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The role of selective serotonin reuptake inhibitors and tricyclic antidepressants in addressing reduction of Meniere's disease burden:A scoping review

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World Journal of Otorhinolaryngology-head and neck surgery 2024年第3期10卷 206-212页

作者： Alexander A.Missner Mana Sheykhsoltan Amir Hakimi Michael Hoa Georgetown University School of Medicine WashingtonDistrict of ColumbiaUSA department of otolaryngology-head and neck surgery Georgetown University Medical CenterWashingtonDistrict of ColumbiaUSA Auditory Development and Restoration Program National Institute on Deafness and Other Communication DisordersNational Institutes of HealthBethesdaMarylandUSA

Objective:To assess the effect of selective serotonin reuptake inhibitors(SSRIs)and tricyclic antidepressants(TCAs)in reducing vertigo,tinnitus,and hearing loss among patients with Meniere's disease(MD).Data Sources:The following databases were utilized in this scoping review:Ovid Medline,PubMed-NCBI,CINAHL,Cochrane Library,Web of Science,and ***:Studies were identified through the following search phrases:"serotonin specific reuptake inhibitors"OR"tricyclic antidepressants"AND"Meniere's disease."References from included manuscripts were examined for possible inclusion of additional ***:The literature search yielded 23 results,which were screened by three independent *** studies and three duplicates were *** examination of references from the included studies yielded two additional publications.A total of four published studies assessing SSRIs and TCAs among 147 patients with MD were ultimately *** studies described significant reductions in vertigo attack frequency among patients treated with either SSRIs or TCAs compared to their pretreatment *** studies assessed the drugs'effects on hearing,of which none found a significant difference among patients treated with SSRIs or *** study found a significant decrease in patient-reported tinnitus following treatment with TCAs or SSRIs compared to their pretreatment ***:Data exploring SSRIs and TCAs among patients with MD suggests that these medications may reduce the frequency of tinnitus and vertigo,although there was significant heterogeneity in outcome *** remains a need for larger-scale prospective studies that emphasize objective data to evaluate their effective-ness in reducing common MD symptoms.

关键词： aural fullness clinical trials Meniere's disease scoping review sensorineural hearing loss serotonin specific reuptake inhibitors tricyclic antidepressants vertigo

Anatomical variation of the posterior septal artery leads to refractory epistaxis

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World Journal of Otorhinolaryngology-head and neck surgery 2024年第3期10卷 241-243页

作者： Dong-Jiao An Zu-Fei Li Xiao-Chang Zhao Jin-Feng Liu department of Anaesthesiology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina department of Otorhinolaryngology head and neck surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina

Purpose:To report a rare variant of the posterior septal artery(PSA),which supplies blood to the posterior mucosa of the contralateral nasal *** report:A 31-year-old female patient underwent suture removal 14 days after septoplasty and developed left-sided epistaxis 6 h after suture *** safely and effectively relieve the patient from epistaxis,the cauterization of the left PSA was performed under general ***,24 h after the first surgical hemostasis,the patient experienced epistaxis again in the right nasal *** have reviewed the patient's sinus computed tomography again and found a rare variant of PSA,which is the right-sided PSA passing through a bony canal in the left-sided nasal ***:The variant of PSA well explained the failure of the first hemostatic ***,we again performed a cauterization of the right-sided PSA,after which the patient recovered and no further epistaxis ***:When cauterization of PSA is used to manage posterior epistaxis,it is necessary to pay attention to the possible variation in PSA.

关键词： cauterization nasal endoscopy posterior septal artery refractory epistaxis sphenopalatine artery

Analysis of the Influence of Sound Source Position and Electrode Placement on the Stimulation Pattern of the Cochlear Implant under Noise Conditions: Optimization of Auditory Perceptual Effects

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International Journal of otolaryngology and head & neck surgery 2024年第3期13卷 194-212页

作者： Johannes Burkart School of Advanced Education Research and Accreditation Castell&#243n de la Plana Spain department of Otorhinolaryngology Head and Neck Surgery University Hospital Mannheim Mannheim Germany

Background: Cochlear implants (CI) are widely used to restore hearing in people with severe to profound hearing loss. However, optimizing CI performance, especially in difficult listening environments with background noise, remains a major challenge. Understanding the influence of factors such as sound source position and electrode placement on CI stimulation patterns is critical to improving auditory perception. Methods: In this study, an analysis was conducted to investigate the influence of sound source position and electrode placement on CI stimulation patterns under noisy conditions. For this purpose, a special measurement setup with a CI speech processor-microphone test box was used to simulate realistic listening scenarios and measure CI performance. Results: The results show that the effectiveness of CI noise reduction systems is influenced by factors such as the position of the sound source and electrode placement. In particular, the beamforming ultra zoom mode showed significantly better noise reduction than the omnidirectional mode, especially under real listening conditions. Furthermore, differences in electrode responses indicate individual variability in the CI user experience, highlighting the importance of personalized fitting algorithms. Conclusions: The results demonstrate the importance of considering environmental factors and individual differences when optimizing CI performance. Future research efforts should focus on the development of personalized fitting algorithms and the exploration of innovative strategies, such as the integration of artificial intelligence, to improve CI functionality in different listening environments. This study contributes to our understanding of CI stimulation patterns and lays the foundation for improving auditory perception in CI users.

关键词： Cochlear Implants Noise Reduction Ultra Zoom Beamforming Anatomical Variations Personalized Fittings

Obstructive Tumor of the Palate in the Old Person: A Case Report

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Open Journal of Stomatology 2024年第5期14卷 199-205页

作者： Silly Toure Mouhamadou Makhtar Ndiaye Abibou Ndiaye Mamadou Coume Mame Sanou Diouf Baye Karim Diallo Maxillofacial surgery and Stomatology department Aristide Le Dantec University Hospital of Dakar Dakar Senegal Geriatrics department Aristide Le Dantec University Hospital of Dakar Dakar Senegal ENT and head and neck surgery department FANN University Hospital of Dakar Dakar Senegal

Introduction: Pleomorphic adenoma or mixed salivary gland tumor is a heterogeneous benign tumor of the salivary glands. The most common site is the parotid gland. Its extra-parotid locations, particularly in the accessory salivary glands, are rarer. We report a case of a pleomorphic adenoma of the posterior palate which posed management problems. Observation: This is an 85-year-old patient who consulted for a tumor of the posterior palate that had been evolving for 3 years. The examination revealed a globular tumor of the posterior palate extending beyond the midline by approximately 7 cm in long axis, shooting towards the oropharynx and hindering breathing, speech and eating, indicating a life-saving tracheotomy. A CT scan of the facial area revealed a well-circumscribed tumor at the expense of the soft palate, with multiple sites of bone lysis. The biopsy performed was in favor of a pleomorphic adenoma. The patient underwent total surgical excision of a huge tumor on the palate. The aftermath of the operation was marked by a loosening of the sutures with an oronasal fistula requiring the creation of an obturator plate due to the patient’s refusal to have another operation. Conclusion: Large pleomorphic adenoma of the posterior palate is a rare entity that can cause respiratory problems and surgical difficulties. His prognosis is generally good.

关键词： Pleomorphic Adenoma Posterior Palate Respiratory Disorders Prognosis Obturator Plaque

Primary chordoma of the nose

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Chinese Medical Journal 2003年第1期116卷 154-156页

作者：牟忠林刘兆华 department of otolaryngology-head and neck surgery

Chordoma as a rare malignant tumor arising from remnants of the notochord, accounts for 4% of malignant bone tumors. It occurs twice as frequently in men compared with women and is uncommon in individuals less than 40 years of age.1-3 Topographic distribution is spheno-occipital (35% to 44%), vertebral (15%), and sacrococcygeal (42% to 50%).4 Unusual locations include the mandible and the maxilla, and lesions in these locations have been called ectopic or dental chordomas. Some chordomas with nasal and paranasal presentations have been reported, but primary chordoma of the nose occurs rarely. To our knowlege only two cases have been reported so far according to the literature.4,5 In this paper, we present primary chordoma of the nose, its characteristics and our experiences with it.

关键词： EXPERIENCE

An intelligent prediction model of epidemic characters based on multi-feature

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 595-607页

作者： Xiaoying Wang Chunmei Li Yilei Wang Lin Yin Qilin Zhou Rui Zheng Qingwu Wu Yuqi Zhou Min Dai Information Center Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina School of Computer Science Qufu Normal UniversityRizhaoChina department of Allergy Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhou China 4department of Otorhinolaryngology‐head and neck surgery Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina department of Pulmonary and Critical Care Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina department of Traditional Chinese Medicine Third Affiliated Hospital of Sun Yat‐sen UniversityGuangzhouChina

The epidemic characters of Omicron(***-scale transmission)are significantly different from the initial variants of *** data generated by large-scale transmission is important to predict the trend of epidemic ***,the re-sults of current prediction models are inaccurate since they are not closely combined with the actual situation of Omicron *** consequence,these inaccurate results have negative impacts on the process of the manufacturing and the service industry,for example,the production of masks and the recovery of the tourism *** authors have studied the epidemic characters in two ways,that is,investigation and ***,a large amount of data is collected by utilising the Baidu index and conduct questionnaire survey concerning epidemic ***,theβ-SEIDR model is established,where the population is classified as Susceptible,Exposed,Infected,Dead andβ-Recovered persons,to intelligently predict the epidemic characters of *** thatβ-Recovered persons denote that the Recovered persons may become Sus-ceptible persons with probabilityβ.The simulation results show that the model can accurately predict the epidemic characters.

关键词： artificial intelligence big data data analysis evaluation feature extraction intelligent information processing medical applications

考虑各向异性变形的人耳鼓膜纤维增强细观本构模型

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Acta Mechanica Sinica 2024年第5期40卷 184-197页

作者：向书毅杜智博施汇斌严子铭孙永涛王杰柳占立 School of Aerospace Engineering Tsinghua University Beijing China department of Mechanics and Tianjin Key Lab of Nonlinear Dynamics and Control Tianjin University Tianjin China department of Otorhinolaryngology head and neck surgery Beijing Tongren Hospital Capital Medical University Beijing China Beijing Engineering Research Center of Audiological Technology Beijing China

鼓膜是听觉系统的重要组成部分,位于外耳道末端,是一种含胶原的多层软组织膜。鼓膜的纤维沿着径向和环向方向高度取向,其独特而复杂的超微结构使得力学行为呈现各向异性非线性,这对于声音传输很重要.然而,同时包含这两个特征的鼓膜本构... 详细信息

鼓膜是听觉系统的重要组成部分,位于外耳道末端,是一种含胶原的多层软组织膜。鼓膜的纤维沿着径向和环向方向高度取向,其独特而复杂的超微结构使得力学行为呈现各向异性非线性,这对于声音传输很重要.然而,同时包含这两个特征的鼓膜本构模型尚未提出.在本研究中,我们建立了考虑鼓膜纤维分布的细观本构模型,模型能够同时捕捉各向异性和非线性弹性力学行为.鼓膜被认为是包含两族胶原纤维的连续纤维增强复合材料,并通过整合沿厚度方向异质材料性质建立整体力学性质.均匀化的力学性质被假定沿着厚度方向均匀分布,并由径向胶原纤维,环向胶原纤维和等效各向同性基质的三个非耦合弹性贡献叠加组成.通过逆方法并使用文献数据校准模型.仿真结果表明,特定的胶原纤维排列是鼓膜条带试样变形呈现显著空间非均匀性及各向异性的原因。通过与纤维变形相关的强度准则,可以捕获在实验中观察到的鼓膜条带各向异性局部化失效模式。胶原纤维束的旋转和非线性性质是单轴加载下鼓膜条带非线性力学行为的起源.该细观本构模型为鼓膜的各向异性和非线性弹性力学行为提供了不同的视角.这项研究提高了我们对鼓膜力学行为的理解,并有助于仿生移植物的发展.

关键词：非线性弹性力学胶原纤维细观本构模型移植物空间非均匀性非线性性质听觉系统非线性力学行为

Chirality discerning and monitoring in a metal cladding optofluidic chip

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Chinese Optics Letters 2024年第8期22卷 52-57页

作者： Qiheng Wei Xueqian Wang Hongrui Shan Yi Lai He Li Hailang Dai Xianfeng Chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China department of head and neck surgery and department of Traditional Chinese Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

The metabolic process of chiral drugs plays a significant role in clinics and in research on ***,we experimentally demonstrate by all-optical means that the chiral molecules can be quickly discriminated and monitored with the ultrahighorder modes excited in a metal cladding optofluidic chip,achieving over 5 times sensitivity with a low-dosage *** show that the varying concentration of the chiral drugs can be monitored both in cell and animal experiments,presenting a significant difference between chiral enantiomers at the optimal function time and the effect of the *** our knowledge,this approach provides a new way to achieve important chiral discrimination for the pharmacokinetics and the pharmacodynamics and may present opportunities in indicating the health status of humans.

关键词： chiral detection ultrahigh-order guided modes metal cladding optofluidic chip high sensitivity circularly polarized light

Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-head and neck surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna department of surgery Londrina State UniversityLondrinaBrazil department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil department of Otorhinolaryngology University of São PauloSao PauloBrazil department of Otorhinolaryngology:head and neck surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss