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Role of variation coefficient of stone density in determining success of shock wave lithotripsy in urinary calculi

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World Journal of Nephrology 2025年第1期14卷 110-118页

作者： Nadeem Iqbal Aisha Hasan Sajid Iqbal Sadaf Noureen Saeed Akhter department of urology and kidney Transplant Shifa Intl HospitalsIslamabad 44790Pakistan department of urology Pakistan Kidney and Liver InstituteLahore 54000PunjabPakistan department of Biochemistry Riphah International UniversityRawalpindi 44000PunjabPakistan department of Rehabilitation PNS KarachiKarachi 75950SindhPakistan department of Medicine Groves Medical CenterNew MaldenLondon KT33PBUnited Kingdom department urology Shifa International Hospital IslamabadIslamabad 44000Pakistan

BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free *** To assess the role of VCSD in determining success of SWL in urinary *** Charts review was utilized for collection of data *** patients were subjected to SWL,using an electromagnetic *** stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)*** of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically *** There were a total of 407 patients included in the *** mean age of the subjects in this study was 38.89±14.61 *** total,165 out of the 407 patients could not achieve stone free *** successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.

关键词： Computed tomography Shock wave lithotripsy Stone heterogeneity Variation coefficient of stone density kidney stones

Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease:A systematic review

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World Journal of Nephrology 2025年第1期14卷 127-137页

作者： Jaydeep Jain Mahendra Singh Shashank Kumar Om Kumar Yadav Ankit Shettar Shiv Charan Navriya Deepak Prakash Bhirud Gautam Ram Choudhary Arjun Singh Sandhu department of urology All India Institute of Medical SciencesJodhpur 342008RājasthānIndia

BACKGROUND End-stage renal disease(ESRD)is associated with a multitude of physical,psychological,and social health challenges,including a profound impact on sexual and reproductive *** males with ESRD,erectile dysfunction(ED)is highly prevalent due to factors such as underlying comorbidities,including diabetes and hypertension,and the physiological effects of long-term *** transplantation(KTx)has been proposed as a potential intervention to mitigate the effects of ED by restoring renal function and improving hormonal ***,the evidence surrounding the effectiveness of KTx in improving sexual function,specifically erectile function(EF),remains *** systematic review and meta-analysis aim to evaluate the effects of KTx on sexual dysfunction(SexDys),particularly ED,in male ESRD *** To evaluate the benefits and potential harms of KTx compared to other forms of renal replacement therapy in improving EF in adult males with ESRD,assessed using the international index of EF(IIEF),to survey the prevalence of SexDys in this population,and to assess the correlation between various factors and SexDys through regression *** A systematic search of PubMed,EMBASE,Cochrane Library,Scopus,***,and Google Scholar was conducted,following the PRISMA 2020 *** and retrospective cohort studies,as well as cross-sectional studies assessing EF pre-and post-transplantation,were *** studies used validated tools such as the IIEF to measure ***-analyses were performed using a random-effects model to estimate standardized mean differences(SMD)and hazard ratios(HR)with 95%confidence intervals(CI).Heterogeneity was assessed using the I²statistic,and publication bias was evaluated with a funnel plot and the Egger’s *** A total of 2419 studies were identified,with 362 abstracts screened and 193 full-text articles ***,11 studies were included for qualitative analys

关键词： kidney transplantation Sexual dysfunction Erectile dysfunction International index of erectile function Syste-matic review Meta analyses

Donor-specific antibodies against HLA-C,HLA-DP and HLA-DQ and their implications in kidney transplantation

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World Journal of transplantation 2025年第2期15卷 30-48页

作者： Muhammad Abdul Mabood Khalil Nihal Mohammed Sadagah Ishida Hediki Jackson Tan Salem H Al-Qurashi Center of Renal Diseases and transplantation King Fahad Armed Forces Hospital JeddahJeddah 23311Saudi Arabia department of urology and transplantation Tokyo Women's Medical University HospitalTokyo 162-8666Japan department of Nephrology RIPAS Hospital Brunei DarussalamBrunei Muara BA1710Brunei Darussalam

HLA-C,HLA-DP and HLA-DQ are thought to be benign due to low expression and few initial negative ***,most allocation programs used HLA-A,HLA-B and HLA-DR antigens for *** the advent and use of single-bead antigen assays,more was learned about donor-specific antibodies(DSAs)against these *** in these antigens and antibodies grew when cases of acute antibody-mediated rejection(AMR),mixed rejections,chronic AMR,and reduced graft survival were reported with DSAs against these *** the deleterious effects of these DSAs are more pronounced in retransplants,harmful effects have also been observed in first-time *** against each of these antigens can trigger rejection *** combination with DSAs against HLA-A,HLA-B and HLA-DR can cause more *** has been shown that strategies that reduce mismatches for these antigen lead to fewer rejections and better graft *** is a need for greater consensus on the universal typing of these antigens prior to transplantation for better patient and graft *** review focuses on the interaction of these antigens with lymphocytes and killer immunoglobulin receptors,arguments for not typing them,detailed analyses of the literature about their harmful effects,potential strategies moving forward,and recommendations for the future.

关键词： kidney transplantation HLA-C HLA-DP HLA-DQ Donor specific antibodies Review

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China(Life Sciences) 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu department of Hepatobiliary and Pancreatic Surgery People’s Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui UniversityLishui 323000China NHFPC Key Laboratory of Combined Multi-Organ transplantation Hangzhou 310003China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People’s HospitalHangzhou 310006China department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of urology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310011China Hangzhou Medical College Hangzhou 310059China Zhejiang University School of Medicine Hangzhou 310058China

Dear Editor,Liver transplantation(LT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;Ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32.8%in 6 months after LT,is one of the major post-transplant complications(Toshima et al.,2020).With the prolongation of the recipient’s survival time,the incidence of PTHT is increasing,becoming an important factor that affects the recipient’s quality of life and survival *** with various metabolic complications,including PTHT,have a 1.78 times higher risk of atherosclerotic cardiovascular disease(ASCVD)development and death than recipients without these complications(Jiménez Pérez et al.,2016).Studies have shown that PTHT,accompanied by other posttransplant metabolic complications and immunosuppressants,are important risk factors for post-transplant ASCVD and mediate 19%–42% of nongraft-related deaths(Davis and Shadab Siddiqui,2017;Jiménez-Pérez et al.,2016).However,early prediction of PTHT remains a major challenge.

关键词： liver graft

Comparative study of living donor kidney transplants:Right vs left

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World Journal of transplantation 2025年第1期15卷 115-123页

作者： Taqi Khan Nadeem Ahmad Qaisar Iqbal Muneeb Hassan Lajward Asnath Naveed Khan Sajid Shakeel kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

Future of non-invasive graft evaluation:A systematic review of proteomics in kidney transplantation

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World Journal of transplantation 2025年第1期15卷 135-149页

作者： Eleni Avramidou Konstantina Psatha Kallisti St John Georgios Tsoulfas Michalis Aivaliotis department of transplantation Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece Laboratory of Medical Biology-Genetics School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Functional Proteomics and Systems Biology(FunPATh) Center for Interdisciplinary Research and Innovation(CIRI-AUTH)Thessaloniki GR-57001Greece Laboratory of Biological Chemistry School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered *** biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies(serum,urine)represent a promising innovation in the monitoring of kidney transplant *** To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft *** A systematic review was conducted in accordance with PRISMA guidelines,based on research results from the PubMed and Scopus *** primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related *** criteria included protein biomarkers and urine and blood samples,while exclusion criteria were language other than English and the use of low resolution and sensitivity *** selected research articles,were categorized based on the biological sample,condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and *** and network analysis of the selected proteins was *** In 17 included studies,58 proteins were studied,with the cytokine CXCL10 being the most *** pathways related to immune response and fibrosis have shown to be *** of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were ***,all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods,as far as renal graft assessment is *** Our review suggests that protein biomarkers,evaluated in specific biological fluids,can make a significant contribution to the timely,valid and non-invasive assessment of kidney graft.

关键词： Proteomics kidney transplantation Graft evaluation Non-invasive diagnosis kidney graft function

Basiliximab is superior to low dose rabbit anti-thymocyte globulin in pediatric kidney transplant recipients: The younger, the better

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中华医学杂志(英文版) 2025年第2期138卷 225-227页

作者： Zhu Lan Zhang Lei Shang Wenjun Liu Wenhua Sa Rula Guo Zhiliang Liu Longshan Tan Jinghong Zhang Hengxi Feng Yonghua Zhao Wenyu Cong Wenqi Wu Jianyong Wang Changxi Chen Gang Institute of Organ transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Organ Transplantation Ministry of Education NHC Key Laboratory of Organ Transplantation Key Laboratory of Organ Transplantation Chinese Academy of Medical Sciences Wuhan Hubei China department of Organ transplantation First Affiliated Hospital Naval Medical University Shanghai China department of Renal transplantation First Affiliated Hospital Zhengzhou University Zhengzhou Henan China Clinical Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Organ Transplant Center The First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong China Center of Nephrology First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China

Predictive value of tacrolimus concentration/dose ratio in first posttransplant week for CYP3A5-polymorphism in kidney-transplant recipients

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World Journal of transplantation 2025年第2期15卷 197-204页

作者： Pham-Thai Dung Hoang-Xuan Su Nguyen-Chi Tue Nguyen-Huu Ben Nguyen-Minh Phuong Tuan-Ngoc Tran Phan-Ba Nghia Diem-Thi Van Nguyen Thi-Thuy Dung Hoang-Trung Vinh Lionel Rostaing Pham-Quoc Toan Center of Critical Care Medicine Emergency and Clinical ToxicologyMilitary HospitalHanoï100000Viet Nam Institute of Biomedicine and Pharmacy Vietnam Military Medical UniversityHanoï100000Viet Nam department of Post-Transplant Intensive Care and Treatment Center of Organ Transplantation-Military HospitalHanoï100000Viet Nam department of Occupational Medicine Vietnam Military Medical UniversityHanoï100000Viet Nam department of Military Medical Command and Organization Vietnam Military Medical UniversityHanoï100000Viet Nam department of Nephrology and Dialysis Military HospitalHanoï100000Viet Nam department of Nephrology HemodialysisApheresisand Kidney TransplantationGrenoble University HospitalGrenoble 38043Auvergne-Rhone-AlpesFrance

BACKGROUND Tacrolimus(TAC)is metabolized primarily by the CYP3A-encoded enzyme family(CYP3A4,CYP3A5,and CYP3A7).Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to reach therapeutic *** To evaluate the predictive value of the TAC concentration-to-dose(C0/D)ratio for identifying CYP3A5 poly-morphisms in renal transplant *** Eighty-six de novo kidney transplant recipients with TAC-based immunosuppression from the department of Nephrology and Dialysis at Military Hospital 103(Hanoi,Vietnam)were included in this retrospective *** samples were collected within the first week post-transplantation to monitor TAC levels and to perform genotyping for CYP3A5 genetic *** The CYP3A53/3 genotype was identified in 37 patients(43%),CYP3A51/3 in 40 patients(46.5%),and CYP3A51/1 in 9 patients(10.5%).Patients carrying the CYP3A51/3 or CYP3A51/1 genotype,classified as fast metabolizers(CYP3A5 expressers),had significantly lower TAC C0 concentrations and C0/D ratios compared to slow meta-bolizers(CYP3A53/3 genotype)at multiple time points during follow-up(all P<0.001).Notably,the TAC C0/D ratio obtained on day 1(0.91)was shown to predict CYP3A5 polymorphism with a sensitivity of 84.6%and a specificity of 84.6%.CONCLUSION This study demonstrates that the TAC C0/D ratio provides a reliable predictive value for CYP3A5 polymorphisms,which can be used to individualize TAC dosing in renal transplant recipients in Vietnam and other low-income countries.

关键词： Tacrolimus CYP3A5 Renal transplant recipient Concentration-to-dose kidney transplant

Providing care for kidney transplant recipients:An overview for generalists

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World Journal of Nephrology 2025年第1期14卷 41-51页

作者： Amer A Belal Alfonso H Santos Jr Amir Kazory Abhilash Koratala department of Nephrology Hypertension and Renal TransplantationUniversity of FloridaGainesvilleFL 32610United States department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

kidney transplantation is the preferred treatment for patients with advanced chronic kidney disease and end-stage kidney disease,offering superior quality of life and survival compared to *** manuscript provides an updated overview of post-transplant care,highlighting recent advancements and current practices to assist generalists in managing these *** covers key areas such as immunosuppression strategies,drug interactions,and the management of transplant-specific acute kidney *** focus includes the use of sodium-glucose cotransporter-2 inhibitors and cell-free DNA monitoring for evaluating allograft health and immune-mediated *** manuscript reviews the fundamentals of immunosuppression,including both induction and maintenance therapies,and underscores the importance of monitoring kidney function,as well as addressing hypertension,diabetes,and *** also provides recommen-dations for vaccinations and cancer screening tailored to kidney transplant reci-pients and emphasizes lifestyle management strategies,such as exercise and so-dium intake,to reduce post-transplant complications.

关键词： kidney transplantation Clinical practice guidelines Immunosuppression Cell-free DNA Sodium-glucose cotransporter-2 inhibitors Pregnancy