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Retrospective Study of 23 Cases of Psoriasis Association with HIV infection Observed in the department of Dermatology-STD in the University Hospital of Donka Conakry Guinea

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第1期8卷 1-5页

作者： M. Keita M. M. Soumah T. M. Tounkara D. Sylla B. F. Diané F. B. Sako H. Baldé M. Cissé department of Dermatology-STD in the University Hospital of Donka Conakry Guinea department of Intensives Cares Medico-Surgeon Urgences in the University Hospital of Donka Conakry Guinea department of Tropical infection Diseases in the University Hospital of Donka Conakry Guinea

Introduction :The psoriasis is one of the inflammatory dermatoses with unknown etiology, with chronic evolution having episodic appearance and disappearance. Its prevalence in HIV patients varied from 2% to 5% in most of the times. Objective of this study was to describe the demographic, clinical and therapeutic characteristics of psoriasis patients infected with HIV. Methods: It is a descriptive retrospective study done from January 2003 to December 2013 based on the information from the hospital card of hospitalized patients and outpatients taken care in the department of Dermatology-STD for psoriasis at the University hospital center in Donka Conakry. We included all the cases of psoriasis associated with HIV infection diagnosed from clinical and paraclinical elements. Results: We recorded 23 (24.73%) cases of psoriasis associated with HIV infection among 93 patients observed for psoriasis in which there are 4 cases of psoriasis vulgaris, 10 cases of erythrodermic psoriasis and 9 cases of arthropathic form among these numbers. We had 7 women and 16 men. The medium age of our patients was 44.5 ± 12 years [27 - 62 years]. The delayed duration time of consultation varied from 30 to more than 180 days. The psoriasis was the circumstance of the discovery of the HIV infection among 55% of cases. The pruritus was the functional sign which is the most frequent in 20 cases among 23 cases and 71.4% of cases were accompanied with pain. Family history was found in 7.10% of cases. Anxiety was the dominant factor cause in 42% and the infection 38%. The cutaneous alteration was noted in all patients;92.9% of patients had nails alteration and intertrigineous association in 78.6% of cases. The clinical forms found were psoriasis vulgaris 4/23 cases, arthropathic psoriasis 9/23 cases, erythrodermic psoriasis 10/23. More than half (13/23) cases of our patients were diagnosed stage III of the classification of WHO. The complicated forms like erythrodermic and arthropathic psoriasis

关键词： Psoriasis HIV infection Epidemiology Clinical Therapeutic Guinea

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu department of infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review

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World Journal of Critical Care Medicine 2025年第1期14卷 49-59页

作者： Angajendra N Ghosh Calum J Walsh Matthew J Maiden Tim P Stinear Adam M Deane department of Intensive Care The Northern HospitalEpping 3076VictoriaAustralia department of Microbiology and Immunology The Peter Doherty Institute for Infection and ImmunityMelbourne 3052VictoriaAustralia department of Intensive Care The Royal Melbourne HospitalThe University of MelbourneParkville 3050VictoriaAustralia department of Intensive Care Medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly *** strategies to modulate the GI microbiota during chronic diseases have demonstrated *** changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain *** fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI *** aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical *** controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were *** show dietary fibres have an impact on faecal microbiota in health and *** fibre,inulin,has a marked and specific effect on increasing the abundance of faecal *** chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient *** few trials have evaluated the effect of dietary fibre on the GI microbiota during critical *** research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关键词： Gastrointestinal microbiota Dietary fibre Health Critical illness Short chain fatty acids

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Influenza virus H1N1 induced apoptosis of mouse astrocytes and the effect on protein expression

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 572-575页

作者： Xu-Dong Pei Yu-Feng Zhai Huai-Hong Zhang department of infection and Liver Disease Nanyang Central Hospital

Objective:To investigate the effects of influenza A virus H1N1 infection on the proliferation and apoptosis of mouse astrocytes cells and its protein ***:After mouse astrocytes was infected with purified influenza A virus H1N1 in vitro,viral integration and replication status of the cells were detected by RT-PCR assay,cell proliferation and apoptosis was determined by MTT method and flow cytometry,*** protein expression was delected by Western ***:Agarose gel electrophoresis showed H1N1 virus can infect astrocytes and can be *** staining showed H1N1 virus infection can inhibit the proliferation of mouse astrocytes,which makes cell viability decreased *** cytometry showed that the proportion of Annein V staining positive vascular endothelial cells in the influenza A virus group was significantly higher than that in the control *** blot analysis showed after24 h and 32 h of infection,there were cells caspase-3 protein and the expression of its active form(lysed caspase-3 protein)*** proportion of Bax/Bcl-2 also ***:Influenza A virus can infect human vascular endothelial cells and proliferation and it can induce apoptosis of endothelial cells.

关键词： Influenze virus H1N1 Apoptosis

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Intestinal detoxification time of hand-foot-and-mouth disease in children with EV71 infection and the related factors

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World Journal of Pediatrics 2015年第4期11卷 380-385页

作者： Shu Teng Yi Wei Shi-Yong Zhao Xian-Yao Lin Qi-Min Shao Juan Wang department of Pediatric infection Hangzhou Children's HospitalHangzhouChina

Background:Hand-foot-and-mouth disease(HFMD)is a common pediatric infectious disease caused by a variety of intestinal *** 71(EV71)is the primary pathogen that might cause severe symptoms and even death in children with *** study aimed to investigate the intestinal detoxification time of HFMD children with EV71 infection and its related ***:Sixty-five HFMD children with EV71 infection were followed *** stool samples were collected once every 4 to 7 *** nucleic acids were detected byfl uorescent polymerase chain reaction until the results became *** positive rates of viral nucleic acids were analyzed by the Kaplan-Meier *** Log-rank test and Cox-Mantel test were used to analyze factors affecting the HFMD children with EV71 ***:On the 2nd,4th,6th and 10th week,the positive rates of viral nucleic acids in stool samples of the 65 children were 94.6%,48.1%,17.2%and 0,*** analysis showed that the intestinal detoxification time of the children were related to gender,pre-admission disease course,severity of disease,and use of steroids or gamma globulin(Pinfection was 10 *** severity of disease was an important factor affecting the intestinal detoxification time of HFMD children with EV71 *** HFMD children with EV71 infection had a longer intestinal detoxification time.

关键词： detoxification time enterovirus 71 hand-foot-and-mouth disease relative factor

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Pathological process of liver sinusoidal endothelial cells in liver diseases

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World Journal of Gastroenterology 2017年第43期23卷 7666-7677页

作者： yao ni juan-mei li ming-kun liu ting-ting zhang dong-ping wang wen-hui zhou ling-zi hu wen-liang lv department of infection Guang’anmen HospitalChina Academy of Chinese Medical Sciences

Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix,which is closely related to liver sinusoidal endothelial cells(LSECs). Damaged LSECs can synthesize transforming growth factor-beta and platelet-derived growth factor,which activate hepatic stellate cells and facilitate the synthesis of extracellular matrix. Herein,we highlight the angiogenic cytokines of LSECs related to liver fibrosis and cirrhosis at different stages and focus on the formation and development of liver fibrosis and cirrhosis. Inhibition of LSEC angiogenesis and antiangiogenic therapy are described in detail. Targeting LSECs has high therapeutic potential for liver diseases. Further understanding of the mechanism of action will provide stronger evidence for the development of anti-LSEC drugs and new directions for diagnosis and treatment of liver diseases.

关键词： Sinusoidal endothelial cells Hepatitis Fibrosis Cirrhosis Liver disease

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Identification of a CD4 T-cell epitope in the hemagglutinin stalk domain of pandemic H 1N 1 influenza virus and its antigen-driven TCR usage signature in BALB/c mice

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Cellular & Molecular Immunology 2017年第6期14卷 511-520页

作者： I-Na Lu Sophie Farinelle Aurelie Sausy Claude P Muller department of infection and Immunity Luxembourg Institute of Health Esch-sur-Alzette L-4354 Luxembourg

The stalk region of the influenza virus hemagglutinin is relatively well conserved compared with the globular head domain, which makes it a potential target for use as a universal vaccine against influenza. However, the role of CD4 T cells in the hemagglutinin stalk-specific immune response is not clear. Here we identified a mouse CD4 T-cell epitope that encompasses residues HA2113-131 from the hemagglutinin stalk domain after a sub-lethal infection of influenza. In response to stimulation with the identified epitope, splenocytes derived from the infected mice showed significant polyfunctionality as shown by IL-2, TNF-a and IFN-7 production as well as degranulation. Moreover, mice immunized with the peptide corresponding to this CD4 T-cell epitope exhibited interindividual sharing of the CD4 T-cell receptor I~ sequences, and they had a higher survival rate following a challenge with a lethal dose of pandemic H IN 1 influenza virus. Thus, our data demonstrated a crucial role of hemagglutinin stalk-specific CD4 T cells in the host immune resoonse a^ainst influenza virus infection.

关键词： H1N1 hemagglutinin influenza T-cell receptor

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The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1211-1221页

作者： Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria Ebel Till Strowig Jochen Huehn Joern Pezoldt department Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany department Microbial Immune Regulation Helmholtz Centre for Infection ResearchBraunschweigGermany department of Computational Biology for Individualised Medicine Centre for Individualised Infection MedicineHelmholtz Centre for Infection Research and Hannover Medical SchoolHannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical SchoolHannoverGermany Laboratory of Systems Biology and Genetics École Polytechnique Fédérale de LausanneLausanneSwitzerland

Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and *** bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(SCFAs),have been reported to promote Treg homeostasis in the intestinal lamina ***,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully ***,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of *** mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within *** molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic ***,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs.

关键词： Peripheral regulatory T cells Microbiota Tolerance

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Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 609-633页

作者： Ghaliah Alhamzi Badr Saad TAlkahtani Ravi Shanker Dubey Mati ur Rahman department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh13318Saudi Arabia department of Mathematics College of ScienceKing Saud UniversityRiyadh11989Saudi Arabia department of Mathematics Amity School of Applied SciencesAmity University RajasthanJaipur302002India School of Mathematical Sciences Jiangsu UniversityZhenjiang212013China department of Computer Science and Mathematics Lebanese American UniversityBeirut13-5053Lebanon

This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary *** HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered *** total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,*** proposed model is tested separately for unique solutions and existence on bi *** numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons *** proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler *** cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said *** study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered *** obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.

关键词： HIV infection model qualitative scheme approximate solution piecewise global operator neural network

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Indole-3-propionic Acid-aggravated CCl_(4)-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway

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Journal of Clinical and Translational Hepatology 2021年第6期9卷 917-930页

作者： Fei Liu Changfeng Sun Yuanfang Chen Fei Du Yuxiang Yang Gang Wu department of Infectious Diseases Department of TuberculosisLaboratory of Infection and ImmunityThe Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanChina

Background and Aims:The pathogenesis of liver fibrosis involves liver damage,inflammation,oxidative stress,and intestinal ***-3-propionic acid(IPA)has been demonstrated to have antioxidant,anti-inflammatory and anticancer activities,and a role in maintaining gut *** current study aimed to investigate the role of IPA in carbon tetrachloride(CCl4)-induced liver fibrosis and explore the underlying ***:The liver fibrosis model was established in male C57BL/6 mice by intraperitoneal injection of CCl4 twice *** intervention was made orally(20 mg/kg daily).The degree of liver injury and fibrosis were assessed by serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and ***-linked immunosorbent assay and quantitative real-time polymerase chain reaction(qPCR)were used to detect the inflammatory *** malondialdehyde(MDA),glutathione,glutathione peroxidase,superoxide dismutase,and catalase were determined via commercial *** apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling *** expression of mRNA and protein was assayed by qPCR,Western blotting,or immunohistochemical ***:After IPA treatment,the ALT and AST,apoptotic cells,and pro-inflammatory factor levels were enhanced ***,IPA intervention up-regulated the expression of collagen I,α-smooth muscle actin,tissue inhibitor of matrix metalloproteinase-1,matrix metalloproteinase-2,transforming growth factor-β1(TGF-β1),Smad3,and phosphorylated-Smad2/***,IPA intervention did not affect the MDA ***,the administration of IPA remodeled the gut flora ***:IPA aggravated CCl_(4)-induced liver damage and fibrosis by activating HSCs via the TGF-β1/Smads signaling pathway.

关键词： Indole-3-propionic acid CCl_(4) Hepatic fibrosis HSCs TGF-β1

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