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Advances in clinical applications of bioceramics in the new regenerative medicine era

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World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： Noha Elshazly Fayza Eid Nasr Ayat Hamdy Safa Saied Mohamed Elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and electrospinning.The new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic properties.All these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue wounds.Multiple clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass nanofibers.The results were promising and opened new frontiers for utilizing these materials on a larger scale.The same results were mentioned when using different forms and formulas of bioceramics in hard defect regeneration.Some bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical properties.All this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine Bioceramics Chronic wounds Bone defects Clinical applications

Targeting autophagy by polyphenols to prevent glycative stress-toxicity in the brain

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Neural Regeneration Research 2024年第5期19卷 941-942页

作者： Alejandro Ponce-Mora Eloy Bejarano department of Biomedical Sciences School of Health Sciences and Veterinary SchoolUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain

Glycative stress-a pathological hub in brain dysfunction:The nervous system is an intricate network that requires precise and complex maintenance.In recent years,growing evidence highlights the detrimental impact of glycative stress on brain homeostasis,which disables a network of vital processes,necessary for optimal function(Gómez et al.,2021).

关键词： homeostasis stress

Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla Law Eduardo Rosa Medina Garcia Chad Hastad Deborah Murray Pedro E.Urriola Andres Gomez department of animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare chal-lenges.These challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous counterparts.Little is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig microbiomes.Therefore,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic post-weaning.At weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(P<0.01),with differences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu group.Conclusions Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance when combined with pharmacological levels of Zn

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

Experimental models of high-risk bowel anastomosis in rats:A systematic review

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World Journal of Experimental medicine 2024年第2期14卷 114-131页

作者： Georgios Ntampakis Manousos-Georgios Pramateftakis Elissavet Anestiadou Stefanos Bitsianis Orestis Ioannidis Chryssa Bekiari George Koliakos Maria Karakota Anastasia Tsakona Angeliki Cheva Stamatios Angelopoulos Fourth department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Laboratory of Anatomy and Histology School of Veterinary MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Experimental and Research Center Papageorgiou General Hospital of ThessalonikiThessaloniki 56403Greece Laboratory of Biochemistry Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece department of Pathology Faculty of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of life.Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation.Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features.Despite the advances in experimental protocols and techniques,designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.AIM To review current state of the art for experimental protocols in high-risk anastomosis in rats.METHODS This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.To identify eligible studies,a comprehensive literature search was performed in the electronic databases PubMed(MEDLINE)and Scopus,covering the period from conception until 18 October 2023.RESULTS From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis.Methods of assessing anastomotic healing were extracted and were individually appraised.CONCLUSION Anastomotic healing studies have evolved over the last decades,but the findings are yet to be translated into human studies.There is a need for high-quality,well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.

关键词： High-risk anastomosis Rats Experimental models Bowel Colon Anastomotic leak Colon resection Inflammatory bowel disease Intra-abdominal sepsis Bursting pressure

Adding chitosan nanoparticles of green tea extract in diluent and thawing temperatures ameliorate the post-thawed quality of Boer buck semen

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Asian pacific Journal of Reproduction 2024年第1期13卷 42-48页

作者： Suherni Susilowati Imam Mustofa Tri Wahyu Suparyogi Adeyinka Oye Akintunde Djoko Agus Purwanto Wurlina Wurlina Suzanita Utama Sri Mulyati Division of veterinary Reproduction Faculty of Veterinary MedicineUniversitas AirlanggaKampus C UnairMulyorejoSurabaya 60115Indonesia department of Agriculture and Industrial Technology Babcock UniversityIlishan-RemoOgun State 121103Nigeria department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas AirlanggaKampus C MulyorejoSurabaya 601155East JavaIndonesia

Objective:To improve the quality of post-thawing Boer buck semen for artificial insemination by adding green tea extract chitosan nanoparticles to skimmed egg yolk diluent,and the proper thawing temperature.Methods:The ejaculate of Boer buck was added to skimmed egg yolk diluent without(the control group)and with adding 1μg of chitosan nanoparticles of green tea extract per mL of diluent(the treatment group).Then,the diluted semen was filled in French mini straws containing 60×106 live sperm per straw,frozen in a standard protocol,and stored as frozen semen at−196℃for a week.Six replicates from each group were diluted for 30 s at 37℃or 39℃sterile water to evaluate the semen quality.Results:Post-thawing(at 37℃or 39℃)of live sperm,progressive motility,and plasma membrane integrity were lower compared to those of the pre-freezing stage(P0.05).The live sperm,progressive motility,and plasma membrane of the treatment group in the pre-freezing stage,and post-thawed at 39℃were higher compared to those of the control group(P0.05).Conclusions:Higher quality post-thawing Boer buck semen is achieved by adding 1μg/mL of chitosan nanoparticles of green tea extract to the skimmed egg yolk diluent and thawing at 39℃.

关键词： Boer buck semen Chitosan nanoparticles Semen diluent Higher post-thawing semen quality Prevent undernutrition

Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

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Current Medical Science 2024年第1期44卷 144-155页

作者： Lin WANG Qing-guang CHEN Hao LU department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China department of Traditional Chinese medicine Naval Medical UniversityShanghai 200433China

Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic function.While the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains uncertain.This study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and inflammation.Methods Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were assessed.RNA sequencing was utilized to analyze differential gene expression and identify potential therapeutic targets.In vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 cells.Cell viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and ELISA.Protein expression levels were determined by Western blotting analysis.The investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein levels.Results The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in cardiomyocytes.Furthermore,JPQHF downregulated

关键词： Jianpi Qinghua formula diabetic cardiomyopathy AP-1 transcription factor apoptosis inflammation

Review of construction and demolition waste management tools and frameworks with the classification,causes,and impacts of the waste

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Waste Disposal and Sustainable Energy 2024年第1期6卷 95-121页

作者： Dewan Sabbir Ahammed Rayhan Iftekhar Uddin Bhuiyan Institute of Appropriate Technology(IAT) Bangladesh University of Engineering and Technology(BUET)DhakaBangladesh department of Industrial and production Engineering(IPE) National Institute of Textile Engineering and Research(NITER)NayarhatSavarDhakaBangladesh

This review looks over the current construction and demolition waste management(C&DWM)situations by scrutinizing the definition,classification,components,compositions,generated sources and causes,impacts of generated construction and demolition wastes(C&DWs),waste management hierarchy(WMH),3R principles(Reduce,Reuse,and Recycle),Circular Economy(CE),frameworks,tools,and approaches of C&DWM.After reviewing the literature this study contributes to the literature by the following means:(a)suitable working definitions of C&DW and C&DWM are provided,(b)an expanded WMH for construction and demolition operations is presented,(c)frameworks of C&DWM are identified and listed as follows:frameworks based on WMH,including 3R principles and CE concept,frameworks focusing on the quantification,estimation,and prediction of generated C&DW,frameworks focusing on effective and sustainable C&DWM,frameworks focusing economic,social,and environmental performance assessment,frameworks based on multi-criteria analysis(MCA),frameworks based on post-disaster recovery period,and other miscellaneous frameworks,and(d)four categories of tools utilized in C&DWM are identified and explained,namely,approaches employed in C&DWM,information technology(IT)tools employed in C&DWM,multi-criteria decision analysis(MCDA)tools employed in C&DWM,and C&DWM technologies.Moreover,this study also found that CE,and green rating system(GRS)are widely used approaches,Building Information Modeling(BIM),Radio Frequency Identification(RFID),Geographic Information System,and Big Data are the extensively used IT tools,Analytical Hierarchy Process,FUZZY,TOPSIS(Technique for Order Preference by Similarity to the Ideal Solution),Weighted Summation,Elimination and Choice Expressing the Reality II,Elimination and Choice Expressing the Reality III,Evaluation of Mixed Data,and REGIME(REG)are the widely used MCA tools in C&DWM,and Prefabricated Construction and Modular Construction are broadly used C&DWM technologies.Furthermore,it has been observed that the application of

关键词： Construction and demolition waste Construction and demolition waste management Frameworks and tools 3R principles(Reduce,Reuse,&Recycle) Waste management hierarchy

Cattle production and Lumpy Skin Disease of Smallholder Farmers in Svay Rieng Province

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Journal of Environmental Science and Engineering(B) 2024年第1期13卷 39-46页

作者： Kimeang Chay Tola Ka Sokun Khoeun Chann Bun Kouch Theng Kampong Cheuteal Institute of Technology Prasat Sambour District 060403Kampong Thom ProvinceCambodia Faculty of Agriculture University of Svay RiengSvay Rieng 200705Cambodia General Directorate of animal Health and production Phnom Penh 120603Cambodia Faculty of veterinary medicine Royal University of AgriculturePhnom Penh 12400Cambodia

The cattle production in Romeas Haek district,Svay Rieng province,was developed remarkably,since there were some households raising cattle in large number,more than 20 heads.The grazing method of cattle was tethering and free grassing in the commune grass,since the natural grass and rice straw were the main source of cattle feed,however some of them supplemented their cattle with crop-byproducts,planting grass or concentrated feed.For the majority,BCS(Body Condition Scoring)of the cattle in those areas was 3 accounting for 52%-73.33%,but it was found the thin cattle has low BCS of 2 accounting for 11.11%to 40.00%and also fat cattle has BCS of 4 up to 27.78%.However,the average BCS varied with village which ranged from 2.68 to 3.17,but is not different in term of commune and sex of cattle.Besides facing with shortage of feed,the experience with diseases was also another concern,since 85.71%to 95.83%of the households faced this problem last year.Among the clinical signs found,lumpy skin was 100%,i.***.no one escaped from this problem,thus making them aware of vaccinating their cattle against some diseases such as FMD(Foot and Mouth Disease),HS(Hemorrhagic Septicemia)and LSD(Lumpy Skin Disease),but mostly vaccination was used against FMD.Because the LSD has occurred in these areas since 2020,then the seroprevalence was found in high positive up to 72.62%by Enzyme-Linked Immunosorbent Assay(ELISA)test.This positive rate was also varying by villages,ranging from 53.3%to 94.44%.But there was no association between positive cattle with commune,BCS,sex and age of cattle.In conclusion,the cattle production in Romeas Haek district,Svay Rieng province had developed markedly,however the shortage of feed and disease occurrence are the main challenges for farmer cattle producers,especially LSD outbreak last year.However,most of the farmers have been aware of the benefit of vaccination and had vaccinated their cattle against those main disease,such as FMD,HS and LSD.

关键词： Cattle production lumpy skin smallholder farmers seroprevalance

Correcting distortions of thin-walled machined parts by machine hammer peening

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Chinese Journal of Aeronautics 2024年第6期37卷 439-453页

作者： Aitor MADARIAGA Mikel CUESTA Gorka ORTIZ-DE-ZARATE Eneko SAENZ-DE-ARGANDONA Denis SORIANO Michael B.PRIME Pedro Jose ARRAZOLA department of Materials University of ManchesterOxford RoadManchester M139PLUnited Kingdom Mechanical and Industrial production department Faculty of EngineeringMondragon UnibertsitateaArrasate 20500Spain Los Alamos National Laboratory Los AlamosNew MexicoUSA

Thin-walled aerostructural components frequently get distorted after the machining process.Reworking to correct distortions or eventually rejecting parts significantly increases the cost.This paper proposes a new approach to correct distortions in thin-walled components by strategically applying hammer peening on target surfaces of a machined component.Aluminium alloy 7475-T7351 was chosen for this research.The study was divided in two stages.First,the residual stresses(RS)induced by four different pneumatic hammer peening conditions(modifying the stepover distance and initial offset)were characterised in a test coupon,and one of the conditions was selected for the next stage.In the second stage,a FEM model was used to predict distortions caused by machining in a representative workpiece.Then,the RS induced by hammer peening were included in an FEM model to define two hammer peening strategies(varying the coverage area)to analyse the capability to reduce distortions.Two workpieces were machined and then treated with the simulated hammer peening strategies for experimental validation.Results in the test coupon showed that pneumatic hammer peening can generate high compressive RS(-50 to350 MPa)up to 800 lm depth,with their magnitude increasing with a reduced stepover distance.Application of hammer peening over 4% of the surface of the representative workpiece reduced the machininginduced distortions by 37%,and a coverage area of 100% led to and overcorrection by a factor of five.This confirms that hammer peening can be strategically applied(in target areas and changing the percentage of coverage)to correct low or severe distortions.

关键词： Aeronautics Machining,Hammer Peening Aluminium alloy Distortions Residual Stress