR in the heart,and their potential application towards the treatment of heart disease are dis-cussed in this review.

关键词： arrhythmias calcium release channel heart failure pharmacology ryanodine receptor

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An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning

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National Science Review 2024年第5期11卷 186-201页

作者： Mingyue Lv Ruyi Cai Renzimo Zhang Xiju Xia Xuelin Li Yipan Wang Huan Wang Jianzhi Zeng Yifei Xue Lanqun Mao Yulong Li State Key Laboratory of Membrane Biology School of Life SciencesPeking University State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences PKU-IDG/Mc Govern Institute for Brain Research Yuanpei College Peking University Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies Peking University Peking University–Tsinghua University–National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary Studies Peking University Institute of Molecular physiology Shenzhen Bay Laboratory College of Chemistry Beijing Normal University Chinese Institute for Brain Research

Octopamine（OA）,analogous to norepinephrine in vertebrates,is an essential monoamine neurotransmitter in invertebrates that plays a significant role in various biological functions,including olfactory associative ***,the spatial and temporal dynamics of OA in vivo remain poorly understood due to limitations associated with the currently available methods used to detect *** overcome these limitations,we developed a genetically encoded GPCR activation-based（GRAB） OA sensor called *** sensor is highly selective for OA and exhibits a robust and rapid increase in fluorescence in response to extracellular *** GRABOA1.0,we monitored OA release in the Drosophila mushroom body（MB）,the fly's learning center,and found that OA is released in response to both odor and shock stimuli in an aversive learning *** OA release requires acetylcholine（ACh） released from Kenyon cells,signaling via nicotinic ACh ***,we discovered that OA amplifies aversive learning behavior by augmenting dopamine-mediated punishment signals via Octβ1R in dopaminergic neurons,leading to alterations in synaptic plasticity within the ***,our new GRABOA1.0sensor can be used to monitor OA release in real time under physiological conditions,providing valuable insights into the cellular and circuit mechanisms that underlie OA signaling.

关键词： octopamine dopamine GRAB sensor learning and memory

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Nicotine as a mitogenic stimulus for pancreatic acinar cell proliferation

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World Journal of Gastroenterology 2006年第46期12卷 7428-7432页

作者： Parimal Chowdhury Kodetthoor B Udupa departments of physiology and biophysics University of Arkansas for Medical Sciences 4301 W Markham Street Little Rock Arkansas 72205 United States departments of physiology and biophysics and geriatrics University of Arkansas for Medical Sciences 4301 W Markham Street Little Rock Arkansas 72205 United StatesMedical Service Central Arkansas Veterans Healthcare System Little Rick Arkansas 72205 United States

Cell proliferation is an important process in life for growth of normal and cancer cells. The signal transduction pathways activated during this process are strictly regulated. This editorial focuses on the role of nicotine, a mitogen, in the induction of signaling pathways resulting in proliferation of pancreatic tumor cells and compares these events with those in normal acinar cells isolated from the rat pancreas. The data shows striking similarities between these two cellular systems. In addition, the editorial reviews very recent literature of the contribution of MAPK signaling in cell lines associated with human diseases. A prospective cellular model of nicotine induced activation of MAPK cascade is presented.

关键词： Cell Proliferation Nicotine AR42J cells Pancreatic acinar cells ERK activation

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Apoptosis in skeletal muscle and its relevance to atrophy

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World Journal of Gastroenterology 2006年第46期12卷 7463-7466页

作者： Esther E Dupont-Versteegden University of Arkansas for Medical Sciences Departments of Geriatrics and Physiology and Biophysics 4301 West Markham #807 Little Rock AR 72205 and University of Kentucky Department of Rehabilitation Sciences Division of Physical Therapy 900 S Limestone Lexington KY 40536-0200 United States

Apoptosis is necessary for maintaining the integrity of proliferative tissues, such as epithelial cells of the gastrointestinal system. The role of apoptosis in post mitotic tissues, such as skeletal muscle, is less well defined. Apoptosis during muscle atrophy occurs in both myonuclei and other muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely unknown. Caspase-dependent as well as -independent pathways have been implicated and the mode by which atrophy is induced likely determines the apoptotic mechanisms that are utilized. It remains to be determined whether a decrease in apoptosis will alleviate atrophy and distinct research strategies may be required for different causes of skeletal muscle loss.

关键词： Skeletal muscle Apoptosis Disuse atrophy Aging

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Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

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Neural Regeneration Research 2015年第10期10卷 1565-1567页

作者： Anuradha Kalani Neetu Tyagi Department of physiology and biophysics School of Medicine University of Louisville

Exosomes：Exosomes are a sub-population of micro-vesicles ranging from 40–100 nm that were earlier thought as artefacts under electron *** recently came into attention for their storage of biological information,cell-to-cell communication,serving as biomarkers and potential use in neural protection and regeneration （Kalani et al., 2013, 2014a）.

关键词： Exosomes in neurological disease neuroprotection problems and perspectives repair and therapeutics

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Functional significance of erythropoietin receptor on tumor cells

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World Journal of Gastroenterology 2006年第46期12卷 7460-7462页

作者： Kodetthoor B Udupa Reynolds Institute on Aging Department of Geriatrics Physiology and Biophysics University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System 4300 West Seventh Street Little Rock AR United States

Erythropoietin (Epo) is the regulator of red blood cell formation. Its receptor (EpoR) is now found in many cells and tissues of the body. EpoR is also shown to occur in tumor cells and Epo enhances the proliferation of these cells through cell signaling. EpoR antagonist can reduce the growth of the tumor in vivo. In view of our current knowledge of Epo, its recombinant forms and receptor, use of Epo in cancer patients to enhance the recovery of hematocrit after chemotherapy treatment has to be carefully evaluated.

关键词： Erythropoietin Tumor cell Receptor Cell signaling Proliferation Erythroid cell

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