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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

Journal of integrative medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical psychiatry

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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Neurostatistical imaging for diagnosing dementia:translational approach from laboratory neuroscience to clinical routine

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Neuroscience Bulletin 2014年第5期30卷 755-764页

作者： Etsuko Imabayashi Tomio Inoue integrative Brain Imaging Center National Center of Neurology and Psychiatry Department of Radiology Yokohama City University Graduate School of Medicine and School of Medicine

Statistical analysis in neuroimaging （referred to as “neurostatistical imaging”） is important in clinical neurology. Here, neurostatistical imaging and its superiority for diagnosing dementia are reviewed. In neurodegenerative dementia, the proportional distribution of brain perfusion, metabolism, or atrophy is important for understanding the symptoms and status of patients and for identifying regions of pathological damage. Although absolute quantitative changes are important in vascular disease, they are less important than relative values in neurodegenerative dementia. Even under resting conditions in healthy individuals, the distribution of brain perfusion and metabolism is asymmetrical and differs among areas. To detect small changes, statistical analysis such as the Z-score - the number of standard deviations by which a patient＇s voxel value differs from the normal mean value - comparing normal controls is useful and also facilitates clinical assessment. Our recent finding of a longitudinal one-year reduction of glucose metabolism around the olfactory tract in Alzheimer＇s disease using the recently-developed DARTEL normalization procedure is also presented. Furthermore, a newly-developed procedure to assess brain atrophy with CT-based voxel-based morphometry is illustrated. The promising possibilities of CT in neurostatistical imaging are also presented.

关键词： neurostatistical imaging Neurostat 3DSSP eZIS VSRAD neurodegenerative disease CT segmentation

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Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul Madley-Dowd Harriet Forbes Jessica Rast Caichen Zhong Renee M Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson Michael Lundberg Daniel Berglind Neil M Davies Brian K Lee Cecilia Magnusson Dheeraj Rai Department of Global Public Health Karolinska InstitutetStockholmSweden Medical Research Council integrative Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic Mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Department of Epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Development Pennsylvania State UniversityState CollegePAUSA Department of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology and Community medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of psychiatry University Collge LondonLondonUK Department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample Mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,p<0.001)—a correlation that was more pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,p<0.001).Findings from Mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

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Angelica tenuissima Nakai Ameliorates Cognitive Impairment and Promotes Neurogenesis in Mouse Model of Alzheimer's Disease

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Chinese Journal of integrative medicine 2018年第5期24卷 378-384页

作者： Minji Choi Younghyurk Lee Seung-Hun Cho Department of psychiatry Hospital of Korean Medicine Kyung Hee University Medical Center

Objective: To research Angelica tenuissima Nakai(ATN) for use in novel Alzheimer’s disease(AD) therapeutics. Methods: The effect of a 30% ethanol extract of ATN(KH032) on AD-like cognitive impairment and neuropathological and neuroinflammatory changes induced by bilateral intracerebroventricular injections of β-amyloid(Aβ) peptide(Aβ1-42) was investigated. Male C57 Bl/6 mice were randomly divided into 4 groups, 10 in each group. KH032-treated groups were administrated with a low or high dose of KH032(50 and 200 mg/kg, respectively), intragastrically for 16 days; distilled water was applied in the sham and negative groups. Open field test, Y maze and Morris water maze test were used for behavior test and cognitive ability. In addition, the neuroprotective effects of KH032 in Aβ1-42-infused mice on the histopathological markers [neuronspecific nuclear protein(Neu N), Aβ1-42] of neurodegeneration were examined. The levels of glial fibrillary acidic protein(GFAP), Neu N, phosphorylation extracellular signal-regulated kinase(ERK)/ERK, brain-derived neurotrophic factor(BDNF), phosphorylation c AMP response element-binding(CREB)/CREB protein expression were measured by Western blot. Results: KH032 treatment ameliorated cognitive impairments, reduced the overexpression of Aβ1-42, and inhibited neuronal loss and neuroinflammatory response in the Aβ1-42-infused mice. Moreover, KH032 treatment enhanced BDNF expression levels in the hippocampus. Finally, KH032 treatment increased phosphorylation of ERK1/2 and CREB, vital for ERK-CREB signaling. Conclusions: KH032 attenuated cognitive deficits in the Aβ1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflammatory response, suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.

关键词： Alzheimer's disease Angelica tenuissima Nakai beta amyloid cognitive impairment neurogenesis

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Acupuncture in living liver and kidney donors: a feasibility study

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Journal of integrative medicine 2019年第1期17卷 3-7页

作者： Michelle T.Jesse Mathew Kulas Josephine Unitis Nemie Beltran Marwan Abouljoud Transplant Institute Henry Ford Health System Psychosomatic medicine Behavioral Health Services Henry Ford Health System Center for Health Policy & Health Services Research Henry Ford Health System psychiatry and Neurosciences Wayne State School of Medicine Center for integrative medicine Henry Ford Health System Transplant and Hepatobiliary Surgery Henry Ford Health System

Objective: The purpose of this study was to test the feasibility of integrating acupuncture into the routine care of living liver and kidney donors during the process of donation and ***: This is a pilot study on the feasibility of a brief acupuncture intervention for living liver and kidney donors. Participants received acupuncture immediately prior to organ donation surgery, every day as inpatients, while recovering from donation, and at a 2-week follow-up. Prior to surgery, questionnaires were completed on acupuncture outcome expectations and the State–Trait Anxiety Inventory. After participating, those who received acupuncture provided feedback. Following the active intervention, a retrospective chart review was conducted, using donors who did not receive acupuncture as a comparison ***: Forty donor candidates were approached and recruited, 32 consented and ultimately 25 donors participated in the acupuncture intervention(15 of kidney, 10 of liver), 68% female, and 88% Caucasian;only one had prior experience with acupuncture. Participants received an average of 4 sessions while inpatient(range 2–8). Those who expected acupuncture to be more helpful prior to the intervention reported lower inpatient pain scores(P = 0.04). Qualitative feedback from patients was predominantly positive,indicating acupuncture was helpful for relaxation and pain. However, a few patients reported feeling overburdened during postdonation recovery, and that the study was viewed as additional ***: Preliminary findings suggest it is feasible to integrate acupuncture into inpatient recovery for living organ donation. Tailoring interventions to the specific needs of patients is important to address ongoing concerns. Larger studies are needed to further ascertain benefits of peri-operative acupuncture.

关键词： Acupuncture Living organ donation Pain Pilot projects Feasibility studies

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Complementary and alternative medicine practices,traditional healing practices,and cultural competency in pediatric oncology in Hawai'i

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Journal of integrative medicine 2016年第5期14卷 374-379页

作者： Asad Ghiasuddin Joyce Wong Andrea M.Siu Department of psychiatry John A. Burns School of MedicineUniversity of Hawai'i integrative Services Coordinator Kapi'olani Medical Center for Women and Children Regulatory Document Coordinator Hawai'i Pacific Health Research Institute

OBJECTIVE： Hawai＇i is an ethnically diverse island state with a high rate of both traditional healing （TH） and complementary and alternative medicine （CAM） use. The aim of this project was to assess TH and CAM use within the pediatric oncology population in Honolulu and improve the delivery of culturally competent care. METHODS： A 9-item survey was distributed to all pediatric oncology patients at Kapi＇olani Medical Center for Women and Children for 3 months. The survey inquired about patient ethnicity, TH practices CAM practices and perception of cultural competence of the care received. Descriptive statistics were calculated for the survey items. Qualitative analysis was done with participant comments to identify themes. RESULTS： Sixty-two surveys were completed. TH was used by 39% of the respondents in the home, and 10% in the hospital （top method was traditional foods）. CAM was used by 27% of the respondents in the home, and 68% in the hospital （top method was healing touch）. Ninety-seven percent of the respondents reported receiving culturally competent care. Areas for improvement included language services and dietary choices. CONCLUSION： CAM and TH are used frequently by pediatric oncology patients in Hawai＇i, and the vast majority of patients and families felt that the care they received was culturally competent.

关键词： cultural competency medicine, complementary and alternative traditional healing ethnicity pediatric, cancer

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Cognitive dissonance and mindset perturbations during crisis:“ecosocio-psycho-somatic”perspectives

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World Journal of psychiatry 2024年第2期14卷 215-224页

作者： Felix Tretter Henriette Löffler-Stastka Department of Systems medicine and Healthcare Systems Bertalanffy Center for the Study of Systems ScienceVienna 1040Austria Department of Psychoanalysis and Psychotherapy Medical University ViennaVienna 1090Austria

Mandatory and restrictive health regulations during the corona pandemic caused psychic disorders in many people,which even led to clinically relevant mental *** the same time,there was gradually a polarization of opinions among the *** order to improve future pandemic management,an integrative understanding of these psychosocial processes therefore seems *** we start theoretically with the mental effects of inconsistencies of the information environment by referring to concepts such as the theory of cognitive *** a next step,we use the psychodynamic theory to understand the affective-motivational defense mechanisms underlying these cognitive states and ***,a broader theoretical framework of psychoanalysis seems to make sense,because self-referential processing also influences the style of *** this reason,we use a more comprehensive psychological systems theoretical framework model to integrate these different *** integrative view refers in part to basic knowledge of health psychology regarding the resistance of unhealthy ways of thinking and behaviors and the possibilities for interventions for *** then extend this model to a broader picture that also covers the relationship between men and their *** results in the perspective of a multidimensional socioecological theoretical framework,which as a heuristic reference model and related to other ecological approaches could also be helpful for various theoretical questions for public health,and could provide a better public understanding of health *** line with this perspective,we hypothesize that with regard to the coronavirus disease 2019 pandemic,the acceptance of public health narratives could be increased if a more consistent picture of the scientific descriptions and explanations of the pandemic-similar to the model proposed-could be provided,which would enable the understanding of the origin,course and countermeasur

关键词： Infodemic Affective-cognitive dissonance Systems model of the mind Socioecological model

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The effect of drug loading and multiple administration on the protein corona formation and brain delivery property of PEG-PLA nanoparticles

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2043-2056页

作者： Yuyun Tang Jinchao Gao Tao Wang Qian Zhang Antian Wang Meng Huang Renhe Yu Hongzhuan Chen Xiaoling Gao Department of Pharmacology and Chemical Biology Shanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Geriatric psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineAlzheimer’s Disease and Related Disorder CenterShanghai Jiao Tong UniversityShanghai 200025China Institute of Interdisciplinary integrative Biomedical Research Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201210China

The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting *** has been shown that α-mangostin(αM)-loaded poly(ethylene glycol)-poly(l-lactide)(PEG-PLA)nanoparticles(NP-αM)specifically increased low density lipoprotein receptor(LDLR)expression in microglia and improved clearance of amyloid beta(Aβ)after multiple ***,how do the nanoparticles cross the blood‒brain barrier and access microglia remain ***,we studied the brain delivery property of PEG-PLA nanoparticles under different conditions,finding that the nanoparticles exhibited higher brain transport efficiency and microglia uptake efficiency afterαM loading and multiple *** reveal the mechanism,we performed proteomic analysis to characterize the composition of protein corona formed under various conditions,finding that both drug loading and multiple dosing affect the composition of protein corona and subsequently influence the cellular uptake of nanoparticles in ***3 and BV-2 *** proteins,immunoglobulins,RAB5A and CD36 were found to be enriched in the corona and associated with the process of nanoparticles ***,we bring a mechanistic understanding about the modulator role of protein corona on targeted drug delivery,and provide theoretical basis for engineering brain or microglia-specific targeted delivery system.

关键词： Protein corona Nanoparticles Brain delivery Microglia PEG-PLA

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The Model of Western integrative medicine:The Role of Chinese medicine

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Chinese Journal of integrative medicine 2011年第1期17卷 11-20页

作者： Gustav Dobos Iven Tao Department of Complementary and integrative medicine University of Duisburg-EssenKliniken Essen MitteKnappschafts-KrankenhausAm Deimelsberg 34a45276 EssenGermany

The basic concept of integrative medicine（IM） is that by combining mainstream（biomedicine） with complementary and alternative medicine（CAM）, synergistic therapeutic effects can be *** the methods of mind/body medicine（MBM） are added to this combination,as in Western countries,a new concept emerges that drastically changes the approach toward illness. It is interesting to note that the joining of traditional Chinese medicine and Western medicine in the early days of the Peoples＇ Republic of China preceded the Western model of IM by almost 50 *** elements that make up the key components of IM as practiced today in the West were already present in the Chinese version of IM,and Chinese medicine has played and continues to play an important role in advancing ***,one of the major differences between the Chinese and the Western models of IM today,besides MBM and some other treatment options,is that Western integrative medicine（WIM） strictly requires its CAM methods to be supported by scientific evidence. The therapeutic methods of IM and their applications are many and ***,they are most frequently employed to treat chronic medical conditions,e.g.,bronchial asthma,rheumatic disease, chronic inflammatory bowel disorder and chronic *** fields in which IM may be applied are internal medicine（inflammatory bowel diseases and cardiovascular diseases）,musculoskeletal disorders,oncology （chemotherapy-induced side effects）,obstetrics and gynecology（dysmenorrhea,endometriosis,infertility and menopausal complaints）,pediatrics,geriatrics,neurology（migraine and chronic headache）,and psychiatry （anxiety and depression）. The concept of WIM is discussed here in detail by reviewing its scope and implications for the practice of medicine and focusing on the role of Chinese medicine in WIM.

关键词： integrative medicine complementary and alternative medicine traditional Chinese medicine integrative oncology evidence-based medicine Chinese herbal medicine acupuncture

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