检索结果-南通市图书馆

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On Wong department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 794-806页

作者： K JAMES Jintu KIM Heuy Dong department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT Korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

Event-triggered sliding mode control of linear repetitive processes and its application in metal rolling process

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第3期67卷 167-181页

作者： Xinyu LV Yugang NIU James LAM Key Laboratory of Smart Manufacturing in Energy Chemical Process (East China University of Science and Technology) Ministry of Education department of Mechanical Engineering The University of Hong Kong

This paper investigates the design problem of a sliding mode controller for linear repetitive processes(LRPs) with a finite pass length on each pass. Under limited communication resources, an eventtriggered mechanism is implemented from the sensors to the controller, whose triggered sequence is consistent with the evolution direction of LRPs. To periodically orchestrate communication between the controller and actuator, a round-robin scheduling mechanism is established based on the pass length. A sliding function involving the state and pass profile is constructed, and the sliding mode controller is designed using triggered states and pass profile signals. Feasible controller gains are attained to ensure the stability of the resultant closed-loop system. Finally, the proposed strategy is implemented for a multi-roll metal rolling process.

关键词： event-triggered mechanism linear repetitive processes metal rolling process round-robin scheduling sliding mode control

同方期刊数据库

Effectiveness of a theory-based tailored mHealth physical activity intervention for women undergoing chemotherapy for breast cancer:A quasi-experimental study

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2024年第4期11卷 405-413页

作者： Zhaohui Geng Jingting Wang Weibo Lyu Xinyu Li Wenjia Ye Wei Zheng Juan Yang Li Ning Lingzhi Cai Ying Liu Yingting Zhang Fulei Wu Changrong Yuan School of Nursing Shanghai University of Traditional Chinese MedicineShanghaiChina School of Nursing Navy Medical UniversityShanghaiChina department of Breast Surgery Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina department of Breast Surgery Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina department of Nursing Hangzhou First People’s HospitalHangzhouChina department of Breast Surgery Hangzhou First People’s HospitalHangzhouChina department of Nursing Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghaiChina School of Nursing Fudan UniversityShanghaiChina

Objectives:This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity(PA)intervention among patients with breast cancer undergoing ***:A quasi-experimental study design was adopted.A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August *** to the admission order,30 patients wereﬁrst included in the control group,followed by 30 patients in the intervention group.A smartphone application(app)named“Breast Care”was developed based on social cognitive theory,self-efﬁcacy theory,and the theory of planned *** app integrated various functions,including information browsing,PA monitoring and feedback,symptom reporting,and social *** in the intervention group received three months of personalized online PA guidance in addition to routine *** control group received routine *** and post-intervention investigations after three months were conducted in two groups using the Short Form of International Physical Activity Questionnaire,the Hospital Anxiety and Depression Scale,and the Functional Assessment of Cancer TherapydBreast ***:After three months of intervention,compared to the control group,breast cancer patients in the intervention group showed signiﬁcant improvements in walking,moderate PA,and overall PA(P<0.05).Compared to the baseline data,breast cancer patients in the intervention group had signiﬁcant improvements in walking and overall PA after three months(P<0.05),whereas the control group experienced signiﬁcant declines in walking,moderate PA,and overall PA after three months(P<0.05).There were statistically differences between the two groups in scores for anxiety,overall quality of life,and its dimensions,such as physical well-being,emotional well-being,and additional breast cancer well-being(P<0.05).Conclusions:The theory-based tailored mHealth PA intervention has

关键词： Anxiety Breast cancer Chemotherapy Depression Patients Physical activity Telemedicine

Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2024年第1期17卷 113-130页

作者： Haotian Zhang Xiaoxiao Ding Weirong Zhang Weijia Zhang Yingli Xuan Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China department ofArchitecture TokyoPolytechnic UniversityTokyoJapan

As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection ***-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork ***,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated ***,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module *** fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped *** phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the *** indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is *** contaminant discharge can be achieved when the line of outlets is located directly above the infected *** this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk.

关键词： multi-vent module-based adaptive ventilation computational fluid dynamics indoor air quality infection control

Multiple interface coupling on natural tourmaline enables high-efficiency removal of antibiotic:Superior property and mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第6期140卷 242-254页

作者： Jingjing Cui Xiangyu Liu Feifan Qie Chengzhe Xie Qingdong He Jian Liu Steven L.Suib Wenbo Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China department of Chemistry University of ConnecticutStorrsCT 06269-3060United States

Reasonably designing highly active,environmentally friendly,and cost-effective catalysts for efficient elimination of pollutants from water is desirable but ***,an efficient heterogeneous photo-Fenton catalyst tourmaline(TM)/tungsten oxide(WO_(3-x))(named TW10)containing tungsten/boron/iron(W/B/Fe)synergistic active centers and 90%of cheap natural tourmaline(TM)mineral rich in Fe and B *** TW10 catalyst can quickly activate peroxymonosulfate(PMS)to generate massive active free radicals,which may induce the rapid and efficient degradation of tetracycline(TC).The TW10/PMS/Visible light system can effectively degrade up to 98.7%of tetracycline(TC)in actual waters(***,Yellow River,and Yangtze River water),and the catalytic degradation rates reach 1.65,5.569,and 2.38 times higher than those of TM,WO_(3-x),and commercial P25(Degussa,Germany),*** addition,the catalyst can be recycled and reused multiple *** spin resonance spectroscopy(EPR),X-ray photoelectron spectroscopy(XPS),and liquid chromatograph-mass spectrometer(LC-MS)analyses confirm that the synergistic catalytic effect of W/B/Fe sites on the TW10 catalyst accelerates the electron transfer between Fe(Ⅱ)and Fe(Ⅲ),as well as between W(Ⅴ)and W(Ⅵ),and thus promotes the rapid degradation of *** catalytic reaction mechanism and degradation pathway of TC were *** work provides a feasible route for the design and development of new eco-friendly and efficient catalyst.

关键词： Tourmaline(TM) Fenton-like catalyst Tungsten oxide Peroxymonosulfate Antibiotic

Wigner function of optical cumulant operator and its dissipation in thermo-entangled state representation

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第6期33卷 205-210页

作者：张科李兰兰范洪义 School of Electronic Engineering Huainan Normal UniversityHuainan 232038China department of Material Science and Engineering University of Science and Technology of ChinaHefei 230026China

To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive the general evolution formula of the Wigner function, and its relation to Weyl correspondence is also discussed. The method of integration within the ordered product of operators is essential to our discussion.

关键词： Wigner function optical cumulant operator dissipation evolution thermo-entangled state representation integration within ordered product of operators

The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第2期11卷 311-315页

作者： Makoto Taguchi Kaneki Yasuda Hidefumi Kinoshita department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter

Subpicosecond laser ablation behavior of a magnesium target and crater evolution:Molecular dynamics study and experimental validation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第7期33卷 613-622页

作者：江国龙周霞 State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsFaculty of Vehicle Engineering and MechanicsDalian University of TechnologyDalian 116024China

The micro-ablation processes and morphological evolution of ablative craters on single-crystal magnesium under subpicosecond laser irradiation are investigated using molecular dynamics(MD) simulations and *** simulation results exhibit that the main failure mode of single-crystal Mg film irradiated by a low fluence and long pulse width laser is the ejection of surface atoms,which has laser-induced high ***,under high fluence and short pulse width laser irradiation,the main damage mechanism is nucleation fracture caused by stress wave reflection and superposition at the bottom of the *** addition,Mg[0001] has higher pressure sensitivity and is more prone to ablation than Mg[0001].The evolution equation of crater depth is established using multi-pulse laser ablation simulation and verified by *** results show that,under multiple pulsed laser irradiation,not only does the crater depth increase linearly with the pulse number,but also the quadratic term and constant term of the fitted crater profile curve increase linearly.

关键词： laser-material interaction molecular dynamics(MD)simulation ablation crater morphology magnesium