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Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第8期23卷 1397-1405页

作者： Keita Kai Hiroki Koga Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro department of Pathology Saga University Hospital departments of Surgery Saga University Hospital Pathology and microbiology Saga University Hospital Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma(NBNC-HCC), and we investigated the patients' clinicopathological characteristics according to smoking *** We retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of nonalcoholic steatohepatitis(NASH) was based on both clinical information and pathological *** Alcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival(P = 0.0058) and disease-specific survival(P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery(P = 0.0002) and more likely to abuse alcohol(P = 0.0188) and to have multiple tumors(P = 0.023).CONCLUSION Current smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.

关键词： Hepatocellular 癌 Non-B Non-C 吸烟外科预后

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SARS-CoV-2 involvement in central nervous system tissue damage

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Neural Regeneration Research 2022年第6期17卷 1228-1239页

作者： Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah HFarran Abdullah Shaito Esber SSaba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri department of Biochemistry and Molecular Genetics Faculty of MedicineAmerican University of BeirutBeirutLebanon Faculty of Health Sciences University of BalamandBeirutLebanon Faculty of Medicine University of BalamandKouraLebanon Faculty of Science Lebanese UniversityBaabdaLebanon Program for Neurotrauma Neuroproteomics&Biomarkers ResearchDepartments of Emergency MedicineUniversity of FloridaGainesvilleFLUSA department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirutLebanon Biomedical Research Center Qatar UniversityDohaQatar department of Experimental Pathology Immunology and MicrobiologyFaculty of MedicineAmerican University of BeirutBeirutLebanon Laboratory of Cancer Biology and Molecular Immunology Faculty of Sciences ILebanese UniversityHadathBeirutLebanon Faculty of Medicine Lebanese UniversityNeuroscience Research Center(NRC)BeirutLebanon Neuroscience Institute Neurology DepartmentGeisinger Health SystemPAUSA department of Psychiatry American University of BeirutBeirutLebanon

As the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to spread globally,it became evident that the SARS-CoV-2 virus infects multiple organs including the *** clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening *** the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood,several theories have been suggested including direct and indirect pathways induced by the *** possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct *** findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain ***,the indirect mechanisms,including blood-clotting abnormalities and prolonged activation of the immune system,can result in further tissue and organ damages seen during the course of the *** overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.

关键词： autoantibodies CNS infection coagulopathy COVID-19 encephalitis neuroinflammation renin-angiotensin system viral encephalopathy

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Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni

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World Journal of Gastroenterology 2016年第33期22卷 7402-7414页

作者： Anand Kumar Dharanesh Gangaiah Jordi B Torrelles Gireesh Rajashekara 170 Food Animal Health Research Program and department of veterinary Preventive Medicine College of Veterinary MedicineThe Ohio State University Biosecurity and Public Health Bioscience DivisionLos Alamos National Laboratory department of microbiology and Immunology Indiana University School of Medicine department of Microbial Infection and Immunity Center for Microbial Interface Biologythe Ohio State University

Campylobacter jejuni(C. jejuni),a Gram-negative microaerophilic bacterium,is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide. Despite its importance as a major foodborne pathogen,our understanding of the molecular mechanisms underlying C. jejuni stress survival and pathogenesis is limited. Inorganic polyphosphate(poly P) has been shown to play significant roles in bacterial resistance to stress and virulence in many pathogenic bacteria. C. jejuni contains the complete repertoire of enzymes required for poly P metabolism. Recent work in our laboratory and others have demonstrated that poly P controls a plethora of C. jejuni properties that impact its ability to survive in the environment as well as to colonize/infect mammalian hosts. This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes. Additionally,the review article identifies potential areas for future investigation that would enhance our understanding of the role of poly P in C. jejuni and other bacteria,which ultimately would facilitate design of effective therapeutic/preventive strategies to reduce not only the burden of C. jejuni-caused foodborne infections but also of other bacterial infections in humans.

关键词： Campylobacter jejuni Stress tolerance Inorganic polyphosphate Virulence Colonization/ infection

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CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

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Cellular & Molecular Immunology 2013年第4期10卷 303-310页

作者： Dandan Lv Yan Zhang Ha-Jeong Kim Lixing Zhang Xiaojing Ma Sheng Yushou Center of Cell Biology and Immunology School of Life Science and Biotechnology Shanghai Jiaotong University Shanghai China department of microbiology and Immunology Weill Cornell Medical College New York NY USA

Breast cancer （BC） is a leading cause of mortality among women in the world. To date, a number of molecules have been established as disease status indicators and therapeutic targets. The best known among them are estrogen receptor-α （ER-α）, progesterone receptor （PR） and H ER-2/neu. About 15%-20% BC patients do not respond effectively to thera pies targeting these classes of tumor-promoting factors. Thus, additional targets are strongly and urgently sought after in therapy for human BCs negative for ER, PR and HER-2, the so-called triple-negative BC （TNBC）. Recent clinical work has revealed that CC chemokine ligand 5 （CCL5） is strongly associated with the progression of BC, particularly TNBC. How CCL5 contributes to the development of TN BC is not well understood. Experimental animal studies have begun to address the mechanistic issue. In this article, we will review the clinical and laboratory work in this area that has led to our own hypothesis that targeting CCL5 in TNBCs will have favorable therapeutic outcomes with minimal adverse impact on the general physiology.

关键词： triple negative breast cancer CCL5 myeloid derived suppressor cell immunotherapy

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PCR Detection and Sequence Analysis of Duck Circovirus in Sick Muscovy Ducks

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Virologica Sinica 2008年第4期23卷 265-271页

作者： Shi-jin JIANG Xing-xiao ZHANG Shao-ning LIU Yu WANG Yi-bo KONG Xiu-li WEI Ya-ni SUN Qin ZHAO College of Animal Science and veterinary Medicine Shandong Agricultural University Tai＇an 271018 China department of Basic Medical Sciences Taishan Medical College Tai＇an 271000 China

在从福建省的病了的鸭的鸭 circovirus (DuCV ) 感染被调查。有传染 serositis 的 43 只病了的俄国鸭的肝样品在福建省从 12 个鸭农场被收集。基于 DuCV 的出版序列，二份教材为 DuCV 的察觉被设计，四份教材被设计放大盖住 DuCV 的完... 详细信息

在从福建省的病了的鸭的鸭 circovirus (DuCV ) 感染被调查。有传染 serositis 的 43 只病了的俄国鸭的肝样品在福建省从 12 个鸭农场被收集。基于 DuCV 的出版序列，二份教材为 DuCV 的察觉被设计，四份教材被设计放大盖住 DuCV 的完全的染色体的四重叠碎片。特定的聚合酶链反应产品从积极样品被放大。碎片然后被克隆进 pMD18-T 向量并且定序，并且 DuCV 的 FJ0601 isolate 的完整的长度染色体组的顺序被获得。聚合酶链反应分析证明积极因为 circovirus 从 12 个农场是 79% 和 10 的鸭的比例是积极的。顺序分析证明 DuCV-FJ0601 的完全的染色体是 1988 bp 并且拥有了对包括了茎环结构和议员蛋白质主题的家庭 Circoviridae 普通的特征。相同分析证明 DuCV 的那 FJ0601 isolate 有到所有四个台湾的身份孤立的 97.3%∼97.5% 核苷酸序列(TC1/2002， TC2/2002， TC3/2002， TC4/2002 ) ，到美洲(33753-52 )isolate 的 82.9% 身份和到德国的 82.3% 身份孤立。然而，有 Clustal W 的种系发生的分析证明 DuCV 的那 FJ0601 isolate 在有台湾的一个普通分支上孤立，并且德国和美洲孤立属于另外的分支。

关键词：美洲家鸭病毒全长基因组序列分析

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Profiles of HIV-infected anti-retroviral therapy naïve children from Mumbai,India

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世界儿科杂志:英文版 2016年第4期12卷 430-435页

作者： Supriya Mayur Paranjpe Purva Pankaj Sarkate Nayana Avinash Ingole Shweta Sadanand Raut Preeti Rajeev Mehta department of microbiology 5th floorMulti-Storey BuildingSeth G.S.Medical College and K.E.M.HospitalParelMumbaiIndia

Background:This study aimed to investigate the demographic profiles of human immunodifficiency virus(HIV)infected anti-retroviral therapy(ART)naïve children in our hospital and their relations to the clinical,immunological and nutritional ***:A cross-sectional study was conducted in an Integrated Counselling and Testing Center(ICTC)at a tertiary care hospital in *** naïve HIV positive children were enrolled in the *** demographic profiles,clinical features,immunological(CD4%/CD4 count)and nutritional status of these children were *** agreement between clinical,immunological and nutritional staging was determined using Cohen’s kappa ***:In 192 HIV-infected ART naive children enrolled with a median age of 9 years(range 3 months-14 years),97.4%acquired infection through vertical *** most common clinical presentation was fever(39.6%),followed by generalized lymphadenopathy(32.3%),cough(22.4%)and diarrhoea(9.9%).Tuberculosis was seen in 22.9%of the *** agreement was fair between clinical and immunological staging,and slight between nutritional,immunological and clinical ***:Perinatal transmission is the most common mode of acquiring HIV infection in *** Prevention of Parent to Child Transmission(PPTCT)program should be strengthened for lowering the transmission rate by providing extended ART to mothers during pregnancy and *** remains a major concern in HIV-infected *** poor correlation between WHO clinical and immunological staging emphasizes the importance of making CD4 facilities available in HIV prevalent *** cannot be used as a surrogate marker for predicting stage or severity as it is common at all stages of HIV disease.

关键词： anti-retroviral therapy CD4 count clinical stage HIV nutritional status

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Prevalence and antimicrobial resistance pattern of bacterial strains isolated from patients with urinary tract infection in Messalata Central Hospital, Libya

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 749-754页

作者： Mahmoud A.Mohammed Tarig MS Alnour Osama M.Shakurfo Mariam M.Aburass department of Medical Laboratory Technology Faculty of Medical Technologies-Messalata Almergib University department of Food Hygiene and Control Faculty of Veterinary Medicine Mansoura University department of Medical Laboratory Technology Faculty of Medical Technologies-MessalataAlmergib University department of Medical Laboratory Technology Faculty of Applied Medical Sciences University of Tabuk

Objective: To investigate the prevalence of urinary tract infection among patients at Messalata Central Hospital, Libya, to identify the causative bacteria, and to explore their resistance pattern to antimicrobials. Methods: A total number of 1 153 urine samples were collected from patients, who attended daily to Messalata Central Hospital, Libya, in a study extended for one year. Antimicrobial susceptibility testing and isolates typing were done using Phoenix BD(BD diagnostic). Resistance was confirmed manually using agar disk diffusion method. Results: Of the 1 153 urine samples tested, 160(13.9%) samples were positive, from which 17 different, solely Gram negative, uropathogens were identified. Escherichia coli were the most prevalent(55.6%) bacteria, followed by Klebsiella pneumoniae subspecies pneumoniae(16.3%), Proteus mirabilis(6.3%), Pseudomonas aeruginosa(5.6%), Enterobacter cloacae and Klebsiella oxytoca(2.5%, each), Citrobacter koseri and Providencia rettgeri(1.9%, each), Acinetobacter baumannii, Enterobacter aerogenes and Proteus vulgaris(1.3%, each), and Aeromonas caviae, Citrobacter freundii, Cronobacter sakazakii, Enterobacter amnigenus biogroup 2, Pseudomonas putida and Serratia marcescens(0.6%, each). The isolated uropathogens showed increased levels of resistance ranged from 10.5% to 64.5%, with an overall resistance of 28.9%. Amikacin was the most effective antimicrobial followed by Imipenem and Meropenem(0%, 0.6% and 2.5% resistance, respectively); while, Cephalothin and Ampicillin were the least(80.6% and 90.0% resistance, respectively) effective. Conclusions: The obtained results emphasized the emergence of highly resistant bacteria to most of tested antimicrobials and raise the alarm for physicians to change their treatment pattern depending on antimicrobial susceptibility results.

关键词： Urinary tract infection(UTI) Uropathogens Significant Bacteruria Antimicrobial susceptibility testing(AST) Antimicrobial resistance Enterobacteriaceae

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Parsley: a review of ethnopharmacology, phytochemistry and biological activities

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Journal of Traditional Chinese Medicine 2013年第6期33卷 815-826页

作者： Mohammad Hosein Farzaei Zahra Abbasabadi Mohammad Reza Shams Ardekani Roja Rahimi Fatemeh Farzaei Faculty of Pharmacy Kermanshah University of Medical Science department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Science department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Science department of Traditional Pharmacy Faculty of Traditional Medicine Tehran University of Medical Science College of veterinary Medicine Kermanshah Razi University

OBJECTIVE:To summarize comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of parsley. METHODS: Databases including PubMed, Scopus, Google Scholar, and Web of Science were searched for studies focusing on the ethnomedicinal use, phytochemical compounds and biological and pharmacological activities of parsley. Data were collected from 1966 to 2013. The search terms were: "Parsley" or "Petroselinum crispum" or "Petroseli-num hortence ". RESULTS: Parsley has been used as carminative, gastro tonic, diuretic, antiseptic of urinary tract, anti-urolithiasis, anti-dote and anti-inflammatory and for the treatment of amenorrhea, dysmenorrhea, gastrointestinal disorder, hypertension, cardiac disease, urinary disease, otitis, sniffle, diabetes and also various dermal disease in traditional and folklore medicines. Phenolic compounds and flavonoids particularly apigenin, apiin and 6"-Acetylapiin; essential oil mainly myristicin and apiol; and also coumarins are the active compounds identified in Petroselinum crispum. Wide range of pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, immunosuppressant, anti-platelet, gastroprotective, cytoprotective, laxative, estrogenic, diuretic, hypotensive, antibacterial and antifungal activities have been exhibited for this plant in modern medicine. CONCLUSION: It is expectant that this study resulted in improvement the tendencies toward Petroselinum crispum as a useful and important medicinal plant with wide range of proven medicinal activity.

关键词：植物化学香菜生物黄酮类化合物胃肠道疾病审查逻辑泌尿系统疾病

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Functions of Lysosomes in Mammalian Female Reproductive System

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Reproductive and Developmental Medicine 2020年第2期4卷 109-122页

作者： Yuehuan Li Zidao Wang Christian L.Andersen Xiaoqin Ye department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA

The lysosome is the most acidic membrane-bound intracellular *** acidity is primarily maintained by vacuolar H+-ATPase(V-ATPase)and counter ion *** are>60 hydrolytic enzymes in the lysosome for its fundamental digestive *** also play important roles in endocytosis,exocytosis,autophagy,and cell *** that have implicated roles of lysosomes in the female reproductive system are reviewed *** the ovary,lysosomes are implicated in the preparation of free cholesterol for steroidogenesis and degradation of regulators of steroidogenesis,regulation of follicular atresia,follicle rupture during ovulation,luteal cell survival,and luteal *** the oviduct,lysosomes are involved in endocytosis of both serum and oviductal luminal *** the uterus during the menstrual/estrous cycle,lysosomes are associated with endometrial secretion,apoptosis,and *** the uterus during early pregnancy,lysosomes are involved in the temporal and directional changes of endocytosis,uterine epithelial acidification upon embryo implantation initiation,and embryo-maternal mutual communications via extracellular *** the placenta,lysosomes are implicated in nutrient transport and placental separation from the uterus for *** the mammary gland,lysosomes are important for mammary gland development and *** findings suggest/demonstrate functions of lysosomes in multiple processes of female reproduction,from ovulation to ovarian steroidogenesis for pregnancy maintenance,and from essential in utero nurturing of developing embryos/fetuses via embryo/fetal-maternal communications,to optional postpartum nurturing of newborns via *** studies using genetically or modified animal models and pharmacological approaches will provide novel insights into the functions and mechanisms of lysosomes in the mammalian female reproductive system.

关键词： Autophagy Endocytosis Lysosome Ovary Steroidogenesis Uterus

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Antimicrobial susceptibility profile of community acquired and nosocomial isolates of Escherichia coli from clinical blood culture specimens at a Nigerian university teaching hospital

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Asian Pacific Journal of Tropical Medicine 2010年第8期3卷 662-665页

作者： Jombo GTA Akpan S Epoke J Denen Akaa P Eyong KI Gyuse AN department of Medical microbiology and Parasitology College of Health SciencesBenue State UniversityPMB 102119 MakurdiNigeria department of Medical microbiology and Parasitology College of Medical SciencesUniversity of CalabarPMB 1115 Calabar.Nigeria department of Surgery College of Health SciencesBenue state University MakurdiPMB 102119 MakurdiNigeria department of Paediatrics College of Medical SciencesUniversity of Calabar.PMB 1115 CalabarNigeria department of Family Medicine College of Medical SciencesUniversity of Calabar.PMB 1115 CalabarNigeria

Objective:To ascertain the antibiotic susceptibility patterns of Escherichia coli recovered from blood culture specimens in ***:The study was retrospective in nature and was carried out at University of Calabar Teaching Hospital(UCTH) *** generated from blood culture specimens over a five year period(Feb.2004-Feb.2009) was compiled, relevant information such as age,sex,organism recovered and antibiotic susceptibility patterns were obtained from patients *** were collected,transported,stored and processed using standard laboratory *** obtained was analysed using Epi Info 6 statistical ***:Escherichia coli was responsible for 15.3%(31/203) of the blood infections being the third most common microorganism *** community acquired(CA) isolates of the organism were significantly less resistant(P0.05).Majority(>95.0%) of the NC isolates of Escherichia coli were resistant to six of the antibiotics ***:Control mechanisms for hospital acquired infections should be stepped up so as lo limit the spread of the highly resistant bacterial *** the sale and consumption of antibiotics by the public need to be regulated.

关键词： Susceptibility Antimicrobial Escherichia coli Community acquired Nosocomial Resistance

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