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Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen School of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China departments of diagnostic radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China School of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

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Cholecystitis-an uncommon complication following thoracic duct embolization for chylothorax: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8775-8781页

作者： Le Viet Dung Ma Mai Hien Thieu-Thi Tra My Doan Tien Luu Le Tuan Linh Nguyen Minh Duc diagnostic imaging and Interventional radiology Center Hanoi Medical University HospitalHanoi 100000Vietnam Department of radiology Hanoi Medical UniversityHanoi 100000Vietnam Department of radiology Pham Ngoc Thach University of MedicineHo Chi Minh 700000Vietnam

BACKGROUND Chylothorax is an uncommon condition in which chyle leaks into the pleural cavity,and biliary peritonitis is a rare complication of thoracic duct embolization in clinical *** SUMMARY We describe the case of a 50-year-old woman who presented with chylothorax and underwent thoracic duct embolization using a coil and a mixture of histoacryl glue and *** patient developed upper abdominal pain and fever after the *** was diagnosed with biliary peritonitis and treated with cholecystectomy at Hanoi Medical University *** Although thoracic duct embolization is considered a safe and minimally invasive procedure,it is not without *** thoracic duct embolization,severe or persistent abdominal pain should be explored utilizing imaging data and laboratory results to determine problems as soon as possible.

关键词： Lymphangiography Thoracic duct embolization Cholecystitis Chyle leakage Biliary peritonitis Case report

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Long TR three-dimensional inversion recovery sequence with real reconstruction(3D real IR)for quantifying inner ear endolymphatic hydrops

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中国医学影像技术 2024年第8期40卷 1174-1178页

作者： WU Di ZHAO Menglong ZENG Mengsu LIU Kai ZHANG Shujie SUN Wei Department of radiology Zhongshan Hospital of Fudan UniversityShanghai 200032China

Objective To observe the value of long TR three-dimensional inversion recovery sequence with real reconstruction(3D real IR)for quantifying inner ear endolymphatic hydrops(EH).Methods Totally 46 Ménière's disease(MD)patients and 21 healthy volunteers were prospectively *** scanning for inner ear based on 3D real IR and 3D fluid attenuated inversion recovery(3D FLAIR)sequence 4—6 h after administration of contrast agents were *** imaging qualities were scored and compared between *** endolymphatic space area and the membranous labyrinth area of cochlea and vestibule,as well as endolymph/membranous labyrinth area percentage were calculated,the present or not of EH and the grade of EH were *** inner ears of MD patients were enrolled in EH group,while inner ears of healthy volunteers were taken as controls(control group).The endolymphatic space area,membranous labyrinth area and endolymph/membranous labyrinth area percentage of cochlea and vestibule were compared between *** receiver operating characteristic(ROC)curve was drawn to calculate the diagnostic efficacy of the above *** Cochlear and/or vestibular EH were detected in 56 ears,including cochlear EH in 52 ears and vestibular EH in 45 ears among 46 MD patients(EH group),but not in 42 ears in control *** subjective quality scores of 3D real IR images were higher than those of 3D-FLAIR(both P<0.05).Quantitative analysis based on 3D real IR images revealed that,compared with control group,significantly larger endolymph areas and endolymph/membranous labyrinth area percentages in both cochlea and vestibule were found in EH group(all P<0.001).The area under the curve(AUC)of cochlear or vestibular endolymph/membranous labyrinth area percentage for identifying inner ear EH was 0.999 and 0.985,*** 13.64%and 24.13%as the critical value of cochlear or vestibular endolymph,the specificity was 100%and 92.86%,respectively,and the sensitivity was 96.43%an

关键词： endolymphatic hydrops magnetic resonance imaging prospective studies

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Energy spectrum computed tomography multi-parameter imaging in preoperative assessment of vascular and neuroinvasive status in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2511-2520页

作者： Jing Wang Jian-Cheng Liang Fa-Te Lin Jun Ma Department of radiology Pingluo County People's HospitalShizuishan 753400Ningxia Hui Autonomous RegionChina Department of Gastrointestinal Surgery Jiangsu Provincial People's HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Vascular and nerve infiltration are important indicators for the progression and prognosis of gastric cancer(GC),but traditional imaging methods have some limitations in preoperative *** recent years,energy spectrum computed tomography(CT)multiparameter imaging technology has been gradually applied in clinical practice because of its advantages in tissue contrast and lesion detail *** To explore and analyze the value of multiparameter energy spectrum CT imaging in the preoperative assessment of vascular invasion(LVI)and nerve invasion(PNI)in GC *** Data from 62 patients with GC confirmed by pathology and accompanied by energy spectrum CT scanning at our hospital between September 2022 and September 2023,including 46 males and 16 females aged 36-71(57.5±9.1)years,were retrospectively *** patients were divided into a positive group(42 patients)and a negative group(20 patients)according to the presence of LVI/*** CT values(CT40 keV,CT70 keV),iodine concentration(IC),and normalized IC(NIC)of lesions in the upper energy spectrum CT images of the arterial phase,venous phase,and delayed phase 40 and 70 keV were measured,and the slopes of the energy spectrum curves[K(40-70)]from 40 to 70 keV were *** Core Tip:To investigate the application value of multiparameter energy spectrum computed tomography(CT)imaging in the preoperative assessment of vascular and nerve infiltration in patients with gastric cancer(GC).The imaging data of GC patients were retrospectively analyzed to evaluate the accuracy and sensitivity of CT for identifying and quantifying vascular and nerve infiltration and for comparison with postoperative pathological *** purpose of this study was to verify the clinical feasibility and potential advantages of multiparameter energy spectrum CT imaging in guiding preoperative diagnosis and treatment decision-making and to provide a new imaging basis for improving the diagnostic accuracy

关键词： Tomography X-ray computer Energy spectrum computed tomography Gastric cancer Vascular invasion Nerve invasion Cross-sectional study

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Comparison of whole body MRI and radioisotope bone scintigram for skeletal metastases detection

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Chinese Medical Journal 1997年第6期110卷 87-91页

作者： ChanYuleung ChanKamwing LamWaiman MetreweliConstantine Department of diagnostic radiology and organ imaging The Chinese University of Hong Kong Prince Wales Hospital Ngan Shing Street Shatin Hong Kong

ＣｏｍｐａｒｉｓｏｎｏｆｗｈｏｌｅｂｏｄｙＭＲＩａｎｄｒａｄｉｏｉｓｏｔｏｐｅｂｏｎｅｓｃｉｎｔｉｇｒａｍｆｏｒｓｋｅｌｅｔａｌｍｅｔａｓｔａｓｅｓｄｅｔｅｃｔｉｏｎＣｈａｎＹｕｌｅｕｎｇ，ＣｈａｎＫａｍｗｉｎｇ，Ｌ... 详细信息

ＣｏｍｐａｒｉｓｏｎｏｆｗｈｏｌｅｂｏｄｙＭＲＩａｎｄｒａｄｉｏｉｓｏｔｏｐｅｂｏｎｅｓｃｉｎｔｉｇｒａｍｆｏｒｓｋｅｌｅｔａｌｍｅｔａｓｔａｓｅｓｄｅｔｅｃｔｉｏｎＣｈａｎＹｕｌｅｕｎｇ，ＣｈａｎＫａｍｗｉｎｇ，ＬａｍＷａｉｍａｎａｎｄＭｅｔｒｅｗ...

关键词： metastases skeletal body

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Compromised blood flow in osteoporosis

Compromised blood flow in osteoporosis

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第七届国际骨质疏松研讨会暨第五届国际骨矿研究会议

作者： James F Griffith Department of diagnostic radiology and organ imaging Chinese University of Hong Kong

＜正＞Over the past five years,several studies have provided indirect evidence of a link between arterial disease and reduced bone *** example,osteoporosis is a good predictor of subsequent death from a cardiovascular or cerebrovascular event;is strongly associated with aortic calcification and also arterial intimal thickening.

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Evaluation of Medical Prescribers’ Theoretical Knowledge on Medical imaging in the Northern Region of Burkina Faso

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Open Journal of radiology 2024年第2期14卷 33-41页

作者： Some Milckisédek Judicaël Marouruana Ouedraogo Pakisba Ali Tankoano Aïda Ida Savadogo Habibou Kindo Bassirou Ouedraogo Nina-Astrid Bamouni Yomboé Abel Diallo Ousseini Department of Medical imaging Ouahigouya Regional University Hospital University of Ouahigouya Ouahigouya Burkina Faso Department of Medical imaging Souro Sanou University Hospital Nazi Boni University Bobo Dioulasso Burkina Faso Department of Medical imaging Bogodogo University Hospital Joseph Ki Zerbo University Ouagadougou Burkina Faso Workers Health Office Joseph Ki Zerbo University Ouagadougou Burkina Faso Department of Medical imaging Yalgado Oudraogo University Hospital Joseph Ki Zerbo University Ouagadougou Burkina Faso

Introduction: Medical imaging is a medical specialty that involves producing images of the human body and interpreting them for diagnostic, therapeutic purposes, and for monitoring the progress of pathologies. We aimed to assess the theoretical knowledge of doctors and interns in medical imaging in the northern region of Burkina Faso. Methodology: This was a descriptive cross-sectional survey based on a self-administered questionnaire. Prescribers knowledge was estimated based on scores derived from questionnaire responses. Results: We collected 106 questionnaires out of 163, i.e. a participation rate of 65.03%. The average knowledge score was 81.71% for the contribution of medical imaging to patient management. It was 60.02% for the indications/counter-indications of radiological examinations and 72.56% for the risks associated with exposure to radiation during these examinations. The score was 59.83% for the methods used to select the appropriate radiological examination. As regards the completeness of the clinical and biological information on the forms requesting imaging examinations, the score was 96.65%. Specialist doctors had the highest overall level of knowledge (74.68%). Conclusion: Improved technical facilities, good initial and in-service training, and interdisciplinary collaboration will help to ensure that imaging tests are properly prescribed, leading to better patient care.

关键词： Theoretical Knowledge Medical imaging Northern Region Burkina Faso

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What happened in 133 consecutive hepatic artery reconstruction in liver transplantation in 1 year?

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 10-18页

作者： Tsan-Shiun Lin Nelamangala Ramakrishnaiah Vishnu Prasad Chao-Long Chen Johnson Chia-Shen Yang Yuan-Cheng Chiang Pao-Jen Kuo Chih-Chi Wang Shih-Ho Wang Yueh-Wei Liu Chee-Chien Yong Yu-Fan Cheng Liver Transplantation Program and departments of Surgery and Diagnostic RadiologyKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiungTaiwan

Background:The immediate challenges during microvascular reconstruction of hepatic artery(HAR)during liver transplantation(LT)can be ***,in order to give a cross sectional view of these problems this study over a period of 1 year,showing our routine practice,was taken ***:From January 2015 to December 2015,a total of 133 LTs were performed in Kaohsiung Chang Gung Memorial Hospital,*** hepatic artery(HA)reconstructions were performed by a microvascular surgeon under an operating ***:In the 133 patients,one artery was anastomosed in 123(92.5%)patients,two in 9(6.8%)patients and three in 1(0.7%)of the ***(8.3%)arteries were less than 2 mm in size(1–1.9 mm).There were intimal dissections(IDs)involving either the donor or the recipient arteries of mild to severe nature in 9(6.8%)*** following graft arterial anastomosis,either there was no flow or an intraoperative hepatic artery thrombosis(HAT)was found in nine(7.1%—8 LDLT,4.8%—1 DDLT)*** re-do anastomosis was done in all of these patients who did well in the *** overall post-operative success rate was 99.2%.One patient(0.8%)developed postoperative HAT due to infection during follow up and died due to ***:Small vessels or HA injury are the frequently encountered problems by a micro vascular *** other problems could be ID,need to do multiple reconstructions,immediate HAT and ability to re-do the HAR immediately.

关键词： Hepatic artery(HA) thrombosis liver transplantation(LT) microvascular surgery reconstruction

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Budd-Chiari syndrome in China: A 30-year retrospective study on survival from a single center

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World Journal of Gastroenterology 2018年第10期24卷 1134-1143页

作者： Wei Zhang Qiao-Zheng Wang Xiao-Wei Chen Hong-Shan Zhong Xi-Tong Zhang Xu-Dong Chen Ke Xu Department of Interventional radiology Shenzhen People’s Hospital the Second Affiliated Hospital of Jinan University Department of radiology The First Affiliated Hospital of China Medical University Key Laboratory of diagnostic imaging and Interventional radiology of Liaoning Province The First Affiliated Hospital of China Medical University

AIM To investigate 30-year treatment outcomes associated with Budd-Chiari syndrome(BCS) at a tertiary hospital in *** A total of 256 patients diagnosed with primary BCS at our tertiary hospital between November 1983 and September 2013 were followed and retrospectively studied. Cumulative survival rates and cumulative mortality rates of major causes were calculated by Kaplan-Meier analysis, and the independent predictors of survival were identified using a Cox regression model. RESULTS Thirty-four patients were untreated; however, 222 patients were treated by medicine, surgery, or interventional radiology. Forty-four patients were lost to follow-up; however, 212 patients were followed, 67 of whom died. The symptom remission rates of treated and untreated patients were 81.1%(107/132) and 46.2%(6/13), respectively(P = 0.009). The cumulative 1-, 5-, 10-, 20-, and 30-year survival rates of the treated patients were 93.5%, 81.6%, 75.2%, 64.7%, and 58.2%, respectively; however, the 1-, 5-, 10-, 20-, and 30-year survival rates of the untreated patients were 70.8%, 70.8%, 53.1%, 0%, and unavailable, respectively(P = 0.007). Independent predictors of survival for treated patients were gastroesophageal variceal bleeding(HR = 3.043, 95%CI: 1.363-6.791, P = 0.007) and restenosis(HR = 4.610, 95%CI: 1.916-11.091, P = 0.001). The cumulative 1-, 5-, 10-, 20-, and 30-year mortality rates for hepatocellular carcinoma were 0%, 2.6%, 3.5%, 8%, and 17.4%, *** Long-term survival is satisfactory for treated Chinese patients with BCS. Hepatocellular carcinoma is a chronic complication and should be monitored with long-term follow-up.

关键词： Budd-Chiari syndrome Chinese Survival Interventional radiology

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Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women

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Neural Regeneration Research 2013年第4期8卷 346-356页

作者： Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang Department of Neurology Dongguan People's Hospital Department of diagnostic radiology and organ imaging the Chinese University of Hong Kong Department of Medicine and Therapeutics the Chinese University of Hong Kong Graylands Hospital School of Psychiatry & Clinical NeurosciencesUniversity of Western AustraliaPerth 6005Australia Department of Psychiatry the Chinese University of Hong Kong

This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with non-aphasic ischemic stroke aged -〉 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited. Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex, along with its subdivisions： anterior cingulate cortex, orbitofrontal cortex and dorsolateral prefrontal cortex. The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke. At 3 months poststroke, left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only （partial coefficient = 0.453, P = 0.045）, after controlling for age, education, diabetes, neurological deficit, white matter lesions volume, as well as the location and volume of infarcts. At 15 months poststroke, there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.661, P = 0.001） and between the left prefrontal cortex volume and Verbal Fluency Test （partial coefficient = 0.573, P = 0.004） in female patients after the same adjustments. These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke. Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke.

关键词： neural regeneration neuroimaging brain atrophy verbal fluency executive function stroke sex differences prefrontal cortex dorsolateral prefrontal cortex magnetic resonance imaging grants-supported paper photographs-containing paper neuroregeneration

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