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Chinese Journal of chemistry 2003年第10期21卷 1395-1399页

作者：李振秦金贵李绍军叶成 department of chemistry Center for molecular Science

A new strategy, a post coupling method to develop the polyphosphazene (P2) functionalized with carbazolyl groups and nonlinear optical (NLO) chromophores, has been explored. P2 exhibits good solubility in common organic solvents. The poled film of P2 exhibits a resonant d 33 value of 42 pm/V by second harmonic generation (SHG) measurements.

关键词： post coupling method polyphosphazene synthesis

Crystal Structure of 2,6-Dihistidine Dimethyl Ester Pyridine Acylamine Monohydrate

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Chinese Journal of Structural chemistry 2010年第2期29卷 255-259页

作者：刘艳玲霍方俊阴彩霞杨频 department of chemistry Lvliang Teacher's College Research Institute of Applied chemistry Shanxi University Institute of molecular Science Chemical Biology and Molecular Engineering Laboratory of Education MinistryShanxi University

The crystal structure of the title compound,C21H25N7O7,has been determined in the orthorhombic space group C222（1） with a=8.993（10）,b=12.149（14）,c=22.20（2）A and Z=*** exist intramolecular C-H…O and N-H…N hydrogen bonds in the title crystal *** intermolecular N-H…N and C-H…O hydrogen bonds together with π-π stacking interactions（face-to-face） link the molecules into an infinite three-dimensional supramolecular network.

关键词： histidine crystal structure π-π stacking interaction hydrogen bonds

Investigation of the Inhibition of Cyanide on Metabolism of Fish Liver Mitochondria by Microcalorimetry

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Chinese Journal of chemistry 2006年第5期24卷 627-630页

作者：李会荣刘义戴捷覃彩芹张忠海屈松生 department of Chemical biology College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China department of chemistry Xiaogan University Xiaogan Hubei 432100 China

A microcalorimetric technique based on the metabolic heat-output was explored to evaluate the inhibition of cyanide on the mitochondrial metabolism of aquatic animal, Cyprinus carpio. The power-time curves could be divided into four parts： lag phase, active recovery phase, stationary phase, and decline phase, and the corresponding thermokinetic parameters were obtained. The maximum heat production rate Pmax decreased in a linear manner with the increase of concentration of cyanide, however, such mitochondria of aquatic animal were still metabolized actively even under the action of high concentration of cyanide. All the observations suggested that the mitochondria of this aquatic animal should exhibit considerable ability of cyanide-resistant respiration.

关键词： mitochondria microcalorimetry metabolism sodium cyanide

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

Apoptosis induced by NaYF_4:Eu^(3+) nanoparticles in liver cells via mitochondria damage dependent pathway

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Science China chemistry 2017年第1期60卷 122-129页

作者： Shaohan Zhang Shizhu Chen Chunyue Gao Yi Jin Guang Jia Zhenhua Li Dandan Liu Xingjie Liang Xinjian Yang Jinchao Zhang College of chemistry & Environmental Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei University CAS Key Laboratory for biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

As lanthanide-doped sodium yttrium flouride(NaYF_4)nanoparticles have great potential inbiomedical applications,their biosafety is important and has attracted significant *** the present work,three different sized NaYF_4:Eu^(3+)nanoparticles have been *** BRL 3 A cell was used as a cell model to evaluate their biological *** viability and apoptosis assays were used to confirm the cytotoxicity induced by NaYF_4:Eu^(3+)*** from the elevated malondialdehyde(MDA),the decrease of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)and catalase(CAT)activity indicated reactive oxygen species(ROS)generation,which were associated with oxidative *** decrease of mitochondrial membrane potential(MMP)value demonstrated the occurrence of mitochondria ***,release of cytochrome c from mitochondria and activation of caspase-3 confirmed that NaYF_4:Eu^(3+)NPs induced apoptosis was mitochondria damage-dependent.

关键词： NaYF4 nanoparticles liver cells apoptosis oxidative stress mitochondria damage

Higher-order assemblies in immune signaling:supramolecular complexes and phase separation

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Protein & Cell 2021年第9期12卷 680-694页

作者： Shiyu Xia Zhenhang Chen Chen Shen Tian-Min Fu department of biological chemistry and molecular Pharmacology Harvard Medical Schooland Program in Cellular and Molecular MedicineBoston Children's HospitalBostonMA 02115USA department of biological chemistry and Pharmacology The Ohio State UniversityColumbusOH 43210USA The Ohio State University Comprehensive Cancer Center ColumbusOH 43210USA

Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune ***-order assemblies have recently emerged as a central principle that governs immune signaling and,by extension,cellular communication in *** are mainly two types of higher-order assemblies:1)ordered,solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions,and 2)liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular *** review covers key examples of both types of higher-order assemblies in major immune *** placing emphasis on the molecular structures of the examples provided,we discuss how their structural organization enables elegant mechanisms of signaling regulation.

关键词： higher-order assembly phase separation signalosome cGAS inflammasome TCR BCR TLR RLR TNFR death domain immune signaling

Interface formation energy,bonding,energy band alignment in α-NaYF4 related core shell models:For future multi-layer core shell luminescence materials

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Journal of Rare Earths 2017年第4期35卷 315-334页

作者：黄勃龙董浩 Wong Ka-Leung 孙聆东严纯华 department of Applied biology and Chemical Technology The Hong Kong Polytechnic University Beijing National Laboratory for molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking University department of chemistry Hong Kong Baptist University

To break through the bottle-neck of quantum yield in upconversion （UC） core-shell system, we elucidated that the energy transfer efficiency in core-shell system had an evident contribution from the charge transfer of interface with related to two factors：（i） band offsets and （2） binding energy area density. These two variables were determined by material intrinsic properties and core-shell thickness ratio. We further unraveled the mechanism of non-radiative energy transfer by charge transfer induced dipole at the inter- face, based on a quasi-classical derivation from F6rster type resonant energy transfer （FRET） model. With stable bonding across the interface, the contributions on energy transfer in both radiative and non-radiative energy transfer should also be accounted together in Auzel＇s energy transfer （ETU） model in core-shell system. Based on the discussion about interface bonding, band offsets, and forma- tion energies, we figured out the significance of interface bonding induced gap states （IBIGS） that played a significant role for influ- encing the charge transfer and radiative type energy transfer. The interface band offsets were a key factor in dominating the non-radiative energy transfer, which was also correlated to core-shell thickness ratio. We found that the energy area density with re- lated to core/shell thickness ratio followed the trend of Boltzman sigmoidal growth function. By the physical trend, this work contrib- uted a reference how the multi-layered core-shell structure was formed starting from the very beginning within minimum size. A route was paved towards a systematic study of the interface to unveil the energy transfer mechanism in core-shell systems.

关键词： interface band-offset core-shell energy-transfer rare earths

Expression profiles and transactivation analysis of a novel ethylene-responsive transcription factor gene GhERF5 from cotton

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Progress in Natural Science:Materials International 2009年第5期19卷 563-572页

作者： Longguo Jin, Bo Huang, Hui Li, Jinyuan Liu Laboratory of molecular biology and MOE Laboratory of Protein Science, department of biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China [a]Laboratory of molecular biology and MOE Laboratory of Protein Science Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China

Plant AP2/EREBP transcription factors play important roles in plant development and in plant responses to biotic and abiotic stresses. A novel gene for ethylene-responsive element binding protein (EREBP), designated GhERF5, which encodes a protein of 255 amino acids, was isolated by RACE-PCR from cotton (Gossypium hirsutum) seedlings. Sequence alignment revealed that GhERF5 contains a typical AP2/ERF domain, and belongs to the B3 subgroup of the ERF subfamily. Particle bombardment assay showed that GhERF5 functions as an in vivo transcription activator in tobacco cells, and it is located in the nuclei of onion epidermis cells. Semi-quantitative RT-PCR revealed that the expression of GhERF5 was highly and rapidly induced when plants were treated with exogenous ethylene, abscisic acid (ABA), salt, cold and drought. Promoter analysis indicated that there are conserved cis-acting elements induced by these stresses in the 50-upstream region of the GhERF5 gene. These results suggest that the GhERF5 gene might play an important role in cotton response to ethylene, ABA and environmental stresses.

关键词： Ethylene-responsive element binding factor (ERF) Abiotic stresses Nuclear localization Transactivation Gossypium hirsutum

Identification and Characterization of a Rat Novel Gene RSEP4 Expressed Specifically in Central Nervous System

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 501-507页

作者： Xi-Dao WANG1,2, Ling-Wei KONG1, Zhi-Qin XIE1, Yu-Qiu ZHANG3, Zhi-Xin LIN2, Zhi-Qi ZHAO3,Lei YU4, and Nai-He JING1* 1 Laboratory of molecular Cell biology, Laboratory of Stem Cell biology, Institute of Biochemistry and Cell biology, Shanghai Institutes for biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China School of Life Science and Biotechnology, 2 Shanghai Jiaotong University, Shanghai 200030, China Institute of Neurobiology, Fudan University, Shanghai 200433, China 3 4 department of Cell biology, Neurobiology and Anatomy, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA Laboratory of molecular Cell biology and Stem Cell biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China

The low-abundantly expressed genes composed the majorities of the mRNAs expressed in the central nervous system (CNS), and were thought to be important for the normal brain functions. Through differential screening a low-abundance cDNA sublibrary with mRNA from neuropathic pain of chronic constriction injury (CCI) model, we have identified a novel rat gene, rat spinal-cord expression protein 4 gene (RSEP4). The total length of RSEP4 cDNA is 2006 bp, with a 501 nucleotide open reading frame (ORF) that encodes a 167 amino acid polypeptide. Northern blot revealed that RSEP4 was expressed specifically in the CNS. In situ hybridization showed that the mRNA of RSEP4 was strongly expressed in the CA1, CA2, CA3 and DG regions of hippocampus, the Purkinje cells of cerebellum, and the small sensory neurons of dorsal horn and large motor neurons of ventral horn of spinal cord. Over-expression of RSEP4-EGFP fusion protein in the human embryonic kidney 293T cells showed that RSEP4 protein was mainly localized in the cell cytoplasm. These results suggest that RSEP4 may play some roles in the CNS.

关键词： central nervous system (CNS) rat Northern blot in situ hybridization

Multiple factors correlating with wing malformations in the population of Parnassius apollo (Lepidoptera: Papilionidae) restituted from a low number of individuals: A mini review

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Insect Science 2019年第3期26卷 380-387页

作者： Karolina Pierzynowska Marta Skowron Volponi Grzegorz Wegrzyn department of molecular biology University of Gdansk Gdansk Poland

The Apollo butterfly, Parnassius apollo (Linnaeus), was common in Europe over 100 years ago, but currently it is considered as near threatened. Different conservation programs have promoted the persistence of this species;however, it is still endangered. An example of such programs was the action devoted to reestablish the Apollo butterfly population in Pieniny National Park (Poland) from only 20-30 individuals which had survived till the last decade of the 20th century. This reintroduction has been successful;however, unexpected developmental problems appeared. Butterflies with deformed or reduced wings became frequent in the population living in the natural habitat, and particularly among those reared under seminatural conditions (in the same environment, but fenced by a net). Until recently, reasons for these malformations remained unknown. However, reports published during last months indicated that there are genetic, biochemical, and microbiological factors contributing to this phenomenon. In the malformed individuals, lesions in the wingless gene and dysfunctions of laccase 1 and 2 were found to be significantly more frequent than in normal insects. A large fraction of butterflies with deformed or reduced wings was devoid of the prokaryotic symbiont Wolbachia, which was present in most normal individuals. Moreover, Yersinia pseudotuberculosis (Pfeiffer) Smith and Thai, and Serratia sp., bacteria pathogenic to insects, were detected in the biological material from both normal and malformed butterflies from this population. These findings are summarized and discussed in this review, in the light of conservation of insects and restitution of their populations from a low number of individuals.

关键词： Apollo butterfly laccases malformed wings population reconstitution wingless gene Wolbachia