检索结果-南通市图书馆

Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi Ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： Hirohito Mori Hideki Kobara Noriko Nishiyama Tsutomu Masaki departments of Gastroenterology and neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

Management of a large mucosal defect after duodenal endoscopic resection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第29期22卷 6595-6609页

作者： Shintaro Fujihara Hirohito Mori Hideki Kobara Noriko Nishiyama Tae Matsunaga Maki Ayaki Tatsuo Yachida Tsutomu Masaki departments of Gastroenterology and neurology Kagawa University Faculty of Medicine

Duodenal endoscopic resection is the most difficult type of endoscopic treatment in the gastrointestinal tract(GI) and is technically challenging because of anatomical specificities. In addition to these technical difficulties, this procedure is associated with a significantly higher rate of complication than endoscopic treatment in other parts of the GI tract. Postoperative delayed perforation and bleeding are hazardous complications, and emergency surgical intervention is sometimes required. Therefore, it is urgently necessary to establish a management protocol for preventing serious complications. For instance, the prophylactic closure of large mucosal defects after endoscopic resection may reduce the risk of hazardous complications. However, the size of mucosal defects after endoscopic submucosal dissection(ESD) is relatively large compared with the size after endoscopic mucosal resection, making it impossible to achieve complete closure using only conventional clips. The over-the-scope clip and polyglycolic acid sheets with fibrin gel make it possible to close large mucosal defects after duodenal ESD. In addition to the combination of laparoscopic surgery and endoscopic resection, endoscopic full-thickness resection holds therapeutic potential for difficult duodenal lesions and may overcome the disadvantages of endoscopic resection in the near future. This review aims to summarize the complications and closure techniques of large mucosal defects and to highlight some directions for management after duodenal endoscopic treatment.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Duodenum Complication Bleeding Perforation Over-the-scope clip Clip Closure Endoscopic full-thickness resection

Oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第39期23卷 7185-7190页

作者： Hirohito Mori Hideki Kobara Yu Guan Yasuhiro Goda Nobuya Kobayashi Noriko Nishiyama Tsutomu Masaki Department of Gastroenterology and neurology Kagawa University departments of Pharmacology Kagawa University

Gastric submucosal tumors(SMTs) less than 2 cm are generally considered benign neoplasms, and endoscopic observation is recommended, but SMTs over 2 cm, 40% of which are gastrointestinal stromal tumors(GISTs), have malignant potential. Although the Japanese Guidelines for GIST recommend partial surgical resection for GIST over 2 cm with malignant potential as well as en bloc large tissue sample to obtain appropriate and large specimens of SMTs, several reports have been published on tissue sampling of SMTs, such as with endoscopic ultrasound sound fine needle aspiration, submucosal tunneling bloc biopsy, and the combination of bite biopsy and endoscopic mucosal resection. Because a simpler, more accurate method is needed for appropriate treatment, we developed oval mucosal opening bloc biopsy after incision and widening by ring thread traction for submucosal tumor(OMOB) approach. OMOB was simple and enabled us to obtain large samples under direct procedure view as well as allowed us to restore to original mucosa.

关键词： Gastric submucosal tumors Gastrointestinal stromal tumor Reversible opening biopsy Endoscopic ultrasonography Large sample

MRI and glymphatic system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular neurology 2019年第2期4卷 75-77页

作者： Quan Jiang departments of neurology Henry Ford HospitalDetroitMichiganUSA

Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information related to understand the glymphatic system dynamics, pathways, and provide quantitative maps for diagnosis, monitoring and prognosis of the disease. The non-invasive nature of MRI might more readily help with translation of glymphatic measurements from the laboratory to the clinic.

关键词： lymphatic diagnosis diseases

Bell's palsy at high altitude——an unsuspected finding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2016年第3期31卷 173-175页

作者： K.V.S.Hari Kumar K.P.Shijith F.M.H.Ahmad departments of Endocrinology Command Hospital departments of Radiology Command Hospital departments of neurology Command Hospital

Background:Bell's palsy is a common condition seen in clinical *** aetiology of this condition is not clearly defined and neuroimaging is essential to exclude intracranial causes of infra-nuclear facial *** presentation:We report a young soldier,who presented with Bell's palsy and neuroimaging revealed an unsuspected finding of multiple intracranial *** evaluation revealed the additional diagnosis of vitamin D deficiency and secondary hyperparathyroidism due to lack of sun exposure at high altitude ***:The health care practitioners,looking after the soldiers at high altitude areas should be aware of the measures to prevent vitamin D *** calcifications are uncommon in hyperparathyroidism and Bell's palsy.

关键词： Bell’s palsy Hyperparathyroidism Vitamin D deficiency Intracranial calcification

Advances in mechanical thrombectomy for acute ischaemic stroke from large vessel occlusions

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular neurology 2021年第4期6卷 649-657页

作者： Xu Guo Zhongrong Miao Intervetional neurology Capital Medical University Affiliated Anzhen HospitalChaoyang-quChina Interventinal neuroradiology Beijing Tiantan HospitalBeijingChina

Advances in endovascular treatment of acute ischaemic stroke from intracranial large vessel occlusions have continued in the past ***,we performed a detailed review of all the new trials and studies that had the highest evidence,the guidelines for mechanical thrombectomy,the selection of the particular population outside the guidelines and endovascular therapeutic strategies for acute ischemic stroke from occluded intracranial arteries.

关键词： acute throm occlusion

Accurate hemostasis with a new endoscopic overtube for emergency endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第17期19卷 2723-2726页

作者： Hirohito Mori Hideki Kobara Shintaro Fujihara Noriko Nishiyama Makoto Oryu Kazi Rafiq Tsutomu Masaki departments of Gastroenterology and neurology Kagawa Medical University School of Medicine departments of Pharmacology Kagawa Medical University School of Medicine

Endoscopic hemostasis performed in the emergency room is difficult due to the presence of blood clots and food residue that makes obtaining a clear view of the bleeding vessel difficult. We experienced the efficacy of a newly developed inverted overtube to shorten the hemostatic time and obtain a clear endoscopic view with upper gastrointestinal bleeding patient who were transferred by ambulance car and required emergency endoscopy. The technique improved the endoscopic views and enabled us to perform the hemostatic procedures from the conventional standing position while freely and easily changing the patient's position. The presence of blood clots and food residue in the gastric fornix or upper gastric body makes identifying a bleeding exposed vessel impossible. This set-up significantly shortened the procedure time. The inverted overtube helped us obtain a clear view in patients who were laid in the right lateral position. Rapid identification of ex-posed vessels resulted in success of hemostasis.

关键词： Emergency endoscopic hemostasis Right lateral decubitus position Identification of exposed vessel Newly developed inverted overtube Clear endoscopic view

The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第6期12卷 912-913页

作者： Eleanor Drummond Thomas Wisniewski Center for Cognitive neurology Department of Neurology New York University School of Medicine departments of neurology Pathology and Psychiatry New York University School of Medicine

Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD（Murray et al.,2011）.

关键词： amyloid pathogenesis proteomics localized impairment plaques Murray targeted progression brains