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Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-Yin Chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael Wong Anthony Chi-Fai Ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina department of urology Juntendo University Graduate School of MedicineTokyoJapan department of urology National University HospitalSingapore department of urology Beijing United Family HospitalBeijingChina department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of urology Department of SurgeryTuen Mun HospitalHong Kong department of urology Ramathibodi HospitalMahidol UniversitySalayaThailand department of urology Beijing HospitalBeijingChina department of urology Chiangmai Ram HospitalChiang MaiThailand International urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： TheFundamentalsof Laparoscopic Surgery The Objective Structured Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

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Outcomes of a non-randomised audit of single pigtail suture stents in urolithiasis management of Asian patients in Singapore

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Asian Journal of urology 2024年第2期11卷 324-330页

作者： Ee Jean Lim Zhen Wei Choo Reshma Mangat Pradeep Durai Sarvajit Biligere Yiquan Tan Loh Hin Yeung Marcus Nicole Andrea Seet Li Ting Chin Tiong Heng Stefania Ferreti Vineet Gauhar urology department Singapore General HospitalSingapore urology department Tan Tock Seng HospitalSingapore urology department Ng Teng Fong HospitalSingapore urology department Azienda Ospedaliera-Uiversitaria(Hospital and University of Parma)ParmaItaly

Objective:Double-J(DJ)ureteric stents are commonly placed perioperatively for semirigid or flexible ureteroscopic renal *** is believed that lesser stent material within the bladder mitigates stent-related *** study aimed to evaluate the J-Fil ureteral stent,a single pigtail suture stent compared with conventional DJ stent in relation to stent symptoms in an Asian population undergoing ureterorenal ***:Based on internal audit committee recommendation approval,the records of 50 patients retrieved,available data of 41 patients who were prospectively enrolled into two groups(Group 1[J-Fil stent group],n=21 and Group 2[DJ stent group],n=20)between August 2020 to January 2021,were *** compared were nature of procedure,stone location and size,ease of deployment or removal,and complications.A modified universal stent symptom questionnaire was used to assess morbidity of stent symptoms within 48 h of insertion and at ***:Both groups had similar median age,distribution in male to female ratio,and stone *** overall median universal stent symptom questionnaire score at insertion was similar for bladder pain,flank or loin pain,and quality of life between Group 1 and 2;however,at removal Group 1 fared significantly better than Group 2,especially for flank or loin pain and pain at *** groups had similar ease in insertion with no hospital ***:Our audit favoured the single pigtail suture stent in Asian ureters in mitigating stent-related *** showed a good safety profile with easy deployment and *** promises a new standard in stenting.

关键词： Stent Ureteroscopy Pigtail suture stent Asianpatient Flexible ureteroscopic renal surgery

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Long-term tadalafil once daily in Chinese men with erectile dysfunction:a 2-year final analysis of a post-marketing,multicenter,randomized,open-label trial

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Asian Journal of Andrology 2024年第3期26卷 282-287页

作者： Hui Jiang Lian-Ming Zhao Su Yan Ji-Hong Liu Zhao-Hui Zhu Jin-Dan Luo Yu-Tian Dai Fu-Biao Li Hao-Cheng Lin Zhi-Chao Zhang department of urology Peking University First HospitalBeijing 100000China department of urology Peking University Third HospitalBeijing 100191China department of urology Peking Union Medical College HospitalBeijing 100730China department of urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of urology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China departmentof Andrology Nanjing Drum Tower HospitalNanjing 210008China department of Andrology The First Hospital of Jilin UniversityChangchun 130021China Andrology Center Department of UrologyPeking University First HospitalBeijing 100034China

The long-term safety and effectiveness of once-daily tadalafil is crucial,but limited data are available in Chinese patients witherectile dysfunction(ED).In this post-marketing,multicenter,randomized,open-label trial with 2-year follow-up,635 ED caseswere randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months,of whom 580 continued once-daily tadalafil 5 mg for21 ***-emergent adverse events in the 12-month and 24-month period were similar,with the most common beingviral upper respiratory tract infection,upper respiratory tract infection,and *** improvement from baseline inthe International Index of Erectile Function-Erectile Function(IIEF-EF)score was detected at month 12(least squares mean[LSM]change:7.9,95%confidence interval[CI]:7.5–8.4,P<0.001)and was maintained to month 24(LSM change:8.6,95%CI:8.1–9.0,P<0.001).The proportions of patients regaining normal erectile function(IIEF-EF score≥26)were 43.7%and 48.0%at months 12 and 24,*** Assessment Questionnaire results showed improved erection function in 97.5%ofpatients and improved ability to engage in sexual activity in 95.9%of patients at month 12;these values were 96.1%and 95.0%at month 24,*** quality of sexual life score based on the Sexual Life Quality Questionnaire(SLQQ)was increased by52.2%at month 12 and by 55.3%at month 24(both P<0.001).The treatment satisfaction score determined by SLQQ(mean±standard deviation)was 62.4±21.0 at month 12 versus 65.9±20.2 at month ***-year daily application of tadalafil 5mg in Chinese men with ED showed a favorable safety profile and durable improvement in sexual performance and satisfaction.

关键词： clinical trial erectile dysfunction long-term safety once-daily dosing tadalafil

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A multicenter uroflowmetry study of healthy women in China

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Chinese Medical Journal 2024年第10期137卷 1225-1227页

作者： Xiaodong Liu Lingfeng Meng Jiawen Wang Tianming Ma Benkang Shi Hai Huang Qingwei Wang Min Chen Limin Liao Hong Shen Zhongqing Wei Yuansong Xiao Tiejun Pan Jian Ren Peng Zhang Xiaojun Tian Yaoguang Zhang department of urology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China department of urology Qilu HospitalShandong UniversityJinanShandong 250013China department of urology SUN YAT-SEN Memorial HospitalGuangzhouGuangdong 510235China department of urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450003China department of urology Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030China department of urology China Rehabilitation Research CenterBeijing 100068China department of urology West China HospitalChengduSichuan 610041China department of urology The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China department of urology General Hospital of Southern Theatre CommandGuangzhouGuangdong 510010China department of urology General Hospital of Central Theatre CommandWuhanHubei 430071China department of urology China-Japan Friendship HospitalBeijing 100029China department of urology Beijing Chao-Yang HospitalBeijing 100027China department of urology Peking University Third HospitalBeijing 100191China

Uroflowmetry is an uroflow measurement technique used to record the voided volume(VV)and flow rate,which can help clinicians objectively evaluate lower urinary tract ***,few uroflowmetry studies have focused on the female population,[1]especially on the uroflow curve standard ***,we sought to establish dependable uroflow reference values and nomograms for Chinese women and to evaluate the relationship between uroflow patterns and demographic data.

关键词： function. flowmetry analysis.

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M2 macrophage-related molecular subtypes and prognostic index for prostate cancer patients through integrating single-cell and bulk RNA sequencing analysis

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Genes & Diseases 2024年第4期11卷 131-133页

作者： Dechao Feng Xu Shi Dengxiong Li Ruicheng Wu Jie Wang Wuran Wei Ping Han department of urology Institute of UrologyWest China HospitalSichuan UniversityChengduSichuan 610041China

Prostate cancer(PCa)is considered as an age-related disease and accounts for the most prevalence of urinary malignancies in men.1 We previously analyzed the cellular landscape of tumor microenvironment in PCa patients,where we found that cancer-related fibroblasts might play an important role in tumorigenesis and the development of PCa and tumor-associated macrophage(TAM)could function synergistically with them.2 Thus,we further integrated single-cell and bulk RNA sequencing with meta-analysis to specify the prognostic effect of TAM on PCa and construct molecular subgroups and predictive index to guide clinical practice.

关键词： patients macrophage cancer

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Prevalence and risk evaluation of cardiovascular disease in the newly diagnosed prostate cancer population in China:A nationwide,multi-center,population-based cross-sectional study

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Chinese Medical Journal 2024年第11期137卷 1324-1331页

作者： Weiyu Zhang Huixin Liu Ming Liu Shi Ying Renbin Yuan Hao Zeng Zhenting Zhang Sujun Han Zhannan Si Bin Hu Simeng Wen Pengcheng Xu Weimin Yu Hui Chen Liang Wang Zhitao Lin Tao Dai Yunzhi Lin Tao Xu department of urology Peking University People’s HospitalBeijing 100044China department of Clinical Epidemiology and Biostatistics Peking University People’s HospitalBeijing 100044China department of urology Beijing HospitalNational Center of GerontologyBeijing 100005China Institute of Geriatric Medicine Chinese Academy of Medical SciencesBeijing 100005China department of urology Wuhan Union HospitalHuazhong University of Science&TechnologyWuhanHubei 430022China department of urology The Third People’s Hospital of ChengduChengduSichuan 610014China department of urology West China Hospital of Sichuan UniversityChengduSichuan 610041China department of Urologic Oncology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China department of urology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China National Cancer Center Beijing 100021China National Clinical Research Center for Cancer Beijing 100021China department of urology Liaoning Cancer HospitalShenyangLiaoning 110801China department of urology The Second Hospital of Tianjin Medical UniversityTianjin 300141China Tianjin Institute of urology Tianjin Medical UniversityTianjin 300141China department of urology Lu’an Affiliated Hospital of Anhui Medical UniversityLu’anAnhui 237322China department of urology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of urology Harbin Medical University Affiliated Cancer HospitalHarbinHeilongjiang 150081China department of urology The Second Hospital of Dalian Medical UniversityDalianLiaoning 116023China department of urology Surgery Fujian Cancer HospitalFuzhouFujian 350014China department of urology Surgery Hunan Cancer HospitalChangshaHunan 410031China department of urology Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China

Background:Cardiovascular disease(CVD)has emerged as the leading cause of death from prostate cancer(PCa)in recent decades,bringing a great disease burden *** with preexisting CVD have an increased risk for major adverse cardiovascular events when treated with androgen deprivation therapy(ADT).The present study aimed to explore the prevalence and risk evaluation of CVD among people with newly diagnosed PCa in ***:Clinical data of newly diagnosed PCa patients were retrospectively collected from 34 centers in China from 2010 to 2022 through convenience *** was defined as myocardial infarction,arrhythmia,heart failure,stroke,ischemic heart disease,and *** risk was estimated by calculating Framingham risk scores(FRS).Patients were accordingly divided into low-,medium-,and high-risk groups.χ2 or Fisher’s exact test was used for comparison of categorical ***:A total of 4253 patients were enrolled in the present study.A total of 27.0%(1147/4253)of patients had comorbid PCa and CVD,and 7.2%(307/4253)had two or more *** enrolled population was distributed in six regions of China,and approximately 71.0%(3019/4253)of patients lived in urban *** imaging and pathological evaluation,most PCa patients were diagnosed at an advanced stage,with 20.5%(871/4253)locally progressing and 20.5%(871/4253)showing *** of them initiated prostatectomy(46.6%,1983/4253)or regimens involving ADT therapy(45.7%,1944/4253)for prostate *** the present PCa cohort,43.1%(1832/4253)of patients had hypertension,and half of them had poorly controlled blood *** FRS stratification,as expected,a higher risk of CVD was related to aging and metabolic ***,we also found that patients with treatment involving ADT presented an originally higher risk of CVD than those without *** was in accordance with clinical practice,i.e.,aged patients or patients at advanced oncological stages were inclined to accept sys

关键词： Prostate cancer Castration Cardiovascular disease Prevalence Cardiovascular risk

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Prevention of complications in endourological management of stones:What are the basic measures needed before,during,and after interventions?

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Asian Journal of urology 2024年第2期11卷 180-190页

作者： Eric Edison Giorgio Mazzon Vimoshan Arumuham Simon Choong department of urology University College Hospital LondonLondonUK department of urology San Bassiano HospitalVicenzaItaly

Objective:This narrative review aims to describe measures to minimise the risk of complications during percutaneous nephrolithotomy(PCNL),ureteroscopy,and retrograde intrarenal ***:A literature search was conducted from the PubMed/PMC database for papers published within the last 10 years(January 2012 to December 2022).Search terms included“ureteroscopy”,“retrograde intrarenal surgery”,“PCNL”,“percutaneous nephrolithotomy”,“complications”,“sepsis”,“infection”,“bleed”,“haemorrhage”,and“hemorrhage”.Key papers were identified and included meta-analyses,systematic reviews,guidelines,and primary *** references of these papers were searched to identify any further relevant papers not included ***:The evidence is assimilated with the opinions of the authors to provide *** practice pathways for patient care in the pre-operative,intra-operative,and post-operative periods are described,including the identification and management of residual *** complications(sepsis and stent issues)that are relevant for any endourological procedure are then be ***-specific considerations are then *** measures for PCNL include optimising access to minimise the chance of bleeding or visceral *** role of endoscopic combined intrarenal surgery in this regard is *** measures for ureteroscopy and retrograde intrarenal surgery include planning and technique to minimise the risk of ureteric *** role of anaesthetic assessment is *** importance of specific comorbidities on each step of the pathway is highlighted as ***:This review demonstrates that the principles of meticulous planning,interdisciplinary teamworking,and good operative technique can minimise the risk of complications in endourology.

关键词： Endourology Ureteroscopy Retrogradeintrarenal surgery Percutaneous nephrolithotomy Complications Sepsis Stent

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Diagnosing upper tract urothelial carcinoma: A review of the role of diagnostic ureteroscopy and novel developments over last two decades

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Asian Journal of urology 2024年第2期11卷 242-252页

作者： Paul Gravestock Daniel Cullum Bhaskar Somani Rajan Veeratterapillay urology department Freeman HospitalNewcastle Upon TyneUK department of urology University Hospital SouthamptonSouthamptonUK

Objective: The role of ureteroscopy in the diagnosis of upper tract urothelial carcinoma is yet to be fully determined. We aimed to provide an up to date evaluation of its role and the emerging technologies in the ***: A literature search of the last two decades (from 24th May, 2001 to 24th May, 2021) was carried out identifying 147 papers for potential inclusion within this narrative ***: Diagnostic ureteroscopy is undeniably useful in its ability to visualise and biopsy indeterminate lesions, and to risk stratify malignant lesions that may be suitable for kidney sparing surgery. However, an increased risk of intravesical recurrence following nephroureterectomy when a prior diagnostic ureteroscopy has been performed, inadequate sampling at biopsy, complications from the procedure, and difficult ureteric access are all potential drawbacks. Furthermore, whilst generally an accurate diagnostic procedure, it risks missing carcinoma in-situ lesions. Despite this, evidence shows that routine use of ureteroscopy changes the management of patients in a large proportion of cases, preventing unnecessary surgery or facilitating kidney sparing surgery. The overall rate of complications is low, and improved biopsy techniques and the use of tissue biomarkers for improved staging and grading are encouraging. The risks of delays to definitive management and post-ureteroscopy intravesical recurrence do not seem to affect survival, and trials are in progress to determine whether intravesical therapy can mitigate the latter. Further promising techniques are being investigated to improve shortcomings, particularly in relation to improved diagnosis of carcinoma in situ and preoperative ***: Ureteroscopy has a role in the diagnosis of upper tract malignancy, though whether it should be used routinely is yet to be determined.

关键词： Ureteroscopy Carcinoma Transitional cell Ureteralneoplasms Urinary bladder neoplasms Carcinomainsitu Biopsy

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Effect of high-protein peptide-based formula compared with isocaloric isonitrogenous polymeric formula in critically ill surgical patient

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1765-1774页

作者： Preeda Sumritpradit Prapimporn Chattranukulchai Shantavasinkul Winai Ungpinitpong Pinit Noorit Chotip Gajaseni Division of Trauma Surgery and Surgical Critical Care Department of SurgeryFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Division of Nutrition and Biochemical Medicine Department of MedicineFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand Graduate Program in Nutrition Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand department of Surgery Surin HospitalSurin 32000Thailand department of Surgery Chonburi HospitalChonburi 20000Thailand department of Nursing Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkok 10400Thailand

BACKGROUND Malnutrition is common in critically ill patients,and it is associated with an increased risk of *** enteral nutrition with adequate caloric and protein intake is critical nevertheless it is difficult to ***-based formulas have been shown to be beneficial in patients with feeding ***,there are limited studies showing the efficacy and safety of high-protein peptide-based formula in critically ill surgical *** To determine the effects of a high-protein peptide formulation on gastrointestinal tolerance,nutritional status,biochemical changes,and adverse events in patients in the surgery intensive care unit(SICU)compared to an isocaloric isonitrogenous standard polymeric *** This study was a multi-center double-blind,randomized controlled *** enrolled adult patients in the surgical intensive care unit,age≥15 years and expected to receive enteral feeding for at least 5-14 d *** were randomly assigned to receive either the high-protein peptide-based formula or the isocaloric isonitrogenous standard formula for 14 *** residual volume(GRV),nutritional status,body composition and biochemical parameters were assessed at baseline and on days 3,5,7,9,11,and *** A total of 19 patients were enrolled,9 patients in the peptide-based formula group and 10 patients in the standard formula *** the study period,there were no differences of the average GRV,body weight,body composition,nutritional status and biochemical parameters in the patients receiving peptide-based formula,compared to the standard ***,participants in the standard formula lost their body weight,body mass index(BMI)and skeletal muscle mass *** body weight,BMI and muscle mass were maintained in the peptide-based formula,from baseline to day ***,the participants in the peptide-based formula tended to reach their caloric target faster than the standard ***

关键词： Peptide-based formula Surgical intensive care Hydrolyzed protein Surgery Nutritional support

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Prostate health index can stratify patients with Prostate Imaging Reporting and Data System score 3 lesions on magnetic resonance imaging to reduce prostate biopsies

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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-Kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho Ip Ada Tsui-Lin Ng Yiu-Chung Lam Division of urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with Prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary hospital and Princess Margaret hospital,Hong Kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had Prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had Prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health index<25.0,7.4%in prostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(P<0.01).Among the patients,26.9%could have avoided a biopsy with a prostate health index<25.0,at the expense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with Prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

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