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Delivering Microrobots in the Musculoskeletal System

Nano-Micro Letters 2024年第11期16卷 585-617页

作者： Mumin Cao Renwang Sheng Yimin Sun Ying Cao Hao Wang Ming Zhang Yunmeng Pu Yucheng Gao Yuanwei Zhang Panpan Lu Gaojun Teng Qianqian Wang Yunfeng Rui department of Orthopaedics Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuPeople’s Republic of China School of Medicine Southeast UniversityNanjing 210009People’s Republic of China Orthopaedic Trauma Institute(OTI) Southeast UniversityNanjing 210009People’s Republic of China Jiangsu Key Laboratory for Design and Manufacture of Micro‑Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 210009People’s Republic of China Center of Interventional Radiology and vascular surgery Department of RadiologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009People’s Republic of China

Disorders of the musculoskeletal system are the major contributors to the global burden of disease and current treatments show limited *** often suffer chronic pain and might eventually have to undergo end-stage ***,future treatments should focus on early detection and intervention of regional *** have been gradually used in organisms due to their advantages of intelligent,precise and minimally invasive targeted *** the combination of control and imaging systems,microrobots with good biosafety can be delivered to the desired area for *** the musculoskeletal system,microrobots are mainly utilized to transport stem cells/drugs or to remove hazardous substances from the *** to traditional biomaterial and tissue engineering strategies,active motion improves the efficiency and penetration of local targeting of cells/*** review discusses the frontier applications of microrobotic systems in different tissues of the musculoskeletal *** summarize the challenges and barriers that hinder clinical translation by evaluating the characteristics of different microrobots and finally point out the future direction of microrobots in the musculoskeletal system.

关键词： Microrobot Musculoskeletal system Targeted delivery Microrobotic systems Magnetic actuation

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Intraoperative cholangio-ultrasonography(IOCUS)during hepatectomy with resection of the biliary confluence:An effective alternative to intraoperative cholangiography

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 417-420页

作者： Daniele Del Fabbro Fabio Procopio Jacopo Galvanin Guido Costa Simone Famularo Angela Palmisano Matteo Donadon Guido Torzilli Division of Hepatobiliary surgery Department of SurgeryIRCCS Humanitas Research HospitalVia A.Manzoni 56Rozzano 20089MilanItaly department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 4Pieve Emanuele 20072MilanItaly

Intraoperative ultrasonography(IOUS)in hepatobiliary surgery is well known as an essential tool for radical and safe hepatectomies,allowing to perform parenchymal sparing surgery and,as consequence,to expand the surgical indications for patients otherwise considered ***,since many years,despite its effectiveness in the study of vascular anatomy of the liver,the gold standard for the assessment of biliary anatomy during surgery is intraoperative cholangiography(IOC),which is used for the validation of preoperative imaging as well as for guiding reconstruction in case of bile duct injury or resection.

关键词： anatomy biliary ultrasonography

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Atherosclerosis-related biomarker PABPC1 predicts pan-cancer events

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Stroke & vascular Neurology 2024年第2期9卷 108-125,I0001-I0005页

作者： Miao Lin Liubing Hu Si Shen Jiyue Liu Yanyan Liu Yixian Xu Honglin Chen Kazuo Sugimoto Jianshuang Li Ikuo Kamitsukasa Takaki Hiwasa Hao Wang Anding Xu Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina department of Anesthesiology The First Affiliated HospitalJinan UniversityGuangzhouChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhouChina department of Radiology Medical Imaging CenterThe First Affiliated HospitalJinan UniversityGuangzhouChina department of Biochemistry and Genetics Graduate School of MedicineChiba UniversityChibaJapan department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina department of Neurology Chiba Rosai HospitalChibaJapan department of Neurology Chibaken Saiseikai Narashino HospitalChibaJapan department of Neurological surgery Graduate School of MedicineChiba UniversityChibaJapan

Background Atherosclerosis(AS)and tumours are the leading causes of death worldwide and share common risk factors,detection methods and molecular ***,searching for serum markers shared by AS and tumours is beneficial to the early diagnosis of *** The sera of 23 patients with AS-related transient ischaemic attack were screened by serological identification of antigens through recombinant cDNA expression cloning(SEREX),and cDNA clones were *** function enrichment analysis was performed on cDNA clones to identify their biological pathways and determine whether they were related to AS or ***,gene–gene and protein–protein interactions were performed and AS-associated markers would be *** expression of AS biomarkers in human normal organs and pan-cancer tumour tissues were ***,immune infiltration level and tumour mutation burden of various immune cells were *** curves analysis could show the expression of AS markers in *** AS-related sera were screened by SEREX,and 83 cDNA clones with high homology were *** functional enrichment analysis,it was found that their functions were closely related to AS and tumour *** multiple biological information interaction screening and the external cohort validating,poly(A)binding protein cytoplasmic 1(PABPC1)was found to be a potential AS *** assess whether PABPC1 was related to pan-cancer,its expression in different tumour pathological stages and ages was *** AS-associated proteins were closely related to cancer immune infiltration,we investigated and found that PABPC1 had the same role in ***,analysis of Kaplan-Meier survival curves revealed that high PABPC1 expression in pan-cancer was associated with high risk of *** Through the findings of SEREX and bioinformatics pan-cancer analysis,we concluded that PABPC1 might serve as a potential biomarker for the

关键词： diagnosis cancer organs

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Association of a complete breast cancer pathologic response with axillary lymph node metastasis via neoadjuvant chemotherapy:Results from the CSBrS-012 study

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Chinese Medical Journal 2024年第11期137卷 1369-1371页

作者： Le Ma Pin Gao Zhenzhen Liu Dechuang Jiao Rui Ling Jingjing Xiao Yi Zhao Yitong Wang Hongjian Yang Yunjiang Liu Ke Liu Jianguo Zhang Guangyan Li Dahua Mao Yinglei Deng Jianjun He Maimaitiaili Amina Zhigang Yu Wang Fei Yinhua Liu Peifen Fu Minya Yao Jiandong Wang Li Zhu Hongchuan Jiang Zuowei Zhao Xingsong Tian Zhongwei Cao Xinyu Ma Kejin Wu Shaomei Fu Ailin Song Yanwei Wang Jin Feng Zhimin Fan department of Breast surgery General Surgery CenterThe First Hospital of Jilin UniversityChangchunJilin 130021China department of Breast Disease Henan Breast Cancer CenterAffiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China department of Thyroid Breast and Vascular SurgeryXijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Surgical Oncology department Shengjing Hospital of China Medical UniversityShenyangLiaoning 110022China department of Breast surgery The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310022China department of surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 052360China Fourth department of Breast surgery Jilin Cancer HospitalChangchunJilin 130012China department of Breast surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China department of Breast surgery Affiliated Wudang Hospital of Guizhou Medical UniversityGuiyangGuizhou 550009China department of Breast surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China department of Breast surgery The Second HospitalCheeloo College of MedicineShandong UniversityJinanShandong 250033China Breast Disease Center Peking University First HospitalBeijing 100034China department of Breast surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China department of General surgery The First Medical CenterChinese PLA General HospitalBeijing 100852China department of Breast surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China department of Breast surgery The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China department of Breast and Thyroid surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinan

To the Editor:In the last decade,neoadjuvant chemotherapy(NAC)has become a well-accepted treatment option for breast cancer,although few detailed description of NAC in China has yet been reported.[1]A previous study found that among patients with clinically node-negative(cN0)breast cancer,97.7%(432/442)with breast pathologic complete response(bpCR)had ypN0(absence of metastases in the axillary lymph nodes);and 71.6%(882/1232)without bpCR achieved ypN0(P<0.001).As for human epidermal growth factor receptor 2(HER2)positive or triple-negative breast cancer(TNBC)that achieved bpCR.

关键词： breast pathologic chemotherapy

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Hypoxia in the pulmonary vein increases pulmonary vascular resistance independently of oxygen in the pulmonary artery

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Animal Models and Experimental Medicine 2024年第2期7卷 156-165页

作者： Sigridur Olga Magnusdottir Carsten Simonsen Dan Stieper Karbing Bodil Steen Rasmussen Benedict Kjaergaard Biomedical Research Laboratory Aalborg University HospitalAalborgDenmark department of Clinical Medicine Aalborg UniversityAalborgDenmark department of Cardiothoracic surgery Aalborg University HospitalAalborgDenmark department of Health Science and Technology Aalborg UniversityAalborgDenmark department of Anesthesia and Intensive Care Aalborg University HospitalAalborgDenmark

Introduction:Hypoxic pulmonary vasoconstriction(HPV)can be a challenging clinical *** is not fully elucidated where in the circulation the regulation of resistance takes *** is often referred to as if it is in the arteries,but we hypothesized that it is in the venous side of the pulmonary ***:In an open thorax model,pigs were treated with a veno-venous extra corporeal membrane oxygenator to either oxygenate or deoxygenate blood passing through the pulmonary *** the same time the lungs were ventilated with extreme variations of inspired air from 5%to 100%oxygen,making it possible to make combinations of high and low oxygen content through the pulmonary circulation.A flow probe was inserted around the main pulmonary artery and catheters in the pulmonary artery and in the left atrium were used for pressure monitoring and blood *** different combinations of oxygenation,pulmonary vascular resistance(PVR)was ***:With unchanged level of oxygen in the pulmonary artery and reduced inspired oxygen fraction lowering oxygen tension from 29 to 6.7 kPa in the pulmonary vein,PVR was *** more extreme hypoxia PVR suddenly *** with low oxygenation in the pulmonary artery did not systematic influence PVR if there was enough oxygen in the inspired air and in the pulmonary ***:The impact of hypoxia occurs from the alveolar level and forward with the blood *** experiments indicated that the regulation of PVR is mediated from the venous side.

关键词： animal models cardiopulmonary support Hypoxic pulmonary vasoconstriction pulmonary circulation

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Development of a novel difficulty scoring system for laparoscopic liver resection procedure in patients with intrahepatic duct stones

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World Journal of Gastrointestinal surgery 2024年第10期16卷 3133-3141页

作者： Bo Luo Si-Kai Wu Ke Zhang Pei-Hong Wang Wei-Wei Chen Ning Fu Zhi-Ming Yang Jing-Cheng Hao department of Hepatobiliary and vascular surgery The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina department of General surgery The Western Theater Command General HospitalChengdu 610500Sichuan ProvinceChina department of Hepatobiliary and Pancreatic surgery Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

BACKGROUND For intrahepatic duct(IHD)stones,laparoscopic liver resection(LLR)is currently a reliable ***,the current LLR difficulty scoring system(DSS)is only available for patients with hepatocellular *** To explore the development of a DSS for IHD stone patients with LLR and the validation of its *** We used clinical data from 80 patients who received LLR for IHD ***-six of these patients were used in multiple linear regression to construct a scoring *** 34 patients from different centers were used as external *** completeness of our DSS was then evaluated in patients with varying degrees of surgical difficulty based on documented surgical outcomes in the study group of *** The following five predictors were ultimately included and scored by calculating the weighted contribution of each factor to the prediction of operative time in the training cohort:Location of stones,number of stones≥3,stones located in the bile ducts of several grades,previous biliary surgery less than twice,distal bile duct ***,the data set was validated using a DSS developed from the *** following variables were identified as statistically significant in external validation:Operative time,blood loss,intraoperative transfusion,postoperative alanine aminotransferase,and Clavien-Dindo grading≥*** variables demonstrated statistically significant differences in patients with three or more *** Patients with IHD stones have varying degrees of surgical difficulty,and the newly developed DSS can be validated with external data to effectively predict risks and complications after LLR surgery.

关键词： Intrahepatic duct stones Laparoscopic liver resection Difficulty scoring system Outcome Complication

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Laparoscopic partial splenectomy in the treatment of splenic ectopic pregnancy

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Hepatobiliary surgery and Nutrition 2024年第3期13卷 569-572页

作者： Ke-Xi Liao Li Cao Yan-Zhou Wang Bao-Lin Wang Shu-Guo Zheng Jian-Wei Li Institute of Hepatobiliary surgery First Affiliated HospitalArmy Medical UniversityChongqingChina department of Gynecology and Obstetrics First Affiliated HospitalArmy Medical UniversityChongqingChina

Ectopic pregnancy is a pregnancy that occurred outside the uterus,usually in the fallopian tube,followed by other abdominal *** pregnancy could not develop normally to term and requires sufficient evaluation and intervention with medication or surgery in most cases(1).As a rare form of abdominal pregnancy(2),splenic ectopic pregnancy could be treated by drug treatment(3)or surgical interventions,including laparotomy and laparoscopy,which focused on total splenectomy(4,5).A previous study(6)indicated that laparoscopic partial splenectomy for selected patients was safe and *** to the fragile texture of the spleen,the suture method during laparoscopic partial splenectomy was technically demanding since it might encounter higher risk of splenic vascular hemorrhage than total ***,few reports focused on the treatment of splenic ectopic pregnancy via laparoscopic partial splenectomy(7).In order to avoid the potential severe complications such as hemoperitoneum(8)caused by drug treatment alone,and to avert impaired hematopoietic and immune function caused by total splenectomy,we herein presented a case(Video 1)of a 30-year-old woman(gravida 2,para 1)undergoing laparoscopic partial splenectomy performed by hepatobiliary surgeons to treat splenic ectopic pregnancy.

关键词： pregnancy splenectomy impaired

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Optimal timing for plastic surgical procedures for common congenital anomalies:A review

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World Journal of Clinical Pediatrics 2024年第2期13卷 38-61页

作者： Aakanksha Goel Arun Goel Divine Aesthetic surgery New Delhi 110048India department of Plastic surgery Lok Nayak Hospital and Associated Maulana Azad Medical CollegeNew Delhi 110002India

Apart from listening to the cry of a healthy newborn,it is the declaration by the attending paediatrician in the labour room that the child is normal which brings utmost joy to *** global incidence of children born with congenital anomalies has been reported to be 3%-6%with more than 90%of these occurring in low-and middle-income group *** exact percentages/total numbers of children requiring surgical treatment cannot be estimated for several *** children are operated under several surgical disciplines,viz,paediatric-,plastic reconstructive,neuro-,cardiothoracic-,orthopaedic surgery *** conditions may be life-threatening,e.g.,trachea-oesophageal fistula,critical pulmonary stenosis,*** require immediate surgical ***,e.g.,hydrocephalus,may need intervention as soon as the patient is fit for ***,e.g.,patent ductus arteriosus need‘wait and watch’policy up to a certain age in the hope of spontaneous *** extremely important category is that of patients where the operative intervention is done based on their *** all the congenital anomalies coming under care of a plastic surgeon are operated as elective surgery(many as multiple stages of correction)at appropriate *** are advantages and disadvantages of intervention at different *** this article,we present a review of optimal timings,along with reasoning,for surgery of many of the common congenital anomalies which are treated by plastic ***,paediatricians and general practitioners/family physicians,who most often are the first ones to come across such children,must know to guide the parents appropriately and convincingly impress upon the them as to why their child should not be operated immediately and also the consequences of too soon or too late.

关键词： Plastic surgery Congenital anomalies Pediatric plastic surgery Facial cleft Microtia vascular anomalies Syndactyly Hypospadias Optimal timing Pediatric surgery

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Bone tissue engineering scaffold materials: Fundamentals, advances, and challenges

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Chinese Chemical Letters 2024年第2期35卷 176-186页

作者： Chang Xu Zhize Liu Xi Chen Yang Gao Wenjun Wang xijing Zhuang Hao Zhang Xufeng Dong department of Cardiovascular surgery Central Hospital of Dalian University of TechnologyDalian 116089China School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China department of Orthopaedics Central Hospital of Dalian University of TechnologyDalian 116089China department of Dermatology Allergologyand VenereologyUniversity of LübeckLübeck 23562Germany

Bone damage caused by trauma and tumors is a serious problem for human health, therefore, three-dimensional (3D) scaffolding materials that stimulate and promote the regeneration of broken bone tissues have become the focus of current research in the field of bone damage *** this regard, a preferential combination of materials and preparation techniques is considered crucial for the preparation of advanced bone tissue engineering scaffolds to better facilitate the regeneration of broken *** this review, current research advances and challenges in bone tissue engineering scaffolds are discussed and analyzed in ***, we elucidated the structure and self-healing mechanism of bone ***, the main applications of different materials, including inorganic and organic materials, in bone tissue engineering scaffolds are ***, we overview the latest research progress of the mainstream preparation strategies of bone tissue engineering scaffolds, and provide an in-depth analysis of the different advantages of each ***, promising future directions and challenges of bone tissue engineering scaffolds are systematically discussed.

关键词： Biomaterials Bone defects Tissue engineering Scaffolds Osteogenesis

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Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection

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National Science Review 2024年第6期11卷 273-284页

作者： Zhanhang Guo Yunhao Wu Bo Chen Mengdie Kong Peng Xie Yan Li Dongfang Liu Renjie Chai Ning Gu Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Medical Science and Technology Innovation Center Shandong First Medical University &Shandong Academy of Medical Sciences State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast University Institute of Materials Science and Devices School of Materials Science and Engineering Suzhou University of Science and Technology Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging &Interventional Radiology & vascular surgery Department of Radiology Medical School Zhongda Hospital Southeast University Co-Innovation Center of Neuroregeneration Nantong University School of Medical Technology Institute of Engineering MedicineBeijing Institute of Technology department of Otolaryngology Head and Neck surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Southeast university Shenzhen research institute Cardiovascular Disease Research Center Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Medical School Nanjing University

Noise-induced hearing loss(NIHL) is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxide nanoparticle assembly(SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. This modulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of the intestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea. Additionally, gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut–inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway, which further contributes to the restoration of hearing function. Our study confirms the role of the microbiota–gut–inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

关键词： superparamagnetic iron oxide nanoparticle hearing loss gut microbiota inflammation sphingolipid metabolism microbiota–gut–inner ear axis

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