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SBi4211阻断HIV-1 gp41促进新生隐球菌对人脑微血管内皮细胞的黏附作用

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微生物学通报 2019年第6期46卷 1496-1501页

作者：魏轶彭亮李莉何肖龙吴学东曾志节杨伟军曹虹黄胜和南方医科大学公共卫生学院广东省热带病研究重点实验室微生物学系广东广州510515 广州医科大学附属第五医院检验科广东广州510700 Saban Research institute Children's Hospital Los Angeles University of Southern California Los Angeles 90027 America 昆明市儿童医院云南省儿科研究所昆明市儿童感染与免疫重点实验室云南昆明650228 南方医科大学南方医院儿科系广东广州510515

【背景】目前艾滋病和新型隐球菌性脑膜炎共病因素导致其高发病率和死亡率的机制尚不明确。【目的】探索S100B抑制剂SBi4211对HIV-1 gp41促进新生隐球菌黏附人脑微血管内皮细胞的影响和可能机制。【方法】黏附实验分析SBi4211是否能阻断... 详细信息

【背景】目前艾滋病和新型隐球菌性脑膜炎共病因素导致其高发病率和死亡率的机制尚不明确。【目的】探索S100B抑制剂SBi4211对HIV-1 gp41促进新生隐球菌黏附人脑微血管内皮细胞的影响和可能机制。【方法】黏附实验分析SBi4211是否能阻断HIV-1 gp41诱导下新生隐球菌黏附人脑微血管内皮细胞。使用免疫印迹方法进一步检测在此过程中SBi4211对脑微血管内皮细胞上新生隐球菌透明质酸受体CD44表达的影响。【结果】SBi4211可显著抑制HIV-1gp41对新生隐球菌黏附脑微血管内皮细胞的增强作用,且呈时间、剂量效应(P<0.05);免疫印迹结果显示SBi4211可抑制新生隐球菌和/或HIV-1 gp41增加脑微血管内皮细胞上新生隐球菌透明质酸受体CD44的表达。【结论】SBi4211可通过下调受体CD44来阻断HIV-1 gp41对新生隐球菌黏附人脑微血管内皮细胞的增强效应,这为了解HIV-1与新生隐球菌共病机制及其防治策略提供了新思路。

关键词：新生隐球菌 S100B抑制剂 HIV-1 gp41 CD44 人脑微血管内皮细胞

Prospective of Indian Tropical Tasar Silkworm, Antheraea Mylitta Drury （Lepidoptera： Saturniidae） as Feasible Forest Wealth

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Journal of Life Sciences 2011年第10期5卷 850-855页

作者： Rangareddygari Manohar Reddy Pathapalli Muneerappa Muniswamy Reddy Gangadharaiah Lokesh Reddivari Dayananda Reddy Cheluri Siva Reddy Andanur Manjula Vankadara Sivaprasad P2 Basic Seed Farm Central Silk Board Parigi 515261 India Central Tasar Research ＆ Training institute Central Silk Board Ranchi 835303 India Silkworm Seed Production Centre Central Silk Board Hindupur 515202 India National Silkworm Seed Organization Central Silk Board Bangalore 560068 India

Commercially important polyphagous tropical tasar silk insect, Antheraea mylitta Drury is distributed along central India (12-31° N latitude, 72-96° E longitude), which on adaptation formed in to forty four ecoraces of varied phenotypes. Its wild ecoraces like Raily, Modal, Jata, Sarihan, Laria, Bhandara and Andhra, besides domesticated Daba and Sukinda are contributing for livelihood of forest based aboriginals. However, the deforestation and extensive collection of nature grown cocoons led to declination of wild population and even have endangered few ecoraces. The government and Non Government Organizations (NGOs), although promote ecorace conservation, it could upkeep the insect wildlife only to limited extent. But the forest department with associated self help societies has advantage in conserving tasar insect as prospective forest wealth, with better knowledge and access to its habitats. The co-ordinate efforts from forest, sericulture departments to participate native aboriginals of such societies can facilitate conserving tasar-biodiversity as most feasible forest associated resource.

关键词：森林砍伐热带印度财富天蚕鳞翅目蚕蛾非政府组织

Households＇ Assessment of the Water Quality and Services of Multi-model Urban Water Supply System in the Informal Settlements of Dar es Salaam, Tanzania

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Journal of Civil Engineering and Architecture 2018年第5期12卷 362-381页

作者： Francis Dakyaga Alphonce G. Kyessi Joel M. Msami Faculty of Planning and Land Management University for Development Studies P. O. Box UPW03 Wa Ghana institute of Human Settlements Studies Ardhi University P.O. Box 35124 Dar es Salaam Tanzania Department of Urban and Regional Planning Ardhi University P.O. Box 35124 Dar es Salaam Tanzania

Potential carrier priming effect in Australian infants after 7-valent pneumococcal conjugate vaccine introduction

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World Journal of Clinical pediatrics 2016年第3期5卷 311-318页

作者： Mohamed Tashani Sanjay Jayasinghe Zitta B Harboe Harunor Rashid Robert Booy National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases the Children’s Hospital at Westmead the Discipline of Child and Adolescent Health Sydney Medical SchoolUniversity of Sydney Neisseria and Streptococcus Reference Laboratory Department of Microbiology and Infection ControlStatens Serum Institut Marie Bashir institute for Infectious Diseases and Biosecurity School of Biological Sciences and Sydney Medical SchoolUniversity of Sydney World Health Organization Collaborating Centre for Mass Gatherings and High Consequence/High Visibility Events Flinders University

AIM:To investigate evidence of clinical protection in infants after one dose of 7-valent pneumococcal conjugate vaccine(7vPCV) owing to carrier ***:Using Australian National Notifiable Diseases Surveillance System data,we conducted a descriptive analysis of cases of vaccine type invasive pneumococcal disease(VT-IPD) during "catch-up" years,when 7vPCV was carrier primed by prior administration of DTPa *** compared the number of VT-IPD cases occurring 2-9 wk after a single dose of 7vPCV(carrier primed),with those < 2 wk post vaccination,when no protection from 7vPCV was expected *** comparison was conducted to compare the occurrence of VT-IPD cases vs non-VT-IPD cases after a single carrier-primed dose of ***:We found four VT-IPD cases occurring <2 wk after one carrier primed dose of 7vPCV while only one case occurred 2-9 wk *** further comparison with the non-VT-IPD cases that occurred after one carrier primed dose of 7vPCV,two cases were detected within 2 wk,whereas seven occurred within2-9 wk later;suggesting a substantial level of protection from VT-IPD occurring from 2 wk after carrier-primed dose of ***:This data suggest that infants may benefit from just one dose of 7vPCV,likely through enhanced immunity from carrier priming *** this is proven,an adjusted 2-dose schedule(where the first dose of PCV is not given until after DTPa) may be sufficient and more cost-effective.

关键词： Carrier priming Conjugate vaccine Infant Invasive pneumococcal disease