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Osteocyte viability and bone density in cadmium chloride-induced osteoporosis ameliorated with Pilostigma thonningii stem bark-extracted D-3-O-methy-chiroinositol

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Animal Models and Experimental Medicine 2019年第1期2卷 25-33页

作者： Edwin Aihanuwa Uwagie-Ero Clifford Nwabugwu Abiaezute Chinaka O.Nwaehujor Theophilus Okafor Nnaji Eugene Amienwanlen Odigie Oyetunde Kazeem Ekeolu Ohiemi Benjamin Ocheja department of Surgery Faculty of Veterinary MedicineUniversity of Benin department of Anatomy Faculty of Veterinary MedicineUniversity of Nigeria department of Biochemistry College of Basic Medical SciencesUniversity of Calabar department of Surgery Faculty of Veterinary MedicineUniversity of Nigeria department of Anatomy Faculty of Veterinary MedicineUniversity of Benin department of Physiology and Biochemistry Faculty of Veterinary MedicineUniversity of Benin

Background : This study examined the ameliorative effect of D-3-O-methylchiroinositol, isolated from the stem bark of Piliostigma thonningii, on cadmium chloride-induced osteoporosis in male Wistar rats. Methods : Thirty-six rats were assigned to three treatment groups(n = 12). Group A(2 mL distilled water), group B:(2.5 mg/kg b.w. CdCl_2) and group C:(2.5 mg/kg b.w. CdCl_2 and D-3-O-methyl-chiroinositol 2 mg/kg b.w.). Bone ash, calcium, phosphate, magnesium, and zinc content, as well as bone histological changes were determined at the end of months 1, 2, and 3. Results : There were significant differences( P ≤ 0.05) in the weight of the cervical, tibia, and femoral bones in all groups. The serum concentration of CdCl_2 was significantly different across the three groups with time. There was significant variation( P < 0.005) in the mean bone ash across groups. The concentration of OH-proline was significantly different( P < 0.0001) across groups. There were significant differences( P < 0.0001) in bone calcium, magnesium, zinc, and phosphorus concentrations. Histology revealed high levels of bone mineralisation in the CdCl_2-treated group, indicative of osteoporosis with hypertrophied osteocytes, while the femur of Wistar rats treated with D-3-O-methyl-chiroinositol showed bone trabeculae and viable osteocytes. Conclusion : The study concluded that D-3-O-methyl-chiroinositol extract from Piliostigma thionningii stem bark ameliorated cadmium chloride-induced osteoporosis in male Wistar rats.

关键词： cadmium chloride D-3-O-methyl-chiroinositol osteocytes osteoporosis toxicity amelioration

Epidemiology of ixodid ticks in cattle population of various agroclimatic zones of Punjab,India

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Asian Pacific Journal of Tropical Medicine 2013年第12期6卷 947-951页

作者： NirbhayKumarSingh ShitanshuShekharRath department of veterinary Parasitology College of Veterinary ScienceGuru Angad Dev Veterinary and Animal Sciences UniversityLudhianaPunjab141004India

Objective:To determine the epidemiology of ixodid ticks in bovines of different agroclimatic zones of Punjab state,***:A total of 4 459 cattle of all age groups and sex were examined from eighteen districts of five major agro-climatic zones of Punjab state,***:The overall prevalence of ixodid ticks,Rhipicephalus microplus(***),Hyalomma anatolicum anatolicum(***)and mixed infestation were 58.06%,50.16%,11.34%and 3.45%,*** the various agro-climatic zones highest prevalence rate of *** and *** were recorded in submountain undulating region(79.36%)and western region(20.40%),respectively indicating that *** prefers a hot and humid environment whereas,arid and semi arid conditions suit better for *** overall prevalence of ixodid ticks was highest in monsoon season(83.74%),followed by summer(69.01%)and least in winters(31.64%)and a significant variation(P1 year age group(55.02%)and the difference was statistically significant(P<0.01),Also a significantly higher(P<0.01)infestation rates of ixodid ticks was observed in ***:The findings of the current study would provide a basis for evolving effective control strategy for the management of ticks in bovines of the region.

关键词： Cattle Epidemiology Hyalomma anatolicum anatolicum Punjab Rhipicephalus microplus

Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 645-650页

作者： Angela J Umosen Suleiman F Ambali Joseph O Ayo Bisala Mohammed Chidiebere Uchendu department of veterinary Pharmacology Ahmadu Bello University department of veterinary Physiology Ahmadu Bello University department of veterinary Pathology Ahmadu Bello University

Objective:To evaluate the alleviating effects of melatonin on oxidative changes in the testes and pituitary gland induced by subacute chlopyrifos（CPF） exposure in ***:Forty adult male Wistar rats divided into 4 groups of 10 animals were used for the *** I received soya oil（2 mL/kg） while group II was administered with melatonin（0.5 mg/kg）.Group III was administered CPF only(8.5 mg/kg l/10th of the LD50) while group Ⅳ was pretreated with melatonin（0.5 mg/kg） and then exposed to CPF（8.5 mg/kg）,10 min *** regimens were administered by gavage once daily for a period of 28 *** the end of the exposure period, the rats were sacrificed and the testicular tissues and pituitary glands were evaluated for the malonaldehyde（MDA） concentration and activities of superoxide dismutase（SOD） and catalase（CAT）.Results:CPF increased MDA concentrations and reduced the activities of SOD and CAT in the testes and pituitary *** pretreatment reduced the testicular and pituitary MDA concentrations and improves the SOD and CAT ***:the study showed that subacute CPF-induced oxidative stress in the testes and pituitary glands were alleviated by melatonin due to its antioxidant property.

关键词： Chlorpyrifos Oxidative stress Testes Pituitary glands Alleviation Melatonin

Naringin attenuates oxidative stress,inflammation,apoptosis,and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 223-232页

作者： Volkan Gelen Serkan Yıldırım EminŞengül AliÇınar FikretÇelebi Merve Küçükkalem Melahat Gök department of Physiology Faculty of Veterinary MedicineKafkas UniversityKarsTurkey department of Pathology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey department of Physiology Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey

Objective:To explore the possible effects of naringin on acrylamide-induced nephrotoxicity in ***:Sprague-Dawley rats weighing 200-250 g were randomly divided into five *** control group was given intragastric(i.g.)saline(1 mL)for 10 *** acrylamide group was given *** in saline(38.27 mg/kg titrated to 1 mL)for 10 *** treatment groups were administered with naringin in saline(50 and 100 mg/kg,respectively)for 10 d and given ***(38.27 mg/kg)1 h after naringin *** naringin group was given ***(100 mg/kg)alone for 10 *** day 11,intracardiac blood samples were obtained from the rats when they were under anesthesia,after which they were *** and creatinine concentrations of blood serum samples were analyzed with an ***-linked immunosorbent assay was used to quantify malondialdehyde,superoxide dismutase,glutathione,glutathione peroxidase,catalase,tumor necrosis factor-α,nuclear factor-κB,interleukin(IL)-33,IL-6,IL-1β,cyclooxygenase-2,kidney injury molecule-1,mitogen-activated protein kinase-1,and caspase-3 in kidney *** tissues were also evaluated by histopathological and immunohistochemical examinations for 8-OHdG and ***:Naringin attenuated acrylamide-induced nephrotoxicity by significantly decreasing serum urea and creatinine *** increased superoxide dismutase,glutathione,glutathione peroxidase,and catalase activities and decreased malondialdehyde levels in kidney *** addition,naringin reduced the levels of inflammatory and apoptotic parameters in kidney *** histopathological assay showed that acrylamide caused histopathological changes and DNA damage,which were ameliorated by ***:Naringin attenuated inflammation,apoptosis,oxidative stress,and oxidative DNA damage in acrylamide-induced nephrotoxicity in rats.

关键词： Acrylamide Nephrotoxicity Apoptosis Inflammation Naringin Oxidative stress Oxidative DNA damage

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

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Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM Kyung-Hyun CHO Sung-Pil LEE Hui-Ju KIM Yae-Ji JUNG Ju-Young department of veterinary Medicine&Institute of veterinary Science Chungnam National UniversityDaejeon 34134Korea department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

Primary oral and nasal transmissible venereal tumor in a mix-breed dog

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 443-445页

作者： Mahdieh Rezaei Shahrzad Azizi Shima Shahheidaripour Sara Rostami department of Clinical Science Faculty of Veterinary MedicineShahid Bahonar University department of Pathobiology Faculty of Veterinary MedicineShahid Bahonar University Faculty of veterinary Medicine Shahid Bahonar University

Transmissible venereal tumor(TVT) is a coitally transmitted tumor of dogs with widespread distribution. The present study describes the occurrence of the primary oral and nasal TVT in a 10-year-old, female, mix-breed dog. The case was presented with a history of anorexia, inability to swallow and dyspnea. Clinical examinations revealed the emaciation, muzzle deformity due to the presence of a friable, fleshy, cauliflower-like mass in the oral cavity and submandibular lymphadenopathy. TVT was diagnosed based on histopathological findings. The dog was discharged with therapeutic intervention with vincristine. Unfortunately, the case died before readmission because of the progressive worsening of the general condition. Our findings highlight the need for considering TVT for the differential diagnosis of the extragenital masses in dogs.

关键词： Transmissible venereal tumor Primary Oral Nasal Dog

Persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第4期10卷 280-284页

作者： Xun TAN Ye-wen JIANG Yi-jun HUANG Song-hua HU department of veterinary Medicine Zhejiang University Hangzhou 310029 China

This study was designed to investigate persistence of gentamicin residues in milk after the intramammary treatment of lactating cows for mastitis. Milk samples were collected at a 1-d interval after the last administration from 34 individual cows that had received intramammary infusions of gentamicin. The doses and treatment times evaluated in this study represented those that have been applied by veterinarians in practice. The tetrazolium chloride assay was used to determine whether there were significant residues of the antibiotic in the samples. Persistence of detectable drug residues in milk from 33 cows (28 cows, ≤6 infusions at ≤0.7 g gentamicin; and 5 cows, 2 infusions at 0.8 g gentamicin) did not exceed 5 d; but 1 cow (5 infusions at 0.8 g gentamicin) had detectable residues in its milk for 9 d. Our results suggest that a 5-d milk withdrawal period might be insufficient to secure the clearance of the contamination of gentamicin, because treatment times and dosages contribute to the antibiotic clearance. A larger scale of samples are needed for further investigations.

关键词： Gentamicin Mastitis Intramammary infusion Residue

Morphological Variations,Distribution and Population Estimation of Indian Spiny Tailed Liza rd(Uromastyx hardwickii Gray,1827)from District Bahawalnagar,Punjab,Pakistan

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Asian Herpetological Research 2020年第3期11卷 257-262页

作者： Waqas ALI Arshad JAVID Saddam HUSSAIN Ali HUSSAIN Syed Mohsin BUKHARI department of Wildlife and Ecology University of Veterinary and Animal SciencesLahorePakistan

This study was conducted in selected sites of District Bahawalnagar namely,Shaheed Chowk,Chak40/F,Chak 163/7 R and Fareedkot Tiba between March 2019 and August *** techniques included recording of burrows,flooding,burrow exaction,noose traps and pit fall traps were used to capture Uromast yx *** this survey150 individuals were captured from study area for morphological measurement and population *** average snout to vent length(SVL)of male,female and juveniles were(172.50±19.71)mm,(155.50±18.72)mm and(86.25±11.72)mm *** average weight of male,female and juvenile was(93.06±8.56)g,(88.16±7.95)g and(40.16±4.30)g *** relative abundance(Pi)of males,females and juveniles were 0.53,0.33 and *** spiny tailed lizard(***)has been listed in the IUCN Red list and *** threats to the species in the study area are increase in urbanization,habitat fragmentation,illegal hunting for meat and *** this regard strict implementation of the Wildlife act is needed to protect the wildlife of ***,comprehensive surveys are required in throughout Punjab to declare conservation status of ***.

关键词： habitat morphological characters population Uromastyx hardwickii

Determining the IgG concentrations in bovine colostrum and calf sera with a novel enzymatic assay

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Journal of Animal Science and Biotechnology 2019年第1期10卷 239-247页

作者： M.Drikic C.Windeyer S.Olsen Y.Fu L.Doepel J.De Buck department Production Animal Health Faculty of Veterinary MedicineUniversity of Calgary

Background: Immune protection in newborn calves relies on a combination of the timing,volume and quality of colostrum consumed by the calf after *** quality colostrum with inadequate immunoglobulin concentration contributes to failed transfer of passive immunity in calves,leading to higher calf morbidity and ***,estimating colostrum quality and ensuring the transfer of passive immunity on farm is of critical ***,there are no on-farm tools that directly measure immunoglobulin content in colostrum or *** aim of this study was to apply a novel molecular assay,split trehalase immunoglobulin G assay(STIGA),to directly estimate immunoglobulin content in dairy and beef colostrum and calf sera,and to examine its potential to be developed as on-farm *** STIGA is based on a split version of trehalase TreA,an enzyme that converts trehalose into glucose,enabling the use of a common glucometer for signal *** a first study,60 dairy and64 beef colostrum and 83 dairy and 84 beef calf sera samples were tested with STIGA,and the resulting glucose production was measured and compared with radial immunodiffusion,the standard method for measuring immunoglobulin ***: Pearson correlation coefficients between the methods were determined and the sensitivity,specificity,and accuracy of the test were calculated for different colostrum quality and failed transfer of passive immunity cut-off *** correlations of the STIGA measured by colorimetric enzymatic reaction compared to radial immunodiffusion for dairy and beef colostrum were 0.72 and 0.73,respectively,whereas the correlations for dairy and beef sera were 0.9 and 0.85,***,STIGA was tested in a blinded study with fresh colostrum and serum samples where the correlation coefficient was 0.93 and 0.94,***,the performance of STIGA followed by glucometer readings resulted in correlations with radial immunodiffusion of 0.7 and

关键词： Cattle Colostrum Immunoglobulins Passive immunity Radial immunodiffusion Split trehalase