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A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion

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Engineering 2024年第6期37卷 138-151页

作者： Peng Wang Liping Qian Huixin Liang Jianhao Huang Jing Jin Chunmei Xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng Jiang Lan Li Qing Jiang State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China Jiangsu Engineering Research Center for 3D Bioprinting Nanjing 210008China Institute of Medical 3D Printing Nanjing UniversityNanjing 210093China Centre for Experimental Animals Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing UniversityNanjing 210008China College of Aeroplane Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of PhysicsNanjing UniversityNanjing 210093China department of Chemical Engineering Stanford UniversityStanfordCA 94305USA department of Orthopedic surgery The Second Affiliated Hospital Zhejiang University School of MedicineOrthopedic Research Institute of Zhejiang UniversityKey Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang ProvinceHangzhou 310009China

Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of ***,the mechanical properties of hydrogel scaffolds and natural skin are substantially ***,we developed a polyvinyl alcohol(PVA)/acrylamide based interpenetrating network(IPN)hydrogel that was surface modified with polydopamine(PDA)and termed *** Dopa-gel exhibited mechanical properties similar to native skin tissue and a superior ability to modulate paracrine ***,a tough scaffold with tensile resistance was fabricated using this hydrogel by three-dimensional *** results showed that the interpenetration of PVA,alginate,and polyacrylamide networks notably enhanced the mechanical properties of the *** modification with PDA endowed the hydrogels with increased secretion of immunomodulatory and proangiogenic *** an in vivo model,Dopa-gel treatment accelerated wound closure,increased vascularization,and promoted a shift in macrophages from a proinflammatory M1 phenotype to a prohealing and anti-inflammatory M2 phenotype within the wound ***,the focal adhesion kinase(FAK)/extracellular signal-related kinase(ERK)signaling pathway may mediate the promotion of skin defect healing by increasing paracrine secretion via the ***,proangiogenic factors can be induced through Rho-associated kinase-2(ROCK-2)/vascular endothelial growth factor(VEGF)-mediated paracrine secretion under tensile stress *** together,these findings suggest that the multifunctional Dopa-gel,which has good mechanical properties similar to those of native skin tissue and enhanced immunomodulatory and angiogenic properties,is a promising scaffold for skin tissue regeneration.

关键词： Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways

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Efficacy of percutaneous mechanical thrombus removal in acute lower extremity deep venous thrombosis

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World Journal of Clinical Cases 2024年第21期12卷 4590-4600页

作者： Jun-Qiang Xue Ping Yin Jian-Ping He Hui Wei Cui-Jie Geng Yu-Xian Luo department of vascular surgery Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina department of Laboratory Medicine Shijiazhuang Hospital of Traditional Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Catheter Room Shijiazhuang People's HospitalShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Acute lower extremity deep venous thrombosis(LEDVT)is a common vascular emergency with significant morbidity risks,including post-thrombotic syndrome(PTS)and pulmonary *** treatments like catheter-directed thrombolysis(CDT)often result in variable success rates and *** To investigate the therapeutic efficacy of percutaneous mechanical thrombus removal in acute *** A retrospective analysis was performed to examine 58 hospitalised patients with acute LEDVT between August 2019 and August *** patients were categorised into the percutaneous mechanical thrombectomy(PMT)group(n=24)and CDT group(n=32).The follow-up,safety and treatment outcomes were compared between the two *** main observational indexes were venous patency score,thrombus removal effect,complications,hospitalisation duration and *** The venous patency score was 9.04±1.40 in the PMT group and 8.81±1.60 in the CDT group,and the thrombus clearance rate was 100%in both *** complication rate was 8.33%in the PMT group and 34.84%in the CDT group,and the difference was statistically significant(Phospitalisation duration was 6.54±2.48 days in the PMT group and 8.14±3.56 days in the CDT *** incidence of PTS was lower in the PMT group than in the CDT group;however,the difference was not statistically significant(Phospitalisation duration and reduced incidence of complications,such as infections and small *** results indicate that PMT has substantial beneficial effects in the treatment of LEDVT.

关键词： Post-thrombotic syndrome Catheter-directed thrombolysis Percutaneous mechanical thrombectomy Acute lower extremity deep venous thrombosis

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Identifying coronary artery bypass grafting patients at high risk for adverse long-term prognosis using serial health-related quality of life assessments

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Chinese Medical Journal 2024年第9期137卷 1069-1077页

作者： Juncheng Wang Hanning Liu Chao Yue Limeng Yang Kai Yang Yan Zhao Huan Ren Ying Zhang Zhe Zheng National Clinical Research Center for Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Cardiovascular surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of vascular surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Cardiac surgery Wuhan Asia Heart HospitalWuhanHubei 430022China

Background:Patients who undergo coronary artery bypass grafting(CABG)are known to be at a significant risk of experiencing long-term adverse events,emphasizing the importance of regular *** health-related quality of life(HRQoL)serves as a direct method to gauge *** objective is to ascertain the prognostic significance of consecutive HRQoL assessments using the Physical Component Summary(PCS)and Mental Component Summary(MCS)derived from the Short-Form 36(SF-36)health survey in CABG ***:The study population consisted of 433 patients who underwent isolated elective CABG at Fuwai hospital between 2012 and ***-36 assessments were conducted during both the hospitalization period and *** primary endpoint of the study was all-cause mortality,while the secondary outcome was a composite measure including death,myocardial infarction,stroke,and repeat *** assessed the relationships between the PCS and MCS at baseline,as well as their changes during the first 6 months after the surgery(referred to asΔPCS andΔMCS,respectively),and the observed ***:The patients were followed for an average of 6.28 years,during which 35 individuals(35/433,8.1%)*** adjusting for clinical variables,it was observed that baseline MCS scores(hazard ratio[HR]for a 1-standard deviation[SD]decrease,1.57;95%confidence interval[CI],1.07-2.30)andΔMCS(HR for a 1-SD decrease,1.67;95%CI,1.09-2.56)were associated with all-cause ***,baseline PCS scores andΔPCS did not exhibit a significant relationship with all-cause ***,there was a dose-response relationship observed betweenΔMCS and the likelihood of all-cause mortality(HRs for the 2nd,3rd and 4th quartiles compared to the 1st quartile,0.33,0.45 and 0.11,respectively).Conclusions:Baseline MCS and changes in MCS were independent predictors for long-term mortality of *** mental health status and recovery indicated better prognosis.

关键词： Coronary artery bypass grafting Coronary artery disease Prognosis Quality of life Short-Form 36 Risk factor Serial measurements

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Oyster-derived Anticoagulant Peptide Mitigates Thrombin-induced Barrier Dysfunction and Prothrombotic Phenotype in Human Pulmonary Microvascular Endothelial Cells

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Food Science and Human Wellness 2024年

作者： Shuzhen Cheng Siyi Wang Ximing Yang Minghao Xie Qi Yang Lushun Yuan Ming Du National Engineering Research Center of Seafood， Collaborative Innovation Center of Seafood Deep Processing， Dalian Polytechnic University department of vascular surgery， Shanghai General hospital， Shanghai Jiao Tong University SKL of Marine Food Processing & Safety Control， School of Food Science and Technology， Dalian Polytechnic University

Thrombin blockers have been shown to be effective for various pathological conditions， but their use is limited due to the potential for serious bleeding adverse effects. This study introduced a novel bioactive peptide (P-2-CG) from oyster， that mitigated thrombin-mediated barrier dysfunction and prothrombotic phenotypes in human pulmonary microvascular endothelial cells (HPMECs). P-2-CG significantly attenuated the increase in endothelial monolayer permeability induced by thrombin through the possible attenuation of RhoA activation and it promoted barrier recovery by enhancing endothelial cell adhesion. Additionally， P-2-CG was found to decrease the pro-thrombotic phenotype induced by thrombin in HPMEC by reducing the extrinsic trigger TF mRNA expression， which resulted in prolonged plasma clotting time， decreased FXa activation， and reduced thrombin generation. Moreover， P-2-CG inhibited thrombosis efficiently by blocking ICAM-1 and VCAM-1 expression via tyrosine phosphorylation of RelA/p65. P-2-CG inhibits thrombin mediated inflammation and provides a potential therapeutic option for treating endothelial dysfunction and thrombosis.

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Efficacy and safety of a neurointerventional operation robotic assistance system in cerebral angiography

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Stroke & vascular Neurology 2024年第3期9卷 243-251,I0210-I0240页

作者： He Liu Conghui Li Shaohua Ren Tong Li Hongliang Zhong Jianwen Jia Hongchao Yang Yi Qi Junqiang Feng Youxiang Li Yang Wang department of Neurosurgery Beijing Chao-Yang HospitalCapital Medical UniversityBeijingChina department of Neurosurgery Hebei Medical University First Affiliated HospitalShijiazhuangHebeiChina department of Neurosurgery Shanxi Provincial People’s HospitalShanxiTaiyuanChina department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background At present,neurointerventional surgery requires angiographers to perform operations in the digital subtraction angiography(DSA)*** radiation and chronic joint damage are still unavoidable for ***,we researched and developed a neurointerventional robot-assisted system,which is operated by angiographers in an operating room outside the DSA *** have conducted a prospective,multicentre,randomised controlled trial to evaluate the safety and efficacy of a robot-assisted system in human cerebral *** the future,this research will provide a platform for the research and development of an intelligent surgical system and bring revolutionary progress in neurointerventional *** From December 2020 to December 2021,260 patients were enrolled from three medical centres,who were randomly and equally divided into a robot-assisted system group and a clinical routine cerebral angiography *** success rate of angiography,the rate of the catheter reaching the target vessel,the operation time,X-ray radiation exposure and the incidence of related adverse events were compared between the two *** A total of 257 patients completed this trial;baseline characteristics of the two groups did not differ *** success rate of angiography in both the control group and the experimental group was 100%.The rate of the catheter reaching the target vessel was 99.23%and 100.00%in the control and experimental groups,*** the control versus experimental groups,the angiographic operation time was 48.59±25.60min versus 47.94±27.49min,respectively;the X-ray radiation dose was 735.01±554.77mGy versus 821.65±705.45mGy,respectively;and the incidence of adverse events was 23.44%versus 22.48%,*** statistical differences were present between the two *** The robot-assisted surgical system is more convenient for cerebral angiography and is as safe and effective as the traditional cerebr

关键词： cerebral operation routine

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Analysis of Osteoporosis Risk Factors in 148 Retired Employees Based on Physical Examination Results

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Proceedings of Anticancer Research 2024年第4期8卷 116-123页

作者： Sunhang Cao Zhengfeng Liu Guiyu Cheng Dongmei Zhai Peng Li Chunshui Huang Physical Examination and Rehabilitation Centre Civil Aviation General HospitalBeijing 100123China department of vascular surgery Civil Aviation General HospitalBeijing 100123China China TravelSky Holding Co.Ltd. Beijing 101318China

Objective:To investigate and thoroughly understand the physical examination results of retired employees from a certain unit in Beijing,analyze their bone mineral density(BMD),and identify risk factors that may indicate *** provides a reference for the individualized prevention,identification,and control of osteoporosis among retired ***:The bone mineral density and potential factors of 148 retired employees from a unit in 2023 were analyzed and categorized into osteoporosis and non-osteoporosis *** factors from the physical examinations of the two groups were ***’s correlation analysis was used to determine the correlation between key factors and *** key factors were included in a regression analysis.A multivariate binary logistics regression was employed to identify risk factors indicative of ***:Correlation analysis revealed that gender,age,and ECG ST-segment length were significantly associated with *** analysis showed that for each additional year of age,the likelihood of developing osteoporosis increased by 1.058 times;females were 2.865 times more likely to develop osteoporosis compared to males;the longer the ECG ST-segment,the higher the likelihood of ***:Gender,age,and ECG ST-segment length are significantly associated with *** indicators can provide reference points for early identification,early intervention,and reducing the incidence of osteoporosis in clinical settings.

关键词： Osteoporosis Gender Age ECG ST-segment Correlation analysis

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Prosthetic venous valves for chronic venous insufficiency:Advancements and future design directions

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Medicine in Novel Technology and Devices 2024年第1期21卷 10-22页

作者： Qiushuo Zong Jing Liu Yunfei Chen Yuanyuan Kong Yiping Dang Zhihong Wang department of vascular surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Institute of Transplant Medicine Nankai University School of MedicineTianjin300071China

With the serious aging population and lifestyle changes,chronic venous insufficiency accounts for approximately 25.95%of the population,which may lead to lower limb edema and leg heaviness,as well as severe infections of skin ulcers that can result in sepsis and necessitate *** treatment and other supportive measures can only slow the disease's progression but are unable to drastically reverse it;surgical interventions are rarely used due to the high risk of catastrophic postoperative *** one of the most promising minimally invasive therapies,percutaneous prosthetic valve replacement has emerged in light of this situation,providing novel alternatives for patients with deep venous valve *** reviewed the historical prosthetic venous valve designs,including their structure and materials,animal evaluation models,and assessment *** the basis of the findings from in vitro tests,animal studies,and clinical trials,we summarized the major challenges and potential solutions for the development of advanced prosthetic venous valves.

关键词： Prosthetic venous valves Interventional venous valves Deep venous valve insufficiency Deep venous valve reflux Valve leaflets Valve design

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Prognostic value of ultrasound in early arterial complications post liver transplant

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World Journal of Gastrointestinal surgery 2024年第1期16卷 13-20页

作者： Ning-Bo Zhao Yi Chen Rui Xia Jian-Bo Tang Dong Zhao department of Ultrasound National Clinical Research Centre for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina department of Thyroid and Hernia surgery The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 51800Guangdong ProvinceChina department of Liver surgery and Organ Transplantation Center Shenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina

Liver transplantation is the primary therapeutic intervention for end-stage liver ***,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** clinical manifestations associated with early arterial complications following liver transplantation are often *** timely intervention,these complications can result in graft fai-lure or patient ***,early diagnosis and the formulation of an op-timal treatment plan are *** examination remains the pre-dominant imaging modality for detecting complications post liver *** article comprehensively reviews common causes and clinical present-ations of early hepatic artery complications in the post-transplantation period and delineates abnormal sonographic findings for accurate diagnosis of these ***,ultrasound offers the advantages of convenience,safety,effect-iveness,and *** enables real-time,dynamic,and precise evalua-tion,making it the preferred diagnostic method for post-liver transplantation *** Liver transplantation stands as the primary therapeutic approach for end-stage liver *** advancements in surgical techniques and the application of novel immunosuppressive agents contribute to ongoing improvements in the success rate and overall survival in patients undergoing liver transplantation *** these advan-cements,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** the early stages following liver transplantation(within the first 30 d),proper hepatic artery function is crucial for hepatic arterial blood *** later stages,collateral circulation,including arteries such as the phrenic artery,right gastric artery,and gastroduodenal artery,becomes important for maintaining hepatic blood *** is now understood that the establishment of effective collat

关键词： Liver transplantation vascular complication Arterial complication Ultrasound

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Analysis of Blood Lipids, Blood Glucose, Blood Uric Acid, and Blood Routine Test Results in Retired Employees of a Unit in the Civil Aviation System

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Journal of Clinical and Nursing Research 2024年第8期8卷 67-74页

作者： Sunhang Cao Zhengfeng Liu Guiyu Cheng Dongmei Zhai Ke Gong Chunshui Huang Medical Examination and Rehabilitation Center Civil Aviation General HospitalBeijing 100123China department of vascular surgery Civil Aviation General HospitalBeijing 100123China China TravelSky Holding Co. Ltd.Beijing 101318China Laboratory department Civil Aviation General HospitalBeijing 100123China

Objective:To investigate and analyze the annual physical examination results of retired employees from a unit in the civil aviation system,focusing on blood lipids,blood glucose,blood uric acid,and blood routine *** study aims to provide relevant references for formulating reasonable disease management measures for preventing and controlling hyperlipidemia,hyperuricemia,and other conditions in retired ***:The examination results of 231 participants were collected and *** participants were divided into four groups based on age:middle-aged group,young-old group,middle-old group,and old-old *** blood test results were compared across these groups,and an assessment of atherosclerotic cardiovascular disease(ASCVD)risk levels was completed in conjunction with medical *** test results were also compared by ***:There were no significant statistical differences in blood test results when grouped by ***,the prevalence of hyperuricemia was higher in males than in females,while the prevalence of hypercholesterolemia was higher in females than in *** LDL-C target achievement rate was lower in the moderate-and-high-risk group as well as the very high-risk group as defined by ASCVD risk ***:Management of hyperuricemia and hyperlipidemia in retired employees(elderly patients)should be strengthened to reduce the risk of ASCVD events and alleviate the potential medical burden associated with disease progression.

关键词： Physical examination Blood routine Blood lipids Blood uric acid Blood glucose Atherosclerotic cardiovascular disease

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Cardiac surgery at Yaoundé General hospital by a Local Team: Activity Report from September 2022 to January 2024

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World Journal of Cardiovascular surgery 2024年第6期14卷 87-94页

作者： Laurence Carole Ngo Yon Charles Mve Mvondo Hermann Nestor Tsague Kengni Zephanie Kobe Fokalbo Sépolin Lowe Mireille Dakleu Alain Patrick Menanga William Ngatchou Djomo Vincent De Paul Djientcheu department of Cardiothoracic and vascular surgery Yaound General Hospital Yaound Cameroon department of surgery and Specialities Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon department of Clinical Sciences Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon department of Clinical Sciences Faculty of Medicine and Biomedical Sciences University of Yaound Yaound Cameroon department of surgery and Specialities Faculty of Medicine and Biomedical Sciences University of Yaound Yaound Cameroon

Introduction: The practice of cardiac surgery (CS) in sub-Saharan Africa faces a number of challenges. We report on the surgical activities of the first 17 months of the program launched at the Yaoundé General hospital (YGH), describing the types of interventions and the early results. Patients and Methods: This was a descriptive cross-sectional study including patients who underwent CS from September 2022 to January 2024 at the YGH. Clinical, operative and postoperative data were collected and analysed retrospectively by R software. Results: A total of 37 patients underwent CS during the study period, divided into 23 (62.2%) open-heart and 14 (37.8%) closed-heart cases. Males predominated (sex ratio 1.17). The median age and interquartile range (IQR) were 36 years (9 - 51). Isolated valve surgery, in 15 (40.5%) cases, was the most common procedure in open-heart surgery cases. Closed-heart surgery involved closure of the patent ductus arteriosus in 9 (24.3%) cases, coronary artery bypass grafting in 3 (8.1%) cases, and pericardectomy in 2 (5.4%) cases. The median duration of extracorporeal circulation and aortic cross-clamping was 101 min (IQR 84 - 143) and 74 min (IQR 54 - 112) respectively. The median duration of mechanical ventilation was 2 hours (IQR 2 - 3). The median intensive care unit stay and median hospital stay were 2 days (IQR 2 - 3) and 7 days (IQR 5 - 8) respectively. Operative mortality was 2 (5.4%). Conclusion: Cardiac surgery remains a major challenge for African populations. The early results achieved by the local team are satisfactory. An increase in surgical activity should be strongly encouraged to facilitate local training and ensure the sustainability of the activity.

关键词： Cardiac surgery Sub-Saharan Africa Cameroon

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