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中国组织化学与细胞化学杂志 2004年第3期13卷 353-354页

作者： YuanLi LeiCao BaozhiWang ShurongLi GuishengLiu departmentofhumananatomy HebeiMedicalUniversityShijiazhuang050017P.R.China ExperimentalCenterofElectronMicroscopy HebeiMedicalUniversityShijiazhuang050017P.R.China

Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma

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World Journal of Gastroenterology 2005年第5期11卷 744-747页

作者： Hong-BingMa Hai-TaoHu Zheng-LiDi Zuo-RenWang Jing-SenShi Xi-JingWang YiLi DepartmentofCancerSurgery SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina departmentofhumananatomy MedicalCollegeofXi'anJiaotongUniversityXi'an710068ShaanxiProvinceChina DepartmentofNeurology Xi'anCenterHospitalXi'an710003ShaanxiProvinceChina DepartmentofHepatobiliarySurgery FirstHospitalofXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To investigate the role of cyclin D1, p16 and retinoblastoma in cancerous process of gallbladder carcinomas and to assess the relation between cyclin D1, p16, Rb and the biological characteristics of gallbladder carcinoma. METHODS: Forty-one gallbladder carcinoma, 7 gallbladder adenoma and 14 chronic cholecystitis specimens were immunohistochemically and histopathologically investigated for the relation of cyclin D1, p16 and Rb with Nevin staging and pathologic grading. RESULTS: The expression rates of abnormal cyclin Dl in gallbladder carcinoma (68.3%)and gallbladder adenoma (57.1%) were significantly higher than those in chronic cholecystitis (7.1%) (P<0.05). No significant difference was found both among the pathological grades G1, G2 and G3 and among Nevin stagings S1-S2, S3 and S4-S5 of gallbladder carcinoma. The positive rates of p16 (48.8%) and Rb (58.5%) in gallbladder carcinoma were significantly lower compared to those in adenoma (100.0%) and cholecystitis (100.0%) (P<0.05). The positive rates of p16 and Rb in Nevin stagings S1-S2 (80.0% and 90.0%) and S3 (46.2% and 61.5%) gallbladder carcinomas were significantly higher than those in S4-S5(33.3% and 38.8%) (P<0.05), and those in pathologic grades G1(54.5% and 81.8%) and G2 (50.0% and 62.5%) gallbladder carcinoma were significantly higher than those in G3 (28.6% and 35.7%) (P<0.05). The protein expression of p16 and Rb had a negative-correlation in gallbladder carcinoma (r= -0.2993, P<0.05), and this negative-correlation was correlated with Nevin staging (P<0.05). Moreover, the protein expression of p16 and cyclin Dl had a negative-correlation in gallbladder carcinoma (r = -0.9417, P<0.05). CONCLUSION: Cyclin Dl may play a role in the early stage of gallbladder carcinoma. Mutation of p16 and Rb genes might be correlated with progression of gallbladder carcinoma. Analysis of p16 and Rb can estimate the prognosis of gallbladder carcinoma. Expression of p16 and Rb may be correlated with Nevin staging and

关键词： Gallbladder carcinoma Cyclin Dl p16 protein Retinoblastoma protein Tumor metastasis

The morphological tracing investigation of absorbing and transport pathway for IGMEI injected into rat pancreas

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中国组织化学与细胞化学杂志 2004年第3期13卷 351-351页

作者： LeiCao YuanLi BaozhiWang LiWang YuzhenZhao departmentofhumananatomy HebeiMedicalUniversityShijiazhuang050017P.R.China ExperimentalCenterofElectronMicroscopy HebeiMedicalUniversityShijiazhuang050017P.R.China

Immunohistochemical studies of IP3 receptor in transgenic mice submandibular gland

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中国组织化学与细胞化学杂志 2004年第3期13卷 390-390页

作者： LaoMing departmentofhumananatomy GuangxiMedicalUniversityNanning530021GuangxiP.R.China GodfriedM.RoomansDepartmentofMedicalCellBiologyofUppsalaUniversity Box57175123UppsalaSweden

一氧化氮和一氧化氮合酶在大鼠慢性牙髓炎性疼痛发生中的作用

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中华口腔医学杂志 2009年第Z1期44卷 107-107页

作者： FAN Wen-guo HUANG Fang Qu Huai-gang LI Gui-xia HE Hong-wen DepartmentofOralAnatomyandPhysiology GuanghuaSchoolofStomatology SunYat-senUniversity GuangzhouChina DepartmentofOralAnatomyandPhysiology GuanghuaSchoolofStomatology SunYat-senUniversity GuangzhouChina departmentofhumananatomy&Neurobiology ZhongshanMedicalSchool SunYat-senUniversity GuangzhouChina DepartmentofOralAnatomyandPhysiology GuanghuaSchoolofStomatology SunYat-senUniversity GuangzhouChina DepartmentofOralAnatomyandPhysiology GuanghuaSchoolofStomatology SunYat-senUniversity GuangzhouChina