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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao Lin Lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang Kun Chen department of Public health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China department of Public health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China department of Public health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

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health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency

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Journal of Environmental Sciences 2025年第5期151卷 150-160页

作者： Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia department of Occupational and Environmental health Sciences School of Public HealthPeking UniversityBeijing 100083China School of Engineering medicine and Beijing Advanced Innovation Center for Big Data-Based Precision medicine Beihang UniversityBeijing 100083China department of Toxicology School of Public HealthBaotou Medical CollegeBaotouInner Mongolia 014040China Henan Institute for Occupational medicine Zhengzhou 450052China National Center for Occupational Safety and health Beijing 102308China Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety School of Public HealthPeking UniversityBeijing 100083China

Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain *** on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic *** kernel regressionwas employed to explore the combined effects of elements and the contributions of single *** results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.228 and 0.598 units,respectively,at the 75th *** single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of *** addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关键词： Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect

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Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho Ito Takeshi Kawauchi department of Adaptive and Maladaptive Responses in health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

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Real-world cost-effectiveness of targeted temperature management in out-of-hospital cardiac arrest survivors: results from an academic medical center

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World Journal of Emergency medicine 2025年第1期16卷 28-34页

作者： Wachira Wongtanasarasin Daniel K.Nishijima Wanrudee Isaranuwatchai Jeff rey S.Hoch department of Emergency medicine Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand department of Emergency medicine University of California Davis School of MedicineSacramento 95817USA health Intervention and Technology Assessment Program Ministry of Public HealthBangkok 11000Thailand Institute of health Policy Management and EvaluationUniversity of TorontoToronto M5T 3M6Canada Division of health Policy and Management Department of Public Health SciencesUniversity of California Davis School of MedicineSacramento 95817USA Center for healthcare Policy and Research University of California Davis School of MedicineSacramento 95817USA

BACKGROUND: Targeted temperature management(TTM) is a common therapeutic intervention, yet its cost-effectiveness remains uncertain. This study aimed to evaluate the real-world cost-effectiveness of TTM compared with that of conventional care in adult out-of-hospital cardiac arrest(OHCA) survivors using clinical patient-level ***: We conducted a retrospective cohort study at an academic medical center in the USA to assess the cost-effectiveness of TTM in adult non-traumatic OHCA survivors between 1 January, 2019 and 30 June, 2023. The primary outcome was survival to hospital discharge. Incremental cost-effectiveness ratios(ICERs) were calculated and compared with various decision makers' willingness to pay. Cost-effectiveness acceptability curves were utilized to evaluate the economic attractiveness of TTM. Uncertainty about the incremental cost and effect was explored with a 95% confidence ***: Among 925 non-traumatic OHCA survivors, only 30(3%) received TTM. After adjusting for potential confounders, the TTM group did not demonstrate a significantly lower cost(delta cost-$5,141, 95% confidence interval [95% CI]: $-35,347 to $25,065, P=0.79) and higher survival to hospital discharge(delta effect 6%, 95% CI:-11% to 23%, P=0.41). Additionally, a 95% confidence ellipse indicated uncertainty reflected by evidence that the true value of the ICER could be in any of the quadrants of the cost-effectiveness ***: Although TTM did not demonstrate a clear survival benefit in this study, its potential cost-effectiveness warrants further investigation with larger sample sizes. These findings highlight the need for additional research to optimize TTM use in OHCA care and inform resource allocation decisions.

关键词： Out-of-hospital cardiac arrest Targeted temperature management Cost-effectiveness Survival Real-world data

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Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 222-228页

作者： Ahmet Mehmet Somuncu Busra Parlak Somuncu Ahmet Duhan Ozbay Ibrahim Cicek Bahadir Suleyman Renad Mammadov Seval Bulut Tugba Bal Tastan Taha Abdulkadir Coban Halis Suleyman Aliyev Aydin Trabzon Kanuni Education and Research Hospital Health Sciences UniversityTrabzon 61250Turkiey Provincial health Directorate Ministry of Health of the Republic of TurkeyTrabzon 61040Turkiey department of Ophthalmology Erzurum City HospitalHealth Sciences UniversityErzurum 25240Turkiey department of Ophthalmology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey department of Pharmacology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey department of Histology and Embryology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey department of Biochemistry Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey department of Pharmacology Azerbaijan Medical UniversityBakuAZ1022Azerbaijan

AIM:To investigate the effects of adenosine triphosphate(ATP)and melatonin,which have antioxidant and antiinflammatory activities,on potential 5-fluorouracil(5-FU)-induced optic nerve damage in ***:Twenty-four rats were categorized into four groups of six rats:healthy(HG),5-FU(FUG),ATP+5-FU(AFU),and melatonin+5-FU(MFU).ATP(4 mg/kg)and melatonin(10 mg/kg)were administered intraperitoneally and orally,*** hour after ATP and melatonin administration,rats in the AFU,MFU,and FUG were intraperitoneally injected with 5-FU(100 mg/kg).ATP and melatonin were administered once daily for 10d.5-FU was administered at a single dose on days 1,3,and 5 of the *** 10d,the rats were euthanized and optic nerve tissues were *** nerve tissues were biochemically and histopathologically ***:ATP and melatonin treatments inhibited the increase in malondialdehyde(MDA)and interleukin-6(IL-6)levels,which were elevated in the *** treatments also prevented the decrease in total glutathione(tGSH)levels and the superoxide dismutase(SOD)and catalase(CAT)activities(P<0.001).This inhibition was higher in the ATP group than in the melatonin group(P<0.001).ATP prevented histopathological damage better than melatonin(P<0.05).CONCLUSION:ATP and melatonin have the potential to be used in alleviating 5-FU-induced optic nerve *** addition,ATP treatment shows better protective effects than melatonin.

关键词： adenosine triphosphate melatonin 5-fluorouracil optic nerve damage antioxidant antiinflammatory

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Solid pseudopapillary neoplasm of the pancreas in an adolescent:A case report and review of the literature

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 424-430页

作者： Aakriti Sapkota Rajesh Paudel Sandip Pandey Navin Bhatt department of medicine B.P.Koirala Institute of Health SciencesDharan 56700KoshiNepal department of Radiodiagnosis and Imaging B.P.Koirala Institute of Health SciencesDharan 56700KoshiNepal department of medicine NYC Health+Hospitals/ElmhurstIcahn School of Medicine at Mount SinaiElmhurstNY 11373United States

BACKGROUND Solid pseudopapillary neoplasm(SPN)of the pancreas is a rare epithelial tumor that primarily affects young *** the condition is often asymptomatic or presents with non-specific symptoms,its diagnosis can be *** SUMMARY This report details the case of a 15-year-old girl who presented with a 2-year history of abdominal pain,with no significant findings during physical *** ultrasound revealed a well-defined heterogeneous solidcystic mass in the epigastric region,likely originating from the tail of the pancreas.A subsequent contrast-enhanced computed tomography scan indicated a welldefined cystic lesion with an enhancing solid component and capsule in the tail of the pancreas,suggestive of a cystic *** patient underwent an open distal pancreatectomy with splenectomy,and histopathological analysis confirmed the diagnosis of SPN of the *** This case highlights the risk of SPN in adolescent girls and the necessity of early diagnosis and intervention for better outcomes.

关键词： Adolescents Pseudopapillary neoplasm Pancreas Pancreatectomy Splenectomy Postoperative pancreatic fistula Case report

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy department of Internal medicine Texas Tech University Health Sciences CenterLubbockTXUSA department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA department of Public health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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DNA methylation in the association between pesticide exposures and type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 237-245页

作者： Guang-Jun Zheng Zheng-Er Fang Bi-Ying Zhou Lei Zuo Xia Chen Ming-Liang Liu Lei Yu Chun-Xia Jing Guang Hao department of Public health and Preventive medicine School of MedicineJinan UniversityGuangzhou 510632Guangdong ProvinceChina department of Pathophysiology School of MedicineJinan UniversityGuangzhou 510632Guangdong ProvinceChina Guangdong Key Laboratory of Environmental Exposure and health Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Guangdong Provincial Engineering Research Center of Public health Detection and Assessment School of Public HealthGuangdong Pharmaceutical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes(T2D);however,the underlying mechanisms remain *** methylation may play a role in this *** To identify the genes associated with pesticide exposure and T2D by reviewing the current *** We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation,and studies on DNA methylation and T2D through January 15,*** We identified six genes(Alu,CABLES1,CDH1,PDX1,PTEN,PTPRN2)related to pesticide exposure and *** also suggested future research directions to better define the role of DNA methylation in the association between pesticide exposure and *** DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.

关键词： DNA methylation Pesticide exposure Type 2 diabetes Gene Mechanisms

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