检索结果-南通市图书馆

Two Cytotoxic Eremophilanolides from Senecio tsoongianus

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第3期16卷 362-364页

作者： QiJunZHANG HuiDOU ChangXinZHOU ZhaoJunXU HuaPENG YuZHAO departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031 KunmingInstituteofBotany ChineseAcademyofSciencesKunming650204

Two new eremophilanolides, tsoongianolide E and F, were isolated from Senecio tsoongianus. Their structures were elucidated on the basis of NMR and MS spectra. Both of these two compounds showed in vitro cytotoxicity ... 详细信息

关键词： Sesquiterpenes eremophilanolide Seneciotsoongianus.

New Eudesmane and Eremophilane Derivatives from Laggera Alata

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2003年第4期14卷 393-396页

作者： QunXiongZHENG ZhaoJunXU XianFengSUN FrancoiseGUERITTE MicheleC DepartmentofBiochemistry TheChineseUniversityofHongKongShatinHongKong departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofpharmaceuticalSciencesZhejiangUniversityHangzhou310031 I

From the aerial part of Laggera alata, a novel eremophilanoid (1) as well as two new eudesmanoids (2-3) were isolated. Their structures were elucidated by 2D-NMR technique and X-ray diffraction studies. The cytotox... 详细信息

关键词： Laggera alata sesquiterpene eremophilanoid eudesmanoid X-ray diffraction cytotoxicity.

Synthesis of 2-En-1-one-ebelactonyl Benzoates of Territrem B Analogues from Jujubogenin

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第1期16卷 11-14页

作者： JinHaoZHAO YanGuangWANG HaiBoLI FengZHAO LeiXiangYANG HuaBAI ShoeiShengLEE YuZHAO departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031／／DepartmentofChemistryCollegeofSciencesZhejiangUniversityHangzhou310027 DepartmentofChemistry CollegeofSciencesZhejiangUniversityHangzhou310027 departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031 ZhejiangHisunNaturelitePharmaceuticalR＆DCo. Ltd.Hangzhou310007 DepartmentofPharmacy CollegeofMedicineNationalTaiwanUniversityTaipei10018

Two series of territrem B analogues (10a-10c and 18) have been designed and synthesized from jujubogenin 5a which was prepared from jujubogenin glycosides 5b obtained from the leaves of Zizyphus jujuba. The structures of the new compounds were confirmed by H-, 1 13C-NMR and MS data. Compounds 10c and 18 showed weak inhibitory effect on AChE at 10-4 mol/L.

关键词： Territrem B analogues acetylcholinesterase (AChE) inhibitor jujubogenin.

Two Series of Synthetic Territrem B Analogues and their Biological Activities

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2005年第4期16卷 457-460页

作者： FengZHAO JinHaoZHAO HaiBoLI LeiXiangYANG HuaBAI YanGuangWANG ShoeiShengLEE YuZHAO departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031 DepartmentofChemistry CollegeofSciencesZhejiangUniversityHangzhou310027 ZhejiangHisunNaturelitePharmaceuticalR＆DCo. Ltd.Hangzhou310007 DepartmentofPharmacy CollegeofMedicineNationalTalwanUniversityTalpei10018 departmentoftraditionalchinesemedicineandnaturaldrugresearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031／／DepartmentofChemistryCollegeofSciencesZhejiang＂Uni-vers-ityHangzhou310027

Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds 5a, 5b, 6a and 11b showed moderate cytotoxicity on cultured KB cells at 10-6 mol/L. Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD).

关键词： Territrem B analogues acetylcholinesterase (AChE) inhibitor cytotoxicity on KB cells oxygen-glucose deprivation (OGD).