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Outbreaks of salmonellosis in three different poultry farms of Kerala,India

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 496-500页

作者： Ramachandranpillai Rajagopal Mangattumuruppel Mini department of veterinary Microbiology College of Veterinary and Animal Sciences

Avian salmonellosis is an important disease causing serious impediment to the development of poultry industry especially in developing countries of Asia and *** no"effective"immunoprophylactic measures are available for the disease till date,strict biosecurity is the only alternative to preclude the *** formulating the control measures,an understanding of the epidemiology of the disease,proper diagnosis and identification of the causative agent is *** report sheds light on three different outbreaks of salmonellosis in three different farms in Kerala(India)describing the disease diagnosis,antibiotic resistance and the suggested control *** the three isolates were revealed to be Salmonella gallinarum and were resistant to at least three of the antimicrobial agents tested.

关键词： Avian salmonella Biochemical identification Antibiotic sensitivity testing Drug resistance

Pharmacokinetics of Two Ingredients of the Compound Chinese Herbal Medicine Transdermal Preparation in Cows

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Agricultural Sciences in China 2009年第9期8卷 1138-1142页

作者： WANG Gui-xia LI Rui ZHANG Xiu-ying department of Basic veterinary Science College of Veterinary Medicine Northeast Agricultural University Harbin 150030 P.R.China

The topical administration of the compound Chinese herbal medicine transdermal preparation has been widely used in treating the mastitis of cows. In order to understand the metabolic process, four cows suffering from clinical mastitis were selected for the pharmacokinetic study. The transdermal preparation was applied to the diseased part of breast. Then the plasma and milk samples were collected respectively at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 36 h, The concentrations of baicalin and phillyrin in plasma and milk were determined by HPLC and the data of time-concentrations were analyzed by the pharmacokinetic software. The results showed that two ingredients in the plasma were not detectable, but they in the milk had linear relationship with the time. The peak concentration of baicalin [（2.84 ±0.15）μg mL^-1] appeared at （4.93 ± 0.35） h, AUC0.1OQ was （27.32 ± 7.91） mg L^-1 h^-1, and the mean retention time was （28.31 ±0.49） h. The peak concentration of phillyrin [（0.49 ± 0.41） μg mL^-1] achieved at （3.68 ± 3.14） h, AUC0-LOQ was （4.10± 0.31） mg L^-1 h^-1, and the mean retention time was （14.52 ± 0.02） h. These suggested that two ingredients had slow absorbing speed and high absorbing degree. They could not be eliminated in a short time, thus exerted the topical curative effect.

关键词： Chinese herbal medicine pharmacokinetics transdermal preparation active ingredients mastitis

A study of scientific publications on the greater cane rat (Thryonomys swinderianus, Temminck 1827)

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Animal Models and Experimental Medicine 2020年第1期3卷 40-46页

作者： Oluwaseun Ahmed Mustapha Ebunoluwa Elizabeth Teriba Oluwaseun Samuel Ezekiel Ayokunle Matthew Olude Adebayo Koyuum Akinloye James Olukayode Olopade department of veterinary Anatomy College of Veterinary MedicineFederal University of AgricultureAbeokutaNigeria department of veterinary Anatomy Faculty of Veterinary MedicineUniversity of IbadanIbadanNigeria department of Animal Production and Health Federal University of Technology AkureAkureNigeria

Background:The greater cane rat(GCR),reputed to be African's second largest rodent,is a precocial hystricomorph with an uncommon phenotype and life *** and socio-economic interests in the GCR have led to heightened research efforts targeted towards a better understanding of its biology and exploration of its economic and translational ***:Records of all online scientific publications on the GCR from Google,Google Scholar,PubMed,***,Ebscohost and Worldwide science,with the exception of research theses,proceedings,unpublished projects and abstracts,were collated and analyzed using descriptive ***:A total of 146 published scholarly articles spanning about six decades were retrieved,with 98%of the GCR publications originating from African *** boasts the highest number of publications(58.22%)followed by Ghana(21.23%)and South Africa(5.48%)while Senegal contributed the least(0.69%).Publications were sorted into ten field *** field with the highest number of articles(41.78%)was animal breeding and management recording,closely followed by anatomy(37.67%).Lesser contributions were made by parasitology(5.48%),biochemistry/hematology(4.8%),pharmacology/toxicology(4.11%),pathology(2.06%),and surgery/anesthesia and physiology(1.37%apiece).The fields with fewest contributions were microbiology and developmental biology(0.69%each).Conclusion:This study chronicles the spectrum of knowledge available on the GCR,highlighting the knowledge gap that still exists in various fields in order to provide advocacy for new frontiers in research efforts on this *** suggest the need for a clearly defined and well integrated national/regional policy aimed at establishing Africa's foremost micro-livestock rodent,the greater cane rat,on the world's scientific radar.

关键词： African rodent grasscutter greater cane rat micro-livestock review wildlife

Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 871-876页

作者： Benjaporn Sornpet Teerapong Potha Yingmanee Tragoolpua Kidsadagon Pringproa Central veterinary Diagnostic Laboratory Faculty of Veterinary MedicineChiang Mai UniversityChiang Mai 50100Thailand department of Biology Faculty of SciencesChiang Mai UniversityChiang Mai 50200Thailand department of veterinary Biosciences and veterinary Public Health Faculty of Veterinary MedicineChiang Mai UniversityChiang Mai 50100Thailand

Objective: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus(H5N1).Methods: Crude extracts of Andrographis paniculata, Curcuma longa(C. longa),Gynostemma pentaphyllum, Kaempferia parviflora(K. parviflora), and Psidium guajava obtained by both water and ethanol extractions were investigated for their cytotoxicity in the Madin–Darby canine kidney cells. Thereafter, they were investigated in vitro for antiviral activity and cytokine response upon H5N1 virus ***: The results revealed that both water and ethanol extracts of all the five studied plants showed significant antiviral activity against H5N1 virus. Among these plants,C. longa and K. parviflora showed strong anti-H5N1 activity. Thus, they were selected for further studies on their cytokine response upon virus infection. It was found that ethanol and water crude extracts of C. longa and K. parviflora induced significant upregulation of TNF-a and IFN-b m RNA expressions, suggesting their roles in the inhibition of H5N1 virus ***: To the best of the authors' knowledge, this study is among the earliest reports to illustrate the antiviral property of these Asian medicinal plants against the highly pathogenic avian H5N1 influenza virus. The results of this study shed light on alternative therapeutic sources for treatment of H5N1 influenza virus infection in the future.

关键词： Antiviral activity H5N1 influenza virus Medicinal plants Cytokine response

Biochar and Compost Increase Crop Yields but the Effect is Short Term on Sandplain Soils of Western Australia

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Pedosphere 2015年第5期25卷 720-728页

作者： David J.M.HALL Richard W.BELL department of Agriculture and Food School of veterinary and Life Sciences Murdoch University

Sandplain soils on the south coast of Western Australia have low inherent fertility, which is mainly due to poor nutrient retention caused by insufficient clay and organic colloidal material. Previous research has shown the benefits in nutrient levels and retention from adding clay to sandplain soils; however, there is almost no information on the addition of organic amendments. A field experiment was established at the Esperance Downs Research Station, Western Australian, in May 2010, to assess the effects of wheat straw(WS) and chicken manure(CM) biochars and compost with and without phosphorus(P) addition on soil properties and crop production over five growing seasons. The five seasons alternated between winter and summer crops. The CM and WS biochar and compost treatments significantly increased crop yields and P uptake in 3, 2 and 1 of the five seasons, respectively. The yield increases(P < 0.05) were no more than 8%. By the end of the third season, no differences in crop yields were found that could be attributed to the organic amendments. The addition of P increased crop yields in each winter cropping season. Phosphorus addition explained more than 30%of the variation in crop yields. Despite marginal P levels and summer drought conditions, arbuscular mycorrhizal root colonisation was not affected by the organic amendments. There were no significant interactions between the organic amendments and P addition in terms of crop yields, P uptake or P uptake efficiency. We conclude that much of the effect of the organic amendments was due to direct nutrient addition which dissipated over time.

关键词： mycorrhizal root colonisation nutrient retention organic amendments P addition P uptake

Melatonin alleviates oxidative stress,inflammation,apoptosis,and DNA damage in acrylamide-induced nephrotoxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第3期13卷 121-130页

作者： Fatmaİbaokurgil Hakan Aydin Serkan Yildirim Emin Sengul department of Physiology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey department of Virology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey department of Pathology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey

Objective:To investigate the effects of melatonin on renal inflammation,oxidative stress,apoptosis,as well as DNA and tissue damage in acrylamide-induced nephrotoxicity in ***:Fifty male rats were randomly divided into five *** control group received distilled water by gastric lavage for 11days and the acrylamide group was administered acrylamide(50 mg/kg,i.g.)for 11 *** MEL10+ACR and MEL20+ACR groups received intraperitoneal melatonin 10 and 20 mg/kg,respectively,for 11 days,and acrylamide(50 mg/kg,i.g.)was administered 1h after melatonin *** MEL20 group was injected with melatonin(20 mg/kg)for 11 *** function tests were performed and biochemical and inflammatory parameters were *** addition,histopathological,immunohistochemical,and immunofluorescence examinations were carried ***:Melatonin significantly abated acrylamide-induced rise in serum urea and creatinine *** caused oxidative stress,inflammation,apoptosis,as well as DNA and tissue damage in the *** treatment alleviated acrylamide-induced renal damage by exhibiting antioxidant,anti-inflammatory,and antiapoptotic ***,melatonin significantly ameliorated acrylamide-caused histopathological changes in kidney ***:Melatonin attenuates acrylamide-induced renal oxidative stress,inflammation,apoptosis,and DNA damage in rats.

关键词： Acrylamide Apoptosis Inflammation Melatonin Nephrotoxicity Oxidative stress Rat

Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1331-1335页

作者： Poornima D.E.Weerasinghe-Mudiyanselage Jeongtae Kim Yuna Choi Changjong Moon Taekyun Shin Meejung Ahn department of veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea department of veterinary Anatomy College of Veterinary Medicine and BK21 Plus Project TeamChonnam National UniversityGwangjuRepublic of Korea department of Anatomy Kosin University College of MedicineBusanRepublic of Korea department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system *** its precise roles in these processes and involvement in spinal cord injury pathophysiology remain *** blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham *** analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham ***-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive *** findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord *** experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University(approval No.2018-0029) on July 6, 2018.

关键词： astrocytes clip compression injury macrophage microglia neuroinflammation Ninjurin-1 rat spinal cord

Effects of cancer therapy on hippocampus-related function

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Neural Regeneration Research 2015年第10期10卷 1572-1573页

作者： Miyoung Yang Changjong Moon department of Anatomy School of Medicine Wonkwang University department of veterinary Anatomy and Animal Behavior College of Veterinary Medicine Chonnam National University

Cancer treatments such as chemotherapy and radiotherapy are widely used to treat primary and metastatic *** studies have demonstrated that these types of treatment can effectively and successfully extend the lifespan of cancer patients,but they are also associated with various neurological complications such as cognitive deficits, seizures, and emotional problems （Taphoorn and Klein, 2004; Yang and Moon, 2013; Son et al., 2015b）.

关键词： Effects of cancer therapy on hippocampus-related function MTX BDNF

Chronic TCDD exposure results in the dysregulation of gene expression in splenic B-lymphocytes and in the impairments in T-cell and B-cell differentiation in mouse model

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Journal of Environmental Sciences 2016年第1期28卷 218-227页

作者： Yu Feng Jijing Tian Irina Krylova Tuan Xu Heidi Qunhui Xie Tai L.Guo Bin Zhao Research Center for Eco-Environmental Sciences Chinese Academy of Sciences XCell Assay LLC department of veterinary Biosciences and Diagnostic Imaging College of Veterinary Medicine University of Georgia

2,3,7,8-Tetrachlorodibenzo-p-dioxin（TCDD） exposure in humans is associated with marked immune suppressions and increased incidence of lymphoblastic *** elucidate mechanisms of impairments in humoral immune responses,we used a murine *** a 20-week administration of low doses of TCDD,we observed severely reduced antibody titers,dramatically decreased number of splenic Th1 and Th2 cells and an increase in CD19^＋ B *** profiling of CD19^＋ B cells showed that markers of pre-B cells were significantly elevated,indicating delayed B cell *** changes in B cells were accompanied by decreases of T helper cell numbers and reduced IgM and IgG titers.A transcriptome analysis of splenic B cells followed by Ingenuity Pathway Analysis（IPA） revealed a set of differentially expressed genes known to play roles in tumorigenesis,cell-proliferation and *** most up-regulated transcript gene was Eph receptor A2（EphA2）,a known oncogene,and the most down-regulated transcript was ZBTB16 that codes for a negative transcriptional regulator important in epigenetic chromatin *** identified cAMP-responsive element modulator（CREM） and cAMP-responsive element binding protein 1（CREBl） as top upstream ***,a MAPPER promoter database analysis showed that all top dysregulated genes had CREM and/or CREBl binding sites in their promoter *** summary,our data showed that chronic TCDD exposure in mice caused suppressed humoral immunity accompanied with profound dysregulation of gene expression in splenic B-lymphocytes,likely through cAMP-dependent *** dysregulation resulted in impairments in T-cell and B-cell differentiation and activation of the tumorigenic transcription program.

关键词： Chronic TCDD B cell transcriptome EphA2c AMP