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Bell's palsy at high altitude——an unsuspected finding

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Journal of Medical Colleges of PLA(China) 2016年第3期31卷 173-175页

作者： K.V.S.Hari Kumar K.P.Shijith F.M.H.Ahmad departments of Endocrinology Command Hospital departments of Radiology Command Hospital departments of neurology Command Hospital

Background:Bell's palsy is a common condition seen in clinical *** aetiology of this condition is not clearly defined and neuroimaging is essential to exclude intracranial causes of infra-nuclear facial *** presentation:We report a young soldier,who presented with Bell's palsy and neuroimaging revealed an unsuspected finding of multiple intracranial *** evaluation revealed the additional diagnosis of vitamin D deficiency and secondary hyperparathyroidism due to lack of sun exposure at high altitude ***:The health care practitioners,looking after the soldiers at high altitude areas should be aware of the measures to prevent vitamin D *** calcifications are uncommon in hyperparathyroidism and Bell's palsy.

关键词： Bell’s palsy Hyperparathyroidism Vitamin D deficiency Intracranial calcification

Accurate hemostasis with a new endoscopic overtube for emergency endoscopy

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World Journal of Gastroenterology 2013年第17期19卷 2723-2726页

作者： Hirohito Mori Hideki Kobara Shintaro Fujihara Noriko Nishiyama Makoto Oryu Kazi Rafiq Tsutomu Masaki departments of Gastroenterology and neurology Kagawa Medical University School of Medicine departments of Pharmacology Kagawa Medical University School of Medicine

Endoscopic hemostasis performed in the emergency room is difficult due to the presence of blood clots and food residue that makes obtaining a clear view of the bleeding vessel difficult. We experienced the efficacy of a newly developed inverted overtube to shorten the hemostatic time and obtain a clear endoscopic view with upper gastrointestinal bleeding patient who were transferred by ambulance car and required emergency endoscopy. The technique improved the endoscopic views and enabled us to perform the hemostatic procedures from the conventional standing position while freely and easily changing the patient's position. The presence of blood clots and food residue in the gastric fornix or upper gastric body makes identifying a bleeding exposed vessel impossible. This set-up significantly shortened the procedure time. The inverted overtube helped us obtain a clear view in patients who were laid in the right lateral position. Rapid identification of ex-posed vessels resulted in success of hemostasis.

关键词： Emergency endoscopic hemostasis Right lateral decubitus position Identification of exposed vessel Newly developed inverted overtube Clear endoscopic view

The use of localized proteomics to identify the drivers of Alzheimer's disease pathogenesis

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Neural Regeneration Research 2017年第6期12卷 912-913页

作者： Eleanor Drummond Thomas Wisniewski Center for Cognitive neurology Department of Neurology New York University School of Medicine departments of neurology Pathology and Psychiatry New York University School of Medicine

Alzheimer’s disease（AD）is broadly defined by dementia and the presence of specific neuropathological features in the brain（amyloid plaques,neurofibrillary tangles（NFTs）and congophilic amyloid angiopathy）.However,the rate of disease progression,type of cognitive impairment,and extent of neuropathology vary widely in patients with AD（Murray et al.,2011）.

关键词： amyloid pathogenesis proteomics localized impairment plaques Murray targeted progression brains

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Nitric oxide:a newly discovered function on wound healing

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Acta Pharmacologica Sinica 2005年第3期26卷 259-264页

作者： Alex F CHEN departments of Pharmacology and neurology and the Neuroscience Program Michigan State University East Lansing MI 48824-1317 USA

Wound healing impairment represents a particularly challenging clinical problemto which no efficacious treatment regimens currently *** factors ensuringappropriate intercellular communication during wound repair are not *** protein-type mediators are well-established players in thisprocess,emerging evidence from both animal and human studies indicates thatnitric oxide (NO) plays a key role in wound *** beneficial effects of NO onwound repair may be attributed to its functional influences on angiogenesis,inflammation,cell proliferation,matrix deposition,and *** find-ings from in vitro and in vivo studies of NO on wound repair are summarized inthis *** unveiled novel mechanisms support the use of NO-containingagents and/or NO synthase gene therapy as new therapeutic regimens for im-paired wound healing.

关键词： angiogenesis inflammation nitric oxide proliferation wound healing

Stroke-induced immunosuppression and poststroke infection

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Stroke & Vascular neurology 2018年第1期3卷 34-41页

作者： Kaibin Shi Kristofer Wood Fu-Dong Shi Xiaoying Wang Qiang Liu departments of neurology Tianjin Neurological InstituteTianjin Medical University General HospitalTianjinChina departments of neurology Barrow Neurological InstituteSt.Joseph’s Hospital and Medical CenterPhoenixArizonaUSA departments of neurology and Radiology Neuroprotection Research LaboratoryMassachusetts General HospitalNeuroscience ProgramHarvard Medical SchoolBostonMassachusettsUSA

Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these *** for effective management of poststroke infection remain scarce,presenting an urgent need for preventive anti-infection strategies for patients who have suffered a *** evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections,suggesting that the modification of impaired immune defence could be *** this review,we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced *** elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system.

关键词： infection impaired stroke

Reprogram to pluripotency: a new logic and a chemical cocktail

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National Science Review 2014年第1期1卷 6-7页

作者： Hongjun Song Guo-li Ming Institute for Cell Engineering Departments of Neurology and Neuroscience Johns Hopkins University School of Medicine

Somatic cells rom animals and humans can be reprogrammed into pluripotent stem cells by pluripotency *** Deng and colleagues discovered that pluripotency can also be induced with exogenous lineage speciiers via balancing competing diferentiation *** a related study they achieved,for the irst time,restoration of pluripotency in adult somatic cells using a chemical cocktail alone.

关键词： GATA Reprogram to pluripotency a new logic and a chemical cocktail PSCs SOX

Neurofibromatosis:The role of guanosine triphosphatase activating proteins in sensory neuron function

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生理学报 2008年第5期60卷 581-583页

作者： Cynthia M.Hingtgen departments of neurology and Pharmacology and Toxicology Indiana University School of MedicineIndianapolisIndianaUSA

Neurofibromatosis type 1(NF1) is a common autosomal dominant disease characterized by formation of multiple benign and malignant *** with this disorder also experience chronic pain,which can be ***,the protein product of the Nf1 gene,is a guanosine triphosphatase activating protein(GAP) for p21Ras(Ras).Loss of Nf1 results in an increase in activity of the Ras transduction *** of the growing evidence suggesting involvement of downstream components of the Ras transduction cascade in the sensitization of nociceptive sensory neurons,we examined the stimulus-evoked release of the neuropeptides,substance P(SP) and calcitonin gene-related peptide(CGRP),from primary sensory neurons of mice with a mutation of the Nf1 gene(Nf1+/-).Measuring the levels of SP and CGRP by radioimmunoassay,we demonstrated that capsaicinstimulated release of neuropeptides is 3-5 folds higher in spinal cord slices from Nf1+/-mice than that from wildtype mouse *** addition,the potassium-and capsaicin-stimulated release of CGRP from the culture of sensory neurons isolated from Nf1+/-mice was more than double that from the culture of wildtype *** patch-clamp electrophysiological techniques,we also examined the excitability of capsaicin-sensitive sensory *** was found that the number of action potentials generated by the neurons from Nf1+/-mice,responsing to a ramp of depolarizing current,was more than three times of that generated by wildtype *** with that observation,neurons from Nf1+/-mice had lower firing thresholds,lower rheobase currents and shorter firing latencies compared with wildtype *** data clearly demonstrate that GAPs,such as neurofibromin,can alter the excitability of nociceptive sensory *** augmented response of sensory neurons with altered Ras signaling may explain the abnormal pain sensations experienced by people with NF1 and suggests an important role of GAPs in the mechanism of sensor

关键词：感觉神经元神经系统蛋白质多发性神经纤维瘤临床分析

Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

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Eye and Vision 2018年第1期5卷 260-268页

作者： Liang Wang Ohemaa Kwakyi James Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha Department of neurology Johns Hopkins University School of MedicineBaltimoreMDUSA departments of neurology Population Health and OphthalmologyNew York University School of MedicineNew YorkNYUSA departments of neurology and Ophthalmology University of Texas Austin Dell Medical SchoolAustinTXUSA

Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal *** primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC ***:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 *** eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with ***:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in *** strong inter-eye correlations were also found between arteriolar(r=0.84,P<0.001)and venular(r=0.87,P<0.001)BFVs in ***(3.48±0.88 mm/s)and venular(2.75±0.53 mm/s)BFVs in MSNON eyes were significantly lower than in HC eyes(P=0.009 and P=0.005,respectively).Similarly,arteriolar(3.59±0.69 mm/s)and venular(2.80±0.45 mm/s)BFVs in MSON eyes were also significantly lower than in HC eyes(P=0.046 and P=0.048,respectively).Arteriolar and venular BFVs in MSON and MSNON eyes did not differ from each other(P=0.42 and P=0.48,respectively).Conclusions:Inter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly *** findings support prior observations that arteriolar and venular BFVs may be reduced in MS ***,this seems to be the case in both MS eyes with and without a history of ON,raising the possibility of global blood flow alterations in ***

关键词： Inter-eye correlation Blood flow velocity Retinal function imager neurology Multiple sclerosis Optic neuropathy