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FACTORS AFFECTING REMOVAL AND PROGNOSIS OF THYMIC TUMORS

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Chinese Medical Sciences Journal 1995年第4期10卷 229-231页

作者：张志庸戈烽李单清李泽坚孙成孚徐乐天张世农 department of Thoracic surgery PUMC Hospital Beijing.

One hundred and ten cases of thymic tumors were intervened surgically, including 92 thymoma, 8 thymic carcinoid, and 10 thymic carcinoma. In this series, 50. 9% of the cases were complieated with various syndromes, 44. 5 % with myasthenia gravis (MG). Resection rate was correlated with the size and invasion of the tumor. There was significant difference in resection rate among thymoma, thymic carcinoid and thymic carcinoma. The degree of invasion undoubtely influenced on resection. The 3 -,5- and 10- year suvival rate of the thymoma were 82. 7 %, 68. 1% and 40. 0 %, respectively. The prognosis depended on the pathological classification and the severity of the neighbouring invasion, but MG had no significant effect on prognosis. Recurrence and metastasis of the tumor were the main cause of late death.

关键词： thymic tumor surgical mangement prognosis

Endoscopic retrograde appendicitis treatment for periappendiceal abscess: A case report

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World Journal of Clinical Cases 2024年第4期12卷 801-805页

作者： Qiao-Mei Li Bin Ye Jun-Wei Liu Shang-Wen Yang department of Gastroenterology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Acute appendicitis is the most common abdominal *** present,the main treatments for periappendiceal abscess include antibiotics and ***,the complications and mortality of emergency surgery are *** preferred therapy is conservative treatment with antibiotics first,ultrasound-guided puncture drainage or surgical treatment is followed when *** retrograde appendicitis therapy(ERAT)for acute uncomplicated appendicitis have been proved clinically effective,but it is rarely used in periap-pendiceal *** SUMMARY We report a patient admitted to hospital because of“right lower abdominal pain for six days”.The computerized tomography(CT)of patient showed that appendicitis with fecaliths and abscess in the *** patient was treated by CT-guided puncture and drainage of abdominal abscess combined with ERAT to remove appendiceal fecaliths,irrigation and stent *** The patient did not receive surgery because of impoverished *** pain did not recur during the follow-up *** case confirms the value of ERAT in the treatment of periappendiceal abscess.

关键词： Transparent cap Colonoscopy Endoscopic retrograde appendicitis therapy Periappendiceal abscess Case report

A CLINICAL ANALYSIS OF 38 PATIENTS WITH PRIMARY TRACHEO BRONCHIAL TUMORS

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Chinese Medical Sciences Journal 1994年第4期9卷 263-265页

作者：任华柏刚李泽坚张志庸孙成孚徐乐天 department of Cardiothoracic surgery PUMC Hospital Beijing.

During a 17-year period, 38 patients with primary tracheobronchial tumors received surgical treatment in PUMC Hospital. Arnong the 38. 12 had low-malignancy tracheal tumors, 11 had benign tracheal tumors, 14 had low malignancy bronchial tumors and 1 had a benign bronchial tumor. Fifteen operations were perforrned on 12 patients with low-malignancy tracheal tumors, including local resection of the tumor and tracheal wall in 4 and curettage of the tumor plus electrical cauterization in 10. Postoperative radiotherapy was used as an adjuvant treatment in 8 patients with adenocystic carcinoma. Eight patients have survived for more than 5 years and 3 patients have survived for longer than 10 years postoperatively. All 11 patients with benign tumors received curettage of the tumor and were followed up for an average of 6. 5 years. Among them, 9 are still alive. Of the 14 patients with low malignancy bronchial tumors, 5 underwent curettage of the tumor plus electrical cauterization through incision of the main bronchus or intermedial bronchus, and 7 underwent lobectomy or pneumonectomy. The authors conclude that the correct diagnosis rate can be increased by enhancing recognition of this disease and applying tracheal tomography and bronchoscopy.

关键词： tracheobronchial tumors,low malignancy misdiagnosis

A REPORT OF 39 CASES OF BRONCHIOLOALVEOLAR CARCINOMA

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Chinese Medical Sciences Journal 1994年第2期9卷 135-136页

作者：任华李泽坚张志庸孙成孚徐乐天 department of Thoracic surgery PUMC Hospital Beijing.

ＡＲＥＰＯＲＴＯＦ３９ＣＡＳＥＳＯＦＢＲＯＮＣＨＩＯＬＯＡＬＶＥＯＬＡＲＣＡＲＣＩＮＯＭＡ￥ＲｅｎＨｕａ（任华）；ＬｉＺｅｊｉａｎ（李泽坚）；ＺｈａｎｇＺｈｉｙｏｎｇ（张志庸）；ＳｕｎＣｈｅｎｇｆｕ（孙成孚）ａｎｄＸ... 详细信息

ＡＲＥＰＯＲＴＯＦ３９ＣＡＳＥＳＯＦＢＲＯＮＣＨＩＯＬＯＡＬＶＥＯＬＡＲＣＡＲＣＩＮＯＭＡ￥ＲｅｎＨｕａ（任华）；ＬｉＺｅｊｉａｎ（李泽坚）；ＺｈａｎｇＺｈｉｙｏｎｇ（张志庸）；ＳｕｎＣｈｅｎｇｆｕ（孙成孚）ａｎｄＸｕＬｅｔｉａｎ（徐乐天）（Ｄｅｐａ...

关键词： neoplasms bronchioloalveolar carcinoma

Peroneus longus tendon rupture: A case report

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World Journal of Orthopedics 2019年第1期10卷 45-53页

作者： Don Koh Lincoln Liow Joseph Cheah Kevin Koo department of Orthopaedic surgery Singapore General Hospital

BACKGROUND Peroneal tendinopathies are an under-diagnosed and potentially under-treated pathology. If left untreated it can be a cause of chronic lateral hindfoot pain. Its diagnosis is challenging owing to its low incidence and vague clinical *** SUMMARY We share a case of a patient who experienced a chronic lateral ankle pain exacerbated after alighting from a bus. This patient came to our attention only after failing conservative management on two separate occasions. Plain radiographs and magnetic resonance imaging revealed rupture of the peroneus longus tendon(PLT). Findings were confirmed intra-operatively and tenodesis of the PLT to the peroneus brevis was performed. Patient was kept non-weight-bear with his foot everted and in plantarflexion before being converted to an offloading boot at two weeks. Patient was started on a progressive rehabilitation programme at six weeks and was able to return to work shortly after with excellent *** We aim to share our experience in managing this patient and propose some pointers guided by available literature to avoid missing this commonly overlooked pathology.

关键词： Chronic lateral ankle pain Peroneus longus rupture Peroneal tendinopathy Tenodesis Diagnostic challenge Case report

Neutrophil-mediated liver injury during hepatic ischemia-reperfusion in rats

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 436-442页

作者： Motomichi Sato Kanji Kawachi Yuji Abe department of surgery Ⅱ Ehime University EhimeJapan

BACKGROUND: Neutrophil plays an important role in hepatic ischemia-reperfusion injury. We investigated neutrophil infiltration in liver tissue, Kupffer cells' role in neutrophil accumulation, and apoptosis and regeneration of hepatocytes in liver ischemia-reperfusion injury. METHODS: Vascular microclamps were placed across the pedicles of the median and left lateral lobes for 90 minutes after 30% hepatectomy with the resection of caudate, right lateral and quadrate lobes and papillary process. Gadolinium chloride (GdCl3) was used to destroy Kupffer cells. Neutrophil activity was inhibited with Urge-8, a monoclonal antibody against neutrophil produced in our laboratory. GdCl3 (10 mg/kg) and Urge-8 (50 mg/kg) were given intravenously in respective groups. Ischemia control, GdCl3 and Urge-8 groups were compared. RESULTS: Following hepatic reperfusion, serum interleukin-8 (IL-8) levels and hepatic neutrophil counts peaked at 3 hours, and peak concentrations of alanine aminotransferase (ALT) occurred at 6 hours. Animals of the control group showed increases in neutrophil infiltration in liver tissue, liver enzyme levels, and apoptosis index of hepatocytes and decreases in overall survival rate and proliferating cell nuclear antigen (PCNA) expression of hepatocytes. The survival rates and PCNA proportion of hepatocytes were higher and the levels of hepatic neutrophil infiltration, liver enzymes, and hepatocyte apoptosis after reperfusion were lower in the GdCl3 and Urge-8 groups than those in the ischemia control group. CONCLUSIONS: Blockades of Kupffer cells' activity and neutrophil infiltration by GdCl3 and Urge-8 eliminate neutrophil-mediated hepatic injury and enhance subsequent hepatic regeneration during liver ischemiareperfusion.

关键词： neutrophil liver ischemia-reper fusion injury

Isoperistaltic vs antiperistaltic anastomosis after right hemicolectomy:A comprehensive review

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World Journal of Clinical Cases 2023年第8期11卷 1694-1701页

作者： Dimitrios Symeonidis Kostas-Sotirios Karakantas Labrini Kissa Athina A Samara Effrosyni Bompou Konstantinos Tepetes Georgios Tzovaras department of surgery University Hospital of LarissaLarissa 41110Greece

To optimize the efficiency of ileocolic anastomosis following right hemicolectomy,several variations of the surgical technique have been *** include performing the anastomosis intra-or extracorporeally or performing a stapled or hand-sewn *** the least studied is the configuration of the two stumps(i.e.,isoperistaltic or antiperistaltic)in the case of a side-to-side *** purpose of the present study is to compare the isoperistaltic and antiperistaltic side-to-side anastomotic configuration after right hemicolectomy by reviewing the relevant ***-quality literature is scarce,with only three studies directly comparing the two alternatives,and no study has revealed any significant differences in the incidence of anastomosis-related complications such as leakage,stenosis,or ***,there may be a trend towards an earlier recovery of intestinal function following antiperistaltic ***,existing data do not identify a certain anastomotic configuration(i.e.,isoperistaltic or antiperistaltic)as superior over the ***,the most appropriate approach is to master both anastomotic techniques and select between the two configurations based on each individual case scenario.

关键词： Isoperistaltic side-to-side anastomosis Antiperistaltic side-to-side anastomosis Ileocolic anastomosis Right hemicolectomy Scenario

Unusual association of Axenfeld-Rieger syndrome and wandering spleen:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1502-1506页

作者： Yi-Lin Chang Joseph Lin Yu-Hsien Li Lien-Cheng Tsao department of General surgery Changhua Christian HospitalChanghua 50006Taiwan

BACKGROUND Axenfeld-Rieger syndrome(ARS)is an autosomal dominant genetic disease characterized by ocular developmental disorders and its association with torsion of wandering spleen(WS)has not been reported to date to the best of our *** study aimed to describe a rare case of ARS observed at our emergency *** SUMMARY A 25-year-old female presented with a constant lower abdominal pain of increasing *** computed tomography with intravenous contrast material showed a non-homogenously enhanced splenic parenchyma with a twisted vascular ***,an emergent laparoscopic exploration was performed,and an ischemic spleen without its normal ligamentous attachments was ***,the spleen did not regain its normal vascularity after detorsion;thus,we performed the laparoscopic total *** postoperative course was uneventful,and the patient was discharged on the 5th postoperative *** case demonstrates a rare association of WS and *** Early diagnosis of WS in the emergency department is important to prevent pedicle torsion or splenic necrosis and to avoid splenectomy.

关键词： Wandering spleen Axenfeld-Rieger syndrome Laparoscopic splenectomy Autosomal dominant Abdominal pain Emergent surgery Case report

Laparoscopic treatment for suspected gallbladder cancer confined to the wall： a 10-year study from a single institution

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Chinese Journal of Cancer Research 2018年第1期30卷 84-92页

作者： Lingfu Zhang Chunsheng Hou Zhi Xu Lixin Wang Xiaofeng Ling Dianrong Xiu department of general surgery peking university third hospital Beijing 100191 China

Objective： Although laparoscopic treatment of gallbladder cancer（GBC） has been explored in the last decade,long-term results are still rare. This study evaluates long-term results of intended laparoscopic treatment for suspected GBC confined to the gallbladder wall, based on our experience over 10 ***： Between August 2006 and December 2015, 164 patients with suspected GBC confined to the wall were enrolled in the protocol for laparoscopic surgery. The process for GBC treatment was analyzed to evaluate the feasibility of computed tomography（CT） and/or magnetic resonance imaging（MRI） combined with frozen-section examination in identifying GBC confined to the wall. Of 159 patients who underwent the intended laparoscopic radical treatment, 47 with pathologically proven GBC were investigated to determine the safety and oncologic outcomes of a laparoscopic approach to ***： Among the 164 patients, 5 patients avoided further radical surgery because of unresectable disease and12 were converted to open surgery; in the remaining 147 patients, totally laparoscopic treatment was successfully accomplished. Extended cholecystectomy was performed in 37 patients and simple cholecystectomy in 10. The T stages based on final pathology were Tis（n=6）, T1 a（n=2）, T1 b（n=9）, T2（n=26）, and T3（n=4）. Recurrence was detected in 11 patients over a median follow-up of 51 months. The disease-specific 5-year survival rate of these 47 patients was 68.8%, and rose to 85% for patients with a normal cancer antigen 19-9（CA19-9） ***： The favorable long-term outcomes demonstrate the feasibility of combined CT/MRI and frozensection examination in the selection of patients with GBC confined to the gallbladder wall, confirm the oncologic safety of laparoscopic treatment in selected GBC patients, and favor measurement of preoperative CA19-9 in the selection of GBCs suitable for laparoscopic treatment.

关键词： CA19-9 frozen-section diagnosis gallbladder cancer laparoscopic radical cholecystectomy laparoscopic surgery radical cholecystectomy